Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7CKZ | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | Mevidalen | Gs/Beta1/Gamma2 | 3.1 | 2021-03-03 | 10.1016/j.cell.2021.01.028 |
![](/psngpcr/ligands/LDP/LDP_7CKZ_L_L_2.png)
A 2D representation of the interactions of LDP in 7CKZ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V73 | R:R:V77 | 4.81 | 2 | No | No | 8 | 8 | 2 | 2 | R:R:V73 | R:R:W321 | 3.68 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:D103 | R:R:V77 | 4.38 | 2 | Yes | No | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 4.9 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:M78 | R:R:W318 | 8.14 | 2 | Yes | Yes | 7 | 5 | 2 | 2 | R:R:M78 | R:R:W321 | 6.98 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:K81 | R:R:W99 | 11.6 | 2 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:K81 | R:R:W318 | 5.8 | 2 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:K81 | R:R:W321 | 6.96 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:D103 | R:R:W99 | 10.05 | 2 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:D103 | R:R:S107 | 4.42 | 2 | Yes | No | 7 | 7 | 1 | 1 | R:R:D103 | R:R:W321 | 12.28 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | L:L:?2 | R:R:D103 | 11.93 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I104 | R:R:S155 | 6.19 | 0 | No | No | 6 | 7 | 1 | 2 | L:L:?2 | R:R:I104 | 8.79 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:S107 | R:R:W285 | 4.94 | 2 | No | Yes | 7 | 8 | 1 | 2 | L:L:?2 | R:R:S107 | 15.84 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:S202 | R:R:T108 | 6.4 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:S198 | R:R:Y194 | 13.99 | 0 | No | Yes | 7 | 7 | 1 | 2 | L:L:?2 | R:R:S198 | 5.28 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S199 | 7.93 | 2 | Yes | No | 7 | 7 | 1 | 2 | L:L:?2 | R:R:S202 | 9.24 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F203 | R:R:F289 | 23.58 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F288 | R:R:W285 | 5.01 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:W285 | 7.02 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:W285 | R:R:W321 | 3.75 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F288 | R:R:F289 | 12.86 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F288 | R:R:N292 | 6.04 | 2 | Yes | No | 7 | 6 | 1 | 1 | R:R:F288 | R:R:F313 | 5.36 | 2 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:F288 | R:R:V317 | 6.55 | 2 | Yes | No | 7 | 6 | 1 | 2 | L:L:?2 | R:R:F288 | 17.14 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F289 | R:R:N292 | 4.83 | 2 | Yes | No | 7 | 6 | 1 | 1 | L:L:?2 | R:R:F289 | 16.07 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?2 | R:R:N292 | 10.87 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F313 | R:R:V317 | 7.87 | 2 | Yes | No | 4 | 6 | 2 | 2 | R:R:V317 | R:R:W321 | 7.36 | 2 | No | Yes | 6 | 7 | 2 | 1 | R:R:W318 | R:R:W321 | 14.06 | 2 | Yes | Yes | 5 | 7 | 2 | 1 | L:L:?2 | R:R:W321 | 6.01 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?2 | R:R:L190 | 2.43 | 2 | Yes | No | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 10.36 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 39.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| ![](/psngpcr/ligands/LDP/LDP_7CKZ_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/LDP/LDP_7CKZ_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F0T | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | - | Gs/Beta1/Gamma2 | 3.1 | 2022-06-15 | 10.1126/sciadv.abo4158 |
![](/psngpcr/ligands/LDP/LDP_7F0T_L_L_1.png)
A 2D representation of the interactions of LDP in 7F0T colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M78 | R:R:V73 | 3.04 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:V73 | R:R:W321 | 3.68 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:D103 | R:R:V77 | 5.84 | 2 | Yes | No | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 3.68 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:M78 | R:R:W318 | 4.65 | 2 | Yes | Yes | 7 | 5 | 2 | 2 | R:R:M78 | R:R:W321 | 8.14 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:K81 | R:R:W321 | 4.64 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:D103 | R:R:S107 | 4.42 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:D103 | R:R:W321 | 6.7 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D103 | 11.93 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I104 | R:R:S155 | 3.1 | 0 | No | No | 6 | 7 | 1 | 2 | R:R:I104 | R:R:Y194 | 8.46 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:I104 | 10.04 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:S107 | R:R:W285 | 3.71 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:S107 | R:R:W321 | 4.94 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:S107 | 6.6 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:L112 | R:R:T108 | 2.95 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:S151 | R:R:T108 | 4.8 | 0 | No | Yes | 8 | 6 | 2 | 1 | R:R:S202 | R:R:T108 | 9.59 | 0 | No | Yes | 6 | 6 | 2 | 1 | L:L:?1 | R:R:T108 | 5.18 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:L190 | 3.65 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:S198 | R:R:Y194 | 12.72 | 0 | No | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:S198 | 9.24 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S199 | 7.93 | 2 | Yes | No | 7 | 7 | 1 | 2 | R:R:F203 | R:R:W285 | 3.01 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F203 | R:R:F289 | 15 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F288 | R:R:W285 | 4.01 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:W285 | 7.02 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F288 | R:R:F289 | 5.36 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F288 | R:R:N292 | 13.29 | 2 | Yes | No | 7 | 6 | 1 | 1 | R:R:F288 | R:R:F313 | 4.29 | 2 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:F288 | R:R:V317 | 5.24 | 2 | Yes | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:F288 | 12.85 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F289 | 9.64 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F313 | R:R:N292 | 3.62 | 2 | Yes | No | 4 | 6 | 2 | 1 | L:L:?1 | R:R:N292 | 7.25 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F313 | R:R:V317 | 5.24 | 2 | Yes | No | 4 | 6 | 2 | 2 | R:R:V317 | R:R:W321 | 6.13 | 2 | No | Yes | 6 | 7 | 2 | 1 | R:R:W318 | R:R:W321 | 12.18 | 2 | Yes | Yes | 5 | 7 | 2 | 1 | L:L:?1 | R:R:W321 | 3 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I154 | R:R:S198 | 1.55 | 0 | No | No | 5 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 7.94 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 41.00 | Average Links Mediated by Hubs In Shell | 39.00 |
| ![](/psngpcr/ligands/LDP/LDP_7F0T_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/LDP/LDP_7F0T_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F1O | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP; Mg | Gs/Beta1/Gamma2 | 3.13 | 2022-06-15 | 10.1126/sciadv.abo4158 |
![](/psngpcr/ligands/LDP/LDP_7F1O_L_L_1.png)
A 2D representation of the interactions of LDP in 7F1O colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D103 | R:R:V77 | 5.84 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 4.9 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:D103 | R:R:S107 | 4.42 | 1 | Yes | No | 7 | 7 | 1 | 1 | R:R:D103 | R:R:W321 | 5.58 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:D103 | 10.74 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I104 | R:R:Y194 | 7.25 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:I104 | 12.55 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S107 | R:R:W285 | 3.71 | 1 | No | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:S107 | 6.6 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:S202 | R:R:T108 | 9.59 | 0 | No | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:T108 | 3.89 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:I154 | R:R:S198 | 4.64 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:L190 | R:R:Y194 | 5.86 | 1 | No | Yes | 4 | 7 | 1 | 2 | R:R:L190 | R:R:N292 | 4.12 | 1 | No | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:L190 | 3.65 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:S198 | R:R:Y194 | 7.63 | 0 | Yes | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:S198 | 10.56 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S199 | 3.96 | 1 | Yes | No | 7 | 7 | 1 | 2 | R:R:F203 | R:R:W285 | 4.01 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F203 | R:R:F289 | 18.22 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F288 | R:R:W285 | 4.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:W285 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F288 | R:R:F289 | 7.5 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F288 | R:R:N292 | 4.83 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:F288 | R:R:F313 | 6.43 | 1 | Yes | Yes | 7 | 4 | 1 | 2 | L:L:?1 | R:R:F288 | 12.85 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F289 | 7.5 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N292 | 9.66 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:A195 | R:R:N292 | 3.13 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:S197 | R:R:S198 | 1.63 | 0 | No | Yes | 4 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 8.67 | Average Nodes In Shell | 21.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 30.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/LDP/LDP_7F1O_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/LDP/LDP_7F1O_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F1Z | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/Beta1/Gamma2 | 3.46 | 2022-06-15 | 10.1126/sciadv.abo4158 |
![](/psngpcr/ligands/LDP/LDP_7F1Z_L_L_1.png)
A 2D representation of the interactions of LDP in 7F1Z colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M78 | R:R:V73 | 3.04 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:V73 | R:R:W321 | 4.9 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:V77 | R:R:W99 | 6.13 | 1 | Yes | Yes | 8 | 5 | 2 | 2 | R:R:D103 | R:R:V77 | 5.84 | 1 | No | Yes | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 4.9 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:M78 | R:R:W321 | 6.98 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:K81 | R:R:W99 | 8.12 | 1 | No | Yes | 6 | 5 | 2 | 2 | R:R:K81 | R:R:W321 | 3.48 | 1 | No | Yes | 6 | 7 | 2 | 1 | R:R:W321 | R:R:W99 | 3.75 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:D103 | R:R:W321 | 13.4 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D103 | 13.13 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:I104 | R:R:S155 | 3.1 | 0 | No | No | 6 | 7 | 1 | 2 | R:R:I104 | R:R:Y194 | 6.04 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:I104 | 16.32 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S107 | R:R:W285 | 6.18 | 1 | No | Yes | 7 | 8 | 1 | 2 | R:R:S107 | R:R:W321 | 3.71 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:S107 | 11.88 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:L112 | R:R:T108 | 2.95 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:S151 | R:R:T108 | 3.2 | 1 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:S202 | R:R:T108 | 6.4 | 1 | No | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:T108 | 6.48 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:L190 | R:R:Y194 | 7.03 | 1 | No | Yes | 4 | 7 | 1 | 2 | R:R:L190 | R:R:N292 | 4.12 | 1 | No | No | 4 | 6 | 1 | 1 | L:L:?1 | R:R:L190 | 4.87 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:S198 | R:R:Y194 | 10.17 | 0 | No | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:S198 | 10.56 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S202 | 6.61 | 1 | Yes | No | 7 | 6 | 2 | 1 | L:L:?1 | R:R:S202 | 7.92 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F288 | R:R:W285 | 4.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:W285 | 7.02 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:F288 | R:R:F289 | 7.5 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:F288 | R:R:N292 | 10.87 | 1 | Yes | No | 7 | 6 | 1 | 1 | R:R:F288 | R:R:F313 | 6.43 | 1 | Yes | No | 7 | 4 | 1 | 2 | L:L:?1 | R:R:F288 | 10.71 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N292 | 3.62 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:V317 | R:R:W321 | 7.36 | 0 | No | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:W321 | 5.01 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 9.05 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 37.00 | Average Links Mediated by Hubs In Shell | 35.00 |
| ![](/psngpcr/ligands/LDP/LDP_7F1Z_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/LDP/LDP_7F1Z_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F23 | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/Beta1/Gamma2 | 3.58 | 2022-06-15 | 10.1126/sciadv.abo4158 |
![](/psngpcr/ligands/LDP/LDP_7F23_L_L_1.png)
A 2D representation of the interactions of LDP in 7F23 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V73 | R:R:W321 | 3.68 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:D103 | R:R:V77 | 5.84 | 2 | No | No | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 7.36 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:M78 | R:R:W318 | 5.82 | 2 | Yes | Yes | 7 | 5 | 2 | 2 | R:R:M78 | R:R:W321 | 6.98 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:D103 | R:R:W321 | 6.7 | 2 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D103 | 15.51 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:I104 | R:R:Y194 | 8.46 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:I104 | 6.28 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:S107 | R:R:W285 | 7.41 | 0 | No | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:S107 | 5.28 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:S202 | R:R:T108 | 9.59 | 0 | No | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:T108 | 3.89 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:L190 | R:R:Y194 | 4.69 | 0 | No | Yes | 4 | 7 | 1 | 2 | L:L:?1 | R:R:L190 | 3.65 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:F288 | R:R:W285 | 7.02 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:W285 | 5.01 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:F288 | R:R:F289 | 5.36 | 2 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:F288 | R:R:N292 | 10.87 | 2 | Yes | No | 7 | 6 | 1 | 2 | R:R:F288 | R:R:F313 | 6.43 | 2 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:F288 | R:R:V317 | 3.93 | 2 | Yes | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:F288 | 11.78 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F313 | R:R:V317 | 3.93 | 2 | Yes | No | 4 | 6 | 2 | 2 | R:R:V317 | R:R:W321 | 7.36 | 2 | No | Yes | 6 | 7 | 2 | 1 | R:R:W318 | R:R:W321 | 13.12 | 2 | Yes | Yes | 5 | 7 | 2 | 1 | L:L:?1 | R:R:W321 | 6.01 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 7.49 | Average Nodes In Shell | 19.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 26.00 | Average Links Mediated by Hubs In Shell | 24.00 |
| ![](/psngpcr/ligands/LDP/LDP_7F23_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/LDP/LDP_7F23_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F24 | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/Beta1/Gamma2 | 4.16 | 2022-06-15 | 10.1126/sciadv.abo4158 |
![](/psngpcr/ligands/LDP/LDP_7F24_L_L_1.png)
A 2D representation of the interactions of LDP in 7F24 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V77 | R:R:W99 | 3.68 | 2 | No | Yes | 8 | 5 | 2 | 2 | R:R:D103 | R:R:V77 | 5.84 | 2 | Yes | No | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 3.68 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:M78 | R:R:W318 | 6.98 | 2 | Yes | Yes | 7 | 5 | 2 | 2 | R:R:M78 | R:R:W321 | 9.31 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:K81 | R:R:W99 | 8.12 | 0 | No | Yes | 6 | 5 | 2 | 2 | R:R:K81 | R:R:W321 | 5.8 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:D103 | R:R:W99 | 3.35 | 2 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:I104 | R:R:V100 | 3.07 | 0 | No | No | 6 | 5 | 1 | 2 | R:R:D103 | R:R:S107 | 4.42 | 2 | Yes | No | 7 | 7 | 1 | 1 | R:R:D103 | R:R:W321 | 5.58 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D103 | 13.13 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I104 | R:R:Y194 | 8.46 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:I104 | 17.57 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:S107 | R:R:W285 | 3.71 | 2 | No | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:S107 | 10.56 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:S202 | R:R:T108 | 9.59 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:S198 | R:R:Y194 | 10.17 | 0 | No | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:S198 | 9.24 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S199 | 2.64 | 2 | Yes | No | 7 | 7 | 1 | 2 | L:L:?1 | R:R:S202 | 3.96 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F203 | R:R:F289 | 20.36 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F288 | R:R:W285 | 7.02 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:W285 | 5.01 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:W285 | R:R:W321 | 2.81 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F288 | R:R:F289 | 9.65 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F288 | R:R:N292 | 9.67 | 2 | Yes | No | 7 | 6 | 1 | 1 | R:R:F288 | R:R:F313 | 7.5 | 2 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:F288 | R:R:V317 | 3.93 | 2 | Yes | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:F288 | 6.43 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F289 | 5.36 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F313 | R:R:N292 | 3.62 | 2 | Yes | No | 4 | 6 | 2 | 1 | L:L:?1 | R:R:N292 | 9.66 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F313 | R:R:V317 | 2.62 | 2 | Yes | No | 4 | 6 | 2 | 2 | R:R:V317 | R:R:W321 | 8.58 | 2 | No | Yes | 6 | 7 | 2 | 1 | R:R:W318 | R:R:W321 | 14.06 | 2 | Yes | Yes | 5 | 7 | 2 | 1 | L:L:?1 | R:R:W321 | 3 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 8.77 | Average Nodes In Shell | 23.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 37.00 | Average Links Mediated by Hubs In Shell | 35.00 |
| ![](/psngpcr/ligands/LDP/LDP_7F24_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/LDP/LDP_7F24_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7LJD | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | Mevidalen | Gs/Beta1/Gamma1 | 3.2 | 2021-03-03 | 10.1038/s41422-021-00482-0 |
![](/psngpcr/ligands/LDP/LDP_7LJD_L_L_1.png)
A 2D representation of the interactions of LDP in 7LJD colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D103 | R:R:V77 | 2.92 | 1 | Yes | No | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 4.9 | 1 | No | Yes | 8 | 7 | 2 | 1 | R:R:K81 | R:R:W99 | 9.28 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:K81 | R:R:W318 | 4.64 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:K81 | R:R:W321 | 5.8 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:D103 | R:R:W99 | 5.58 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:W321 | R:R:W99 | 2.81 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:D103 | R:R:W321 | 6.7 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D103 | 10.74 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S107 | R:R:W285 | 4.94 | 0 | No | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:S107 | 7.92 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:L112 | R:R:T108 | 2.95 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:S151 | R:R:T108 | 3.2 | 0 | No | Yes | 8 | 6 | 2 | 1 | R:R:I154 | R:R:T108 | 3.04 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:S202 | R:R:T108 | 6.4 | 1 | No | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:T108 | 2.59 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:I111 | R:R:W285 | 11.74 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F289 | R:R:I111 | 2.51 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:I154 | R:R:S198 | 6.19 | 0 | No | No | 5 | 7 | 2 | 1 | R:R:L190 | R:R:N292 | 4.12 | 0 | No | No | 4 | 6 | 2 | 1 | R:R:S198 | R:R:Y194 | 8.9 | 0 | No | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:S198 | 10.56 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S199 | 3.96 | 1 | Yes | No | 7 | 7 | 1 | 2 | R:R:F289 | R:R:S202 | 2.64 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:S202 | 5.28 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F203 | R:R:W285 | 3.01 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F203 | R:R:F289 | 22.51 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F289 | R:R:W285 | 7.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F288 | R:R:F313 | 6.43 | 0 | No | No | 7 | 4 | 1 | 2 | R:R:F288 | R:R:V317 | 3.93 | 0 | No | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:F288 | 10.71 | 1 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F289 | 7.5 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N292 | 6.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:V317 | R:R:W321 | 8.58 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:W318 | R:R:W321 | 9.37 | 1 | Yes | Yes | 5 | 7 | 2 | 1 | L:L:?1 | R:R:W321 | 5.01 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 7.37 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 36.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| ![](/psngpcr/ligands/LDP/LDP_7LJD_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/LDP/LDP_7LJD_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7X2F | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | Mevidalen | Gs/Beta1/Gamma2 | 3 | 2022-06-15 | 10.1038/s41467-022-30929-w |
![](/psngpcr/ligands/LDP/LDP_7X2F_L_L_1.png)
A 2D representation of the interactions of LDP in 7X2F colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D103 | R:R:W321 | 10.05 | 0 | No | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:D103 | 10.74 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:I104 | R:R:S155 | 3.1 | 0 | No | No | 6 | 7 | 1 | 2 | R:R:I104 | R:R:Y194 | 4.84 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:I104 | 3.77 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S107 | R:R:W285 | 4.94 | 0 | No | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:S107 | 9.24 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:L112 | R:R:T108 | 2.95 | 0 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:S151 | R:R:T108 | 4.8 | 0 | No | Yes | 8 | 6 | 2 | 1 | R:R:I154 | R:R:T108 | 4.56 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:S202 | R:R:T108 | 7.99 | 1 | No | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:T108 | 5.18 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:S198 | R:R:Y194 | 8.9 | 0 | No | Yes | 7 | 7 | 1 | 2 | R:R:A195 | R:R:N292 | 3.13 | 0 | No | No | 5 | 6 | 2 | 1 | L:L:?1 | R:R:S198 | 9.24 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S199 | 5.28 | 1 | Yes | No | 7 | 7 | 1 | 2 | R:R:N292 | R:R:S199 | 4.47 | 0 | No | No | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S202 | 7.92 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F203 | R:R:W285 | 3.01 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F203 | R:R:F289 | 18.22 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F288 | R:R:W285 | 4.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:W285 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F288 | R:R:F289 | 4.29 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F288 | R:R:F313 | 6.43 | 1 | Yes | No | 7 | 4 | 1 | 2 | R:R:F288 | R:R:V317 | 3.93 | 1 | Yes | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:F288 | 12.85 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F289 | 8.57 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N292 | 4.83 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:V317 | R:R:W321 | 7.36 | 0 | No | Yes | 6 | 7 | 2 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 8.04 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 29.00 | Average Links Mediated by Hubs In Shell | 26.00 |
| ![](/psngpcr/ligands/LDP/LDP_7X2F_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/LDP/LDP_7X2F_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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