CodeLPS
NameLysophosphotidylserine
SynonymsLYSOPHOSPHOTIDYLSERINE
Identifier(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-(1-hydroxypentadecoxy)propoxy]phosphoryl]oxy-propanoic acid
FormulaC21 H44 N O9 P
Molecular Weight485.549
SMILESCCCCCCCCCCCCCCC(O)OC[C@H](CO[P@](=O)(O)OC[C@@H](C(=O)O)N)O
PubChem17754066
Formal Charge0
Total Atoms76
Total Chiral Atoms4
Total Bonds75
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8KH5 A Orphan A orphans GPR174 Homo sapiens Lysophosphatidylserine - Gs/Beta1/Gamma2 2.83 2023-10-11 10.1038/s41467-023-41654-3

A 2D representation of the interactions of LPS in 8KH5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R18 R:R:T15 5.17 3 Yes Yes 4 4 2 2
R:R:T15 R:R:Y19 16.23 3 Yes Yes 4 5 2 2
R:R:T15 R:R:V170 6.35 3 Yes Yes 4 5 2 1
R:R:D171 R:R:T15 5.78 3 Yes Yes 4 4 2 2
R:R:R18 R:R:Y22 3.09 3 Yes Yes 4 6 2 1
R:R:R18 R:R:V170 6.54 3 Yes Yes 4 5 2 1
R:R:K257 R:R:R18 3.71 3 Yes Yes 5 4 1 2
R:R:R18 R:R:S275 6.59 3 Yes No 4 4 2 2
R:R:Y19 R:R:Y78 2.98 3 Yes Yes 5 5 2 2
R:R:Y19 R:R:Y79 14.89 3 Yes Yes 5 5 2 1
R:R:V170 R:R:Y19 5.05 3 Yes Yes 5 5 1 2
R:R:D171 R:R:Y19 8.05 3 Yes Yes 4 5 2 2
R:R:Y22 R:R:Y26 6.95 3 Yes Yes 6 8 1 1
R:R:Y22 R:R:Y79 11.91 3 Yes Yes 6 5 1 1
R:R:S275 R:R:Y22 11.45 3 No Yes 4 6 2 1
R:R:L278 R:R:Y22 3.52 3 Yes Yes 5 6 1 1
L:L:?1 R:R:Y22 10.49 3 Yes Yes 0 6 0 1
R:R:L72 R:R:Y26 11.72 0 No Yes 8 8 2 1
R:R:R75 R:R:Y26 4.12 3 Yes Yes 6 8 1 1
R:R:K98 R:R:Y26 3.58 3 Yes Yes 6 8 1 1
R:R:S282 R:R:Y26 7.63 0 No Yes 6 8 2 1
L:L:?1 R:R:Y26 4.49 3 Yes Yes 0 8 0 1
R:R:K98 R:R:Q68 6.78 3 Yes Yes 6 7 1 2
R:R:R75 R:R:S71 5.27 3 Yes No 6 7 1 2
R:R:K98 R:R:S71 6.12 3 Yes No 6 7 1 2
R:R:K98 R:R:R75 19.8 3 Yes Yes 6 6 1 1
R:R:F169 R:R:R75 23.52 3 Yes Yes 4 6 2 1
L:L:?1 R:R:R75 7.76 3 Yes Yes 0 6 0 1
R:R:Y78 R:R:Y79 5.96 3 Yes Yes 5 5 2 1
R:R:F169 R:R:Y78 4.13 3 Yes Yes 4 5 2 2
R:R:D171 R:R:Y78 6.9 3 Yes Yes 4 5 2 2
R:R:V170 R:R:Y79 8.83 3 Yes Yes 5 5 1 1
L:L:?1 R:R:Y79 6.74 3 Yes Yes 0 5 0 1
R:R:F95 R:R:Y99 10.32 3 Yes Yes 5 4 1 1
R:R:F95 R:R:R156 6.41 3 Yes Yes 5 5 1 1
R:R:F169 R:R:F95 4.29 3 Yes Yes 4 5 2 1
L:L:?1 R:R:F95 7 3 Yes Yes 0 5 0 1
R:R:K98 R:R:Y99 9.55 3 Yes Yes 6 4 1 1
R:R:K98 R:R:L278 4.23 3 Yes Yes 6 5 1 1
L:L:?1 R:R:K98 3.6 3 Yes Yes 0 6 0 1
R:R:F152 R:R:Y99 13.41 3 Yes Yes 3 4 1 1
R:R:Y246 R:R:Y99 5.96 3 Yes Yes 6 4 2 1
R:R:L278 R:R:Y99 3.52 3 Yes Yes 5 4 1 1
L:L:?1 R:R:Y99 15.73 3 Yes Yes 0 4 0 1
R:R:I145 R:R:V100 3.07 0 No Yes 8 4 1 2
R:R:C149 R:R:V100 6.83 0 No Yes 7 4 2 2
R:R:F152 R:R:Y103 3.09 3 Yes Yes 3 7 1 1
R:R:Y103 R:R:Y246 4.96 3 Yes Yes 7 6 1 2
R:R:H247 R:R:Y103 7.62 3 Yes Yes 8 7 2 1
L:L:?1 R:R:Y103 9.74 3 Yes Yes 0 7 0 1
R:R:I145 R:R:Y107 3.63 0 No Yes 8 5 1 2
L:L:?1 R:R:I145 2.74 3 Yes No 0 8 0 1
L:L:?1 R:R:A148 4.03 3 Yes No 0 4 0 1
R:R:C149 R:R:F152 4.19 0 No Yes 7 3 2 1
R:R:L151 R:R:L155 8.3 3 No No 8 4 1 1
R:R:L151 R:R:M185 8.48 3 No No 8 4 1 2
L:L:?1 R:R:L151 4.42 3 Yes No 0 8 0 1
R:R:F152 R:R:P153 2.89 3 Yes No 3 4 1 2
L:L:?1 R:R:F152 20.23 3 Yes Yes 0 3 0 1
R:R:L155 R:R:M185 5.65 3 No No 4 4 1 2
L:L:?1 R:R:L155 4.42 3 Yes No 0 4 0 1
R:R:L172 R:R:R156 7.29 0 No Yes 4 5 2 1
R:R:R156 R:R:T174 3.88 3 Yes No 5 3 1 2
R:R:K257 R:R:R156 11.14 3 Yes Yes 5 5 1 1
L:L:?1 R:R:R156 12.42 3 Yes Yes 0 5 0 1
R:R:D171 R:R:V170 5.84 3 Yes Yes 4 5 2 1
L:L:?1 R:R:V170 5.71 3 Yes Yes 0 5 0 1
R:R:K257 R:R:T174 3 3 Yes No 5 3 1 2
R:R:F254 R:R:S182 3.96 0 No No 4 4 1 2
R:R:M186 R:R:P251 5.03 0 No No 4 6 2 2
R:R:F254 R:R:M186 4.98 0 No No 4 4 1 2
R:R:E190 R:R:H247 12.31 3 No Yes 5 8 2 2
R:R:E190 R:R:F250 8.16 3 No Yes 5 5 2 1
R:R:E190 R:R:P251 11 3 No No 5 6 2 2
R:R:H247 R:R:Y246 14.16 3 Yes Yes 8 6 2 2
R:R:F250 R:R:Y246 6.19 3 Yes Yes 5 6 1 2
R:R:H274 R:R:Y246 3.27 3 Yes Yes 5 6 1 2
R:R:L278 R:R:Y246 4.69 3 Yes Yes 5 6 1 2
R:R:H274 R:R:S249 8.37 3 Yes No 5 4 1 2
R:R:F250 R:R:P251 5.78 3 Yes No 5 6 1 2
L:L:?1 R:R:F250 10.89 3 Yes Yes 0 5 0 1
R:R:D253 R:R:K257 13.83 3 No Yes 4 5 1 1
R:R:D253 R:R:H274 26.47 3 No Yes 4 5 1 1
L:L:?1 R:R:D253 6.94 3 Yes No 0 4 0 1
L:L:?1 R:R:F254 3.11 3 Yes No 0 4 0 1
L:L:?1 R:R:K257 7.21 3 Yes Yes 0 5 0 1
R:R:H274 R:R:L278 7.71 3 Yes Yes 5 5 1 1
L:L:?1 R:R:H274 7.39 3 Yes Yes 0 5 0 1
L:L:?1 R:R:L278 7.96 3 Yes Yes 0 5 0 1
StatisticsValue
Average Number Of Links21.00
Average Number Of Links With An Hub15.00
Average Interaction Strength7.76
Average Nodes In Shell47.00
Average Hubs In Shell27.00
Average Links In Shell89.00
Average Links Mediated by Hubs In Shell82.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links21.00
Average Number Of Links With An Hub15.00
Average Interaction Strength7.76
Average Nodes In Shell47.00
Average Hubs In Shell27.00
Average Links In Shell89.00
Average Links Mediated by Hubs In Shell82.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)