CodeLPS
NameLysophosphotidylserine
SynonymsLYSOPHOSPHOTIDYLSERINE
Identifier
FormulaC21 H44 N O9 P
Molecular Weight485.549
SMILES
PubChem17754066
Formal Charge0
Total Atoms76
Total Chiral Atoms4
Total Bonds75
Total Aromatic Bonds0
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8KH5 A Orphan Orphan GPR174 Homo Sapiens Lysophosphatidylserine - Gs/Beta1/Gamma2 2.83 2023-10-11 10.1038/s41467-023-41654-3

A 2D representation of the interactions of LPS in 8KH5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y22 9.77 2 Yes Yes 0 6 0 1
L:L:?1 R:R:Y26 4.19 2 Yes Yes 0 8 0 1
L:L:?1 R:R:R75 7.23 2 Yes Yes 0 6 0 1
L:L:?1 R:R:Y79 6.28 2 Yes Yes 0 5 0 1
L:L:?1 R:R:F95 6.52 2 Yes Yes 0 5 0 1
L:L:?1 R:R:Y99 14.65 2 Yes Yes 0 4 0 1
L:L:?1 R:R:Y103 9.07 2 Yes No 0 7 0 1
L:L:?1 R:R:A148 3.75 2 Yes No 0 4 0 1
L:L:?1 R:R:L151 4.12 2 Yes No 0 8 0 1
L:L:?1 R:R:F152 18.85 2 Yes No 0 3 0 1
L:L:?1 R:R:L155 4.12 2 Yes No 0 4 0 1
L:L:?1 R:R:R156 11.57 2 Yes Yes 0 5 0 1
L:L:?1 R:R:V170 5.32 2 Yes Yes 0 5 0 1
L:L:?1 R:R:F250 10.15 2 Yes Yes 0 5 0 1
L:L:?1 R:R:D253 6.46 2 Yes No 0 4 0 1
L:L:?1 R:R:K257 6.71 2 Yes Yes 0 5 0 1
L:L:?1 R:R:H274 6.89 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L278 7.41 2 Yes Yes 0 5 0 1
R:R:R18 R:R:T15 3.88 2 Yes Yes 4 4 2 2
R:R:T15 R:R:Y19 21.22 2 Yes Yes 4 5 2 2
R:R:T15 R:R:V170 6.35 2 Yes Yes 4 5 2 1
R:R:D171 R:R:T15 7.23 2 Yes Yes 4 4 2 2
R:R:R18 R:R:V170 6.54 2 Yes Yes 4 5 2 1
R:R:K257 R:R:R18 3.71 2 Yes Yes 5 4 1 2
R:R:R18 R:R:S275 6.59 2 Yes No 4 4 2 2
R:R:Y19 R:R:Y79 14.89 2 Yes Yes 5 5 2 1
R:R:V170 R:R:Y19 5.05 2 Yes Yes 5 5 1 2
R:R:D171 R:R:Y19 8.05 2 Yes Yes 4 5 2 2
R:R:Y22 R:R:Y26 6.95 2 Yes Yes 6 8 1 1
R:R:Y22 R:R:Y79 11.91 2 Yes Yes 6 5 1 1
R:R:S275 R:R:Y22 11.45 0 No Yes 4 6 2 1
R:R:L72 R:R:Y26 11.72 0 No Yes 8 8 2 1
R:R:R75 R:R:Y26 4.12 2 Yes Yes 6 8 1 1
R:R:S282 R:R:Y26 7.63 0 No Yes 6 8 2 1
R:R:R75 R:R:S71 5.27 2 Yes No 6 7 1 2
R:R:K98 R:R:S71 6.12 2 Yes No 6 7 2 2
R:R:K98 R:R:R75 19.8 2 Yes Yes 6 6 2 1
R:R:F169 R:R:R75 23.52 2 Yes Yes 4 6 2 1
R:R:Y78 R:R:Y79 5.96 2 Yes Yes 5 5 2 1
R:R:F169 R:R:Y78 4.13 2 Yes Yes 4 5 2 2
R:R:D171 R:R:Y78 6.9 2 Yes Yes 4 5 2 2
R:R:V170 R:R:Y79 8.83 2 Yes Yes 5 5 1 1
R:R:F95 R:R:Y99 10.32 2 Yes Yes 5 4 1 1
R:R:F95 R:R:R156 6.41 2 Yes Yes 5 5 1 1
R:R:F169 R:R:F95 4.29 2 Yes Yes 4 5 2 1
R:R:K98 R:R:Y99 9.55 2 Yes Yes 6 4 2 1
R:R:K98 R:R:L278 4.23 2 Yes Yes 6 5 2 1
R:R:F152 R:R:Y99 13.41 2 No Yes 3 4 1 1
R:R:Y246 R:R:Y99 5.96 2 Yes Yes 6 4 2 1
R:R:Y103 R:R:Y246 4.96 2 No Yes 7 6 1 2
R:R:H247 R:R:Y103 7.62 2 Yes No 8 7 2 1
R:R:C149 R:R:F152 4.19 0 No No 7 3 2 1
R:R:L151 R:R:L155 8.3 2 No No 8 4 1 1
R:R:L151 R:R:M185 8.48 2 No No 8 4 1 2
R:R:L155 R:R:M185 5.65 2 No No 4 4 1 2
R:R:L172 R:R:R156 7.29 0 No Yes 4 5 2 1
R:R:R156 R:R:T174 3.88 2 Yes No 5 3 1 2
R:R:K257 R:R:R156 11.14 2 Yes Yes 5 5 1 1
R:R:D171 R:R:V170 5.84 2 Yes Yes 4 5 2 1
R:R:E190 R:R:H247 12.31 2 No Yes 5 8 2 2
R:R:E190 R:R:F250 8.16 2 No Yes 5 5 2 1
R:R:E190 R:R:P251 11 2 No No 5 6 2 2
R:R:H247 R:R:Y246 14.16 2 Yes Yes 8 6 2 2
R:R:F250 R:R:Y246 6.19 2 Yes Yes 5 6 1 2
R:R:L278 R:R:Y246 4.69 2 Yes Yes 5 6 1 2
R:R:H274 R:R:S249 8.37 2 Yes No 5 4 1 2
R:R:F250 R:R:P251 5.78 2 Yes No 5 6 1 2
R:R:D253 R:R:K257 13.83 2 No Yes 4 5 1 1
R:R:D253 R:R:H274 26.47 2 No Yes 4 5 1 1
R:R:H274 R:R:L278 7.71 2 Yes Yes 5 5 1 1
StatisticsValue
Average Number Of Links18.00
Average Number Of Links With An Hub12.00
Average Interaction Strength7.95
Average Nodes In Shell39.00
Average Hubs In Shell22.00
Average Links In Shell70.00
Average Links Mediated by Hubs In Shell65.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links18.00
Average Number Of Links With An Hub11.50
Average Interaction Strength7.95
Average Nodes In Shell39.00
Average Hubs In Shell20.50
Average Links In Shell69.00
Average Links Mediated by Hubs In Shell63.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)