CodeMOI
NameMorphine
Synonyms(5α,6α)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
Identifiern/a
FormulaC17 H19 N O3
Molecular Weight285.338
SMILESC[N@]1CC[C@]23c4c5ccc(c4O[C@H]2[C@H](C=C[C@H]3[C@H]1C5)O)O
PubChem5288826
Formal Charge0
Total Atoms40
Total Chiral Atoms5
Total Bonds44
Total Aromatic Bonds6
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8EF6 A Peptide Opioid MOP Homo sapiens Morphine - Gi1/Beta1/Gamma2 3.2  2022-11-09 10.1016/j.cell.2022.09.041

A 2D representation of the interactions of MOI in 8EF6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D149 R:R:T122 4.34 21 Yes No 5 6 1 2
R:R:D149 R:R:Q126 3.92 21 Yes No 5 6 1 2
R:R:Q126 R:R:Y328 5.64 21 No No 6 7 2 2
R:R:D149 R:R:Y328 9.2 21 Yes No 5 7 1 2
L:L:?1 R:R:D149 10.87 0 Yes Yes 0 5 0 1
R:R:V204 R:R:Y150 6.31 6 No No 5 4 2 1
R:R:L221 R:R:Y150 3.52 6 Yes No 4 4 2 1
L:L:?1 R:R:Y150 15.02 0 Yes No 0 4 0 1
R:R:F154 R:R:M153 3.73 0 Yes No 6 7 2 1
R:R:M153 R:R:W295 5.82 0 No Yes 7 8 1 2
L:L:?1 R:R:M153 10.19 0 Yes No 0 7 0 1
R:R:F154 R:R:V238 7.87 0 Yes No 6 5 2 1
R:R:L221 R:R:V204 2.98 6 Yes No 4 5 2 2
R:R:L234 R:R:V238 2.98 0 No No 6 5 2 1
L:L:?1 R:R:V238 4.77 0 Yes No 0 5 0 1
R:R:F239 R:R:F243 5.36 3 Yes Yes 6 8 2 2
R:R:F239 R:R:H299 5.66 3 Yes Yes 6 7 2 1
R:R:F243 R:R:H299 10.18 3 Yes Yes 8 7 2 1
R:R:H299 R:R:W295 8.46 3 Yes Yes 7 8 1 2
R:R:C323 R:R:I298 3.27 0 No No 6 6 2 1
L:L:?1 R:R:I298 6.86 0 Yes No 0 6 0 1
L:L:?1 R:R:H299 3.09 0 Yes Yes 0 7 0 1
R:R:W320 R:R:Y301 5.79 0 Yes No 4 5 1 2
L:L:?1 R:R:V302 5.96 0 Yes No 0 5 0 1
R:R:K305 R:R:W320 9.28 0 No Yes 3 4 2 1
R:R:H321 R:R:W320 6.35 20 Yes Yes 4 4 2 1
R:R:I324 R:R:W320 7.05 0 No Yes 5 4 2 1
L:L:?1 R:R:W320 4.56 0 Yes Yes 0 4 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.67
Average Nodes In Shell24.00
Average Hubs In Shell10.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.67
Average Nodes In Shell24.00
Average Hubs In Shell10.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell24.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)