CodeOR9
NameApomorphine
Synonyms(R)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol
Identifier(6~{a}~{R})-6-methyl-5,6,6~{a},7-tetrahydro-4~{H}-dibenzo[de,g]quinoline-10,11-diol
FormulaC17 H17 N O2
Molecular Weight267.322
SMILESCN1CCc2cccc-3c2[C@H]1Cc4c3c(c(cc4)O)O
PubChem6005
Formal Charge0
Total Atoms37
Total Chiral Atoms1
Total Bonds40
Total Aromatic Bonds12
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7JVQ A Amine Dopamine D1 Homo sapiens Apomorphine - Gs/Beta1/Gamma2 3 2021-02-24 10.1016/j.cell.2021.01.027

A 2D representation of the interactions of OR9 in 7JVQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D103 R:R:V77 8.76 1 No No 7 8 1 2
R:R:V77 R:R:W321 6.13 1 No Yes 8 7 2 1
R:R:K81 R:R:W318 3.48 1 Yes Yes 6 5 2 2
R:R:K81 R:R:W321 5.8 1 Yes Yes 6 7 2 1
R:R:D103 R:R:W321 11.17 1 No Yes 7 7 1 1
L:L:?1 R:R:D103 18.61 1 Yes No 0 7 0 1
R:R:I104 R:R:S155 3.1 0 No No 6 7 1 2
R:R:I104 R:R:Y194 6.04 0 No Yes 6 7 1 2
L:L:?1 R:R:I104 6.91 1 Yes No 0 6 0 1
L:L:?1 R:R:S107 6.06 1 Yes No 0 7 0 1
R:R:I154 R:R:T108 4.56 0 No No 5 6 2 2
R:R:S202 R:R:T108 3.2 1 No No 6 6 1 2
R:R:I154 R:R:S198 4.64 0 No No 5 7 2 1
R:R:H164 R:R:L190 5.14 0 Yes No 5 4 2 1
R:R:H164 R:R:Y194 5.44 0 Yes Yes 5 7 2 2
R:R:A195 R:R:L190 3.15 0 No No 5 4 2 1
L:L:?1 R:R:L190 7.82 1 Yes No 0 4 0 1
R:R:S198 R:R:Y194 11.45 0 No Yes 7 7 1 2
L:L:?1 R:R:S198 9.69 1 Yes No 0 7 0 1
R:R:F289 R:R:S199 5.28 1 Yes No 7 7 1 2
R:R:N292 R:R:S199 4.47 1 Yes No 6 7 1 2
R:R:F289 R:R:S202 5.28 1 Yes No 7 6 1 1
L:L:?1 R:R:S202 7.27 1 Yes No 0 6 0 1
R:R:F203 R:R:W285 3.01 1 Yes Yes 8 8 2 2
R:R:F203 R:R:F289 21.43 1 Yes Yes 8 7 2 1
R:R:F288 R:R:W285 3.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 6.01 1 Yes Yes 7 8 1 2
R:R:F288 R:R:F289 6.43 1 Yes Yes 7 7 1 1
R:R:F288 R:R:N292 3.62 1 Yes Yes 7 6 1 1
R:R:F288 R:R:F313 6.43 1 Yes No 7 4 1 2
R:R:F288 R:R:V317 3.93 1 Yes No 7 6 1 1
L:L:?1 R:R:F288 13.76 1 Yes Yes 0 7 0 1
R:R:F289 R:R:N292 3.62 1 Yes Yes 7 6 1 1
L:L:?1 R:R:F289 8.84 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N292 8.86 1 Yes Yes 0 6 0 1
R:R:V317 R:R:W321 7.36 1 No Yes 6 7 1 1
L:L:?1 R:R:V317 6.01 1 Yes No 0 6 0 1
R:R:W318 R:R:W321 11.25 1 Yes Yes 5 7 2 1
L:L:?1 R:R:W321 8.27 1 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.28
Average Nodes In Shell25.00
Average Hubs In Shell11.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.28
Average Nodes In Shell25.00
Average Hubs In Shell11.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell33.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)