psnGPCR

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8XGU

Peptide

Kisspeptin

Kiss1

Homo Sapiens

TAK448

Gi1/Beta1/Gamma2

2024-10-30

doi.org/10.1126/sciadv.adn7771

A 2D representation of the interactions of HZP in 8XGU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	19.89	6	No	Yes	0	0	1	1
L:L:?1	L:L:?3	9.72	6	No	Yes	0	0	1	0
L:L:?1	L:L:T5	4.41	6	No	Yes	0	0	1	1
L:L:?2	L:L:?3	20.76	6	Yes	Yes	0	0	1	0
L:L:?2	L:L:T5	3.54	6	Yes	Yes	0	0	1	1
L:L:?2	R:R:Y299	7.5	6	Yes	No	0	4	1	2
L:L:?2	R:R:Y302	2.81	6	Yes	Yes	0	5	1	2
L:L:?3	L:L:N4	5.15	6	Yes	No	0	0	0	1
L:L:?3	L:L:T5	2.76	6	Yes	Yes	0	0	0	1
L:L:?3	R:R:Y190	11	6	Yes	Yes	0	4	0	1
L:L:N4	R:R:L102	6.87	6	No	No	0	5	1	2
L:L:N4	R:R:Y190	11.63	6	No	Yes	0	4	1	1
L:L:F6	L:L:T5	9.08	6	Yes	Yes	0	0	2	1
L:L:T5	R:R:Y302	7.49	6	Yes	Yes	0	5	1	2
R:R:G107	R:R:R188	4.5	6	No	Yes	5	2	2	2
R:R:G107	R:R:Y190	4.35	6	No	Yes	5	4	2	1
R:R:R188	R:R:Y190	15.43	6	Yes	Yes	2	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	9.88
Average Nodes In Shell	12.00
Average Hubs In Shell	7.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	16.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	4.50
Average Number Of Links With An Hub	2.50
Average Interaction Strength	10.77
Average Nodes In Shell	11.00
Average Hubs In Shell	6.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)