psnGPCR

Code	NMM
Name	Tilarginine
Synonyms	L-Ng-monomethyl Arginine
Identifier
Formula	C7 H16 N4 O2
Molecular Weight	188.228
SMILES
PubChem	46906075
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	0
Networks	6

This ligand is also present in the following 6 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8XGO

Peptide

Kisspeptin

Kiss1

Homo Sapiens

TAK448

chim(NtGi1-Gq)/Beta1/Gamma2

2.68

2024-10-30

doi.org/10.1126/sciadv.adn7771

A 2D representation of the interactions of NMM in 8XGO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H181	R:R:N119	21.68	0	No	No	5	5	2	2
L:L:L8	R:R:N119	8.24	0	Yes	No	0	5	1	2
L:L:L8	R:R:Q122	5.32	0	Yes	Yes	0	6	1	2
L:L:W10	R:R:Q122	6.57	0	Yes	Yes	0	6	1	2
R:R:N208	R:R:Q123	11.88	13	Yes	No	5	4	1	2
L:L:W10	R:R:Q123	13.14	0	Yes	No	0	4	1	2
R:R:L212	R:R:V126	4.47	0	Yes	No	6	7	2	2
L:L:W10	R:R:V126	18.39	0	Yes	No	0	7	1	2
R:R:H181	R:R:V177	4.15	0	No	No	5	5	2	2
R:R:F204	R:R:V177	3.93	13	Yes	No	5	5	1	2
R:R:F195	R:R:L180	12.18	13	Yes	No	6	4	1	2
R:R:E193	R:R:H181	9.85	13	No	No	4	5	1	2
R:R:E193	R:R:F195	10.49	13	No	Yes	4	6	1	1
L:L:?9	R:R:E193	11.56	13	Yes	No	0	4	0	1
R:R:F195	R:R:L200	3.65	13	Yes	No	6	3	1	2
R:R:E201	R:R:F195	15.16	0	No	Yes	4	6	2	1
R:R:F195	R:R:F204	8.57	13	Yes	Yes	6	5	1	1
L:L:?9	R:R:F195	3.86	13	Yes	Yes	0	6	0	1
R:R:F204	R:R:N208	8.46	13	Yes	Yes	5	5	1	1
L:L:?9	R:R:F204	10.63	13	Yes	Yes	0	5	0	1
R:R:L212	R:R:N208	6.87	0	Yes	Yes	6	5	2	1
L:L:?9	R:R:N208	4.36	13	Yes	Yes	0	5	0	1
L:L:W10	R:R:I279	3.52	0	Yes	Yes	0	7	1	2
L:L:?7	L:L:L8	8.02	0	No	Yes	0	0	2	1
L:L:?9	L:L:L8	5.49	13	Yes	Yes	0	0	0	1
L:L:?9	L:L:W10	18.07	13	Yes	Yes	0	0	0	1
L:L:W10	R:R:L283	3.42	0	Yes	No	0	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	8.99
Average Nodes In Shell	20.00
Average Hubs In Shell	9.00
Average Links In Shell	27.00
Average Links Mediated by Hubs In Shell	24.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8XGU

Peptide

Kisspeptin

Kiss1

Homo Sapiens

TAK448

Gi1/Beta1/Gamma2

2024-10-30

doi.org/10.1126/sciadv.adn7771

A 2D representation of the interactions of NMM in 8XGU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?7	L:L:L8	8.02	0	No	Yes	0	0	2	1
L:L:?9	L:L:L8	3.29	2	Yes	Yes	0	0	0	1
L:L:?11	L:L:L8	10.28	2	Yes	Yes	0	0	1	1
L:L:L8	R:R:T99	4.42	2	Yes	No	0	6	1	2
L:L:L8	R:R:V118	2.98	2	Yes	No	0	5	1	2
L:L:L8	R:R:N119	6.87	2	Yes	Yes	0	5	1	1
L:L:L8	R:R:Q122	3.99	2	Yes	Yes	0	6	1	2
L:L:?9	L:L:W10	17.16	2	Yes	Yes	0	0	0	1
L:L:?11	L:L:?9	8.15	2	Yes	Yes	0	0	1	0
L:L:?9	R:R:N119	3.27	2	Yes	Yes	0	5	0	1
L:L:?9	R:R:F195	4.83	2	Yes	Yes	0	6	0	1
L:L:?9	R:R:F204	11.59	2	Yes	No	0	5	0	1
L:L:?11	L:L:W10	2.82	2	Yes	Yes	0	0	1	1
L:L:W10	R:R:Q122	3.29	2	Yes	Yes	0	6	1	2
L:L:W10	R:R:Q123	8.76	2	Yes	Yes	0	4	1	2
L:L:W10	R:R:V126	12.26	2	Yes	No	0	7	1	2
L:L:W10	R:R:N208	7.91	2	Yes	Yes	0	5	1	2
L:L:W10	R:R:I279	3.52	2	Yes	Yes	0	7	1	2
L:L:?11	R:R:C95	3.93	2	Yes	Yes	0	7	1	2
L:L:?11	R:R:T99	10.94	2	Yes	No	0	6	1	2
L:L:?11	R:R:Q122	6.59	2	Yes	Yes	0	6	1	2
L:L:?11	R:R:H309	9.55	2	Yes	Yes	0	6	1	2
L:L:?11	R:R:Y313	2.9	2	Yes	Yes	0	7	1	2
R:R:C95	R:R:Q122	6.1	2	Yes	Yes	7	6	2	2
R:R:C95	R:R:Y313	6.72	2	Yes	Yes	7	7	2	2
R:R:T99	R:R:Y313	4.99	2	No	Yes	6	7	2	2
R:R:C115	R:R:N119	4.72	2	Yes	Yes	9	5	2	1
R:R:C115	R:R:H181	2.95	2	Yes	No	9	5	2	2
R:R:Q122	R:R:V118	2.87	2	Yes	No	6	5	2	2
R:R:H181	R:R:N119	15.31	2	No	Yes	5	5	2	1
R:R:Q123	R:R:V177	2.87	2	Yes	No	4	5	2	2
R:R:N208	R:R:Q123	3.96	2	Yes	Yes	5	4	2	2
R:R:F204	R:R:V177	2.62	0	No	No	5	5	1	2
R:R:F195	R:R:L180	6.09	0	Yes	No	6	4	1	2
R:R:E193	R:R:F195	8.16	0	No	Yes	4	6	2	1
R:R:E201	R:R:F195	5.83	33	Yes	Yes	4	6	2	1
R:R:H309	R:R:I279	2.65	2	Yes	Yes	6	7	2	2
R:R:H309	R:R:Y313	10.89	2	Yes	Yes	6	7	2	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	8.05
Average Nodes In Shell	24.00
Average Hubs In Shell	15.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	37.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8ZJE

Peptide

Kisspeptin

Kiss1

Homo Sapiens

TAK-448

chim(NtGi1-Gq)/Beta1/Gamma1

3.07

2024-07-03

doi.org/10.1016/j.celrep.2024.114389

A 2D representation of the interactions of NMM in 8ZJE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F98	R:R:L101	4.87	1	Yes	Yes	6	4	2	2
R:R:F98	R:R:H309	14.71	1	Yes	Yes	6	6	2	2
L:L:L8	R:R:F98	3.65	1	Yes	Yes	0	6	1	2
L:L:L8	R:R:L101	5.54	1	Yes	Yes	0	4	1	2
L:L:L8	R:R:V118	5.96	1	Yes	No	0	5	1	2
R:R:H181	R:R:N119	25.51	1	No	No	5	5	1	1
L:L:L8	R:R:N119	8.24	1	Yes	No	0	5	1	1
L:L:?9	R:R:N119	4.27	1	Yes	No	0	5	0	1
L:L:L8	R:R:Q122	7.99	1	Yes	No	0	6	1	2
L:L:?11	R:R:Q122	9.93	1	Yes	No	0	6	2	2
R:R:F204	R:R:Q123	4.68	1	No	Yes	5	4	1	2
R:R:N208	R:R:Q123	5.28	1	Yes	Yes	5	4	2	2
L:L:W10	R:R:Q123	9.86	1	Yes	Yes	0	4	1	2
L:L:W10	R:R:V126	15.94	1	Yes	No	0	7	1	2
R:R:F195	R:R:L180	7.31	1	Yes	Yes	6	4	1	1
L:L:?9	R:R:L180	3.23	1	Yes	Yes	0	4	0	1
L:L:?9	R:R:H181	11.99	1	Yes	No	0	5	0	1
L:L:?7	R:R:C191	4.08	1	No	Yes	0	9	2	2
L:L:L8	R:R:C191	3.17	1	Yes	Yes	0	9	1	2
R:R:E193	R:R:F195	4.66	0	No	Yes	4	6	2	1
R:R:E201	R:R:F195	13.99	0	No	Yes	4	6	2	1
R:R:F195	R:R:F204	7.5	1	Yes	No	6	5	1	1
L:L:?9	R:R:F195	6.63	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:F204	14.2	1	Yes	No	0	5	0	1
R:R:N208	R:R:Q280	6.6	1	Yes	Yes	5	7	2	2
L:L:W10	R:R:N208	7.91	1	Yes	Yes	0	5	1	2
L:L:W10	R:R:I279	8.22	1	Yes	No	0	7	1	2
L:L:W10	R:R:Q280	4.38	1	Yes	Yes	0	7	1	2
R:R:F282	R:R:K305	19.85	1	Yes	Yes	5	4	2	1
L:L:F6	R:R:F282	4.29	1	Yes	Yes	0	5	2	2
R:R:H309	R:R:K305	11.79	1	Yes	Yes	6	4	2	1
L:L:F6	R:R:K305	4.96	1	Yes	Yes	0	4	2	1
L:L:?9	R:R:K305	3.29	1	Yes	Yes	0	4	0	1
L:L:?11	R:R:H309	6.4	1	Yes	Yes	0	6	2	2
L:L:?7	L:L:L8	4.75	1	No	Yes	0	0	2	1
L:L:?9	L:L:L8	3.23	1	Yes	Yes	0	0	0	1
L:L:?9	L:L:W10	12.39	1	Yes	Yes	0	0	0	1
L:L:?11	L:L:W10	8.5	1	Yes	Yes	0	0	2	1
R:R:L180	R:R:P176	1.64	1	Yes	No	4	6	1	2
R:R:A179	R:R:L180	1.58	0	No	Yes	4	4	2	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	7.40
Average Nodes In Shell	28.00
Average Hubs In Shell	16.00
Average Links In Shell	40.00
Average Links Mediated by Hubs In Shell	39.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	6.67
Average Number Of Links With An Hub	5.00
Average Interaction Strength	8.17
Average Nodes In Shell	23.83
Average Hubs In Shell	12.83
Average Links In Shell	34.17
Average Links Mediated by Hubs In Shell	32.67

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)