CodeLTD
NameLeukotriene D4
Synonyms
  • Leukotriene D4
  • S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteinylglycine
  • LTD4
  • (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine
  • 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid
Identifier
FormulaC25 H40 N2 O6 S
Molecular Weight496.66
SMILES
PubChem5280878
Formal Charge0
Total Atoms74
Total Chiral Atoms3
Total Bonds73
Total Aromatic Bonds0
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IXX A Lipid Leukotriene CysLT2 Homo Sapiens LTD4 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.15 2025-04-02 doi.org/10.1073/pnas.2417148122

A 2D representation of the interactions of LTD in 9IXX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:K37 5.3 5 Yes Yes 0 4 0 1
L:L:?1 R:R:Y119 28.93 5 Yes No 0 5 0 1
L:L:?1 R:R:Y123 13.21 5 Yes No 0 7 0 1
L:L:?1 R:R:S169 8.86 5 Yes No 0 5 0 1
L:L:?1 R:R:L173 2.97 5 Yes No 0 5 0 1
L:L:?1 R:R:L198 7.43 5 Yes No 0 4 0 1
L:L:?1 R:R:R267 3.26 5 Yes Yes 0 5 0 1
L:L:?1 R:R:H284 8.97 5 Yes Yes 0 4 0 1
L:L:?1 R:R:L287 5.2 5 Yes No 0 4 0 1
R:R:H284 R:R:I33 9.28 5 Yes No 4 1 1 2
R:R:F41 R:R:K37 9.93 5 Yes Yes 5 4 2 1
R:R:K37 R:R:Y98 5.97 5 Yes Yes 4 5 1 2
R:R:H284 R:R:K37 7.86 5 Yes Yes 4 4 1 1
R:R:F41 R:R:Y98 22.69 5 Yes Yes 5 5 2 2
R:R:L173 R:R:S115 3 0 No No 5 6 1 2
R:R:L118 R:R:Y119 9.38 0 No No 6 5 2 1
R:R:Y119 R:R:Y263 3.97 0 No Yes 5 7 1 2
R:R:A205 R:R:Y123 5.34 5 No No 5 7 2 1
R:R:R267 R:R:Y123 3.09 5 Yes No 5 7 1 1
R:R:M172 R:R:M201 5.78 0 No Yes 8 5 2 1
R:R:K197 R:R:M201 4.32 0 No Yes 3 5 2 1
R:R:L198 R:R:L271 4.15 0 No No 4 5 1 2
R:R:M201 R:R:T200 3.01 0 Yes No 5 3 1 2
R:R:N202 R:R:R267 14.46 5 Yes Yes 5 5 2 1
R:R:L271 R:R:N202 4.12 0 No Yes 5 5 2 2
R:R:A205 R:R:R267 2.77 5 No Yes 5 5 2 1
R:R:H264 R:R:Y263 7.62 5 Yes Yes 8 7 2 2
R:R:R267 R:R:Y263 8.23 5 Yes Yes 5 7 1 2
R:R:H264 R:R:R267 3.39 5 Yes Yes 8 5 2 1
R:R:H270 R:R:L287 5.14 0 No No 4 4 2 1
R:R:C279 R:R:H284 5.9 0 No Yes 1 4 2 1
L:L:?1 R:R:M201 1.52 5 Yes Yes 0 5 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.56
Average Nodes In Shell26.00
Average Hubs In Shell10.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.50
Average Number Of Links With An Hub3.50
Average Interaction Strength8.86
Average Nodes In Shell24.50
Average Hubs In Shell8.50
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell23.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)