CodeLTB
NameLeukotriene B4
Synonyms
  • LTB4
  • Leukotriene B4
Identifier(5S,6Z,8E,10E,12R,14Z)-5,12-bis(oxidanyl)icosa-6,8,10,14-tetraenoic acid
FormulaC20 H32 O4
Molecular Weight336.466
SMILESCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O
PubChem5280492
Formal Charge0
Total Atoms56
Total Chiral Atoms2
Total Bonds55
Total Aromatic Bonds0
Networks1
 missing image

This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VKT A Lipid Leukotriene BLT1 Homo sapiens LTB4 - Gi1/Beta1/Gamma2 2.9 2022-03-09 10.1038/s41467-022-28820-9

A 2D representation of the interactions of LTB in 7VKT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:A21 R:R:L78 3.15 0 No Yes 5 3 2 1
R:R:I22 R:R:L78 2.85 0 No Yes 5 3 2 1
R:R:F275 R:R:L25 4.87 1 Yes No 6 7 1 2
R:R:F275 R:R:V67 2.62 1 Yes No 6 6 1 2
R:R:F74 R:R:H94 6.79 0 No Yes 6 6 1 2
L:L:?1 R:R:F74 18.93 1 Yes No 0 6 0 1
L:L:?1 R:R:L78 11.18 1 Yes Yes 0 3 0 1
R:R:H94 R:R:V152 4.15 0 Yes No 6 4 2 1
R:R:M101 R:R:W234 3.49 1 No Yes 7 9 1 1
L:L:?1 R:R:M101 5.27 1 Yes No 0 7 0 1
R:R:S145 R:R:Y102 2.54 0 No Yes 8 7 2 1
R:R:L148 R:R:Y102 10.55 1 No Yes 4 7 2 1
R:R:T188 R:R:Y102 3.75 1 Yes Yes 5 7 2 1
L:L:?1 R:R:Y102 4.37 1 Yes Yes 0 7 0 1
R:R:L148 R:R:T188 2.95 1 No Yes 4 5 2 2
L:L:?1 R:R:V152 2.78 1 Yes No 0 4 0 1
R:R:E185 R:R:H181 7.39 0 No Yes 5 5 1 2
R:R:E185 R:R:N241 2.63 0 No No 5 6 1 2
L:L:?1 R:R:E185 8.24 1 Yes No 0 5 0 1
R:R:F230 R:R:W234 5.01 1 Yes Yes 9 9 2 1
R:R:H238 R:R:W234 3.17 0 Yes Yes 8 9 2 1
R:R:A274 R:R:W234 5.19 0 No Yes 8 9 2 1
R:R:S277 R:R:W234 7.41 0 No Yes 9 9 2 1
L:L:?1 R:R:W234 3.54 1 Yes Yes 0 9 0 1
R:R:H238 R:R:Y237 5.44 0 Yes Yes 8 6 2 2
R:R:N241 R:R:Y237 15.12 0 No Yes 6 6 2 2
R:R:I271 R:R:Y237 4.84 1 No Yes 5 6 1 2
L:L:?1 R:R:N268 6.83 1 Yes No 0 4 0 1
R:R:F275 R:R:I271 2.51 1 Yes No 6 5 1 1
L:L:?1 R:R:I271 6.21 1 Yes No 0 5 0 1
L:L:?1 R:R:F275 3.03 1 Yes Yes 0 6 0 1
L:L:?1 R:R:G98 2.13 1 Yes No 0 4 0 1
R:R:C97 R:R:G98 1.96 0 No No 6 4 2 1
R:R:W106 R:R:Y102 1.93 1 No Yes 5 7 2 1
R:R:L78 R:R:S18 1.5 0 Yes No 3 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.59
Average Nodes In Shell30.00
Average Hubs In Shell11.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.59
Average Nodes In Shell30.00
Average Hubs In Shell11.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell33.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)