CodeNAL
NameBeta-(2-Naphthyl)-Alanine
SynonymsBeta-(2-Naphthyl)-Alanine
Identifier(2S)-2-azanyl-3-naphthalen-2-yl-propanoic acid
FormulaC13 H13 N O2
Molecular Weight215.248
SMILESc1ccc2cc(ccc2c1)C[C@@H](C(=O)O)N
PubChem185915
Formal Charge0
Total Atoms29
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds11
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XZJ A Peptide Apelin Apelin Homo sapiens WN353 - Gi1/Beta1/Gamma2 3 2024-03-20 10.1016/j.cell.2024.02.004

A 2D representation of the interactions of NAL in 8XZJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I31 R:R:P292 3.39 1 Yes No 6 4 2 1
R:R:R168 R:R:W85 4 1 Yes Yes 5 6 2 2
L:L:P10 R:R:W85 17.57 1 Yes Yes 0 6 1 2
R:R:R168 R:R:S106 15.81 1 Yes No 5 5 2 2
L:L:P12 R:R:S106 8.91 1 Yes No 0 5 1 2
R:R:I109 R:R:Y299 3.63 0 No Yes 6 7 2 2
L:L:P10 R:R:I109 5.08 1 Yes No 0 6 1 2
L:L:P12 R:R:V164 7.07 1 Yes No 0 4 1 2
R:R:M183 R:R:R168 7.44 1 No Yes 5 5 2 2
L:L:P12 R:R:R168 8.65 1 Yes Yes 0 5 1 2
L:L:P12 R:R:M183 5.03 1 Yes No 0 5 1 2
R:R:K268 R:R:Y264 8.36 1 Yes No 5 6 2 2
R:R:T295 R:R:Y264 3.75 1 Yes No 5 6 1 2
R:R:F291 R:R:V267 5.24 1 Yes No 4 4 1 2
R:R:K268 R:R:M272 4.32 1 Yes Yes 5 5 2 2
L:L:F13 R:R:K268 6.2 1 No Yes 0 5 1 2
L:L:L5 R:R:Y271 3.52 1 Yes No 0 4 1 2
L:L:F13 R:R:M272 4.98 1 No Yes 0 5 1 2
R:R:F291 R:R:T295 3.89 1 Yes Yes 4 5 1 1
L:L:L5 R:R:F291 6.09 1 Yes Yes 0 4 1 1
L:L:?11 R:R:F291 7.33 1 Yes Yes 0 4 0 1
L:L:?11 R:R:P292 4.23 1 Yes No 0 4 0 1
R:R:T295 R:R:Y299 3.75 1 Yes Yes 5 7 1 2
L:L:?11 R:R:T295 13.93 1 Yes Yes 0 5 0 1
L:L:K8 L:L:L5 5.64 1 Yes Yes 0 0 2 1
L:L:?11 L:L:L5 14.27 1 Yes Yes 0 0 0 1
L:L:G9 L:L:P10 4.06 1 No Yes 0 0 1 1
L:L:?11 L:L:G9 14.7 1 Yes No 0 0 0 1
L:L:?11 L:L:P10 18.34 1 Yes Yes 0 0 0 1
L:L:?11 L:L:P12 12.7 1 Yes Yes 0 0 0 1
L:L:?11 L:L:F13 7.33 1 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.60
Average Nodes In Shell23.00
Average Hubs In Shell13.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.60
Average Nodes In Shell23.00
Average Hubs In Shell13.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell31.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)