CodeOLA
NameOLEIC ACID
Synonyms
Identifier
FormulaC18 H34 O2
Molecular Weight282.461
SMILES
PubChem445639
Formal Charge0
Total Atoms54
Total Chiral Atoms0
Total Bonds53
Total Aromatic Bonds0
Networks3
 missing image

This ligand is also present in the following 3 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ID6 A Lipid Free Fatty Acid FFA4 Homo Sapiens Oleic acid - Gi1/Beta1/Gamma2 2.8 2023-03-15  10.1126/science.add6220

A 2D representation of the interactions of OLA in 8ID6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F27 5.69 2 Yes Yes 0 5 0 1
L:L:?1 R:R:F88 4.55 2 Yes Yes 0 7 0 1
L:L:?1 R:R:M118 13.22 2 Yes No 0 7 0 1
L:L:?1 R:R:T119 6.89 2 Yes No 0 5 0 1
L:L:?1 R:R:G122 4.8 2 Yes No 0 7 0 1
L:L:?1 R:R:W198 4.26 2 Yes No 0 7 0 1
L:L:?1 R:R:E204 6.19 2 Yes Yes 0 5 0 1
L:L:?1 R:R:D208 13.96 2 Yes Yes 0 5 0 1
L:L:?1 R:R:F211 4.55 2 Yes No 0 5 0 1
L:L:?1 R:R:I280 6.67 2 Yes No 0 6 0 1
L:L:?1 R:R:I284 9.34 2 Yes No 0 5 0 1
L:L:?1 R:R:I287 14.68 2 Yes No 0 5 0 1
L:L:?1 R:R:F303 9.11 2 Yes Yes 0 4 0 1
R:R:F25 R:R:F27 5.36 2 Yes Yes 5 5 2 1
R:R:F25 R:R:F303 6.43 2 Yes Yes 5 4 2 1
R:R:F27 R:R:L196 4.87 2 Yes No 5 5 1 2
R:R:F27 R:R:F303 5.36 2 Yes Yes 5 4 1 1
R:R:F28 R:R:F303 6.43 2 Yes Yes 8 4 2 1
R:R:F28 R:R:V307 3.93 2 Yes No 8 5 2 2
R:R:F88 R:R:S121 5.28 0 Yes No 7 8 1 2
R:R:F88 R:R:T310 3.89 0 Yes No 7 8 1 2
R:R:F311 R:R:F88 11.79 0 Yes Yes 7 7 2 1
R:R:L114 R:R:M118 2.83 0 Yes No 6 7 2 1
R:R:A170 R:R:T119 3.36 0 No No 7 5 2 1
R:R:L173 R:R:T119 7.37 0 No No 5 5 2 1
R:R:G122 R:R:W277 2.81 0 No Yes 7 9 1 2
R:R:L173 R:R:W207 3.42 0 No Yes 5 6 2 2
R:R:L196 R:R:W198 11.39 0 No No 5 7 2 1
R:R:E204 R:R:W198 22.9 2 Yes No 5 7 1 1
R:R:E204 R:R:L288 9.28 2 Yes Yes 5 4 1 2
R:R:E204 R:R:N291 5.26 2 Yes No 5 2 1 2
R:R:D208 R:R:W207 7.82 2 Yes Yes 5 6 1 2
R:R:F211 R:R:W207 18.04 0 No Yes 5 6 1 2
R:R:D208 R:R:I284 4.2 2 Yes No 5 5 1 1
R:R:D208 R:R:L288 13.57 2 Yes Yes 5 4 1 2
R:R:F211 R:R:N215 14.5 0 No No 5 6 1 2
R:R:I280 R:R:W277 3.52 2 No Yes 6 9 1 2
R:R:T310 R:R:W277 3.64 2 No Yes 8 9 2 2
R:R:I280 R:R:T310 10.64 2 No No 6 8 1 2
R:R:I284 R:R:I287 4.42 2 No No 5 5 1 1
R:R:I287 R:R:I298 2.94 2 No No 5 3 1 2
R:R:F303 R:R:V307 7.87 2 Yes No 4 5 1 2
R:R:F311 R:R:V307 3.93 0 Yes No 7 5 2 2
R:R:F303 R:R:T283 2.59 2 Yes No 4 5 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.99
Average Nodes In Shell31.00
Average Hubs In Shell13.00
Average Links In Shell44.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8TF5 A Orphan Orphan GPR6 Homo Sapiens Oleic acid - - 2.1 2024-12-04 10.2210/pdb8TF5/pdb

A 2D representation of the interactions of OLA in 8TF5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:H128 7.21 1 Yes No 0 5 0 1
L:L:?1 R:R:L148 9.06 1 Yes No 0 5 0 1
L:L:?1 R:R:F152 4.55 1 Yes No 0 6 0 1
L:L:?1 R:R:V219 5.57 1 Yes No 0 4 0 1
L:L:?1 R:R:R220 3.41 1 Yes No 0 4 0 1
L:L:?1 R:R:L230 9.06 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S231 5.62 1 Yes No 0 4 0 1
L:L:?1 R:R:F234 4.55 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F295 10.25 1 Yes Yes 0 6 0 1
L:L:?1 R:R:C299 5.94 1 Yes No 0 6 0 1
L:L:?1 R:R:T311 4.13 1 Yes No 0 4 0 1
L:L:?1 R:R:Y312 9.86 1 Yes Yes 0 4 0 1
L:L:?1 R:R:L315 3.88 1 Yes No 0 5 0 1
R:R:N73 R:R:W75 7.91 1 Yes Yes 6 5 2 2
R:R:D76 R:R:N73 5.39 1 Yes Yes 4 6 2 2
R:R:N73 R:R:Y312 8.14 1 Yes Yes 6 4 2 1
R:R:W75 R:R:Y312 19.29 1 Yes Yes 5 4 2 1
R:R:D76 R:R:Q132 11.75 1 Yes No 4 5 2 2
R:R:D76 R:R:Y312 9.2 1 Yes Yes 4 4 2 1
R:R:L315 R:R:L79 4.15 1 No No 5 6 1 2
R:R:A121 R:R:F152 8.32 0 No No 8 6 2 1
R:R:G124 R:R:L148 3.42 0 Yes No 5 5 2 1
R:R:L125 R:R:L148 4.15 0 No No 7 5 2 1
R:R:H128 R:R:Q132 4.95 0 No No 5 5 1 2
R:R:H128 R:R:T144 8.21 0 No No 5 5 1 2
R:R:L230 R:R:V149 4.47 0 Yes No 6 5 1 2
R:R:F152 R:R:W292 7.02 0 No Yes 6 8 1 2
R:R:L199 R:R:L230 5.54 0 No Yes 5 6 2 1
R:R:C216 R:R:R220 5.57 1 No No 9 4 2 1
R:R:C216 R:R:H304 4.42 1 No Yes 9 4 2 2
R:R:V218 R:R:Y298 10.09 1 No Yes 4 4 2 2
R:R:T311 R:R:V218 6.35 1 No No 4 4 1 2
R:R:L222 R:R:V219 4.47 6 Yes No 4 4 2 1
R:R:H304 R:R:R220 6.77 1 Yes No 4 4 2 1
R:R:H226 R:R:L222 3.86 6 Yes Yes 5 4 2 2
R:R:L222 R:R:V227 4.47 6 Yes No 4 5 2 2
R:R:H226 R:R:L230 10.29 6 Yes Yes 5 6 2 1
R:R:C299 R:R:V227 3.42 1 No No 6 5 1 2
R:R:S231 R:R:V300 3.23 0 No No 4 5 1 2
R:R:F234 R:R:F235 3.22 1 Yes No 7 5 1 2
R:R:F234 R:R:F238 4.29 1 Yes Yes 7 6 1 2
R:R:F234 R:R:F288 4.29 1 Yes Yes 7 9 1 2
R:R:F234 R:R:W292 10.02 1 Yes Yes 7 8 1 2
R:R:F234 R:R:L293 3.65 1 Yes No 7 4 1 2
R:R:A296 R:R:F234 4.16 1 No Yes 6 7 2 1
R:R:A296 R:R:F235 4.16 1 No No 6 5 2 2
R:R:F238 R:R:F288 4.29 1 Yes Yes 6 9 2 2
R:R:F238 R:R:L293 4.87 1 Yes No 6 4 2 2
R:R:F288 R:R:W292 7.02 1 Yes Yes 9 8 2 2
R:R:F295 R:R:W292 3.01 1 Yes Yes 6 8 1 2
R:R:C299 R:R:F295 8.38 1 No Yes 6 6 1 1
R:R:F295 R:R:T314 7.78 1 Yes No 6 6 1 2
R:R:F295 R:R:L315 7.31 1 Yes No 6 5 1 1
R:R:T311 R:R:Y298 6.24 1 No Yes 4 4 1 2
R:R:A308 R:R:Y312 2.67 0 No Yes 1 4 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.39
Average Nodes In Shell41.00
Average Hubs In Shell16.00
Average Links In Shell55.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub4.67
Average Interaction Strength7.46
Average Nodes In Shell33.33
Average Hubs In Shell13.00
Average Links In Shell45.67
Average Links Mediated by Hubs In Shell37.67

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)