CodeLSN
NameLosartan
SynonymsLosartan
Identifier
FormulaC22 H23 Cl N6 O
Molecular Weight422.911
SMILES
PubChem3961
Formal Charge0
Total Atoms53
Total Chiral Atoms0
Total Bonds56
Total Aromatic Bonds22
Networks2
 missing image

This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8TH4 A Peptide Angiotensin AT1 Homo Sapiens Losartan AT118-L Nanobody - 3.3 2024-05-22 doi.org/10.1038/s41589-024-01620-6

A 2D representation of the interactions of LSN in 8TH4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y35 7.13 1 Yes Yes 0 7 0 1
L:L:?1 R:R:W84 26.33 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Y87 7.13 1 Yes Yes 0 5 0 1
L:L:?1 R:R:V108 12.69 1 Yes No 0 6 0 1
L:L:?1 R:R:S109 6.39 1 Yes No 0 4 0 1
L:L:?1 R:R:R167 17.74 1 Yes Yes 0 5 0 1
L:L:?1 R:R:F182 4.45 1 Yes Yes 0 4 0 1
L:L:?1 R:R:K199 7.72 1 Yes Yes 0 5 0 1
L:L:?1 R:R:I288 7.81 1 Yes No 0 6 0 1
L:L:?1 R:R:Y292 7.85 1 Yes Yes 0 7 0 1
R:R:I31 R:R:Y35 3.63 0 No Yes 6 7 2 1
R:R:L81 R:R:Y35 5.86 1 No Yes 8 7 2 1
R:R:C289 R:R:Y35 8.06 0 No Yes 5 7 2 1
R:R:F77 R:R:L81 4.87 1 Yes No 6 8 2 2
R:R:F77 R:R:V108 5.24 1 Yes No 6 6 2 1
R:R:F77 R:R:N111 16.92 1 Yes No 6 8 2 2
R:R:F77 R:R:Y292 9.28 1 Yes Yes 6 7 2 1
R:R:W84 R:R:Y87 6.75 1 Yes Yes 7 5 1 1
R:R:W84 R:R:W94 11.25 1 Yes Yes 7 9 1 2
R:R:A104 R:R:W84 5.19 0 No Yes 6 7 2 1
R:R:S105 R:R:W84 4.94 0 No Yes 5 7 2 1
R:R:C180 R:R:W84 5.22 1 Yes Yes 9 7 2 1
R:R:Y87 R:R:Y92 13.9 1 Yes No 5 4 1 2
R:R:W94 R:R:Y87 6.75 1 Yes Yes 9 5 2 1
R:R:V179 R:R:Y87 3.79 0 No Yes 3 5 2 1
R:R:C180 R:R:W94 5.22 1 Yes Yes 9 9 2 2
R:R:R167 R:R:S105 14.5 1 Yes No 5 5 1 2
R:R:V108 R:R:Y292 6.31 1 No Yes 6 7 1 1
R:R:S109 R:R:S160 4.89 0 No No 4 7 1 2
R:R:N111 R:R:Y292 4.65 1 No Yes 8 7 2 1
R:R:L112 R:R:W253 14.81 1 No Yes 7 8 2 2
R:R:L112 R:R:Y292 4.69 1 No Yes 7 7 2 1
R:R:F182 R:R:H166 9.05 1 Yes No 4 4 1 2
R:R:C180 R:R:R167 4.18 1 Yes Yes 9 5 2 1
R:R:F182 R:R:R167 9.62 1 Yes Yes 4 5 1 1
R:R:F182 R:R:Y184 13.41 1 Yes Yes 4 4 1 2
R:R:F182 R:R:L195 3.65 1 Yes Yes 4 5 1 2
R:R:H256 R:R:K199 3.93 1 Yes Yes 6 5 2 1
R:R:K199 R:R:Q257 8.14 1 Yes Yes 5 8 1 2
R:R:K199 R:R:T260 12.01 1 Yes No 5 6 1 2
R:R:H256 R:R:W253 8.46 1 Yes Yes 6 8 2 2
R:R:Q257 R:R:W253 8.76 0 Yes Yes 8 8 2 2
R:R:W253 R:R:Y292 8.68 1 Yes Yes 8 7 2 1
R:R:H256 R:R:T260 6.85 1 Yes No 6 6 2 2
R:R:H256 R:R:I288 5.3 1 Yes No 6 6 2 1
L:L:?1 W:W:P104 3 1 Yes No 0 0 0 1
L:L:?1 R:R:A163 2.88 1 Yes No 0 4 0 1
R:R:A85 R:R:Y35 1.33 0 No Yes 7 7 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.26
Average Nodes In Shell34.00
Average Hubs In Shell16.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9EAI A Peptide Angiotensin AT1 Homo Sapiens Losartan Nanobody AT209 - 3.1 2025-03-05 doi.org/10.1073/pnas.2423931122

A 2D representation of the interactions of LSN in 9EAI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I31 R:R:Y35 6.04 1 Yes Yes 6 7 2 1
R:R:C289 R:R:I31 3.27 1 No Yes 5 6 2 2
R:R:L81 R:R:Y35 8.21 0 No Yes 8 7 2 1
R:R:A85 R:R:Y35 4 0 No Yes 7 7 2 1
R:R:C289 R:R:Y35 9.41 1 No Yes 5 7 2 1
L:L:?1 R:R:Y35 4.35 1 Yes Yes 0 7 0 1
R:R:F77 R:R:V108 5.24 1 Yes Yes 6 6 1 1
R:R:F77 R:R:N111 16.92 1 Yes Yes 6 8 1 2
R:R:F77 R:R:Y292 14.44 1 Yes Yes 6 7 1 1
R:R:F77 R:R:N295 13.29 1 Yes Yes 6 9 1 2
L:L:?1 R:R:F77 3.02 1 Yes Yes 0 6 0 1
R:R:W84 R:R:Y87 6.75 1 Yes Yes 7 5 1 1
R:R:W84 R:R:W94 14.06 1 Yes Yes 7 9 1 2
R:R:A104 R:R:W84 6.48 0 No Yes 6 7 2 1
R:R:S105 R:R:W84 3.71 1 No Yes 5 7 1 1
R:R:C180 R:R:W84 5.22 0 No Yes 9 7 2 1
L:L:?1 R:R:W84 21.15 1 Yes Yes 0 7 0 1
R:R:Y87 R:R:Y92 7.94 1 Yes Yes 5 4 1 2
R:R:W94 R:R:Y87 11.58 1 Yes Yes 9 5 2 1
R:R:Y87 W:W:I104 3.63 1 Yes No 5 0 1 2
L:L:?1 R:R:Y87 4.35 1 Yes Yes 0 5 0 1
R:R:Y92 W:W:I104 24.18 1 Yes No 4 0 2 2
R:R:R167 R:R:S105 13.18 1 No No 5 5 1 1
L:L:?1 R:R:S105 3.72 1 Yes No 0 5 0 1
R:R:V108 R:R:Y292 6.31 1 Yes Yes 6 7 1 1
L:L:?1 R:R:V108 13.83 1 Yes Yes 0 6 0 1
R:R:S109 R:R:Y113 6.36 0 No Yes 4 7 1 2
R:R:S109 R:R:S160 3.26 0 No No 4 7 1 2
L:L:?1 R:R:S109 6.51 1 Yes No 0 4 0 1
R:R:N111 R:R:Y292 5.81 1 Yes Yes 8 7 2 1
R:R:N111 R:R:N295 12.26 1 Yes Yes 8 9 2 2
R:R:L195 R:R:P162 3.28 1 Yes No 5 6 1 2
R:R:F182 R:R:H166 15.84 1 Yes Yes 4 4 1 2
R:R:H166 R:R:L191 9 1 Yes No 4 1 2 2
R:R:F182 R:R:R167 6.41 1 Yes No 4 5 1 1
L:L:?1 R:R:R167 19.55 1 Yes No 0 5 0 1
R:R:F182 R:R:L191 4.87 1 Yes No 4 1 1 2
R:R:F182 R:R:L195 3.65 1 Yes Yes 4 5 1 1
R:R:F182 W:W:Y108 8.25 1 Yes Yes 4 0 1 2
L:L:?1 R:R:F182 4.52 1 Yes Yes 0 4 0 1
R:R:L195 W:W:Y108 5.86 1 Yes Yes 5 0 1 2
L:L:?1 R:R:L195 4.28 1 Yes Yes 0 5 0 1
R:R:H256 R:R:K199 3.93 1 Yes Yes 6 5 2 1
R:R:K199 R:R:T260 4.5 1 Yes No 5 6 1 2
R:R:K199 W:W:Y106 9.55 1 Yes Yes 5 0 1 1
L:L:?1 R:R:K199 9.6 1 Yes Yes 0 5 0 1
R:R:H256 R:R:W253 8.46 1 Yes Yes 6 8 2 2
R:R:W253 R:R:Y292 6.75 0 Yes Yes 8 7 2 1
R:R:H256 R:R:T260 6.85 1 Yes No 6 6 2 2
R:R:H256 R:R:M284 5.25 1 Yes Yes 6 4 2 2
R:R:H256 R:R:I288 10.61 1 Yes No 6 6 2 1
R:R:H256 W:W:Y106 8.71 1 Yes Yes 6 0 2 1
R:R:T260 W:W:Y106 3.75 1 No Yes 6 0 2 1
R:R:M284 W:W:V105 7.61 1 Yes Yes 4 0 2 2
R:R:M284 W:W:Y106 4.79 1 Yes Yes 4 0 2 1
R:R:I288 W:W:V105 6.14 0 No Yes 6 0 1 2
L:L:?1 R:R:I288 7.95 1 Yes No 0 6 0 1
R:R:N295 R:R:Y292 5.81 1 Yes Yes 9 7 2 1
L:L:?1 R:R:Y292 4.35 1 Yes Yes 0 7 0 1
W:W:V105 W:W:Y106 7.57 1 Yes Yes 0 0 2 1
W:W:Y106 W:W:Y108 5.96 1 Yes Yes 0 0 1 2
L:L:?1 W:W:Y106 10.16 1 Yes Yes 0 0 0 1
L:L:?1 R:R:A163 2.93 1 Yes No 0 4 0 1
R:R:A106 R:R:A163 1.79 0 No No 5 4 2 1
R:R:S107 R:R:V108 1.62 0 No Yes 5 6 2 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub10.00
Average Interaction Strength8.02
Average Nodes In Shell40.00
Average Hubs In Shell23.00
Average Links In Shell65.00
Average Links Mediated by Hubs In Shell62.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links13.50
Average Number Of Links With An Hub8.50
Average Interaction Strength8.64
Average Nodes In Shell37.00
Average Hubs In Shell19.50
Average Links In Shell56.50
Average Links Mediated by Hubs In Shell54.50

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)