CodeMED
NameD-Methionine
SynonymsD-Methionine
Identifier(2R)-2-amino-4-methylsulfanyl-butanoic acid
FormulaC5 H11 N O2 S
Molecular Weight149.211
SMILESCSCC[C@H](C(=O)O)N
PubChem84815
Formal Charge0
Total Atoms20
Total Chiral Atoms1
Total Bonds19
Total Aromatic Bonds0
Networks1
 missing image

This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XZF A Peptide Apelin Apelin Homo sapiens WN561 - Gi1/Beta1/Gamma2 3 2024-03-20 10.1016/j.cell.2024.02.004

A 2D representation of the interactions of MED in 8XZF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V38 R:R:Y299 5.05 0 No Yes 7 7 2 1
R:R:F78 R:R:I109 7.54 3 Yes Yes 6 6 2 1
R:R:F78 R:R:Y299 14.44 3 Yes Yes 6 7 2 1
R:R:I109 R:R:T81 3.04 3 Yes No 6 7 1 2
R:R:L82 R:R:Y299 15.24 0 No Yes 7 7 2 1
L:L:P10 R:R:W85 13.51 3 Yes Yes 0 6 1 2
R:R:I109 R:R:Y299 6.04 3 Yes Yes 6 7 1 1
L:L:P10 R:R:I109 6.77 3 Yes Yes 0 6 1 1
L:L:?11 R:R:I109 5.27 3 Yes Yes 0 6 0 1
R:R:H265 R:R:Y264 10.89 3 Yes Yes 8 6 2 1
R:R:K268 R:R:Y264 11.94 3 Yes Yes 5 6 2 1
R:R:F291 R:R:Y264 6.19 0 Yes Yes 4 6 2 1
L:L:?11 R:R:Y264 19.47 3 Yes Yes 0 6 0 1
R:R:H265 R:R:K268 3.93 3 Yes Yes 8 5 2 2
R:R:F291 R:R:T295 3.89 0 Yes No 4 5 2 1
L:L:?11 R:R:T295 5.44 3 Yes No 0 5 0 1
L:L:?11 R:R:Y299 5.41 3 Yes Yes 0 7 0 1
L:L:G9 L:L:P10 4.06 0 No Yes 0 0 2 1
L:L:?11 L:L:P10 6.06 3 Yes Yes 0 0 0 1
L:L:?11 L:L:G12 7.89 3 Yes No 0 0 0 1
L:L:G12 L:L:P13 4.06 0 No Yes 0 0 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.26
Average Nodes In Shell17.00
Average Hubs In Shell11.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.26
Average Nodes In Shell17.00
Average Hubs In Shell11.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell21.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)