Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DD7 | C | Ion | Calcium-sensing | CaS | Gallus gallus | Ca | Ca; Ca; Tryptophan; Evocalcet | - | 3.2 | 2021-06-16 | 10.1126/sciadv.abg1483 |
![](/psngpcr/ligands/H43/H43_7DD7_W_W_1108.png)
A 2D representation of the interactions of H43 in 7DD7 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E837 | R:R:F668 | 8.16 | 14 | No | Yes | 6 | 8 | 1 | 2 | R:R:F668 | R:R:I841 | 2.51 | 14 | Yes | No | 8 | 8 | 2 | 2 | R:R:P682 | R:R:Q681 | 3.16 | 0 | No | No | 5 | 5 | 2 | 1 | R:R:L773 | R:R:Q681 | 3.99 | 0 | Yes | No | 6 | 5 | 2 | 1 | R:R:Q681 | W:W:?1108 | 11.56 | 0 | No | Yes | 5 | 0 | 1 | 0 | R:R:F684 | R:R:F688 | 7.5 | 0 | No | Yes | 7 | 7 | 1 | 2 | R:R:F684 | R:R:I841 | 13.82 | 0 | No | No | 7 | 8 | 1 | 2 | R:R:F684 | W:W:?1108 | 23.79 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:F688 | R:R:F814 | 7.5 | 0 | Yes | No | 7 | 7 | 2 | 2 | R:R:E767 | R:R:H766 | 3.69 | 0 | No | No | 8 | 7 | 1 | 2 | R:R:E767 | R:R:L773 | 2.65 | 0 | No | Yes | 8 | 6 | 1 | 2 | R:R:E767 | W:W:?1108 | 2.88 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:I777 | W:W:?1108 | 17.56 | 0 | No | Yes | 6 | 0 | 1 | 0 | R:R:F814 | R:R:W818 | 6.01 | 0 | No | No | 7 | 5 | 2 | 1 | R:R:A840 | R:R:W818 | 2.59 | 0 | No | No | 9 | 5 | 2 | 1 | R:R:W818 | W:W:?1108 | 18.95 | 0 | No | Yes | 5 | 0 | 1 | 0 | R:R:I822 | R:R:P823 | 6.77 | 0 | No | No | 9 | 8 | 1 | 2 | R:R:V833 | R:R:Y825 | 6.31 | 0 | No | No | 8 | 6 | 2 | 1 | R:R:E837 | R:R:Y825 | 14.59 | 14 | No | No | 6 | 6 | 1 | 1 | R:R:Y825 | W:W:?1108 | 27.99 | 14 | No | Yes | 6 | 0 | 1 | 0 | R:R:E837 | W:W:?1108 | 16.3 | 14 | No | Yes | 6 | 0 | 1 | 0 | R:R:G685 | W:W:?1108 | 2.48 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:I822 | W:W:?1108 | 2.07 | 0 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 13.73 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 23.00 | Average Links Mediated by Hubs In Shell | 15.00 |
| ![](/psngpcr/ligands/H43/H43_7DD7_W_W_1108_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/H43/H43_7DD7_W_W_1108_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/H43/H43_7DD7_X_X_1110.png)
A 2D representation of the interactions of H43 in 7DD7 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:E837 | S:S:F668 | 7 | 18 | No | Yes | 7 | 8 | 1 | 2 | S:S:F668 | S:S:I841 | 2.51 | 18 | Yes | Yes | 8 | 8 | 2 | 2 | S:S:P682 | S:S:Q681 | 3.16 | 0 | No | No | 5 | 5 | 2 | 1 | S:S:L773 | S:S:Q681 | 3.99 | 0 | Yes | No | 5 | 5 | 2 | 1 | S:S:Q681 | X:X:?1110 | 11.56 | 0 | No | Yes | 5 | 0 | 1 | 0 | S:S:F684 | S:S:F688 | 6.43 | 0 | No | Yes | 6 | 8 | 1 | 2 | S:S:F684 | S:S:I841 | 12.56 | 0 | No | Yes | 6 | 8 | 1 | 2 | S:S:F684 | X:X:?1110 | 22.03 | 0 | No | Yes | 6 | 0 | 1 | 0 | S:S:E767 | S:S:H766 | 3.69 | 0 | No | No | 7 | 7 | 1 | 2 | S:S:E767 | S:S:L773 | 2.65 | 0 | No | Yes | 7 | 5 | 1 | 2 | S:S:E767 | X:X:?1110 | 2.88 | 0 | No | Yes | 7 | 0 | 1 | 0 | S:S:I777 | X:X:?1110 | 17.56 | 0 | No | Yes | 5 | 0 | 1 | 0 | S:S:I822 | S:S:P823 | 6.77 | 0 | No | No | 8 | 8 | 1 | 2 | S:S:V833 | S:S:Y825 | 11.36 | 0 | No | No | 8 | 7 | 2 | 1 | S:S:E837 | S:S:Y825 | 14.59 | 18 | No | No | 7 | 7 | 1 | 1 | S:S:Y825 | X:X:?1110 | 13.57 | 18 | No | Yes | 7 | 0 | 1 | 0 | S:S:E837 | X:X:?1110 | 17.26 | 18 | No | Yes | 7 | 0 | 1 | 0 | S:S:G685 | X:X:?1110 | 2.48 | 0 | No | Yes | 6 | 0 | 1 | 0 | S:S:I822 | X:X:?1110 | 2.07 | 0 | No | Yes | 8 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 11.18 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 19.00 | Average Links Mediated by Hubs In Shell | 14.00 |
| ![](/psngpcr/ligands/H43/H43_7DD7_X_X_1110_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/H43/H43_7DD7_X_X_1110_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7M3G | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 | - | 2.5 | 2021-06-30 | 10.1038/s41586-021-03691-0 |
![](/psngpcr/ligands/H43/H43_7M3G_W_W_901.png)
A 2D representation of the interactions of H43 in 7M3G colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:C661 | R:R:F684 | 2.79 | 10 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:C661 | R:R:F688 | 2.79 | 10 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:F684 | R:R:S664 | 3.96 | 10 | Yes | No | 8 | 6 | 1 | 2 | R:R:E837 | R:R:F668 | 9.33 | 10 | Yes | No | 9 | 9 | 1 | 2 | R:R:E767 | R:R:Q681 | 5.1 | 0 | No | Yes | 7 | 9 | 2 | 1 | R:R:L773 | R:R:Q681 | 2.66 | 10 | No | Yes | 8 | 9 | 1 | 1 | R:R:E837 | R:R:Q681 | 3.82 | 10 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:Q681 | W:W:?901 | 12.52 | 10 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:F684 | R:R:F688 | 11.79 | 10 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:F684 | R:R:I841 | 13.82 | 10 | Yes | No | 8 | 9 | 1 | 2 | R:R:F684 | W:W:?901 | 13.22 | 10 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:F688 | R:R:F814 | 7.5 | 10 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:L773 | W:W:?901 | 3 | 10 | No | Yes | 8 | 0 | 1 | 0 | R:R:G774 | R:R:I777 | 3.53 | 0 | No | No | 4 | 8 | 2 | 1 | R:R:I777 | W:W:?901 | 11.36 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:T780 | W:W:?901 | 6.4 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:C781 | W:W:?901 | 3.44 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:F814 | R:R:W818 | 6.01 | 10 | Yes | No | 9 | 9 | 2 | 1 | R:R:A840 | R:R:W818 | 7.78 | 0 | No | No | 9 | 9 | 2 | 1 | R:R:W818 | W:W:?901 | 23.07 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:I822 | R:R:P823 | 3.39 | 0 | No | No | 7 | 9 | 1 | 2 | R:R:I822 | W:W:?901 | 4.13 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:Y825 | R:R:Y829 | 5.96 | 10 | Yes | No | 9 | 6 | 1 | 2 | R:R:V833 | R:R:Y825 | 5.05 | 0 | No | Yes | 6 | 9 | 2 | 1 | R:R:E837 | R:R:Y825 | 8.98 | 10 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:Y825 | W:W:?901 | 13.57 | 10 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:E837 | W:W:?901 | 5.75 | 10 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:G685 | W:W:?901 | 2.48 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:G778 | R:R:I777 | 1.76 | 0 | No | No | 5 | 8 | 2 | 1 | R:R:L770 | R:R:L773 | 1.38 | 0 | No | No | 3 | 8 | 2 | 1 | R:R:I819 | W:W:?901 | 1.03 | 0 | No | Yes | 6 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 8.33 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 26.00 |
| ![](/psngpcr/ligands/H43/H43_7M3G_W_W_901_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/H43/H43_7M3G_W_W_901_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/H43/H43_7M3G_X_X_901.png)
A 2D representation of the interactions of H43 in 7M3G colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:C661 | S:S:F684 | 2.79 | 8 | No | Yes | 7 | 8 | 2 | 1 | S:S:C661 | S:S:S687 | 3.44 | 8 | No | No | 7 | 6 | 2 | 2 | S:S:C661 | S:S:F688 | 2.79 | 8 | No | Yes | 7 | 8 | 2 | 2 | S:S:F684 | S:S:S664 | 5.28 | 8 | Yes | No | 8 | 6 | 1 | 2 | S:S:E837 | S:S:F668 | 8.16 | 8 | No | No | 9 | 9 | 1 | 2 | S:S:Q681 | S:S:W742 | 3.29 | 8 | No | Yes | 9 | 9 | 1 | 2 | S:S:E767 | S:S:Q681 | 5.1 | 8 | No | No | 7 | 9 | 1 | 1 | S:S:Q681 | X:X:?901 | 14.45 | 8 | No | Yes | 9 | 0 | 1 | 0 | S:S:F684 | S:S:S687 | 2.64 | 8 | Yes | No | 8 | 6 | 1 | 2 | S:S:F684 | S:S:F688 | 7.5 | 8 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:F684 | S:S:I841 | 21.35 | 8 | Yes | No | 8 | 9 | 1 | 2 | S:S:F684 | X:X:?901 | 15.86 | 8 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:F688 | S:S:F814 | 8.57 | 8 | Yes | Yes | 8 | 9 | 2 | 2 | S:S:Q735 | S:S:V689 | 7.16 | 8 | Yes | No | 9 | 7 | 2 | 2 | S:S:T780 | S:S:V689 | 4.76 | 8 | No | No | 7 | 7 | 1 | 2 | S:S:Q735 | S:S:T780 | 2.83 | 8 | Yes | No | 9 | 7 | 2 | 1 | S:S:E767 | X:X:?901 | 2.88 | 8 | No | Yes | 7 | 0 | 1 | 0 | S:S:I777 | S:S:L773 | 4.28 | 8 | No | No | 8 | 8 | 1 | 1 | S:S:L773 | X:X:?901 | 5.01 | 8 | No | Yes | 8 | 0 | 1 | 0 | S:S:I777 | X:X:?901 | 7.23 | 8 | No | Yes | 8 | 0 | 1 | 0 | S:S:T780 | X:X:?901 | 5.33 | 8 | No | Yes | 7 | 0 | 1 | 0 | S:S:F814 | S:S:W818 | 6.01 | 8 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:W818 | S:S:Y825 | 3.86 | 8 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:A840 | S:S:W818 | 7.78 | 0 | No | Yes | 9 | 9 | 2 | 1 | S:S:W818 | X:X:?901 | 16.48 | 8 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:V836 | S:S:Y825 | 5.05 | 0 | No | Yes | 8 | 9 | 2 | 1 | S:S:E837 | S:S:Y825 | 12.35 | 8 | No | Yes | 9 | 9 | 1 | 1 | S:S:Y825 | X:X:?901 | 3.39 | 8 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:E837 | X:X:?901 | 9.59 | 8 | No | Yes | 9 | 0 | 1 | 0 | S:S:V833 | S:S:Y825 | 2.52 | 0 | No | Yes | 6 | 9 | 2 | 1 | S:S:G685 | X:X:?901 | 2.48 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:G778 | S:S:I777 | 1.76 | 0 | No | No | 5 | 8 | 2 | 1 | S:S:L770 | S:S:L773 | 1.38 | 0 | No | No | 3 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 8.27 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 26.00 |
| ![](/psngpcr/ligands/H43/H43_7M3G_X_X_901_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/H43/H43_7M3G_X_X_901_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|