CodeNKP
Name(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms18:1 LPA; oleoyl lysophosphatidic acid
Identifier
FormulaC21 H41 O7 P
Molecular Weight436.52
SMILES
PubChem49837858
Formal Charge0
Total Atoms70
Total Chiral Atoms1
Total Bonds69
Total Aromatic Bonds0
Networks16
 missing image

This ligand is also present in the following 16 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TD0 A Lipid Lysophospholipid LPA1 Homo Sapiens LPA - Gi1/Beta1/Gamma2 2.83 2022-02-09 doi.org/10.1038/s41467-022-28417-2

A 2D representation of the interactions of NKP in 7TD0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I30 R:R:Y34 4.84 2 No Yes 6 6 2 1
R:R:I30 R:R:W121 5.87 2 No Yes 6 9 2 2
R:R:K39 R:R:Y34 11.94 2 Yes Yes 8 6 1 1
R:R:L41 R:R:Y34 8.21 0 No Yes 2 6 2 1
R:R:T113 R:R:Y34 3.75 2 No Yes 5 6 1 1
R:R:W121 R:R:Y34 3.86 2 Yes Yes 9 6 2 1
R:R:P200 R:R:Y34 12.52 2 No Yes 6 6 2 1
L:L:?1 R:R:Y34 7.61 2 Yes Yes 0 6 0 1
R:R:K39 R:R:P200 5.02 2 Yes No 8 6 1 2
R:R:E293 R:R:K39 9.45 2 Yes Yes 4 8 1 1
L:L:?1 R:R:K39 10.17 2 Yes Yes 0 8 0 1
R:R:L105 R:R:Y102 3.52 2 Yes Yes 6 7 1 2
R:R:M106 R:R:Y102 2.39 2 Yes Yes 6 7 2 2
R:R:L297 R:R:Y102 10.55 0 No Yes 6 7 1 2
R:R:E301 R:R:Y102 21.32 0 No Yes 7 7 2 2
R:R:N108 R:R:Y104 8.14 2 No No 5 5 2 2
R:R:R124 R:R:Y104 3.09 2 Yes No 6 5 1 2
R:R:L105 R:R:M106 4.24 2 Yes Yes 6 6 1 2
R:R:L105 R:R:T109 2.95 2 Yes Yes 6 5 1 1
R:R:L105 R:R:R124 7.29 2 Yes Yes 6 6 1 1
R:R:I128 R:R:L105 4.28 2 No Yes 6 6 1 1
L:L:?1 R:R:L105 2.99 2 Yes Yes 0 6 0 1
R:R:M106 R:R:T109 3.01 2 Yes Yes 6 5 2 1
R:R:N108 R:R:R124 2.41 2 No Yes 5 6 2 1
R:R:R124 R:R:T109 5.17 2 Yes Yes 6 5 1 1
L:L:?1 R:R:T109 8.5 2 Yes Yes 0 5 0 1
R:R:R124 R:R:T113 3.88 2 Yes No 6 5 1 1
L:L:?1 R:R:T113 5.32 2 Yes No 0 5 0 1
R:R:L116 R:R:R124 6.07 0 No Yes 6 6 2 1
R:R:Q125 R:R:W121 14.24 2 Yes Yes 4 9 1 2
R:R:A199 R:R:W121 2.59 2 No Yes 4 9 2 2
R:R:W121 R:R:Y202 7.72 2 Yes Yes 9 4 2 2
L:L:?1 R:R:R124 3.5 2 Yes Yes 0 6 0 1
R:R:D129 R:R:Q125 5.22 2 Yes Yes 5 4 1 1
R:R:A199 R:R:Q125 3.03 2 No Yes 4 4 2 1
R:R:Q125 R:R:Y202 11.27 2 Yes Yes 4 4 1 2
L:L:?1 R:R:Q125 17.28 2 Yes Yes 0 4 0 1
R:R:D129 R:R:G126 5.03 2 Yes No 5 6 1 2
R:R:D129 R:R:I128 2.8 2 Yes No 5 6 1 1
L:L:?1 R:R:I128 5.15 2 Yes No 0 6 0 1
R:R:D129 R:R:Y202 8.05 2 Yes Yes 5 4 1 2
R:R:D129 R:R:Y206 6.9 2 Yes Yes 5 7 1 1
L:L:?1 R:R:D129 6.85 2 Yes Yes 0 5 0 1
R:R:L132 R:R:S131 3 2 Yes Yes 7 6 1 2
R:R:L132 R:R:W210 2.28 2 Yes Yes 7 6 1 1
R:R:L132 R:R:W271 6.83 2 Yes Yes 7 8 1 2
R:R:E301 R:R:L132 6.63 0 No Yes 7 7 2 1
L:L:?1 R:R:L132 3.99 2 Yes Yes 0 7 0 1
R:R:M178 R:R:T133 9.03 2 Yes No 5 6 2 2
R:R:T133 R:R:W210 7.28 2 No Yes 6 6 2 1
R:R:M178 R:R:Y206 2.39 2 Yes Yes 5 7 2 1
R:R:M178 R:R:W210 6.98 2 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 9.74 2 No Yes 6 4 2 2
R:R:P182 R:R:Y206 16.69 2 No Yes 6 7 2 1
R:R:W186 R:R:Y206 2.89 0 Yes Yes 6 7 2 1
R:R:L277 R:R:M198 5.65 2 Yes Yes 4 3 1 1
R:R:L278 R:R:M198 2.83 2 No Yes 6 3 1 1
R:R:D281 R:R:M198 5.54 0 Yes Yes 4 3 2 1
R:R:E293 R:R:M198 9.47 2 Yes Yes 4 3 1 1
L:L:?1 R:R:M198 5.1 2 Yes Yes 0 3 0 1
R:R:A199 R:R:Y202 4 2 No Yes 4 4 2 2
R:R:Y202 R:R:Y206 3.97 2 Yes Yes 4 7 2 1
R:R:W210 R:R:Y206 2.89 2 Yes Yes 6 7 1 1
L:L:?1 R:R:Y206 2.54 2 Yes Yes 0 7 0 1
R:R:L207 R:R:L278 5.54 0 No No 6 6 2 1
R:R:N214 R:R:W210 6.78 2 Yes Yes 7 6 2 1
R:R:W210 R:R:W271 6.56 2 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 11.5 2 Yes Yes 0 6 0 1
R:R:N214 R:R:W271 14.69 2 Yes Yes 7 8 2 2
R:R:F296 R:R:P273 8.67 2 Yes No 5 9 1 2
R:R:F296 R:R:G274 4.52 2 Yes No 5 5 1 1
L:L:?1 R:R:G274 3.7 2 Yes No 0 5 0 1
R:R:L277 R:R:V289 4.47 2 Yes No 4 4 1 2
R:R:L277 R:R:Y292 3.52 2 Yes No 4 3 1 2
R:R:F296 R:R:L277 10.96 2 Yes Yes 5 4 1 1
L:L:?1 R:R:L277 2.99 2 Yes Yes 0 4 0 1
L:L:?1 R:R:L278 4.99 2 Yes No 0 6 0 1
R:R:D281 R:R:V289 7.3 0 Yes No 4 4 2 2
R:R:E293 R:R:L290 2.65 2 Yes No 4 3 1 2
R:R:F296 R:R:Y292 4.13 2 Yes No 5 3 1 2
R:R:E293 R:R:K294 5.4 2 Yes No 4 4 1 1
L:L:?1 R:R:E293 5.73 2 Yes Yes 0 4 0 1
L:L:?1 R:R:K294 9.15 2 Yes No 0 4 0 1
L:L:?1 R:R:F296 2.64 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L297 12.98 2 Yes No 0 6 0 1
R:R:F295 R:R:F296 1.07 0 No Yes 4 5 2 1
StatisticsValue
Average Number Of Links20.00
Average Number Of Links With An Hub14.00
Average Interaction Strength6.63
Average Nodes In Shell48.00
Average Hubs In Shell25.00
Average Links In Shell86.00
Average Links Mediated by Hubs In Shell84.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TD1 A Lipid Lysophospholipid LPA1 Homo Sapiens LPA - Gi1/Beta1/Gamma2 3.08 2022-02-09 doi.org/10.1038/s41467-022-28417-2

A 2D representation of the interactions of NKP in 7TD1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I30 R:R:Y34 4.84 0 No Yes 6 6 2 1
R:R:K39 R:R:Y34 9.55 1 No Yes 8 6 1 1
R:R:L41 R:R:Y34 8.21 0 No Yes 2 6 2 1
R:R:W121 R:R:Y34 5.79 1 Yes Yes 9 6 2 1
R:R:P200 R:R:Y34 9.74 0 No Yes 6 6 2 1
L:L:?1 R:R:Y34 3.38 1 Yes Yes 0 6 0 1
R:R:E293 R:R:K39 6.75 1 Yes No 4 8 1 1
L:L:?1 R:R:K39 11.19 1 Yes No 0 8 0 1
R:R:K294 R:R:V52 3.04 1 Yes No 4 5 1 2
R:R:L297 R:R:Y102 10.55 0 No Yes 6 7 1 2
R:R:E301 R:R:Y102 19.08 0 No Yes 7 7 2 2
R:R:R124 R:R:Y104 3.09 1 Yes No 6 5 1 2
R:R:L105 R:R:R124 7.29 0 No Yes 6 6 2 1
R:R:G110 R:R:T109 5.46 0 No No 5 5 2 1
R:R:K294 R:R:T109 3 1 Yes No 4 5 1 1
L:L:?1 R:R:T109 7.44 1 Yes No 0 5 0 1
R:R:R124 R:R:T113 5.17 1 Yes No 6 5 1 1
L:L:?1 R:R:T113 11.69 1 Yes No 0 5 0 1
R:R:L116 R:R:R124 4.86 0 No Yes 6 6 2 1
R:R:R124 R:R:W121 6 1 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 15.33 1 No Yes 4 9 1 2
R:R:W121 R:R:Y202 7.72 1 Yes Yes 9 4 2 2
L:L:?1 R:R:R124 5.26 1 Yes Yes 0 6 0 1
R:R:Q125 R:R:Y202 7.89 1 No Yes 4 4 1 2
L:L:?1 R:R:Q125 14.4 1 Yes No 0 4 0 1
R:R:D129 R:R:G126 5.03 1 Yes No 5 6 1 2
R:R:D129 R:R:I128 2.8 1 Yes No 5 6 1 2
R:R:I128 R:R:L132 2.85 0 No Yes 6 7 2 1
R:R:D129 R:R:Y202 5.75 1 Yes Yes 5 4 1 2
R:R:D129 R:R:Y206 5.75 1 Yes Yes 5 7 1 2
L:L:?1 R:R:D129 7.83 1 Yes Yes 0 5 0 1
R:R:L132 R:R:S131 3 0 Yes No 7 6 1 2
R:R:L132 R:R:W271 6.83 0 Yes Yes 7 8 1 2
R:R:E301 R:R:L132 6.63 0 No Yes 7 7 2 1
L:L:?1 R:R:L132 2.99 1 Yes Yes 0 7 0 1
R:R:M178 R:R:T133 7.53 1 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 1 No Yes 6 6 2 1
R:R:M178 R:R:W210 4.65 1 Yes Yes 5 6 2 1
R:R:L207 R:R:S196 3 0 No No 6 5 1 2
R:R:E293 R:R:M198 8.12 1 Yes No 4 3 1 2
R:R:Y202 R:R:Y206 2.98 1 Yes Yes 4 7 2 2
R:R:W210 R:R:Y206 2.89 1 Yes Yes 6 7 1 2
L:L:?1 R:R:L207 3.99 1 Yes No 0 6 0 1
R:R:N214 R:R:W210 5.65 1 Yes Yes 7 6 2 1
R:R:W210 R:R:W271 5.62 1 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 13.14 1 Yes Yes 0 6 0 1
R:R:N214 R:R:W271 4.52 1 Yes Yes 7 8 2 2
L:L:?1 R:R:L278 2.99 1 Yes No 0 6 0 1
R:R:E293 R:R:K294 5.4 1 Yes Yes 4 4 1 1
L:L:?1 R:R:E293 5.73 1 Yes Yes 0 4 0 1
L:L:?1 R:R:K294 10.17 1 Yes Yes 0 4 0 1
L:L:?1 R:R:L297 9.98 1 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.87
Average Nodes In Shell37.00
Average Hubs In Shell15.00
Average Links In Shell52.00
Average Links Mediated by Hubs In Shell50.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TD2 A Lipid Lysophospholipid LPA1 Homo Sapiens LPA - Gi1/Beta1/Gamma2 3.11 2022-02-09 doi.org/10.1038/s41467-022-28417-2

A 2D representation of the interactions of NKP in 7TD2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y34 5.92 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 12.2 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L105 2 1 Yes Yes 0 6 0 1
L:L:?1 R:R:T109 6.38 1 Yes No 0 5 0 1
L:L:?1 R:R:T113 9.57 1 Yes Yes 0 5 0 1
L:L:?1 R:R:R124 5.26 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Q125 14.4 1 Yes No 0 4 0 1
L:L:?1 R:R:D129 6.85 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L132 3.99 1 Yes Yes 0 7 0 1
L:L:?1 R:R:M198 3.06 1 Yes Yes 0 3 0 1
L:L:?1 R:R:Y206 4.23 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L207 2.99 1 Yes No 0 6 0 1
L:L:?1 R:R:W210 16.43 1 Yes Yes 0 6 0 1
L:L:?1 R:R:W271 2.46 1 Yes Yes 0 8 0 1
L:L:?1 R:R:G274 2.47 1 Yes No 0 5 0 1
L:L:?1 R:R:L278 4.99 1 Yes No 0 6 0 1
L:L:?1 R:R:E293 1.91 1 Yes Yes 0 4 0 1
L:L:?1 R:R:K294 6.1 1 Yes No 0 4 0 1
L:L:?1 R:R:L297 7.99 1 Yes No 0 6 0 1
L:L:?1 R:R:A300 3.41 1 Yes No 0 7 0 1
R:R:I30 R:R:Y34 6.04 1 No Yes 6 6 2 1
R:R:I30 R:R:W121 2.35 1 No Yes 6 9 2 2
R:R:K39 R:R:Y34 9.55 1 Yes Yes 8 6 1 1
R:R:L41 R:R:Y34 5.86 0 No Yes 2 6 2 1
R:R:T113 R:R:Y34 4.99 1 Yes Yes 5 6 1 1
R:R:W121 R:R:Y34 5.79 1 Yes Yes 9 6 2 1
R:R:P200 R:R:Y34 11.13 1 No Yes 6 6 2 1
R:R:K39 R:R:L290 2.82 1 Yes No 8 3 1 2
R:R:E293 R:R:K39 9.45 1 Yes Yes 4 8 1 1
R:R:L105 R:R:Y102 3.52 1 Yes Yes 6 7 1 2
R:R:M106 R:R:Y102 7.18 1 No Yes 6 7 2 2
R:R:I128 R:R:Y102 2.42 1 Yes Yes 6 7 2 2
R:R:L297 R:R:Y102 10.55 1 No Yes 6 7 1 2
R:R:E301 R:R:Y102 17.96 1 Yes Yes 7 7 2 2
R:R:R124 R:R:Y104 3.09 1 Yes No 6 5 1 2
R:R:L105 R:R:M106 2.83 1 Yes No 6 6 1 2
R:R:L105 R:R:R124 7.29 1 Yes Yes 6 6 1 1
R:R:G110 R:R:T109 5.46 1 No No 5 5 2 1
R:R:T109 R:R:T113 3.14 1 No Yes 5 5 1 1
R:R:G110 R:R:T113 3.64 1 No Yes 5 5 2 1
R:R:L116 R:R:R124 3.64 0 No Yes 6 6 2 1
R:R:R124 R:R:W121 3 1 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 8.76 1 No Yes 4 9 1 2
R:R:P200 R:R:W121 2.7 1 No Yes 6 9 2 2
R:R:W121 R:R:Y202 6.75 1 Yes Yes 9 4 2 2
R:R:Q125 R:R:Y202 10.15 1 No Yes 4 4 1 2
R:R:D129 R:R:G126 5.03 1 Yes No 5 6 1 2
R:R:D129 R:R:I128 2.8 1 Yes Yes 5 6 1 2
R:R:I128 R:R:L132 2.85 1 Yes Yes 6 7 2 1
R:R:E301 R:R:I128 2.73 1 Yes Yes 7 6 2 2
R:R:D129 R:R:Y202 5.75 1 Yes Yes 5 4 1 2
R:R:D129 R:R:Y206 10.34 1 Yes Yes 5 7 1 1
R:R:L132 R:R:S131 3 1 Yes No 7 6 1 2
R:R:L132 R:R:W210 2.28 1 Yes Yes 7 6 1 1
R:R:L132 R:R:W271 7.97 1 Yes Yes 7 8 1 1
R:R:E301 R:R:L132 6.63 1 Yes Yes 7 7 2 1
R:R:M178 R:R:T133 6.02 1 Yes Yes 5 6 2 2
R:R:T133 R:R:W210 4.85 1 Yes Yes 6 6 2 1
R:R:M178 R:R:Y206 2.39 1 Yes Yes 5 7 2 1
R:R:M178 R:R:W210 3.49 1 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 11.13 1 Yes Yes 6 4 2 2
R:R:P182 R:R:Y206 13.91 1 Yes Yes 6 7 2 1
R:R:W186 R:R:Y206 3.86 0 Yes Yes 6 7 2 1
R:R:L207 R:R:S196 3 1 No Yes 6 5 1 2
R:R:D281 R:R:S196 7.36 0 No Yes 4 5 2 2
R:R:L277 R:R:M198 5.65 1 No Yes 4 3 2 1
R:R:D281 R:R:M198 5.54 0 No Yes 4 3 2 1
R:R:M198 R:R:V289 4.56 1 Yes No 3 4 1 2
R:R:E293 R:R:M198 17.59 1 Yes Yes 4 3 1 1
R:R:Y202 R:R:Y206 3.97 1 Yes Yes 4 7 2 1
R:R:W210 R:R:Y206 2.89 1 Yes Yes 6 7 1 1
R:R:L207 R:R:L278 5.54 1 No No 6 6 1 1
R:R:N214 R:R:W210 6.78 1 Yes Yes 7 6 2 1
R:R:W210 R:R:W271 7.5 1 Yes Yes 6 8 1 1
R:R:F267 R:R:N214 4.83 1 Yes Yes 9 7 2 2
R:R:N214 R:R:W271 5.65 1 Yes Yes 7 8 2 1
R:R:F267 R:R:W271 12.03 1 Yes Yes 9 8 2 1
R:R:A300 R:R:W271 5.19 1 No Yes 7 8 1 1
R:R:N303 R:R:W271 10.17 0 No Yes 9 8 2 1
R:R:F296 R:R:G274 3.01 0 Yes No 5 5 2 1
R:R:L277 R:R:V289 4.47 1 No No 4 4 2 2
R:R:F296 R:R:L277 9.74 0 Yes No 5 4 2 2
R:R:E293 R:R:L290 2.65 1 Yes No 4 3 1 2
R:R:E301 R:R:L297 2.65 1 Yes No 7 6 2 1
R:R:K294 R:R:V52 1.52 0 No No 4 5 1 2
StatisticsValue
Average Number Of Links20.00
Average Number Of Links With An Hub12.00
Average Interaction Strength6.13
Average Nodes In Shell49.00
Average Hubs In Shell26.00
Average Links In Shell85.00
Average Links Mediated by Hubs In Shell81.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9ITB A Lipid Lysophospholipid LPA6 Homo Sapiens LPA - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 2.89 2025-01-15 doi.org/10.1073/pnas.2415426122

A 2D representation of the interactions of NKP in 9ITB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y97 16.78 2 Yes No 0 5 0 1
L:L:?1 R:R:Y101 4.19 2 Yes Yes 0 7 0 1
L:L:?1 R:R:V144 2.13 2 Yes Yes 0 7 0 1
L:L:?1 R:R:S148 9.67 2 Yes No 0 7 0 1
L:L:?1 R:R:A151 2.25 2 Yes No 0 4 0 1
L:L:?1 R:R:F172 5.23 2 Yes Yes 0 5 0 1
L:L:?1 R:R:W177 10.59 2 Yes Yes 0 1 0 1
L:L:?1 R:R:L181 2.97 2 Yes Yes 0 4 0 1
L:L:?1 R:R:I184 2.04 2 Yes No 0 5 0 1
L:L:?1 R:R:F187 5.23 2 Yes No 0 3 0 1
L:L:?1 R:R:I188 5.11 2 Yes Yes 0 5 0 1
L:L:?1 R:R:V191 4.26 2 Yes Yes 0 4 0 1
L:L:?1 R:R:Y252 5.87 2 Yes Yes 0 4 0 1
L:L:?1 R:R:R256 4.35 2 Yes Yes 0 3 0 1
L:L:?1 R:R:Y273 5.87 2 Yes Yes 0 5 0 1
R:R:M94 R:R:S148 3.07 0 No No 6 7 2 1
R:R:F96 R:R:Y97 3.09 23 Yes No 6 5 2 1
R:R:Y245 R:R:Y97 2.98 2 Yes No 7 5 2 1
R:R:T98 R:R:V144 6.35 0 Yes Yes 5 7 2 1
R:R:S148 R:R:T98 3.2 0 No Yes 7 5 1 2
R:R:M100 R:R:Y101 2.39 0 No Yes 8 7 2 1
R:R:M100 R:R:Y245 2.39 0 No Yes 8 7 2 2
R:R:I188 R:R:Y101 7.25 2 Yes Yes 5 7 1 1
R:R:E189 R:R:Y101 2.24 2 Yes Yes 6 7 2 1
R:R:G192 R:R:Y101 2.9 0 No Yes 5 7 2 1
R:R:V144 R:R:W141 2.45 0 Yes No 7 9 1 2
R:R:F169 R:R:F172 6.43 2 Yes Yes 4 5 2 1
R:R:F172 R:R:P173 4.33 2 Yes No 5 4 1 2
R:R:F172 R:R:T176 5.19 2 Yes Yes 5 2 1 2
R:R:F172 R:R:W177 2 2 Yes Yes 5 1 1 1
R:R:P173 R:R:T176 3.5 2 No Yes 4 2 2 2
R:R:T176 R:R:Y180 2.5 2 Yes Yes 2 1 2 2
R:R:L181 R:R:T176 2.95 2 Yes Yes 4 2 1 2
R:R:L181 R:R:W177 15.94 2 Yes Yes 4 1 1 1
R:R:S253 R:R:W177 2.47 2 Yes Yes 5 1 2 1
R:R:R256 R:R:W177 11 2 Yes Yes 3 1 1 1
R:R:L181 R:R:Y180 4.69 2 Yes Yes 4 1 1 2
R:R:I184 R:R:Y180 6.04 0 No Yes 5 1 1 2
R:R:F187 R:R:I188 2.51 2 No Yes 3 5 1 1
R:R:F187 R:R:V191 3.93 2 No Yes 3 4 1 1
R:R:E189 R:R:I188 4.1 2 Yes Yes 6 5 2 1
R:R:G192 R:R:V191 3.68 0 No Yes 5 4 2 1
R:R:Y245 R:R:Y273 3.97 2 Yes Yes 7 5 2 1
R:R:L277 R:R:Y245 8.21 2 No Yes 6 7 2 2
R:R:R256 R:R:Y252 6.17 2 Yes Yes 3 4 1 1
R:R:V269 R:R:Y252 2.52 0 Yes Yes 5 4 2 1
R:R:R270 R:R:Y252 3.09 2 Yes Yes 4 4 2 1
R:R:Y252 R:R:Y273 10.92 2 Yes Yes 4 5 1 1
R:R:R256 R:R:R270 7.46 2 Yes Yes 3 4 1 2
R:R:P274 R:R:Y273 5.56 0 No Yes 5 5 2 1
R:R:L277 R:R:Y273 2.34 2 No Yes 6 5 2 1
R:R:G102 R:R:V144 1.84 0 No Yes 7 7 2 1
R:R:I190 R:R:V191 1.54 0 No Yes 4 4 2 1
L:L:?1 R:R:T143 1.05 2 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub10.00
Average Interaction Strength5.47
Average Nodes In Shell36.00
Average Hubs In Shell21.00
Average Links In Shell54.00
Average Links Mediated by Hubs In Shell53.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9ITE A Lipid Lysophospholipid LPA6 Homo Sapiens LPA - chim(NtGi2-G13)/Beta1/Gamma2 3.06 2025-01-15 doi.org/10.1073/pnas.2415426122

A 2D representation of the interactions of NKP in 9ITE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y97 10.07 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y101 3.36 1 Yes Yes 0 7 0 1
L:L:?1 R:R:S148 3.22 1 Yes No 0 7 0 1
L:L:?1 R:R:A151 2.25 1 Yes No 0 4 0 1
L:L:?1 R:R:F172 3.49 1 Yes Yes 0 5 0 1
L:L:?1 R:R:W177 11.41 1 Yes Yes 0 1 0 1
L:L:?1 R:R:V185 2.13 1 Yes No 0 5 0 1
L:L:?1 R:R:I188 5.11 1 Yes No 0 5 0 1
L:L:?1 R:R:V191 2.13 1 Yes No 0 4 0 1
L:L:?1 R:R:Y252 5.87 1 Yes Yes 0 4 0 1
L:L:?1 R:R:R256 6.95 1 Yes Yes 0 3 0 1
L:L:?1 R:R:Y273 4.19 1 Yes Yes 0 5 0 1
R:R:V93 R:R:Y97 2.52 0 No Yes 6 5 2 1
R:R:F169 R:R:V93 11.8 0 No No 4 6 2 2
R:R:M94 R:R:S148 7.67 0 No No 6 7 2 1
R:R:F96 R:R:Y97 8.25 0 No Yes 6 5 2 1
R:R:Y245 R:R:Y97 2.98 1 Yes Yes 7 5 2 1
R:R:S148 R:R:T98 3.2 0 No No 7 5 1 2
R:R:I104 R:R:Y101 2.42 1 Yes Yes 8 7 2 1
R:R:I188 R:R:Y101 7.25 1 No Yes 5 7 1 1
R:R:N246 R:R:Y101 5.81 0 No Yes 8 7 2 1
R:R:F169 R:R:F172 7.5 0 No Yes 4 5 2 1
R:R:F172 R:R:P173 4.33 1 Yes No 5 4 1 2
R:R:F172 R:R:W177 3.01 1 Yes Yes 5 1 1 1
R:R:E174 R:R:R256 3.49 0 No Yes 1 3 2 1
R:R:L181 R:R:W177 11.39 0 No Yes 4 1 2 1
R:R:R256 R:R:W177 15.99 1 Yes Yes 3 1 1 1
R:R:I184 R:R:I188 2.94 0 No No 5 5 2 1
R:R:S253 R:R:V185 3.23 0 No No 5 5 2 1
R:R:F187 R:R:V191 7.87 0 No No 3 4 2 1
R:R:Y245 R:R:Y273 5.96 1 Yes Yes 7 5 2 1
R:R:L277 R:R:Y245 8.21 1 No Yes 6 7 2 2
R:R:R256 R:R:Y252 4.12 1 Yes Yes 3 4 1 1
R:R:V269 R:R:Y252 2.52 0 Yes Yes 5 4 2 1
R:R:Y252 R:R:Y273 10.92 1 Yes Yes 4 5 1 1
R:R:R256 R:R:R270 8.53 1 Yes No 3 4 1 2
R:R:P274 R:R:Y273 4.17 1 Yes Yes 5 5 2 1
R:R:L277 R:R:Y273 2.34 1 No Yes 6 5 2 1
L:L:?1 R:R:T143 1.05 1 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub7.00
Average Interaction Strength4.71
Average Nodes In Shell32.00
Average Hubs In Shell12.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IZF A Lipid Lysophospholipid LPA1 Homo Sapiens NKP - Gi1/Beta1/Gamma2 3.14 2025-01-01 doi.org/10.1016/j.jsb.2024.108164

A 2D representation of the interactions of NKP in 9IZF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y34 6.71 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 9.08 1 Yes Yes 0 8 0 1
L:L:?1 R:R:T109 7.38 1 Yes No 0 5 0 1
L:L:?1 R:R:T113 6.33 1 Yes No 0 5 0 1
L:L:?1 R:R:R124 11.3 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Q125 18.1 1 Yes Yes 0 4 0 1
L:L:?1 R:R:D129 12.62 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L132 3.96 1 Yes Yes 0 7 0 1
L:L:?1 R:R:W210 13.85 1 Yes Yes 0 6 0 1
L:L:?1 R:R:E293 9.48 1 Yes Yes 0 4 0 1
L:L:?1 R:R:K294 7.06 1 Yes No 0 4 0 1
L:L:?1 R:R:L297 9.9 1 Yes No 0 6 0 1
R:R:I30 R:R:Y34 3.63 1 No Yes 6 6 2 1
R:R:I30 R:R:W121 4.7 1 No Yes 6 9 2 2
R:R:L41 R:R:Y34 4.69 0 No Yes 2 6 2 1
R:R:T113 R:R:Y34 4.99 1 No Yes 5 6 1 1
R:R:W121 R:R:Y34 11.58 1 Yes Yes 9 6 2 1
R:R:P200 R:R:Y34 8.34 0 No Yes 6 6 2 1
R:R:K39 R:R:P200 10.04 1 Yes No 8 6 1 2
R:R:K39 R:R:L290 4.23 1 Yes No 8 3 1 2
R:R:E293 R:R:K39 6.75 1 Yes Yes 4 8 1 1
R:R:K294 R:R:V52 9.11 0 No No 4 5 1 2
R:R:L105 R:R:Y102 3.52 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 5.86 0 No Yes 6 7 1 2
R:R:E301 R:R:Y102 12.35 0 No Yes 7 7 2 2
R:R:L105 R:R:R124 9.72 0 No Yes 6 6 2 1
R:R:N108 R:R:R124 13.26 0 No Yes 5 6 2 1
R:R:G110 R:R:T109 5.46 0 No No 5 5 2 1
R:R:R124 R:R:W121 13 1 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 13.14 1 Yes Yes 4 9 1 2
R:R:W121 R:R:Y202 3.86 1 Yes Yes 9 4 2 2
R:R:Q125 R:R:R124 3.5 1 Yes Yes 4 6 1 1
R:R:Q125 R:R:Y202 9.02 1 Yes Yes 4 4 1 2
R:R:D129 R:R:Y202 5.75 1 Yes Yes 5 4 1 2
R:R:D129 R:R:Y206 10.34 1 Yes Yes 5 7 1 2
R:R:D129 R:R:W210 13.4 1 Yes Yes 5 6 1 1
R:R:L132 R:R:S131 4.5 0 Yes No 7 6 1 2
R:R:L132 R:R:W271 7.97 0 Yes Yes 7 8 1 2
R:R:E301 R:R:L132 11.93 0 No Yes 7 7 2 1
R:R:M178 R:R:T133 7.53 1 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 1 No Yes 6 6 2 1
R:R:M178 R:R:W210 8.14 1 Yes Yes 5 6 2 1
R:R:L207 R:R:S196 4.5 0 No No 6 5 1 2
R:R:E293 R:R:M198 13.53 1 Yes No 4 3 1 2
R:R:Y202 R:R:Y206 4.96 1 Yes Yes 4 7 2 2
R:R:W210 R:R:Y206 6.75 1 Yes Yes 6 7 1 2
R:R:D281 R:R:L207 4.07 0 No No 4 6 2 1
R:R:N214 R:R:W210 6.78 1 Yes Yes 7 6 2 1
R:R:W210 R:R:W271 5.62 1 Yes Yes 6 8 1 2
R:R:A211 R:R:L278 4.73 0 No No 4 6 2 1
R:R:N214 R:R:W271 7.91 1 Yes Yes 7 8 2 2
R:R:E293 R:R:L290 6.63 1 Yes No 4 3 1 2
L:L:?1 R:R:L207 2.97 1 Yes No 0 6 0 1
L:L:?1 R:R:L278 2.97 1 Yes No 0 6 0 1
L:L:?1 R:R:G274 2.45 1 Yes No 0 5 0 1
L:L:?1 R:R:A300 2.25 1 Yes No 0 7 0 1
R:R:D129 R:R:G126 1.68 1 Yes No 5 6 1 2
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub8.00
Average Interaction Strength7.90
Average Nodes In Shell40.00
Average Hubs In Shell16.00
Average Links In Shell57.00
Average Links Mediated by Hubs In Shell52.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IZG A Lipid Lysophospholipid LPA1 Homo Sapiens NKP - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.04 2025-01-01 doi.org/10.1016/j.jsb.2024.108164

A 2D representation of the interactions of NKP in 9IZG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y34 4.19 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 8.07 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L105 4.95 1 Yes No 0 6 0 1
L:L:?1 R:R:T109 8.44 1 Yes No 0 5 0 1
L:L:?1 R:R:T113 6.33 1 Yes No 0 5 0 1
L:L:?1 R:R:R124 6.95 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Q125 7.62 1 Yes Yes 0 4 0 1
L:L:?1 R:R:D129 9.71 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y202 3.36 1 Yes Yes 0 4 0 1
L:L:?1 R:R:W210 23.63 1 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 5.94 1 Yes No 0 6 0 1
L:L:?1 R:R:E293 5.69 1 Yes Yes 0 4 0 1
L:L:?1 R:R:K294 7.06 1 Yes No 0 4 0 1
L:L:?1 R:R:L297 6.93 1 Yes No 0 6 0 1
R:R:I30 R:R:Y34 3.63 1 No Yes 6 6 2 1
R:R:I30 R:R:W121 5.87 1 No Yes 6 9 2 2
R:R:K39 R:R:Y34 11.94 1 Yes Yes 8 6 1 1
R:R:L41 R:R:Y34 4.69 0 No Yes 2 6 2 1
R:R:W121 R:R:Y34 9.65 1 Yes Yes 9 6 2 1
R:R:P200 R:R:Y34 18.08 1 No Yes 6 6 2 1
R:R:K39 R:R:P200 3.35 1 Yes No 8 6 1 2
R:R:K39 R:R:L290 4.23 1 Yes No 8 3 1 2
R:R:E293 R:R:K39 10.8 1 Yes Yes 4 8 1 1
R:R:L105 R:R:Y102 3.52 1 No Yes 6 7 1 2
R:R:L297 R:R:Y102 3.52 0 No Yes 6 7 1 2
R:R:L105 R:R:Q125 3.99 1 No Yes 6 4 1 1
R:R:G110 R:R:T109 3.64 0 No No 5 5 2 1
R:R:R124 R:R:T113 3.88 1 Yes No 6 5 1 1
R:R:L116 R:R:R124 4.86 0 No Yes 6 6 2 1
R:R:Q125 R:R:W121 9.86 1 Yes Yes 4 9 1 2
R:R:W121 R:R:Y202 3.86 1 Yes Yes 9 4 2 1
R:R:Q125 R:R:R124 14.02 1 Yes Yes 4 6 1 1
R:R:I128 R:R:Q125 4.12 0 No Yes 6 4 2 1
R:R:Q125 R:R:Y202 4.51 1 Yes Yes 4 4 1 1
R:R:D129 R:R:Y202 6.9 1 Yes Yes 5 4 1 1
R:R:D129 R:R:Y206 8.05 1 Yes Yes 5 7 1 2
R:R:M178 R:R:T133 7.53 1 Yes No 5 6 2 2
R:R:T133 R:R:W210 7.28 1 No Yes 6 6 2 1
R:R:M178 R:R:Y206 4.79 1 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 3.49 1 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 11.13 1 No Yes 6 4 2 1
R:R:P182 R:R:Y206 13.91 1 No Yes 6 7 2 2
R:R:E293 R:R:M198 4.06 1 Yes No 4 3 1 2
R:R:A199 R:R:Y202 4 0 No Yes 4 4 2 1
R:R:Y202 R:R:Y206 3.97 1 Yes Yes 4 7 1 2
R:R:N214 R:R:W210 14.69 1 Yes Yes 7 6 2 1
R:R:W210 R:R:W271 3.75 1 Yes Yes 6 8 1 2
R:R:E293 R:R:L290 5.3 1 Yes No 4 3 1 2
R:R:K294 R:R:V52 3.04 0 No No 4 5 1 2
R:R:D129 R:R:G126 1.68 1 Yes No 5 6 1 2
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub8.00
Average Interaction Strength7.78
Average Nodes In Shell34.00
Average Hubs In Shell15.00
Average Links In Shell50.00
Average Links Mediated by Hubs In Shell48.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IZH A Lipid Lysophospholipid LPA1 Homo Sapiens LPA - chim(NtGi2-G13)/Beta1/Gamma2 3.04 2025-01-01 doi.org/10.1016/j.jsb.2024.108164

A 2D representation of the interactions of NKP in 9IZH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:K39 5.04 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L105 2.97 1 Yes Yes 0 6 0 1
L:L:?1 R:R:T109 9.49 1 Yes No 0 5 0 1
L:L:?1 R:R:T113 4.22 1 Yes No 0 5 0 1
L:L:?1 R:R:R124 6.95 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Q125 10.48 1 Yes Yes 0 4 0 1
L:L:?1 R:R:D129 4.86 1 Yes Yes 0 5 0 1
L:L:?1 R:R:M198 5.06 1 Yes Yes 0 3 0 1
L:L:?1 R:R:L207 2.97 1 Yes No 0 6 0 1
L:L:?1 R:R:W210 19.56 1 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 4.95 1 Yes No 0 6 0 1
L:L:?1 R:R:E293 7.59 1 Yes Yes 0 4 0 1
L:L:?1 R:R:L297 2.97 1 Yes No 0 6 0 1
R:R:K39 R:R:Y34 10.75 1 Yes Yes 8 6 1 2
R:R:T113 R:R:Y34 3.75 0 No Yes 5 6 1 2
R:R:W121 R:R:Y34 7.72 1 Yes Yes 9 6 2 2
R:R:P200 R:R:Y34 16.69 1 No Yes 6 6 2 2
R:R:K39 R:R:P200 3.35 1 Yes No 8 6 1 2
R:R:K39 R:R:L290 5.64 1 Yes No 8 3 1 2
R:R:E293 R:R:K39 5.4 1 Yes Yes 4 8 1 1
R:R:L297 R:R:Y102 5.86 0 No Yes 6 7 1 2
R:R:L105 R:R:T109 2.95 1 Yes No 6 5 1 1
R:R:L105 R:R:R124 4.86 1 Yes Yes 6 6 1 1
R:R:I128 R:R:L105 2.85 0 No Yes 6 6 2 1
R:R:L116 R:R:R124 4.86 0 No Yes 6 6 2 1
R:R:R124 R:R:W121 5 1 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 7.67 1 Yes Yes 4 9 1 2
R:R:W121 R:R:Y202 2.89 1 Yes Yes 9 4 2 2
R:R:D129 R:R:Q125 3.92 1 Yes Yes 5 4 1 1
R:R:Q125 R:R:Y202 9.02 1 Yes Yes 4 4 1 2
R:R:D129 R:R:Y202 4.6 1 Yes Yes 5 4 1 2
R:R:D129 R:R:Y206 4.6 1 Yes Yes 5 7 1 2
R:R:M178 R:R:T133 6.02 1 No Yes 5 6 2 2
R:R:T133 R:R:W210 7.28 1 Yes Yes 6 6 2 1
R:R:F213 R:R:T133 5.19 1 Yes Yes 5 6 2 2
R:R:M178 R:R:W210 3.49 1 No Yes 5 6 2 1
R:R:L207 R:R:S196 6.01 0 No No 6 5 1 2
R:R:D281 R:R:S196 4.42 1 Yes No 4 5 2 2
R:R:D281 R:R:M198 8.32 1 Yes Yes 4 3 2 1
R:R:M198 R:R:V289 4.56 1 Yes Yes 3 4 1 2
R:R:E293 R:R:M198 6.77 1 Yes Yes 4 3 1 1
R:R:Y202 R:R:Y206 5.96 1 Yes Yes 4 7 2 2
R:R:F213 R:R:W210 3.01 1 Yes Yes 5 6 2 1
R:R:D281 R:R:V289 4.38 1 Yes Yes 4 4 2 2
R:R:E293 R:R:L290 3.98 1 Yes No 4 3 1 2
L:L:?1 R:R:G274 2.45 1 Yes No 0 5 0 1
R:R:D129 R:R:G126 1.68 1 Yes No 5 6 1 2
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub8.00
Average Interaction Strength6.40
Average Nodes In Shell31.00
Average Hubs In Shell18.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links14.88
Average Number Of Links With An Hub8.19
Average Interaction Strength6.87
Average Nodes In Shell36.00
Average Hubs In Shell16.44
Average Links In Shell52.75
Average Links Mediated by Hubs In Shell49.69

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)