CodeMAE
NameMaleic acid
Synonymscis-Butenedioic acid
Identifier
FormulaC4 H4 O4
Molecular Weight116.072
SMILES
PubChem444266
Formal Charge0
Total Atoms12
Total Chiral Atoms0
Total Bonds11
Total Aromatic Bonds0
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YKX A Alicarboxylic acid Succinate Succinate Homo Sapiens Maleic acid - Gi1/Beta1/Gamma1 2.69 2024-05-29 doi.org/10.1038/s41422-024-00984-7

A 2D representation of the interactions of MAE in 8YKX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E22 R:R:Y83 8.98 0 No Yes 5 5 2 1
R:R:L26 R:R:Y30 8.21 1 Yes Yes 6 8 2 1
R:R:L26 R:R:Y83 5.86 1 Yes Yes 6 5 2 1
R:R:L26 R:R:P282 3.28 1 Yes Yes 6 5 2 2
R:R:L76 R:R:Y30 5.86 0 No Yes 8 8 2 1
R:R:R281 R:R:Y30 5.14 1 Yes Yes 6 8 1 1
R:R:P282 R:R:Y30 11.13 1 Yes Yes 5 8 2 1
R:R:F285 R:R:Y30 9.28 1 Yes Yes 7 8 1 1
L:L:?1 R:R:Y30 11.07 1 Yes Yes 0 8 0 1
R:R:E33 R:R:P282 3.14 0 No Yes 7 5 2 2
R:R:E33 R:R:F285 4.66 0 No Yes 7 7 2 1
R:R:F72 R:R:L102 9.74 1 Yes Yes 7 7 2 1
R:R:F285 R:R:F72 13.93 1 Yes Yes 7 7 1 2
R:R:N98 R:R:T75 10.24 1 Yes No 4 6 2 2
R:R:L102 R:R:T75 7.37 1 Yes No 7 6 1 2
R:R:L79 R:R:Y83 4.69 1 No Yes 6 5 1 1
R:R:L79 R:R:N98 4.12 1 No Yes 6 4 1 2
L:L:?1 R:R:L79 6.53 1 Yes No 0 6 0 1
R:R:D174 R:R:Y83 5.75 1 Yes Yes 5 5 1 1
L:L:?1 R:R:Y83 6.64 1 Yes Yes 0 5 0 1
R:R:I161 R:R:R99 7.52 0 No No 4 6 2 1
R:R:D174 R:R:R99 5.96 1 Yes No 5 6 1 1
L:L:?1 R:R:R99 5.73 1 Yes No 0 6 0 1
R:R:F285 R:R:L102 4.87 1 Yes Yes 7 7 1 1
L:L:?1 R:R:L102 5.23 1 Yes Yes 0 7 0 1
R:R:H103 R:R:I157 3.98 1 No Yes 5 4 1 2
R:R:F175 R:R:H103 9.05 1 Yes No 4 5 2 1
L:L:?1 R:R:H103 7.28 1 Yes No 0 5 0 1
R:R:I157 R:R:I161 4.42 1 Yes No 4 4 2 2
R:R:F175 R:R:I157 11.3 1 Yes Yes 4 4 2 2
R:R:D174 R:R:R281 8.34 1 Yes Yes 5 6 1 1
L:L:?1 R:R:D174 15.37 1 Yes Yes 0 5 0 1
R:R:Y248 R:R:Y277 10.92 1 Yes Yes 7 5 2 2
R:R:R281 R:R:Y248 4.12 1 Yes Yes 6 7 1 2
R:R:R281 R:R:Y277 22.64 1 Yes Yes 6 5 1 2
R:R:F285 R:R:R281 4.28 1 Yes Yes 7 6 1 1
L:L:?1 R:R:R281 28.67 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F285 8.05 1 Yes Yes 0 7 0 1
R:R:I80 R:R:Y30 2.42 0 No Yes 6 8 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.51
Average Nodes In Shell24.00
Average Hubs In Shell15.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.50
Average Nodes In Shell23.50
Average Hubs In Shell13.00
Average Links In Shell36.50
Average Links Mediated by Hubs In Shell34.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)