CodeHYP
NameHydroxyproline
SynonymsHYDROXYPROLINE
Identifier
FormulaC5 H9 N O3
Molecular Weight131.13
SMILES
PubChem5810
Formal Charge0
Total Atoms18
Total Chiral Atoms2
Total Bonds18
Total Aromatic Bonds0
Networks4
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This ligand is also present in the following 4 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZCJ A Peptide Somatostatin SST5 Homo Sapiens Pasireotide - Gi1/Beta1/Gamma1 3.09 2024-07-10 doi.org/10.1038/s41401-024-01314-8

A 2D representation of the interactions of HYP in 8ZCJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:?2 18.22 1 Yes Yes 0 0 1 2
L:L:?1 L:L:?6 20.99 1 Yes No 0 0 1 0
L:L:?1 R:R:I202 4.52 1 Yes Yes 0 5 1 2
L:L:?1 R:R:N268 7.61 1 Yes Yes 0 5 1 2
L:L:?1 R:R:N271 6.53 1 Yes No 0 4 1 1
L:L:?2 R:R:N268 8.69 1 Yes Yes 0 5 2 2
L:L:?5 L:L:Y4 3.65 1 Yes No 0 0 1 2
L:L:?5 L:L:?6 31.44 1 Yes No 0 0 1 0
L:L:?5 R:R:L276 5.39 1 Yes Yes 0 1 1 2
L:L:?5 R:R:S282 5.85 1 Yes No 0 5 1 2
L:L:?5 R:R:Y286 13.69 1 Yes No 0 4 1 2
L:L:?6 R:R:N271 8.76 1 No No 0 4 0 1
R:R:I202 R:R:N268 4.25 1 Yes Yes 5 5 2 2
R:R:N268 R:R:Y286 4.65 1 Yes No 5 4 2 2
R:R:L276 R:R:N271 6.87 1 Yes No 1 4 2 1
R:R:L276 R:R:S282 7.51 1 Yes No 1 5 2 2
L:L:?5 R:R:A283 2.45 1 Yes No 0 4 1 2
L:L:?1 R:R:L272 2.19 1 Yes No 0 4 1 2
L:L:?5 R:R:Q278 2.07 1 Yes No 0 1 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength20.40
Average Nodes In Shell14.00
Average Hubs In Shell6.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZJE A Peptide Kisspeptin Kiss1 Homo Sapiens TAK-448 - chim(NtGi1-Gq)/Beta1/Gamma1 3.07 2024-07-03 doi.org/10.1016/j.celrep.2024.114389

A 2D representation of the interactions of HYP in 8ZJE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S184 R:R:Y190 3.82 0 No No 3 4 2 1
L:L:?3 R:R:Y190 24.58 1 Yes No 0 4 0 1
L:L:N4 R:R:Y190 5.81 0 No No 0 4 2 1
L:L:?7 R:R:C191 4.08 1 No Yes 0 9 1 2
L:L:L8 R:R:C191 3.17 1 Yes Yes 0 9 2 2
R:R:F282 R:R:Q286 5.86 1 Yes No 5 4 2 2
R:R:F282 R:R:K305 19.85 1 Yes Yes 5 4 2 2
L:L:F6 R:R:F282 4.29 1 Yes Yes 0 5 1 2
L:L:F6 R:R:Q286 7.03 1 Yes No 0 4 1 2
L:L:F6 R:R:R297 3.21 1 Yes No 0 2 1 2
L:L:?2 R:R:Y299 5.61 1 No No 0 4 1 2
L:L:F6 R:R:K305 4.96 1 Yes Yes 0 4 1 2
L:L:?1 L:L:?2 24.1 1 No No 0 0 1 1
L:L:?1 L:L:?3 3.24 1 No Yes 0 0 1 0
L:L:?1 L:L:T5 5.67 1 No No 0 0 1 2
L:L:?2 L:L:?3 24.17 1 No Yes 0 0 1 0
L:L:?3 L:L:F6 3.33 1 Yes Yes 0 0 0 1
L:L:?3 L:L:?7 3.25 1 Yes No 0 0 0 1
L:L:?7 L:L:L8 4.75 1 No Yes 0 0 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub1.00
Average Interaction Strength11.71
Average Nodes In Shell16.00
Average Hubs In Shell6.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell14.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub1.50
Average Interaction Strength16.16
Average Nodes In Shell15.00
Average Hubs In Shell5.75
Average Links In Shell18.75
Average Links Mediated by Hubs In Shell15.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)