CodeMK6
NameMK-8666
SynonymsMK-8666
Identifier
FormulaC29 H31 N O6 S
Molecular Weight521.625
SMILES
PubChem73051869
Formal Charge0
Total Atoms68
Total Chiral Atoms3
Total Bonds72
Total Aromatic Bonds18
Networks2
 missing image

This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5TZR A Lipid Free Fatty Acid FFA1 Homo Sapiens - MK8666 - 2.2 2017-06-07 doi.org/10.1038/nsmb.3417

A 2D representation of the interactions of MK6 in 5TZR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P80 W:W:?1 3.03 1 No Yes 7 0 1 0
R:R:A83 W:W:?1 3.87 1 No Yes 6 0 1 0
R:R:V84 W:W:?1 8.24 0 No Yes 6 0 1 0
R:R:F87 W:W:?1 20.95 1 No Yes 6 0 1 0
R:R:Y91 W:W:?1 5.76 1 Yes Yes 8 0 1 0
R:R:L138 W:W:?1 12.75 1 No Yes 6 0 1 0
R:R:G139 W:W:?1 7.35 0 No Yes 4 0 1 0
R:R:F142 W:W:?1 19.45 1 Yes Yes 4 0 1 0
R:R:L158 W:W:?1 5.1 1 No Yes 1 0 1 0
R:R:L171 W:W:?1 3.4 1 No Yes 5 0 1 0
R:R:W174 W:W:?1 7.7 1 Yes Yes 4 0 1 0
R:R:R183 W:W:?1 11.19 1 Yes Yes 6 0 1 0
R:R:Y240 W:W:?1 5.04 1 Yes Yes 8 0 1 0
R:R:R258 W:W:?1 3.73 1 Yes Yes 7 0 1 0
R:R:F142 R:R:P80 5.78 1 Yes No 4 7 1 1
R:R:L158 R:R:P80 6.57 1 No No 1 7 1 1
R:R:A83 R:R:L171 4.73 1 No No 6 5 1 1
R:R:F87 R:R:H86 11.31 1 No Yes 6 6 1 2
R:R:F87 R:R:Y240 3.09 1 No Yes 6 8 1 1
R:R:L90 R:R:Y240 5.86 0 No Yes 7 8 2 1
R:R:L138 R:R:Y91 3.52 1 No Yes 6 8 1 1
R:R:L186 R:R:Y91 17.58 0 No Yes 6 8 2 1
R:R:Y240 R:R:Y91 3.97 1 Yes Yes 8 8 1 1
R:R:N244 R:R:Y91 5.81 1 Yes Yes 7 8 2 1
R:R:L138 R:R:V134 2.98 1 No No 6 7 1 2
R:R:A146 R:R:F142 5.55 1 No Yes 3 4 2 1
R:R:F142 R:R:L158 8.53 1 Yes No 4 1 1 1
R:R:F142 R:R:G159 3.01 1 Yes No 4 4 1 2
R:R:F142 R:R:W174 3.01 1 Yes Yes 4 4 1 1
R:R:A146 R:R:W174 5.19 1 No Yes 3 4 2 1
R:R:G159 R:R:P147 4.06 0 No Yes 4 3 2 2
R:R:P147 R:R:W174 4.05 0 Yes Yes 3 4 2 1
R:R:C170 R:R:L171 3.17 1 No No 9 5 2 1
R:R:E172 R:R:R258 12.79 1 No Yes 6 7 2 1
R:R:E172 R:R:L262 3.98 1 No No 6 5 2 2
R:R:S178 R:R:W174 7.41 0 No Yes 1 4 2 1
R:R:A179 R:R:W174 9.08 0 No Yes 4 4 2 1
R:R:A179 R:R:R183 5.53 0 No Yes 4 6 2 1
R:R:R183 R:R:Y240 3.09 1 Yes Yes 6 8 1 1
R:R:N244 R:R:R183 10.85 1 Yes Yes 7 6 2 1
R:R:R183 R:R:R258 18.13 1 Yes Yes 6 7 1 1
R:R:N244 R:R:Y240 12.79 1 Yes Yes 7 8 2 1
R:R:R258 R:R:Y240 9.26 1 Yes Yes 7 8 1 1
R:R:L262 R:R:Y240 7.03 1 No Yes 5 8 2 1
R:R:L262 R:R:R258 4.86 1 No Yes 5 7 2 1
R:R:R258 R:R:S243 2.64 1 Yes No 7 5 1 2
R:R:V141 R:R:W174 2.45 0 No Yes 5 4 2 1
R:R:F142 R:R:G143 1.51 1 Yes No 4 3 1 2
R:R:D175 R:R:W174 1.12 0 No Yes 6 4 2 1
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.40
Average Nodes In Shell32.00
Average Hubs In Shell10.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5TZY A Lipid Free Fatty Acid FFA1 Homo Sapiens - MK8666; AP8 - 3.22 2017-06-07 doi.org/10.1038/nsmb.3417

A 2D representation of the interactions of MK6 in 5TZY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P80 W:W:?1 3.03 0 No Yes 7 0 1 0
R:R:A83 W:W:?1 3.87 0 No Yes 6 0 1 0
R:R:V84 W:W:?1 8.24 0 No Yes 6 0 1 0
R:R:F87 W:W:?1 22.44 1 Yes Yes 6 0 1 0
R:R:Y91 W:W:?1 4.32 1 Yes Yes 8 0 1 0
R:R:L138 W:W:?1 11.9 1 No Yes 6 0 1 0
R:R:G139 W:W:?1 7.35 0 No Yes 4 0 1 0
R:R:F142 W:W:?1 21.69 0 Yes Yes 4 0 1 0
R:R:L158 W:W:?1 7.65 0 No Yes 1 0 1 0
R:R:L171 W:W:?1 4.25 0 No Yes 5 0 1 0
R:R:R183 W:W:?1 10.45 1 No Yes 6 0 1 0
R:R:L186 W:W:?1 5.1 1 Yes Yes 6 0 1 0
R:R:Y240 W:W:?1 4.32 1 Yes Yes 8 0 1 0
R:R:R258 W:W:?1 5.22 1 Yes Yes 7 0 1 0
R:R:C79 R:R:P80 3.77 1 Yes No 9 7 2 1
R:R:F87 R:R:L90 3.65 1 Yes No 6 7 1 2
R:R:F87 R:R:Y240 4.13 1 Yes Yes 6 8 1 1
R:R:F87 R:R:R258 4.28 1 Yes Yes 6 7 1 1
R:R:F87 R:R:L262 3.65 1 Yes Yes 6 5 1 2
R:R:L186 R:R:Y91 8.21 1 Yes Yes 6 8 1 1
R:R:L190 R:R:Y91 3.52 1 Yes Yes 6 8 2 1
R:R:Y240 R:R:Y91 7.94 1 Yes Yes 8 8 1 1
R:R:N241 R:R:Y91 8.14 1 Yes Yes 9 8 2 1
R:R:N244 R:R:Y91 3.49 1 Yes Yes 7 8 2 1
R:R:H137 R:R:L186 7.71 0 Yes Yes 5 6 2 1
R:R:H137 R:R:L190 11.57 0 Yes Yes 5 6 2 2
R:R:L138 R:R:L186 4.15 1 No Yes 6 6 1 1
R:R:F142 R:R:G159 3.01 0 Yes No 4 4 1 2
R:R:E172 R:R:R258 8.14 1 No Yes 6 7 2 1
R:R:E172 R:R:L262 3.98 1 No Yes 6 5 2 2
R:R:N244 R:R:R183 9.64 1 Yes No 7 6 2 1
R:R:R183 R:R:R258 20.26 1 No Yes 6 7 1 1
R:R:N244 R:R:Y240 10.47 1 Yes Yes 7 8 2 1
R:R:R258 R:R:Y240 10.29 1 Yes Yes 7 8 1 1
R:R:L262 R:R:Y240 7.03 1 Yes Yes 5 8 2 1
R:R:R258 R:R:S243 3.95 1 Yes No 7 5 1 2
R:R:N244 R:R:R258 4.82 1 Yes Yes 7 7 2 1
R:R:L262 R:R:R258 9.72 1 Yes Yes 5 7 2 1
R:R:A146 R:R:F142 2.77 0 No Yes 3 4 2 1
R:R:F142 R:R:G143 1.51 0 Yes No 4 3 1 2
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.56
Average Nodes In Shell27.00
Average Hubs In Shell13.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.48
Average Nodes In Shell29.50
Average Hubs In Shell11.50
Average Links In Shell44.50
Average Links Mediated by Hubs In Shell42.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)