psnGPCR

Code	NKP
Name	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms	18:1 LPA; oleoyl lysophosphatidic acid
Identifier	[(2R)-2-hydroxy-3-phosphonooxy-propyl] (E)-octadec-9-enoate
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES	CCCCCCCC/C=C/CCCCCCCC(=O)OC[C@H](COP(=O)(O)O)O
PubChem	49837858
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0
Networks	3

This ligand is also present in the following 3 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TD0

Lipid

Lysophospholipid (LPA)

LPA1

Homo sapiens

LPA

Gi1/Beta1/Gamma2

2.83

2022-02-09

10.1038/s41467-022-28417-2

A 2D representation of the interactions of NKP in 7TD0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I30	R:R:Y34	4.84	2	No	Yes	6	6	2	1
R:R:I30	R:R:W121	5.87	2	No	Yes	6	9	2	2
R:R:K39	R:R:Y34	11.94	2	Yes	Yes	8	6	1	1
R:R:L41	R:R:Y34	8.21	0	No	Yes	2	6	2	1
R:R:T113	R:R:Y34	3.75	2	No	Yes	5	6	1	1
R:R:W121	R:R:Y34	3.86	2	Yes	Yes	9	6	2	1
R:R:P200	R:R:Y34	12.52	2	No	Yes	6	6	2	1
L:L:?1	R:R:Y34	7.66	2	Yes	Yes	0	6	0	1
R:R:K39	R:R:P200	5.02	2	Yes	No	8	6	1	2
R:R:E293	R:R:K39	9.45	2	Yes	Yes	4	8	1	1
L:L:?1	R:R:K39	10.24	2	Yes	Yes	0	8	0	1
R:R:L105	R:R:Y102	3.52	2	Yes	Yes	6	7	1	2
R:R:M106	R:R:Y102	2.39	2	Yes	Yes	6	7	2	2
R:R:L297	R:R:Y102	10.55	0	No	Yes	6	7	1	2
R:R:E301	R:R:Y102	21.32	0	No	Yes	7	7	2	2
R:R:N108	R:R:Y104	8.14	2	No	No	5	5	2	2
R:R:R124	R:R:Y104	3.09	2	Yes	No	6	5	1	2
R:R:L105	R:R:M106	4.24	2	Yes	Yes	6	6	1	2
R:R:L105	R:R:T109	2.95	2	Yes	Yes	6	5	1	1
R:R:L105	R:R:R124	7.29	2	Yes	Yes	6	6	1	1
R:R:I128	R:R:L105	4.28	2	No	Yes	6	6	1	1
L:L:?1	R:R:L105	3.02	2	Yes	Yes	0	6	0	1
R:R:M106	R:R:T109	3.01	2	Yes	Yes	6	5	2	1
R:R:N108	R:R:R124	2.41	2	No	Yes	5	6	2	1
R:R:R124	R:R:T109	5.17	2	Yes	Yes	6	5	1	1
L:L:?1	R:R:T109	8.57	2	Yes	Yes	0	5	0	1
R:R:R124	R:R:T113	3.88	2	Yes	No	6	5	1	1
L:L:?1	R:R:T113	5.35	2	Yes	No	0	5	0	1
R:R:L116	R:R:R124	6.07	0	No	Yes	6	6	2	1
R:R:Q125	R:R:W121	14.24	2	Yes	Yes	4	9	1	2
R:R:A199	R:R:W121	2.59	2	No	Yes	4	9	2	2
R:R:W121	R:R:Y202	7.72	2	Yes	Yes	9	4	2	2
L:L:?1	R:R:R124	3.53	2	Yes	Yes	0	6	0	1
R:R:D129	R:R:Q125	5.22	2	Yes	Yes	5	4	1	1
R:R:A199	R:R:Q125	3.03	2	No	Yes	4	4	2	1
R:R:Q125	R:R:Y202	11.27	2	Yes	Yes	4	4	1	2
L:L:?1	R:R:Q125	17.4	2	Yes	Yes	0	4	0	1
R:R:D129	R:R:G126	5.03	2	Yes	No	5	6	1	2
R:R:D129	R:R:I128	2.8	2	Yes	No	5	6	1	1
L:L:?1	R:R:I128	5.18	2	Yes	No	0	6	0	1
R:R:D129	R:R:Y202	8.05	2	Yes	Yes	5	4	1	2
R:R:D129	R:R:Y206	6.9	2	Yes	Yes	5	7	1	1
L:L:?1	R:R:D129	6.9	2	Yes	Yes	0	5	0	1
R:R:L132	R:R:S131	3	2	Yes	Yes	7	6	1	2
R:R:L132	R:R:W210	2.28	2	Yes	Yes	7	6	1	1
R:R:L132	R:R:W271	6.83	2	Yes	Yes	7	8	1	2
R:R:E301	R:R:L132	6.63	0	No	Yes	7	7	2	1
L:L:?1	R:R:L132	4.02	2	Yes	Yes	0	7	0	1
R:R:M178	R:R:T133	9.03	2	Yes	No	5	6	2	2
R:R:T133	R:R:W210	7.28	2	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	2.39	2	Yes	Yes	5	7	2	1
R:R:M178	R:R:W210	6.98	2	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	9.74	2	No	Yes	6	4	2	2
R:R:P182	R:R:Y206	16.69	2	No	Yes	6	7	2	1
R:R:W186	R:R:Y206	2.89	0	Yes	Yes	6	7	2	1
R:R:L277	R:R:M198	5.65	2	Yes	Yes	4	3	1	1
R:R:L278	R:R:M198	2.83	2	No	Yes	6	3	1	1
R:R:D281	R:R:M198	5.54	0	Yes	Yes	4	3	2	1
R:R:E293	R:R:M198	9.47	2	Yes	Yes	4	3	1	1
L:L:?1	R:R:M198	5.13	2	Yes	Yes	0	3	0	1
R:R:A199	R:R:Y202	4	2	No	Yes	4	4	2	2
R:R:Y202	R:R:Y206	3.97	2	Yes	Yes	4	7	2	1
R:R:W210	R:R:Y206	2.89	2	Yes	Yes	6	7	1	1
L:L:?1	R:R:Y206	2.55	2	Yes	Yes	0	7	0	1
R:R:L207	R:R:L278	5.54	0	No	No	6	6	2	1
R:R:N214	R:R:W210	6.78	2	Yes	Yes	7	6	2	1
R:R:W210	R:R:W271	6.56	2	Yes	Yes	6	8	1	2
L:L:?1	R:R:W210	11.58	2	Yes	Yes	0	6	0	1
R:R:N214	R:R:W271	14.69	2	Yes	Yes	7	8	2	2
R:R:F296	R:R:P273	8.67	2	Yes	No	5	9	1	2
R:R:F296	R:R:G274	4.52	2	Yes	No	5	5	1	1
L:L:?1	R:R:G274	3.73	2	Yes	No	0	5	0	1
R:R:L277	R:R:V289	4.47	2	Yes	No	4	4	1	2
R:R:L277	R:R:Y292	3.52	2	Yes	No	4	3	1	2
R:R:F296	R:R:L277	10.96	2	Yes	Yes	5	4	1	1
L:L:?1	R:R:L277	3.02	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:L278	5.03	2	Yes	No	0	6	0	1
R:R:D281	R:R:V289	7.3	0	Yes	No	4	4	2	2
R:R:E293	R:R:L290	2.65	2	Yes	No	4	3	1	2
R:R:F296	R:R:Y292	4.13	2	Yes	No	5	3	1	2
R:R:E293	R:R:K294	5.4	2	Yes	No	4	4	1	1
L:L:?1	R:R:E293	5.78	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:K294	9.22	2	Yes	No	0	4	0	1
L:L:?1	R:R:F296	2.65	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:L297	13.07	2	Yes	No	0	6	0	1
R:R:F295	R:R:F296	1.07	0	No	Yes	4	5	2	1

Statistics	Value
Average Number Of Links	20.00
Average Number Of Links With An Hub	14.00
Average Interaction Strength	6.68
Average Nodes In Shell	48.00
Average Hubs In Shell	25.00
Average Links In Shell	86.00
Average Links Mediated by Hubs In Shell	84.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TD1

Lipid

Lysophospholipid (LPA)

LPA1

Homo sapiens

LPA

Gi1/Beta1/Gamma2

3.08

2022-02-09

10.1038/s41467-022-28417-2

A 2D representation of the interactions of NKP in 7TD1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I30	R:R:Y34	4.84	0	No	Yes	6	6	2	1
R:R:K39	R:R:Y34	9.55	1	No	Yes	8	6	1	1
R:R:L41	R:R:Y34	8.21	0	No	Yes	2	6	2	1
R:R:W121	R:R:Y34	5.79	1	Yes	Yes	9	6	2	1
R:R:P200	R:R:Y34	9.74	0	No	Yes	6	6	2	1
L:L:?1	R:R:Y34	3.41	1	Yes	Yes	0	6	0	1
R:R:E293	R:R:K39	6.75	1	Yes	No	4	8	1	1
L:L:?1	R:R:K39	11.27	1	Yes	No	0	8	0	1
R:R:K294	R:R:V52	3.04	1	Yes	No	4	5	1	2
R:R:L297	R:R:Y102	10.55	0	No	Yes	6	7	1	2
R:R:E301	R:R:Y102	19.08	0	No	Yes	7	7	2	2
R:R:R124	R:R:Y104	3.09	1	Yes	No	6	5	1	2
R:R:L105	R:R:R124	7.29	0	No	Yes	6	6	2	1
R:R:G110	R:R:T109	5.46	0	No	No	5	5	2	1
R:R:K294	R:R:T109	3	1	Yes	No	4	5	1	1
L:L:?1	R:R:T109	7.49	1	Yes	No	0	5	0	1
R:R:R124	R:R:T113	5.17	1	Yes	No	6	5	1	1
L:L:?1	R:R:T113	11.78	1	Yes	No	0	5	0	1
R:R:L116	R:R:R124	4.86	0	No	Yes	6	6	2	1
R:R:R124	R:R:W121	6	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	15.33	1	No	Yes	4	9	1	2
R:R:W121	R:R:Y202	7.72	1	Yes	Yes	9	4	2	2
L:L:?1	R:R:R124	5.29	1	Yes	Yes	0	6	0	1
R:R:Q125	R:R:Y202	7.89	1	No	Yes	4	4	1	2
L:L:?1	R:R:Q125	14.5	1	Yes	No	0	4	0	1
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
R:R:D129	R:R:I128	2.8	1	Yes	No	5	6	1	2
R:R:I128	R:R:L132	2.85	0	No	Yes	6	7	2	1
R:R:D129	R:R:Y202	5.75	1	Yes	Yes	5	4	1	2
R:R:D129	R:R:Y206	5.75	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:D129	7.89	1	Yes	Yes	0	5	0	1
R:R:L132	R:R:S131	3	0	Yes	No	7	6	1	2
R:R:L132	R:R:W271	6.83	0	Yes	Yes	7	8	1	2
R:R:E301	R:R:L132	6.63	0	No	Yes	7	7	2	1
L:L:?1	R:R:L132	3.02	1	Yes	Yes	0	7	0	1
R:R:M178	R:R:T133	7.53	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	6.06	1	No	Yes	6	6	2	1
R:R:M178	R:R:W210	4.65	1	Yes	Yes	5	6	2	1
R:R:L207	R:R:S196	3	0	No	No	6	5	1	2
R:R:E293	R:R:M198	8.12	1	Yes	No	4	3	1	2
R:R:Y202	R:R:Y206	2.98	1	Yes	Yes	4	7	2	2
R:R:W210	R:R:Y206	2.89	1	Yes	Yes	6	7	1	2
L:L:?1	R:R:L207	4.02	1	Yes	No	0	6	0	1
R:R:N214	R:R:W210	5.65	1	Yes	Yes	7	6	2	1
R:R:W210	R:R:W271	5.62	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:W210	13.24	1	Yes	Yes	0	6	0	1
R:R:N214	R:R:W271	4.52	1	Yes	Yes	7	8	2	2
L:L:?1	R:R:L278	3.02	1	Yes	No	0	6	0	1
R:R:E293	R:R:K294	5.4	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:E293	5.78	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K294	10.24	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L297	10.05	1	Yes	No	0	6	0	1

Statistics	Value
Average Number Of Links	14.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	7.93
Average Nodes In Shell	37.00
Average Hubs In Shell	15.00
Average Links In Shell	52.00
Average Links Mediated by Hubs In Shell	50.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TD2

Lipid

Lysophospholipid (LPA)

LPA1

Homo sapiens

LPA

Gi1/Beta1/Gamma2

3.11

2022-02-09

10.1038/s41467-022-28417-2

A 2D representation of the interactions of NKP in 7TD2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I30	R:R:Y34	6.04	1	No	Yes	6	6	2	1
R:R:I30	R:R:W121	2.35	1	No	Yes	6	9	2	2
R:R:K39	R:R:Y34	9.55	1	No	Yes	8	6	1	1
R:R:L41	R:R:Y34	5.86	0	No	Yes	2	6	2	1
R:R:T113	R:R:Y34	4.99	1	Yes	Yes	5	6	1	1
R:R:W121	R:R:Y34	5.79	1	Yes	Yes	9	6	2	1
R:R:P200	R:R:Y34	11.13	1	No	Yes	6	6	2	1
L:L:?1	R:R:Y34	5.96	1	Yes	Yes	0	6	0	1
R:R:K39	R:R:L290	2.82	1	No	No	8	3	1	2
L:L:?1	R:R:K39	12.29	1	Yes	No	0	8	0	1
R:R:L105	R:R:Y102	3.52	1	Yes	Yes	6	7	1	2
R:R:M106	R:R:Y102	7.18	1	No	Yes	6	7	2	2
R:R:I128	R:R:Y102	2.42	1	Yes	Yes	6	7	2	2
R:R:L297	R:R:Y102	10.55	1	Yes	Yes	6	7	1	2
R:R:E301	R:R:Y102	17.96	1	Yes	Yes	7	7	2	2
R:R:R124	R:R:Y104	3.09	1	Yes	No	6	5	1	2
R:R:L105	R:R:M106	2.83	1	Yes	No	6	6	1	2
R:R:L105	R:R:R124	7.29	1	Yes	Yes	6	6	1	1
L:L:?1	R:R:L105	2.01	1	Yes	Yes	0	6	0	1
R:R:G110	R:R:T109	5.46	1	No	No	5	5	2	1
R:R:T109	R:R:T113	3.14	1	No	Yes	5	5	1	1
L:L:?1	R:R:T109	6.42	1	Yes	No	0	5	0	1
R:R:G110	R:R:T113	3.64	1	No	Yes	5	5	2	1
L:L:?1	R:R:T113	9.64	1	Yes	Yes	0	5	0	1
R:R:L116	R:R:R124	3.64	0	No	Yes	6	6	2	1
R:R:R124	R:R:W121	3	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	8.76	1	No	Yes	4	9	1	2
R:R:P200	R:R:W121	2.7	1	No	Yes	6	9	2	2
R:R:W121	R:R:Y202	6.75	1	Yes	Yes	9	4	2	2
L:L:?1	R:R:R124	5.29	1	Yes	Yes	0	6	0	1
R:R:Q125	R:R:Y202	10.15	1	No	Yes	4	4	1	2
L:L:?1	R:R:Q125	14.5	1	Yes	No	0	4	0	1
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
R:R:D129	R:R:I128	2.8	1	Yes	Yes	5	6	1	2
R:R:I128	R:R:L132	2.85	1	Yes	Yes	6	7	2	1
R:R:E301	R:R:I128	2.73	1	Yes	Yes	7	6	2	2
R:R:D129	R:R:Y202	5.75	1	Yes	Yes	5	4	1	2
R:R:D129	R:R:Y206	10.34	1	Yes	Yes	5	7	1	1
L:L:?1	R:R:D129	6.9	1	Yes	Yes	0	5	0	1
R:R:L132	R:R:S131	3	1	Yes	No	7	6	1	2
R:R:L132	R:R:W210	2.28	1	Yes	Yes	7	6	1	1
R:R:L132	R:R:W271	7.97	1	Yes	Yes	7	8	1	1
R:R:E301	R:R:L132	6.63	1	Yes	Yes	7	7	2	1
L:L:?1	R:R:L132	4.02	1	Yes	Yes	0	7	0	1
R:R:M178	R:R:T133	6.02	1	Yes	Yes	5	6	2	2
R:R:T133	R:R:W210	4.85	1	Yes	Yes	6	6	2	1
R:R:M178	R:R:Y206	2.39	1	Yes	Yes	5	7	2	1
R:R:M178	R:R:W210	3.49	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	11.13	1	Yes	Yes	6	4	2	2
R:R:P182	R:R:Y206	13.91	1	Yes	Yes	6	7	2	1
R:R:W186	R:R:Y206	3.86	0	Yes	Yes	6	7	2	1
R:R:L207	R:R:S196	3	1	No	Yes	6	5	1	2
R:R:D281	R:R:S196	7.36	0	No	Yes	4	5	2	2
R:R:L277	R:R:M198	5.65	1	Yes	Yes	4	3	2	1
R:R:D281	R:R:M198	5.54	0	No	Yes	4	3	2	1
R:R:M198	R:R:V289	4.56	1	Yes	No	3	4	1	2
R:R:E293	R:R:M198	9.47	1	Yes	Yes	4	3	1	1
L:L:?1	R:R:M198	3.08	1	Yes	Yes	0	3	0	1
R:R:Y202	R:R:Y206	3.97	1	Yes	Yes	4	7	2	1
R:R:W210	R:R:Y206	2.89	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:Y206	4.26	1	Yes	Yes	0	7	0	1
R:R:L207	R:R:L278	5.54	1	No	No	6	6	1	1
L:L:?1	R:R:L207	3.02	1	Yes	No	0	6	0	1
R:R:N214	R:R:W210	6.78	1	Yes	Yes	7	6	2	1
R:R:W210	R:R:W271	7.5	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:W210	16.55	1	Yes	Yes	0	6	0	1
R:R:F267	R:R:N214	4.83	1	Yes	Yes	9	7	2	2
R:R:N214	R:R:W271	5.65	1	Yes	Yes	7	8	2	1
R:R:F267	R:R:W271	12.03	1	Yes	Yes	9	8	2	1
R:R:A300	R:R:W271	5.19	1	No	Yes	7	8	1	1
R:R:N303	R:R:W271	10.17	0	No	Yes	9	8	2	1
L:L:?1	R:R:W271	2.48	1	Yes	Yes	0	8	0	1
R:R:F296	R:R:G274	3.01	0	Yes	No	5	5	2	1
L:L:?1	R:R:G274	2.48	1	Yes	No	0	5	0	1
R:R:L277	R:R:V289	4.47	1	Yes	No	4	4	2	2
R:R:E293	R:R:L277	2.65	1	Yes	Yes	4	4	1	2
R:R:F296	R:R:L277	9.74	0	Yes	Yes	5	4	2	2
L:L:?1	R:R:L278	5.03	1	Yes	No	0	6	0	1
R:R:E293	R:R:K294	2.7	1	Yes	No	4	4	1	1
R:R:E293	R:R:L297	5.3	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:E293	25.99	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K294	6.15	1	Yes	No	0	4	0	1
R:R:E301	R:R:L297	2.65	1	Yes	Yes	7	6	2	1
L:L:?1	R:R:L297	8.04	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:A300	3.43	1	Yes	No	0	7	0	1
R:R:K294	R:R:V52	1.52	1	No	No	4	5	1	2

Statistics	Value
Average Number Of Links	20.00
Average Number Of Links With An Hub	12.00
Average Interaction Strength	7.38
Average Nodes In Shell	49.00
Average Hubs In Shell	27.00
Average Links In Shell	86.00
Average Links Mediated by Hubs In Shell	82.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	18.00
Average Number Of Links With An Hub	11.00
Average Interaction Strength	7.33
Average Nodes In Shell	44.67
Average Hubs In Shell	22.33
Average Links In Shell	74.67
Average Links Mediated by Hubs In Shell	72.00

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)