CodeLDP
NameDopamine
SynonymsDopaminum
Identifier
FormulaC8 H11 N O2
Molecular Weight153.178
SMILES
PubChem681
Formal Charge0
Total Atoms22
Total Chiral Atoms0
Total Bonds22
Total Aromatic Bonds6
Networks20
 missing image

This ligand is also present in the following 20 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CKZ A Amine Dopamine D1 Homo Sapiens Dopamine Mevidalen Gs/Beta1/Gamma2 3.1 2021-03-03 10.1016/j.cell.2021.01.028

A 2D representation of the interactions of LDP in 7CKZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 R:R:D103 11.93 1 Yes Yes 0 7 0 1
L:L:?2 R:R:I104 8.79 1 Yes No 0 6 0 1
L:L:?2 R:R:S107 15.84 1 Yes No 0 7 0 1
L:L:?2 R:R:S198 5.28 1 Yes No 0 7 0 1
L:L:?2 R:R:S202 9.24 1 Yes No 0 6 0 1
L:L:?2 R:R:F288 17.14 1 Yes Yes 0 7 0 1
L:L:?2 R:R:F289 16.07 1 Yes Yes 0 7 0 1
L:L:?2 R:R:N292 10.87 1 Yes No 0 6 0 1
L:L:?2 R:R:W321 6.01 1 Yes Yes 0 7 0 1
R:R:V73 R:R:V77 4.81 1 No No 8 8 2 2
R:R:V73 R:R:W321 3.68 1 No Yes 8 7 2 1
R:R:D103 R:R:V77 4.38 1 Yes No 7 8 1 2
R:R:V77 R:R:W321 4.9 1 No Yes 8 7 2 1
R:R:M78 R:R:W318 8.14 1 Yes Yes 7 5 2 2
R:R:M78 R:R:W321 6.98 1 Yes Yes 7 7 2 1
R:R:K81 R:R:W99 11.6 1 Yes Yes 6 5 2 2
R:R:K81 R:R:W318 5.8 1 Yes Yes 6 5 2 2
R:R:K81 R:R:W321 6.96 1 Yes Yes 6 7 2 1
R:R:D103 R:R:W99 10.05 1 Yes Yes 7 5 1 2
R:R:D103 R:R:S107 4.42 1 Yes No 7 7 1 1
R:R:D103 R:R:W321 12.28 1 Yes Yes 7 7 1 1
R:R:I104 R:R:S155 6.19 0 No No 6 7 1 2
R:R:S107 R:R:W285 4.94 1 No Yes 7 8 1 2
R:R:S202 R:R:T108 6.4 0 No No 6 6 1 2
R:R:S198 R:R:Y194 13.99 0 No Yes 7 7 1 2
R:R:F289 R:R:S199 7.93 1 Yes No 7 7 1 2
R:R:F203 R:R:F289 23.58 1 Yes Yes 8 7 2 1
R:R:F288 R:R:W285 5.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 7.02 1 Yes Yes 7 8 1 2
R:R:W285 R:R:W321 3.75 1 Yes Yes 8 7 2 1
R:R:F288 R:R:F289 12.86 1 Yes Yes 7 7 1 1
R:R:F288 R:R:N292 6.04 1 Yes No 7 6 1 1
R:R:F288 R:R:F313 5.36 1 Yes Yes 7 4 1 2
R:R:F288 R:R:V317 6.55 1 Yes No 7 6 1 2
R:R:F289 R:R:N292 4.83 1 Yes No 7 6 1 1
R:R:F313 R:R:V317 7.87 1 Yes No 4 6 2 2
R:R:V317 R:R:W321 7.36 1 No Yes 6 7 2 1
R:R:W318 R:R:W321 14.06 1 Yes Yes 5 7 2 1
L:L:?2 R:R:L190 2.43 1 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength10.36
Average Nodes In Shell25.00
Average Hubs In Shell13.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F0T A Amine Dopamine D1 Homo Sapiens Dopamine - Gs/Beta1/Gamma2 3.1 2022-06-15 10.1126/sciadv.abo4158

A 2D representation of the interactions of LDP in 7F0T
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D103 11.93 3 Yes Yes 0 7 0 1
L:L:?1 R:R:I104 10.04 3 Yes No 0 6 0 1
L:L:?1 R:R:S107 6.6 3 Yes Yes 0 7 0 1
L:L:?1 R:R:T108 5.18 3 Yes Yes 0 6 0 1
L:L:?1 R:R:L190 3.65 3 Yes No 0 4 0 1
L:L:?1 R:R:S198 9.24 3 Yes No 0 7 0 1
L:L:?1 R:R:F288 12.85 3 Yes Yes 0 7 0 1
L:L:?1 R:R:F289 9.64 3 Yes Yes 0 7 0 1
L:L:?1 R:R:N292 7.25 3 Yes No 0 6 0 1
L:L:?1 R:R:W321 3 3 Yes Yes 0 7 0 1
R:R:M78 R:R:V73 3.04 3 Yes Yes 7 8 2 2
R:R:V73 R:R:W321 3.68 3 Yes Yes 8 7 2 1
R:R:D103 R:R:V77 5.84 3 Yes No 7 8 1 2
R:R:V77 R:R:W321 3.68 3 No Yes 8 7 2 1
R:R:M78 R:R:W318 4.65 3 Yes Yes 7 5 2 2
R:R:M78 R:R:W321 8.14 3 Yes Yes 7 7 2 1
R:R:K81 R:R:W321 4.64 0 No Yes 6 7 2 1
R:R:D103 R:R:S107 4.42 3 Yes Yes 7 7 1 1
R:R:D103 R:R:W321 6.7 3 Yes Yes 7 7 1 1
R:R:I104 R:R:S155 3.1 0 No No 6 7 1 2
R:R:I104 R:R:Y194 8.46 0 No Yes 6 7 1 2
R:R:S107 R:R:W285 3.71 3 Yes Yes 7 8 1 2
R:R:S107 R:R:W321 4.94 3 Yes Yes 7 7 1 1
R:R:L112 R:R:T108 2.95 0 No Yes 5 6 2 1
R:R:S151 R:R:T108 4.8 0 No Yes 8 6 2 1
R:R:S202 R:R:T108 9.59 0 No Yes 6 6 2 1
R:R:S198 R:R:Y194 12.72 0 No Yes 7 7 1 2
R:R:F289 R:R:S199 7.93 3 Yes No 7 7 1 2
R:R:F203 R:R:W285 3.01 3 Yes Yes 8 8 2 2
R:R:F203 R:R:F289 15 3 Yes Yes 8 7 2 1
R:R:F288 R:R:W285 4.01 3 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 7.02 3 Yes Yes 7 8 1 2
R:R:F288 R:R:F289 5.36 3 Yes Yes 7 7 1 1
R:R:F288 R:R:N292 13.29 3 Yes No 7 6 1 1
R:R:F288 R:R:F313 4.29 3 Yes Yes 7 4 1 2
R:R:F288 R:R:V317 5.24 3 Yes No 7 6 1 2
R:R:F313 R:R:N292 3.62 3 Yes No 4 6 2 1
R:R:F313 R:R:V317 5.24 3 Yes No 4 6 2 2
R:R:V317 R:R:W321 6.13 3 No Yes 6 7 2 1
R:R:W318 R:R:W321 12.18 3 Yes Yes 5 7 2 1
R:R:I154 R:R:S198 1.55 0 No No 5 7 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.94
Average Nodes In Shell27.00
Average Hubs In Shell14.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F1O A Amine Dopamine D1 Homo Sapiens Dopamine GDP; Mg Gs/Beta1/Gamma2 3.13 2022-06-15 10.1126/sciadv.abo4158

A 2D representation of the interactions of LDP in 7F1O
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D103 10.96 1 Yes Yes 0 7 0 1
L:L:?1 R:R:I104 12.81 1 Yes No 0 6 0 1
L:L:?1 R:R:S107 6.74 1 Yes No 0 7 0 1
L:L:?1 R:R:T108 3.97 1 Yes No 0 6 0 1
L:L:?1 R:R:L190 3.73 1 Yes No 0 4 0 1
L:L:?1 R:R:S198 10.78 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F288 13.11 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F289 7.65 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N292 9.86 1 Yes Yes 0 6 0 1
R:R:D103 R:R:V77 5.84 1 Yes Yes 7 8 1 2
R:R:V77 R:R:W321 4.9 1 Yes Yes 8 7 2 2
R:R:D103 R:R:S107 4.42 1 Yes No 7 7 1 1
R:R:D103 R:R:W321 5.58 1 Yes Yes 7 7 1 2
R:R:I104 R:R:Y194 7.25 0 No Yes 6 7 1 2
R:R:S107 R:R:W285 3.71 1 No Yes 7 8 1 2
R:R:S202 R:R:T108 9.59 0 No No 6 6 2 1
R:R:I154 R:R:S198 4.64 0 No Yes 5 7 2 1
R:R:L190 R:R:Y194 5.86 1 No Yes 4 7 1 2
R:R:L190 R:R:N292 4.12 1 No Yes 4 6 1 1
R:R:S198 R:R:Y194 7.63 0 Yes Yes 7 7 1 2
R:R:F289 R:R:S199 3.96 1 Yes No 7 7 1 2
R:R:F203 R:R:W285 4.01 1 Yes Yes 8 8 2 2
R:R:F203 R:R:F289 18.22 1 Yes Yes 8 7 2 1
R:R:F288 R:R:W285 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 6.01 1 Yes Yes 7 8 1 2
R:R:F288 R:R:F289 7.5 1 Yes Yes 7 7 1 1
R:R:F288 R:R:N292 4.83 1 Yes Yes 7 6 1 1
R:R:F288 R:R:F313 6.43 1 Yes Yes 7 4 1 2
R:R:A195 R:R:N292 3.13 0 No Yes 5 6 2 1
R:R:S197 R:R:S198 1.63 0 No Yes 4 7 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.85
Average Nodes In Shell21.00
Average Hubs In Shell12.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F1Z A Amine Dopamine D1 Homo Sapiens Dopamine GDP Gs/Beta1/Gamma2 3.46 2022-06-15 10.1126/sciadv.abo4158

A 2D representation of the interactions of LDP in 7F1Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D103 13.39 1 Yes No 0 7 0 1
L:L:?1 R:R:I104 16.65 1 Yes No 0 6 0 1
L:L:?1 R:R:S107 12.12 1 Yes No 0 7 0 1
L:L:?1 R:R:T108 6.61 1 Yes Yes 0 6 0 1
L:L:?1 R:R:L190 4.97 1 Yes No 0 4 0 1
L:L:?1 R:R:S198 10.78 1 Yes No 0 7 0 1
L:L:?1 R:R:S202 8.08 1 Yes No 0 6 0 1
L:L:?1 R:R:F288 10.93 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N292 3.7 1 Yes No 0 6 0 1
L:L:?1 R:R:W321 5.11 1 Yes Yes 0 7 0 1
R:R:M78 R:R:V73 3.04 1 Yes Yes 7 8 2 2
R:R:V73 R:R:W321 4.9 1 Yes Yes 8 7 2 1
R:R:V77 R:R:W99 6.13 1 Yes Yes 8 5 2 2
R:R:D103 R:R:V77 5.84 1 No Yes 7 8 1 2
R:R:V77 R:R:W321 4.9 1 Yes Yes 8 7 2 1
R:R:M78 R:R:W321 6.98 1 Yes Yes 7 7 2 1
R:R:K81 R:R:W99 8.12 1 No Yes 6 5 2 2
R:R:K81 R:R:W321 3.48 1 No Yes 6 7 2 1
R:R:W321 R:R:W99 3.75 1 Yes Yes 7 5 1 2
R:R:D103 R:R:W321 13.4 1 No Yes 7 7 1 1
R:R:I104 R:R:S155 3.1 0 No No 6 7 1 2
R:R:I104 R:R:Y194 6.04 0 No Yes 6 7 1 2
R:R:S107 R:R:W285 6.18 1 No Yes 7 8 1 2
R:R:S107 R:R:W321 3.71 1 No Yes 7 7 1 1
R:R:L112 R:R:T108 2.95 0 No Yes 5 6 2 1
R:R:S151 R:R:T108 3.2 1 Yes Yes 8 6 2 1
R:R:S202 R:R:T108 6.4 1 No Yes 6 6 1 1
R:R:L190 R:R:Y194 7.03 1 No Yes 4 7 1 2
R:R:L190 R:R:N292 4.12 1 No No 4 6 1 1
R:R:S198 R:R:Y194 10.17 0 No Yes 7 7 1 2
R:R:F289 R:R:S202 6.61 1 Yes No 7 6 2 1
R:R:F288 R:R:W285 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 7.02 1 Yes Yes 7 8 2 2
R:R:F288 R:R:F289 7.5 1 Yes Yes 7 7 1 2
R:R:F288 R:R:N292 10.87 1 Yes No 7 6 1 1
R:R:F288 R:R:F313 6.43 1 Yes No 7 4 1 2
R:R:V317 R:R:W321 7.36 0 No Yes 6 7 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.23
Average Nodes In Shell24.00
Average Hubs In Shell12.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F23 A Amine Dopamine D1 Homo Sapiens Dopamine GDP Gs/Beta1/Gamma2 3.58 2022-06-15 10.1126/sciadv.abo4158

A 2D representation of the interactions of LDP in 7F23
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D103 15.83 2 Yes No 0 7 0 1
L:L:?1 R:R:I104 6.4 2 Yes No 0 6 0 1
L:L:?1 R:R:S107 5.39 2 Yes No 0 7 0 1
L:L:?1 R:R:T108 3.97 2 Yes No 0 6 0 1
L:L:?1 R:R:L190 3.73 2 Yes No 0 4 0 1
L:L:?1 R:R:F288 12.02 2 Yes Yes 0 7 0 1
L:L:?1 R:R:W321 6.13 2 Yes Yes 0 7 0 1
R:R:V73 R:R:W321 3.68 0 No Yes 8 7 2 1
R:R:D103 R:R:V77 5.84 2 No No 7 8 1 2
R:R:V77 R:R:W321 7.36 2 No Yes 8 7 2 1
R:R:M78 R:R:W318 5.82 2 Yes Yes 7 5 2 2
R:R:M78 R:R:W321 6.98 2 Yes Yes 7 7 2 1
R:R:D103 R:R:W321 6.7 2 No Yes 7 7 1 1
R:R:I104 R:R:Y194 8.46 0 No Yes 6 7 1 2
R:R:S107 R:R:W285 7.41 0 No Yes 7 8 1 2
R:R:S202 R:R:T108 9.59 0 No No 6 6 2 1
R:R:L190 R:R:Y194 4.69 0 No Yes 4 7 1 2
R:R:F288 R:R:W285 7.02 2 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 5.01 2 Yes Yes 7 8 2 2
R:R:F288 R:R:F289 5.36 2 Yes Yes 7 7 1 2
R:R:F288 R:R:N292 10.87 2 Yes No 7 6 1 2
R:R:F288 R:R:F313 6.43 2 Yes Yes 7 4 1 2
R:R:F288 R:R:V317 3.93 2 Yes No 7 6 1 2
R:R:F313 R:R:V317 3.93 2 Yes No 4 6 2 2
R:R:V317 R:R:W321 7.36 2 No Yes 6 7 2 1
R:R:W318 R:R:W321 13.12 2 Yes Yes 5 7 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.64
Average Nodes In Shell19.00
Average Hubs In Shell9.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F24 A Amine Dopamine D1 Homo Sapiens Dopamine GDP Gs/Beta1/Gamma2 4.16 2022-06-15 10.1126/sciadv.abo4158

A 2D representation of the interactions of LDP in 7F24
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V77 R:R:W99 3.68 2 No Yes 8 5 2 2
R:R:D103 R:R:V77 5.84 2 Yes No 7 8 1 2
R:R:V77 R:R:W321 3.68 2 No Yes 8 7 2 1
R:R:M78 R:R:W318 6.98 2 Yes Yes 7 5 2 2
R:R:M78 R:R:W321 9.31 2 Yes Yes 7 7 2 1
R:R:K81 R:R:W99 8.12 0 No Yes 6 5 2 2
R:R:K81 R:R:W321 5.8 0 No Yes 6 7 2 1
R:R:D103 R:R:W99 3.35 2 Yes Yes 7 5 1 2
R:R:I104 R:R:V100 3.07 0 No No 6 5 1 2
R:R:D103 R:R:S107 4.42 2 Yes No 7 7 1 1
R:R:D103 R:R:W321 5.58 2 Yes Yes 7 7 1 1
L:L:?1 R:R:D103 13.39 2 Yes Yes 0 7 0 1
R:R:I104 R:R:Y194 8.46 0 No Yes 6 7 1 2
L:L:?1 R:R:I104 17.93 2 Yes No 0 6 0 1
R:R:S107 R:R:W285 3.71 2 No Yes 7 8 1 2
L:L:?1 R:R:S107 10.78 2 Yes No 0 7 0 1
R:R:L112 R:R:T108 2.95 0 No No 5 6 2 1
R:R:S202 R:R:T108 9.59 2 No No 6 6 1 1
L:L:?1 R:R:T108 2.64 2 Yes No 0 6 0 1
R:R:S198 R:R:Y194 10.17 0 No Yes 7 7 1 2
L:L:?1 R:R:S198 9.43 2 Yes No 0 7 0 1
R:R:F289 R:R:S199 2.64 2 Yes No 7 7 1 2
L:L:?1 R:R:S202 4.04 2 Yes No 0 6 0 1
R:R:F203 R:R:F289 20.36 0 Yes Yes 8 7 2 1
R:R:F288 R:R:W285 7.02 2 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 5.01 2 Yes Yes 7 8 1 2
R:R:W285 R:R:W321 2.81 2 Yes Yes 8 7 2 1
R:R:F288 R:R:F289 9.65 2 Yes Yes 7 7 1 1
R:R:F288 R:R:N292 9.67 2 Yes No 7 6 1 1
R:R:F288 R:R:F313 7.5 2 Yes Yes 7 4 1 2
R:R:F288 R:R:V317 3.93 2 Yes No 7 6 1 2
L:L:?1 R:R:F288 6.56 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F289 5.46 2 Yes Yes 0 7 0 1
R:R:F313 R:R:N292 3.62 2 Yes No 4 6 2 1
L:L:?1 R:R:N292 9.86 2 Yes No 0 6 0 1
R:R:F313 R:R:V317 2.62 2 Yes No 4 6 2 2
R:R:V317 R:R:W321 8.58 2 No Yes 6 7 2 1
R:R:W318 R:R:W321 14.06 2 Yes Yes 5 7 2 1
L:L:?1 R:R:W321 3.07 2 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.32
Average Nodes In Shell24.00
Average Hubs In Shell12.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7LJD A Amine Dopamine D1 Homo Sapiens Dopamine Mevidalen Gs/Beta1/Gamma1 3.2 2021-03-03 10.1038/s41422-021-00482-0

A 2D representation of the interactions of LDP in 7LJD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D103 R:R:V77 2.92 1 Yes No 7 8 1 2
R:R:V77 R:R:W321 4.9 1 No Yes 8 7 2 1
R:R:K81 R:R:W99 9.28 1 Yes Yes 6 5 2 2
R:R:K81 R:R:W318 4.64 1 Yes Yes 6 5 2 2
R:R:K81 R:R:W321 5.8 1 Yes Yes 6 7 2 1
R:R:D103 R:R:W99 5.58 1 Yes Yes 7 5 1 2
R:R:W321 R:R:W99 2.81 1 Yes Yes 7 5 1 2
R:R:D103 R:R:W321 6.7 1 Yes Yes 7 7 1 1
L:L:?1 R:R:D103 10.74 1 Yes Yes 0 7 0 1
R:R:S107 R:R:W285 4.94 0 No Yes 7 8 1 2
L:L:?1 R:R:S107 7.92 1 Yes No 0 7 0 1
R:R:L112 R:R:T108 2.95 0 No Yes 5 6 2 1
R:R:S151 R:R:T108 3.2 0 No Yes 8 6 2 1
R:R:I154 R:R:T108 3.04 0 No Yes 5 6 2 1
R:R:S202 R:R:T108 6.4 1 No Yes 6 6 1 1
L:L:?1 R:R:T108 2.59 1 Yes Yes 0 6 0 1
R:R:I111 R:R:W285 11.74 1 Yes Yes 8 8 2 2
R:R:F289 R:R:I111 2.51 1 Yes Yes 7 8 1 2
R:R:I154 R:R:S198 6.19 0 No No 5 7 2 1
R:R:L190 R:R:N292 4.12 0 No No 4 6 2 1
R:R:S198 R:R:Y194 8.9 0 No Yes 7 7 1 2
L:L:?1 R:R:S198 10.56 1 Yes No 0 7 0 1
R:R:F289 R:R:S199 3.96 1 Yes No 7 7 1 2
R:R:F289 R:R:S202 2.64 1 Yes No 7 6 1 1
L:L:?1 R:R:S202 5.28 1 Yes No 0 6 0 1
R:R:F203 R:R:W285 3.01 1 Yes Yes 8 8 2 2
R:R:F203 R:R:F289 22.51 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W285 7.02 1 Yes Yes 7 8 1 2
R:R:F288 R:R:F313 6.43 0 No No 7 4 1 2
R:R:F288 R:R:V317 3.93 0 No No 7 6 1 2
L:L:?1 R:R:F288 10.71 1 Yes No 0 7 0 1
L:L:?1 R:R:F289 7.5 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N292 6.04 1 Yes No 0 6 0 1
R:R:V317 R:R:W321 8.58 0 No Yes 6 7 2 1
R:R:W318 R:R:W321 9.37 1 Yes Yes 5 7 2 1
L:L:?1 R:R:W321 5.01 1 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.37
Average Nodes In Shell25.00
Average Hubs In Shell12.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7X2F A Amine Dopamine D1 Homo Sapiens Dopamine Mevidalen Gs/Beta1/Gamma2 3 2022-06-15 10.1038/s41467-022-30929-w

A 2D representation of the interactions of LDP in 7X2F
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D103 10.74 1 Yes No 0 7 0 1
L:L:?1 R:R:I104 3.77 1 Yes No 0 6 0 1
L:L:?1 R:R:S107 9.24 1 Yes No 0 7 0 1
L:L:?1 R:R:T108 5.18 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S198 9.24 1 Yes No 0 7 0 1
L:L:?1 R:R:S202 7.92 1 Yes No 0 6 0 1
L:L:?1 R:R:F288 12.85 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F289 8.57 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N292 4.83 1 Yes No 0 6 0 1
R:R:D103 R:R:W321 10.05 0 No Yes 7 7 1 2
R:R:I104 R:R:S155 3.1 0 No No 6 7 1 2
R:R:I104 R:R:Y194 4.84 0 No Yes 6 7 1 2
R:R:S107 R:R:W285 4.94 0 No Yes 7 8 1 2
R:R:L112 R:R:T108 2.95 0 Yes Yes 5 6 2 1
R:R:S151 R:R:T108 4.8 0 No Yes 8 6 2 1
R:R:I154 R:R:T108 4.56 0 No Yes 5 6 2 1
R:R:S202 R:R:T108 7.99 1 No Yes 6 6 1 1
R:R:S198 R:R:Y194 8.9 0 No Yes 7 7 1 2
R:R:A195 R:R:N292 3.13 0 No No 5 6 2 1
R:R:F289 R:R:S199 5.28 1 Yes No 7 7 1 2
R:R:N292 R:R:S199 4.47 0 No No 6 7 1 2
R:R:F203 R:R:W285 3.01 1 Yes Yes 8 8 2 2
R:R:F203 R:R:F289 18.22 1 Yes Yes 8 7 2 1
R:R:F288 R:R:W285 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 5.01 1 Yes Yes 7 8 1 2
R:R:F288 R:R:F289 4.29 1 Yes Yes 7 7 1 1
R:R:F288 R:R:F313 6.43 1 Yes No 7 4 1 2
R:R:F288 R:R:V317 3.93 1 Yes No 7 6 1 2
R:R:V317 R:R:W321 7.36 0 No Yes 6 7 2 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.04
Average Nodes In Shell22.00
Average Hubs In Shell9.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8TZQ A Amine Dopamine D2 Homo sapiens L-Dopamine - Go/Beta1/Gamma2 3.2 2024-08-21 doi.org/10.1038/s41467-024-50964-z

A 2D representation of the interactions of LDP in 8TZQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D114 10.96 3 Yes Yes 0 8 0 1
L:L:?1 R:R:V115 12.03 3 Yes No 0 8 0 1
L:L:?1 R:R:C118 8.54 3 Yes No 0 8 0 1
L:L:?1 R:R:S193 9.43 3 Yes No 0 9 0 1
L:L:?1 R:R:S197 5.39 3 Yes No 0 8 0 1
L:L:?1 R:R:F389 9.83 3 Yes Yes 0 8 0 1
L:L:?1 R:R:F390 5.46 3 Yes Yes 0 8 0 1
L:L:?1 R:R:H393 8.07 3 Yes Yes 0 8 0 1
L:L:?1 R:R:Y416 3.16 3 Yes Yes 0 8 0 1
R:R:D114 R:R:V87 8.76 3 Yes Yes 8 8 1 2
R:R:M88 R:R:V91 3.04 3 Yes No 9 8 2 2
R:R:M88 R:R:Y416 11.97 3 Yes Yes 9 8 2 1
R:R:V91 R:R:Y416 6.31 3 No Yes 8 8 2 1
R:R:C118 R:R:D114 3.11 3 No Yes 8 8 1 1
R:R:D114 R:R:Y416 9.2 3 Yes Yes 8 8 1 1
R:R:L170 R:R:V115 4.47 25 Yes No 8 8 2 1
R:R:C118 R:R:W386 5.22 3 No Yes 8 9 1 2
R:R:I166 R:R:T119 4.56 26 Yes Yes 8 8 2 2
R:R:S197 R:R:T119 3.2 3 No Yes 8 8 1 2
R:R:I166 R:R:S193 3.1 26 Yes No 8 9 2 1
R:R:F189 R:R:L170 12.18 0 Yes Yes 8 8 2 2
R:R:F189 R:R:S193 9.25 0 Yes No 8 9 2 1
R:R:H393 R:R:V190 11.07 3 Yes No 8 7 1 2
R:R:F390 R:R:S194 7.93 3 Yes No 8 8 1 2
R:R:F390 R:R:S197 6.61 3 Yes No 8 8 1 1
R:R:F198 R:R:W386 4.01 3 Yes Yes 9 9 2 2
R:R:F198 R:R:F390 17.15 3 Yes Yes 9 8 2 1
R:R:F389 R:R:W386 3.01 3 Yes Yes 8 9 1 2
R:R:F390 R:R:W386 7.02 3 Yes Yes 8 9 1 2
R:R:F389 R:R:F390 8.57 3 Yes Yes 8 8 1 1
R:R:F389 R:R:H393 5.66 3 Yes Yes 8 8 1 1
R:R:F389 R:R:Y408 10.32 3 Yes No 8 5 1 2
R:R:F389 R:R:F411 3.22 3 Yes Yes 8 5 1 2
R:R:F389 R:R:T412 5.19 3 Yes No 8 8 1 2
R:R:H393 R:R:Y408 5.44 3 Yes No 8 5 1 2
R:R:T412 R:R:Y408 3.75 3 No No 8 5 2 2
R:R:T412 R:R:Y416 4.99 3 No Yes 8 8 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.10
Average Nodes In Shell24.00
Average Hubs In Shell15.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8U02 A Amine Dopamine D2 Homo sapiens L-Dopamine - Go/Beta1/Gamma2 3.28 2024-08-21 doi.org/10.1038/s41467-024-50964-z

A 2D representation of the interactions of LDP in 8U02
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D114 13.39 1 Yes No 0 8 0 1
L:L:?1 R:R:V115 13.37 1 Yes Yes 0 8 0 1
L:L:?1 R:R:C118 4.27 1 Yes No 0 8 0 1
L:L:?1 R:R:S193 9.43 1 Yes Yes 0 9 0 1
L:L:?1 R:R:S197 4.04 1 Yes No 0 8 0 1
L:L:?1 R:R:W386 4.09 1 Yes Yes 0 9 0 1
L:L:?1 R:R:F389 17.48 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F390 9.83 1 Yes Yes 0 8 0 1
L:L:?1 R:R:H393 11.53 1 Yes Yes 0 8 0 1
L:L:?1 R:R:Y416 3.16 1 Yes Yes 0 8 0 1
R:R:D114 R:R:V87 7.3 1 No No 8 8 1 2
R:R:M88 R:R:V91 3.04 1 No No 9 8 2 2
R:R:M88 R:R:Y416 13.17 1 No Yes 9 8 2 1
R:R:V91 R:R:Y416 3.79 1 No Yes 8 8 2 1
R:R:D114 R:R:Y416 8.05 1 No Yes 8 8 1 1
R:R:S167 R:R:V115 3.23 0 No Yes 9 8 2 1
R:R:L170 R:R:V115 4.47 1 Yes Yes 8 8 2 1
R:R:F189 R:R:V115 3.93 1 Yes Yes 8 8 2 1
R:R:C118 R:R:W386 6.53 1 No Yes 8 9 1 1
R:R:I166 R:R:T119 3.04 0 No Yes 8 8 2 2
R:R:S197 R:R:T119 6.4 1 No Yes 8 8 1 2
R:R:I122 R:R:W386 14.09 0 No Yes 9 9 2 1
R:R:I166 R:R:S193 3.1 0 No Yes 8 9 2 1
R:R:F189 R:R:L170 19.49 1 Yes Yes 8 8 2 2
R:R:F189 R:R:S193 9.25 1 Yes Yes 8 9 2 1
R:R:H393 R:R:V190 13.84 1 Yes No 8 7 1 2
R:R:S193 R:R:S197 3.26 1 Yes No 9 8 1 1
R:R:F390 R:R:S194 7.93 1 Yes No 8 8 1 2
R:R:F198 R:R:W386 5.01 1 Yes Yes 9 9 2 1
R:R:F198 R:R:F390 20.36 1 Yes Yes 9 8 2 1
R:R:F390 R:R:W386 9.02 1 Yes Yes 8 9 1 1
R:R:G415 R:R:W386 8.44 0 No Yes 8 9 2 1
R:R:N418 R:R:W386 7.91 0 No Yes 9 9 2 1
R:R:F389 R:R:F390 9.65 1 Yes Yes 8 8 1 1
R:R:F389 R:R:H393 7.92 1 Yes Yes 8 8 1 1
R:R:F389 R:R:Y408 4.13 1 Yes No 8 5 1 2
R:R:F389 R:R:T412 7.78 1 Yes No 8 8 1 2
R:R:H393 R:R:Y408 5.44 1 Yes No 8 5 1 2
R:R:T412 R:R:Y416 3.75 0 No Yes 8 8 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.06
Average Nodes In Shell27.00
Average Hubs In Shell12.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.05
Average Number Of Links With An Hub3.85
Average Interaction Strength8.68
Average Nodes In Shell22.70
Average Hubs In Shell11.05
Average Links In Shell32.90
Average Links Mediated by Hubs In Shell30.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)