CodeOLM
NameOlmesartan
Synonyms
  • 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
  • Olmesartan medoxomil
  • 4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
  • Olmesartan
Identifier5-(2-oxidanylpropan-2-yl)-2-propyl-3-[[4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
FormulaC24 H26 N6 O3
Molecular Weight446.502
SMILESCCCc1nc(c(n1Cc2ccc(cc2)c3ccccc3c4[nH]nnn4)C(=O)O)C(C)(C)O
PubChem158781
Formal Charge0
Total Atoms59
Total Chiral Atoms0
Total Bonds62
Total Aromatic Bonds22
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4ZUD A Peptide Angiotensin AT1 Homo sapiens Olmesartan - - 2.8 2015-10-07 10.1074/jbc.M115.689000

A 2D representation of the interactions of OLM in 4ZUD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F28 R:R:R23 5.34 1 No No 4 4 2 2
R:R:R23 R:R:Y92 4.12 1 No Yes 4 4 2 1
R:R:F28 R:R:Y92 9.28 1 No Yes 4 4 2 1
R:R:I31 R:R:Y35 6.04 1 Yes Yes 6 7 2 1
R:R:I31 R:R:T88 9.12 1 Yes No 6 5 2 2
R:R:I31 R:R:P285 3.39 1 Yes No 6 5 2 2
R:R:C289 R:R:I31 3.27 1 No Yes 5 6 2 2
R:R:C289 R:R:Y35 4.03 1 No Yes 5 7 2 1
L:L:?1 R:R:Y35 7.95 1 Yes Yes 0 7 0 1
R:R:F77 R:R:V108 6.55 1 Yes No 6 6 2 1
R:R:F77 R:R:N111 12.08 1 Yes Yes 6 8 2 2
R:R:F77 R:R:Y292 13.41 1 Yes Yes 6 7 2 1
R:R:F77 R:R:N295 13.29 1 Yes Yes 6 9 2 2
R:R:W84 R:R:Y87 4.82 1 Yes Yes 7 5 1 2
R:R:W84 R:R:W94 9.37 1 Yes Yes 7 9 1 2
R:R:A104 R:R:W84 3.89 0 No Yes 6 7 2 1
R:R:S105 R:R:W84 4.94 1 No Yes 5 7 1 1
L:L:?1 R:R:W84 25.5 1 Yes Yes 0 7 0 1
R:R:Y87 R:R:Y92 4.96 1 Yes Yes 5 4 2 1
R:R:W94 R:R:Y87 5.79 1 Yes Yes 9 5 2 2
R:R:T88 R:R:Y92 9.99 1 No Yes 5 4 2 1
R:R:P285 R:R:Y92 4.17 0 No Yes 5 4 2 1
L:L:?1 R:R:Y92 3.98 1 Yes Yes 0 4 0 1
R:R:R167 R:R:S105 11.86 1 No No 5 5 1 1
L:L:?1 R:R:S105 3.06 1 Yes No 0 5 0 1
R:R:V108 R:R:Y292 5.05 1 No Yes 6 7 1 1
L:L:?1 R:R:V108 15.16 1 Yes No 0 6 0 1
R:R:S109 R:R:S160 3.26 0 No No 4 7 1 2
L:L:?1 R:R:S109 13.24 1 Yes No 0 4 0 1
R:R:N111 R:R:Y292 8.14 1 Yes Yes 8 7 2 1
R:R:N111 R:R:N295 12.26 1 Yes Yes 8 9 2 2
R:R:F182 R:R:H166 15.84 0 No No 4 4 1 2
L:L:?1 R:R:R167 24.72 1 Yes No 0 5 0 1
R:R:F182 R:R:Y184 15.47 0 No No 4 4 1 2
L:L:?1 R:R:F182 6.61 1 Yes No 0 4 0 1
R:R:H256 R:R:W253 4.23 0 No Yes 6 8 2 2
R:R:W253 R:R:Y292 5.79 0 Yes Yes 8 7 2 1
R:R:H256 R:R:I288 7.95 0 No No 6 6 2 1
L:L:?1 R:R:I288 9.68 1 Yes No 0 6 0 1
R:R:N295 R:R:Y292 3.49 1 Yes Yes 9 7 2 1
L:L:?1 R:R:Y292 3.98 1 Yes Yes 0 7 0 1
R:R:A85 R:R:Y35 2.67 0 No Yes 7 7 2 1
L:L:?1 R:R:A163 2.14 1 Yes No 0 4 0 1
R:R:A106 R:R:A163 1.79 0 No No 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength10.55
Average Nodes In Shell31.00
Average Hubs In Shell12.00
Average Links In Shell44.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength10.55
Average Nodes In Shell31.00
Average Hubs In Shell12.00
Average Links In Shell44.00
Average Links Mediated by Hubs In Shell37.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)