CodeOLM
NameOlmesartan
Synonyms
  • Olmesartan medoxomil
  • 4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
  • Olmesartan
  • 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
Identifier
FormulaC24 H26 N6 O3
Molecular Weight446.502
SMILES
PubChem158781
Formal Charge0
Total Atoms59
Total Chiral Atoms0
Total Bonds62
Total Aromatic Bonds22
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4ZUD A Peptide Angiotensin AT1 Homo Sapiens Olmesartan - - 2.8 2015-10-07 doi.org/10.1074/jbc.M115.689000

A 2D representation of the interactions of OLM in 4ZUD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y35 7.95 1 Yes Yes 0 7 0 1
L:L:?1 R:R:W84 25.5 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Y92 3.98 1 Yes Yes 0 4 0 1
L:L:?1 R:R:V108 15.16 1 Yes No 0 6 0 1
L:L:?1 R:R:S109 13.24 1 Yes No 0 4 0 1
L:L:?1 R:R:R167 24.72 1 Yes No 0 5 0 1
L:L:?1 R:R:F182 6.61 1 Yes No 0 4 0 1
L:L:?1 R:R:I288 9.68 1 Yes No 0 6 0 1
L:L:?1 R:R:Y292 3.98 1 Yes Yes 0 7 0 1
R:R:F28 R:R:R23 5.34 1 No No 4 4 2 2
R:R:R23 R:R:Y92 4.12 1 No Yes 4 4 2 1
R:R:F28 R:R:Y92 9.28 1 No Yes 4 4 2 1
R:R:I31 R:R:Y35 6.04 1 Yes Yes 6 7 2 1
R:R:I31 R:R:T88 9.12 1 Yes No 6 5 2 2
R:R:I31 R:R:P285 3.39 1 Yes No 6 5 2 2
R:R:C289 R:R:I31 3.27 1 No Yes 5 6 2 2
R:R:C289 R:R:Y35 4.03 1 No Yes 5 7 2 1
R:R:F77 R:R:V108 6.55 1 Yes No 6 6 2 1
R:R:F77 R:R:N111 12.08 1 Yes Yes 6 8 2 2
R:R:F77 R:R:Y292 13.41 1 Yes Yes 6 7 2 1
R:R:F77 R:R:N295 13.29 1 Yes Yes 6 9 2 2
R:R:W84 R:R:Y87 4.82 1 Yes Yes 7 5 1 2
R:R:W84 R:R:W94 9.37 1 Yes Yes 7 9 1 2
R:R:A104 R:R:W84 3.89 0 No Yes 6 7 2 1
R:R:S105 R:R:W84 4.94 0 No Yes 5 7 2 1
R:R:Y87 R:R:Y92 4.96 1 Yes Yes 5 4 2 1
R:R:W94 R:R:Y87 5.79 1 Yes Yes 9 5 2 2
R:R:T88 R:R:Y92 9.99 1 No Yes 5 4 2 1
R:R:P285 R:R:Y92 4.17 0 No Yes 5 4 2 1
R:R:R167 R:R:S105 11.86 0 No No 5 5 1 2
R:R:V108 R:R:Y292 5.05 1 No Yes 6 7 1 1
R:R:S109 R:R:S160 3.26 0 No No 4 7 1 2
R:R:N111 R:R:Y292 8.14 1 Yes Yes 8 7 2 1
R:R:N111 R:R:N295 12.26 1 Yes Yes 8 9 2 2
R:R:F182 R:R:H166 15.84 0 No No 4 4 1 2
R:R:F182 R:R:Y184 15.47 0 No No 4 4 1 2
R:R:H256 R:R:W253 4.23 0 No Yes 6 8 2 2
R:R:W253 R:R:Y292 5.79 0 Yes Yes 8 7 2 1
R:R:H256 R:R:I288 7.95 0 No No 6 6 2 1
R:R:N295 R:R:Y292 3.49 1 Yes Yes 9 7 2 1
R:R:A85 R:R:Y35 2.67 0 No Yes 7 7 2 1
L:L:?1 R:R:A163 2.14 1 Yes No 0 4 0 1
R:R:A106 R:R:A163 1.79 0 No No 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.30
Average Nodes In Shell31.00
Average Hubs In Shell12.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9EAH A Peptide Angiotensin AT1 Homo Sapiens Olmesartan Nanobody AT209 - 3.1 2025-03-05 doi.org/10.1073/pnas.2423931122

A 2D representation of the interactions of OLM in 9EAH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y35 11.13 1 Yes Yes 0 7 0 1
L:L:?1 R:R:W84 23.95 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Y87 3.98 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y92 6.36 1 Yes Yes 0 4 0 1
L:L:?1 R:R:V108 19.2 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S109 5.09 1 Yes No 0 4 0 1
L:L:?1 R:R:R167 14.83 1 Yes No 0 5 0 1
L:L:?1 R:R:F182 6.61 1 Yes Yes 0 4 0 1
L:L:?1 R:R:K199 9.57 1 Yes No 0 5 0 1
L:L:?1 R:R:I288 8.71 1 Yes No 0 6 0 1
L:L:?1 R:R:Y292 8.75 1 Yes Yes 0 7 0 1
L:L:?1 W:W:L103 6.57 1 Yes No 0 0 0 1
R:R:I31 R:R:Y35 7.25 0 No Yes 6 7 2 1
R:R:I31 R:R:T88 6.08 0 No No 6 5 2 2
R:R:L81 R:R:Y35 4.69 0 Yes Yes 8 7 2 1
R:R:C289 R:R:Y35 6.72 0 No Yes 5 7 2 1
R:R:F77 R:R:L81 6.09 1 Yes Yes 6 8 2 2
R:R:F77 R:R:V108 5.24 1 Yes Yes 6 6 2 1
R:R:F77 R:R:N111 18.12 1 Yes Yes 6 8 2 2
R:R:F77 R:R:Y292 8.25 1 Yes Yes 6 7 2 1
R:R:W84 R:R:Y87 6.75 1 Yes Yes 7 5 1 1
R:R:W84 R:R:W94 8.43 1 Yes Yes 7 9 1 2
R:R:A104 R:R:W84 6.48 0 No Yes 6 7 2 1
R:R:V108 R:R:W84 3.68 1 Yes Yes 6 7 1 1
R:R:C180 R:R:W84 5.22 1 Yes Yes 9 7 2 1
R:R:Y87 R:R:Y92 6.95 1 Yes Yes 5 4 1 1
R:R:W94 R:R:Y87 11.58 1 Yes Yes 9 5 2 1
R:R:T88 R:R:Y92 4.99 0 No Yes 5 4 2 1
R:R:Y92 W:W:T102 6.24 1 Yes No 4 0 1 2
R:R:C180 R:R:W94 5.22 1 Yes Yes 9 9 2 2
R:R:R167 R:R:S105 14.5 0 No No 5 5 1 2
R:R:V108 R:R:Y292 6.31 1 Yes Yes 6 7 1 1
R:R:S109 R:R:S160 4.89 0 No No 4 7 1 2
R:R:N111 R:R:Y292 6.98 1 Yes Yes 8 7 2 1
R:R:L112 R:R:W253 14.81 1 No Yes 7 8 2 2
R:R:L112 R:R:Y292 5.86 1 No Yes 7 7 2 1
R:R:F182 R:R:H166 5.66 1 Yes No 4 4 1 2
R:R:C180 R:R:R167 6.96 1 Yes No 9 5 2 1
R:R:F182 R:R:Y184 10.32 1 Yes Yes 4 4 1 2
R:R:F182 R:R:L195 8.53 1 Yes No 4 5 1 2
R:R:F182 W:W:F105 5.36 1 Yes No 4 0 1 2
R:R:Y184 W:W:F105 8.25 1 Yes No 4 0 2 2
R:R:H256 R:R:K199 6.55 1 Yes No 6 5 2 1
R:R:K199 R:R:T260 7.51 1 No No 5 6 1 2
R:R:H256 R:R:W253 8.46 1 Yes Yes 6 8 2 2
R:R:W253 R:R:Y292 11.58 1 Yes Yes 8 7 2 1
R:R:H256 R:R:T260 6.85 1 Yes No 6 6 2 2
R:R:H256 R:R:I288 9.28 1 Yes No 6 6 2 1
R:R:A163 R:R:S109 3.42 0 No No 4 4 2 1
R:R:A85 R:R:Y35 1.33 0 No Yes 7 7 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.40
Average Nodes In Shell35.00
Average Hubs In Shell16.00
Average Links In Shell50.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.50
Average Interaction Strength10.85
Average Nodes In Shell33.00
Average Hubs In Shell14.00
Average Links In Shell46.50
Average Links Mediated by Hubs In Shell40.50

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)