CodeHCY
NameHydrocortisone
Synonyms11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
Identifier(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
FormulaC21 H30 O5
Molecular Weight362.46
SMILESC[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
PubChem5754
Formal Charge0
Total Atoms56
Total Chiral Atoms7
Total Bonds59
Total Aromatic Bonds0
Networks1
 missing image

This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7D77 B2 Adhesion Adhesion ADGRG3 Homo sapiens Hydrocortisone - Go/Beta1/Gamma2 2.9 2021-02-03 10.1038/s41586-020-03083-w

A 2D representation of the interactions of HCY in 7D77
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F323 R:R:S272 5.28 6 Yes No 9 8 1 2
R:R:C276 R:R:N320 6.3 0 No Yes 7 7 2 2
R:R:C276 R:R:F323 5.59 0 No Yes 7 9 2 1
R:R:N320 R:R:S279 7.45 6 Yes Yes 7 9 2 2
R:R:N510 R:R:S279 5.96 6 No Yes 9 9 1 2
R:R:L319 R:R:L349 4.15 0 No No 8 7 1 2
L:L:?4 R:R:L319 3.78 6 Yes No 0 8 0 1
R:R:N320 R:R:N510 12.26 6 Yes No 7 9 2 1
R:R:F323 R:R:V327 7.87 6 Yes No 9 5 1 2
R:R:F323 R:R:F345 8.57 6 Yes Yes 9 8 1 1
L:L:?4 R:R:F323 14.14 6 Yes Yes 0 9 0 1
R:R:F345 R:R:N326 8.46 6 Yes No 8 6 1 2
R:R:F345 R:R:W421 7.02 6 Yes Yes 8 8 1 1
L:L:?4 R:R:F345 3.33 6 Yes Yes 0 8 0 1
R:R:F353 R:R:L349 3.65 15 Yes No 8 7 2 2
R:R:F353 R:R:W490 6.01 15 Yes Yes 8 9 2 1
R:R:M356 R:R:W490 5.82 0 No Yes 9 9 2 1
R:R:W421 R:R:Y406 9.65 6 Yes No 8 2 1 2
R:R:F422 R:R:W421 15.03 6 Yes Yes 7 8 2 1
R:R:L431 R:R:W421 3.42 6 No Yes 6 8 2 1
L:L:?4 R:R:W421 3.89 6 Yes Yes 0 8 0 1
R:R:F422 R:R:L431 8.53 6 Yes No 7 6 2 2
R:R:Q513 R:R:W490 7.67 0 No Yes 9 9 2 1
L:L:?4 R:R:W490 3.89 6 Yes Yes 0 9 0 1
R:R:G499 R:R:L498 3.42 0 No Yes 5 4 2 1
R:R:F506 R:R:L498 3.65 0 No Yes 9 4 2 1
L:L:?4 R:R:N510 6.57 6 Yes No 0 9 0 1
L:L:?4 R:R:L498 2.84 6 Yes Yes 0 4 0 1
R:R:L268 R:R:L498 2.77 0 Yes Yes 9 4 2 1
R:R:F345 R:R:G342 1.51 6 Yes No 8 9 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.49
Average Nodes In Shell25.00
Average Hubs In Shell11.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.49
Average Nodes In Shell25.00
Average Hubs In Shell11.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell29.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)