CodeLPD
NameL-PROLINAMIDE
Synonyms
Identifier(2S)-pyrrolidine-2-carboxamide
FormulaC5 H10 N2 O
Molecular Weight114.146
SMILESC1C[C@H](NC1)C(=O)N
PubChem111306
Formal Charge0
Total Atoms18
Total Chiral Atoms1
Total Bonds18
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WKD A Peptide Thyrotropin-releasing hormone TRH Homo sapiens TRH - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.01 2022-06-15 10.1038/s41422-022-00641-x

A 2D representation of the interactions of LPD in 7WKD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V32 R:R:Y310 6.31 0 No Yes 7 7 2 1
R:R:C36 R:R:Y310 4.03 0 No Yes 6 7 2 1
R:R:I109 R:R:V74 9.22 2 Yes No 7 7 1 2
R:R:L75 R:R:Y310 3.52 0 No Yes 7 7 2 1
R:R:A78 R:R:Q105 6.06 2 No Yes 7 7 1 1
R:R:A78 R:R:Y310 4 2 No Yes 7 7 1 1
L:L:?3 R:R:A78 4.33 2 Yes No 0 7 0 1
R:R:G79 R:R:Y310 4.35 0 No Yes 7 7 2 1
R:R:P81 R:R:Q105 3.16 2 No Yes 5 7 2 1
R:R:N82 R:R:R306 8.44 2 No Yes 6 5 2 1
R:R:N82 R:R:Y310 5.81 2 No Yes 6 7 2 1
R:R:T102 R:R:Y106 4.99 2 No Yes 4 5 2 1
L:L:H2 R:R:T102 9.58 2 Yes No 0 4 1 2
L:L:?3 R:R:Q105 13.4 2 Yes Yes 0 7 0 1
R:R:W160 R:R:Y106 36.66 2 Yes Yes 5 5 2 1
R:R:Y106 R:R:Y181 3.97 2 Yes Yes 5 4 1 2
R:R:Y106 R:R:Y192 3.97 2 Yes Yes 5 5 1 2
L:L:H2 R:R:Y106 7.62 2 Yes Yes 0 5 1 1
L:L:?3 R:R:Y106 6.44 2 Yes Yes 0 5 0 1
R:R:I109 R:R:W279 4.7 2 Yes Yes 7 8 1 2
R:R:I109 R:R:R283 3.76 2 Yes Yes 7 6 1 2
L:L:?3 R:R:I109 3.92 2 Yes Yes 0 7 0 1
R:R:W160 R:R:Y192 7.72 2 Yes Yes 5 5 2 2
L:L:H2 R:R:C179 7.37 2 Yes No 0 9 1 2
R:R:Y181 R:R:Y192 10.92 2 Yes Yes 4 5 2 2
L:L:?1 R:R:Y181 4.99 2 Yes Yes 0 4 2 2
L:L:H2 R:R:Y181 5.44 2 Yes Yes 0 4 1 2
R:R:V286 R:R:Y192 11.36 2 No Yes 6 5 2 2
L:L:?1 R:R:Y192 3.74 2 Yes Yes 0 5 2 2
R:R:R283 R:R:W279 8 2 Yes Yes 6 8 2 2
R:R:V286 R:R:Y282 8.83 2 No Yes 6 5 2 1
R:R:C305 R:R:Y282 4.03 0 No Yes 5 5 2 1
R:R:I309 R:R:Y282 7.25 2 No Yes 6 5 1 1
L:L:?1 R:R:Y282 6.24 2 Yes Yes 0 5 2 1
L:L:?3 R:R:Y282 15.02 2 Yes Yes 0 5 0 1
L:L:?1 R:R:V286 7.93 2 Yes No 0 6 2 2
R:R:L302 R:R:R306 3.64 0 No Yes 4 5 2 1
L:L:?1 R:R:L302 5.89 2 Yes No 0 4 2 2
R:R:R306 R:R:Y310 7.2 2 Yes Yes 5 7 1 1
L:L:?3 R:R:R306 12.23 2 Yes Yes 0 5 0 1
L:L:?3 R:R:I309 7.84 2 Yes No 0 6 0 1
L:L:?3 R:R:Y310 3.22 2 Yes Yes 0 7 0 1
L:L:?1 L:L:H2 4.11 2 Yes Yes 0 0 2 1
L:L:?3 L:L:H2 4.71 2 Yes Yes 0 0 0 1
R:R:I35 R:R:Y310 2.42 0 No Yes 7 7 2 1
L:L:H2 R:R:G180 1.59 2 Yes No 0 3 1 2
R:R:A77 R:R:Q105 1.52 0 No Yes 5 7 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.90
Average Nodes In Shell31.00
Average Hubs In Shell14.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.90
Average Nodes In Shell31.00
Average Hubs In Shell14.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell47.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)