Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 2VT4 | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Cyanopindolol | - | - | 2.7 | 2008-06-24 | 10.1038/nature07101 |
![](/psngpcr/ligands/P32/P32_2VT4_L_L_1.png)
A 2D representation of the interactions of P32 in 2VT4 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 5.84 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 5.05 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:V95 | R:R:W330 | 4.9 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:V95 | R:R:Y333 | 3.79 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F201 | R:R:T118 | 7.78 | 1 | Yes | No | 4 | 6 | 1 | 2 | R:R:D121 | R:R:Y333 | 10.34 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D121 | 19.19 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:S173 | R:R:V122 | 4.85 | 1 | Yes | No | 7 | 6 | 2 | 1 | R:R:I177 | R:R:V122 | 4.61 | 1 | Yes | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:V122 | 13.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S173 | R:R:T126 | 7.99 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:S215 | R:R:T126 | 6.4 | 1 | No | Yes | 6 | 6 | 1 | 2 | R:R:S173 | R:R:S215 | 3.26 | 1 | Yes | No | 7 | 6 | 2 | 1 | R:R:I177 | R:R:W182 | 4.7 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F201 | R:R:I177 | 6.28 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:I177 | R:R:Y207 | 3.63 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:F201 | R:R:W182 | 14.03 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:T203 | R:R:W182 | 3.64 | 1 | No | Yes | 4 | 5 | 2 | 2 | R:R:W182 | R:R:Y207 | 5.79 | 1 | Yes | Yes | 5 | 7 | 2 | 1 | R:R:F201 | R:R:T203 | 7.78 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:F201 | R:R:Y207 | 6.19 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | L:L:?1 | R:R:F201 | 9.84 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 6.24 | 1 | No | Yes | 4 | 7 | 2 | 1 | R:R:N204 | R:R:Y207 | 3.49 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:S211 | R:R:Y207 | 15.26 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:Y207 | 3.95 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:S211 | 7.08 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S215 | 4.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:F307 | 33.22 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:F306 | R:R:W303 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F307 | R:R:W303 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F306 | R:R:F307 | 9.65 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:F325 | 4.29 | 1 | Yes | No | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 9.67 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F306 | 8.2 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F307 | 11.48 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N310 | 8.32 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 13.96 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:N329 | 13.87 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 13.5 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y333 | 3.95 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:N310 | R:R:S212 | 2.98 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:P176 | R:R:Y207 | 1.39 | 0 | No | Yes | 7 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 9.36 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 43.00 | Average Links Mediated by Hubs In Shell | 41.00 |
| ![](/psngpcr/ligands/P32/P32_2VT4_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P32/P32_2VT4_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 2YCX | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Cyanopindolol | - | - | 3.25 | 2011-06-01 | 10.1073/pnas.1100185108 |
![](/psngpcr/ligands/P32/P32_2YCX_L_L_1.png)
A 2D representation of the interactions of P32 in 2YCX colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 5.84 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 5.05 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:V95 | R:R:W330 | 6.13 | 1 | No | Yes | 7 | 6 | 2 | 2 | R:R:V95 | R:R:Y333 | 5.05 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:F97 | R:R:W107 | 4.01 | 1 | No | Yes | 4 | 7 | 2 | 2 | R:R:F97 | R:R:W117 | 6.01 | 1 | No | Yes | 4 | 6 | 2 | 1 | R:R:G98 | R:R:W117 | 4.22 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:W107 | R:R:W117 | 10.31 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:T118 | R:R:W117 | 6.06 | 0 | No | Yes | 6 | 6 | 2 | 1 | L:L:?1 | R:R:W117 | 5.37 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F201 | R:R:T118 | 6.49 | 1 | Yes | No | 4 | 6 | 1 | 2 | R:R:D121 | R:R:Y333 | 12.64 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D121 | 20.11 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:S173 | R:R:V122 | 4.85 | 0 | Yes | No | 7 | 6 | 2 | 1 | L:L:?1 | R:R:V122 | 6.02 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S173 | R:R:T126 | 6.4 | 0 | Yes | No | 7 | 6 | 2 | 2 | R:R:S215 | R:R:T126 | 6.4 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:P176 | R:R:Y207 | 5.56 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:F201 | R:R:W182 | 5.01 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:T203 | R:R:W182 | 3.64 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:W182 | R:R:Y207 | 5.79 | 1 | Yes | Yes | 5 | 7 | 2 | 1 | R:R:F201 | R:R:T203 | 7.78 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | R:R:F201 | R:R:Y207 | 4.13 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | L:L:?1 | R:R:F201 | 7.38 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 6.24 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | L:L:?1 | R:R:T203 | 3.97 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:N204 | R:R:Y207 | 3.49 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:S211 | R:R:Y207 | 15.26 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:Y207 | 4.74 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:S211 | 9.1 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S215 | 4.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:Y217 | 10.32 | 1 | No | Yes | 7 | 5 | 2 | 2 | R:R:F216 | R:R:F307 | 34.29 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:F307 | R:R:Y217 | 4.13 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:F306 | R:R:W303 | 8.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F307 | R:R:W303 | 7.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F306 | R:R:F307 | 9.65 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:F325 | 3.22 | 1 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 9.67 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F306 | 9.02 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F307 | 8.2 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F325 | R:R:N310 | 6.04 | 0 | Yes | No | 4 | 6 | 2 | 1 | L:L:?1 | R:R:N310 | 6.47 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 12.79 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:N329 | 12.02 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 15.43 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y333 | 5.53 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:A208 | 2.12 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:A208 | R:R:V314 | 1.7 | 0 | No | Yes | 6 | 5 | 1 | 2 | R:R:S173 | R:R:V172 | 1.62 | 0 | Yes | No | 7 | 5 | 2 | 2 | R:R:S215 | R:R:V172 | 1.62 | 0 | No | No | 6 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 7.44 | Average Nodes In Shell | 33.00 | Average Hubs In Shell | 16.00 | Average Links In Shell | 51.00 | Average Links Mediated by Hubs In Shell | 48.00 |
| ![](/psngpcr/ligands/P32/P32_2YCX_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P32/P32_2YCX_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 2YCY | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Cyanopindolol | - | - | 3.15 | 2011-06-08 | 10.1073/pnas.1100185108 |
![](/psngpcr/ligands/P32/P32_2YCY_L_L_1.png)
A 2D representation of the interactions of P32 in 2YCY colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 5.84 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 6.31 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:V95 | R:R:W330 | 4.9 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:V95 | R:R:Y333 | 5.05 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:W107 | R:R:W117 | 18.74 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:C199 | R:R:W107 | 11.75 | 1 | No | Yes | 9 | 7 | 2 | 2 | R:R:C199 | R:R:W117 | 3.92 | 1 | No | Yes | 9 | 6 | 2 | 1 | L:L:?1 | R:R:W117 | 5.37 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F201 | R:R:T118 | 5.19 | 1 | Yes | No | 4 | 6 | 1 | 2 | R:R:D121 | R:R:Y333 | 10.34 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D121 | 17.37 | 1 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:V122 | 12.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S215 | R:R:T126 | 9.59 | 0 | No | Yes | 6 | 6 | 1 | 2 | R:R:F201 | R:R:W182 | 5.01 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:T203 | R:R:W182 | 6.06 | 1 | No | Yes | 4 | 5 | 2 | 2 | R:R:W182 | R:R:Y207 | 5.79 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:F201 | R:R:T203 | 7.78 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:F201 | R:R:Y207 | 4.13 | 1 | Yes | Yes | 4 | 7 | 1 | 2 | L:L:?1 | R:R:F201 | 8.2 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 6.24 | 1 | No | Yes | 4 | 7 | 2 | 2 | R:R:S211 | R:R:Y207 | 16.53 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S211 | 8.09 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S215 | 4.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:F307 | 27.86 | 0 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F306 | R:R:W303 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F306 | R:R:F307 | 8.57 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:N329 | 13.29 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F306 | 7.38 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F307 | 10.66 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F325 | R:R:N310 | 6.04 | 0 | No | No | 4 | 6 | 2 | 1 | L:L:?1 | R:R:N310 | 3.7 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 6.98 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:N329 | 13.87 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 11.58 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y333 | 3.95 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:G98 | R:R:W117 | 2.81 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:G98 | R:R:W330 | 2.81 | 0 | No | Yes | 6 | 6 | 2 | 2 | R:R:F307 | R:R:S212 | 2.64 | 1 | Yes | No | 7 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 8.61 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| ![](/psngpcr/ligands/P32/P32_2YCY_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P32/P32_2YCY_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 4BVN | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Cyanopindolol | Na | - | 2.1 | 2014-04-02 | 10.1371/journal.pone.0092727 |
![](/psngpcr/ligands/P32/P32_4BVN_L_L_3.png)
A 2D representation of the interactions of P32 in 4BVN colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 7.3 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 3.79 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:V95 | R:R:W330 | 4.9 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:V95 | R:R:Y333 | 3.79 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F201 | R:R:T118 | 7.78 | 1 | Yes | No | 4 | 6 | 1 | 2 | R:R:D121 | R:R:Y333 | 10.34 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?3 | R:R:D121 | 18.28 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:S173 | R:R:V122 | 4.85 | 0 | Yes | No | 7 | 6 | 2 | 1 | L:L:?3 | R:R:V122 | 11.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:V125 | R:R:W303 | 13.48 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?3 | R:R:V125 | 4.01 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S173 | R:R:T126 | 4.8 | 0 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:S215 | R:R:T126 | 9.59 | 0 | No | Yes | 6 | 6 | 1 | 2 | R:R:F201 | R:R:W182 | 11.02 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:T203 | R:R:W182 | 3.64 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:W182 | R:R:Y207 | 6.75 | 1 | Yes | Yes | 5 | 7 | 2 | 1 | R:R:F201 | R:R:T203 | 7.78 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | R:R:F201 | R:R:Y207 | 6.19 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | L:L:?3 | R:R:F201 | 9.02 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 6.24 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | L:L:?3 | R:R:T203 | 2.98 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:N204 | R:R:Y207 | 3.49 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:S211 | R:R:Y207 | 15.26 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?3 | R:R:Y207 | 5.53 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?3 | R:R:S211 | 7.08 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F307 | R:R:S212 | 3.96 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:N310 | R:R:S212 | 2.98 | 1 | No | Yes | 6 | 6 | 1 | 1 | R:R:I311 | R:R:S212 | 3.1 | 0 | No | Yes | 5 | 6 | 2 | 1 | L:L:?3 | R:R:S212 | 3.03 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?3 | R:R:S215 | 4.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:Y217 | 7.22 | 1 | Yes | No | 7 | 5 | 2 | 2 | R:R:F216 | R:R:F307 | 34.29 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F307 | R:R:Y217 | 4.13 | 1 | Yes | No | 7 | 5 | 1 | 2 | R:R:F299 | R:R:W303 | 13.03 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F299 | R:R:N335 | 7.25 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:F306 | R:R:W303 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:F307 | R:R:W303 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:G332 | R:R:W303 | 11.26 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:N335 | R:R:W303 | 4.52 | 1 | No | Yes | 9 | 8 | 2 | 1 | L:L:?3 | R:R:W303 | 3.84 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F306 | R:R:F307 | 8.57 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:F325 | 4.29 | 1 | Yes | No | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 12.08 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?3 | R:R:F306 | 9.02 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?3 | R:R:F307 | 10.66 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?3 | R:R:N310 | 7.4 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 12.79 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?3 | R:R:N329 | 13.87 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 14.47 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?3 | R:R:Y333 | 5.53 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:P176 | R:R:Y207 | 2.78 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:S173 | R:R:V172 | 1.62 | 0 | Yes | No | 7 | 5 | 2 | 2 | R:R:S215 | R:R:V172 | 1.62 | 0 | No | No | 6 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 7.69 | Average Nodes In Shell | 33.00 | Average Hubs In Shell | 16.00 | Average Links In Shell | 53.00 | Average Links Mediated by Hubs In Shell | 51.00 |
| ![](/psngpcr/ligands/P32/P32_4BVN_L_L_3_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P32/P32_4BVN_L_L_3_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5F8U | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Cyanopindolol | - | - | 3.35 | 2015-12-23 | 10.1038/nsmb.3130 |
![](/psngpcr/ligands/P32/P32_5F8U_L_L_1.png)
A 2D representation of the interactions of P32 in 5F8U colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 5.84 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 6.31 | 1 | No | Yes | 7 | 7 | 2 | 2 | R:R:F97 | R:R:W117 | 5.01 | 0 | No | Yes | 4 | 6 | 2 | 1 | R:R:G98 | R:R:W117 | 5.63 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:W107 | R:R:W117 | 11.25 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:T118 | R:R:W117 | 4.85 | 1 | No | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:W117 | 6.14 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F201 | R:R:T118 | 3.89 | 1 | Yes | No | 4 | 6 | 1 | 1 | L:L:?1 | R:R:T118 | 3.97 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:D121 | R:R:Y333 | 6.9 | 1 | No | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:D121 | 20.11 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:S173 | R:R:V122 | 4.85 | 0 | No | No | 7 | 6 | 2 | 1 | L:L:?1 | R:R:V122 | 12.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:V125 | R:R:W303 | 7.36 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:V125 | 4.01 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S173 | R:R:T126 | 4.8 | 0 | No | Yes | 7 | 6 | 2 | 2 | R:R:S215 | R:R:T126 | 4.8 | 0 | No | Yes | 6 | 6 | 1 | 2 | R:R:I177 | R:R:W182 | 5.87 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F201 | R:R:I177 | 3.77 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:I177 | R:R:Y207 | 3.63 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F201 | R:R:W182 | 13.03 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:T203 | R:R:W182 | 8.49 | 1 | No | Yes | 4 | 5 | 2 | 2 | R:R:W182 | R:R:Y207 | 6.75 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:F201 | R:R:T203 | 7.78 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:F201 | R:R:Y207 | 9.28 | 1 | Yes | Yes | 4 | 7 | 1 | 2 | L:L:?1 | R:R:F201 | 9.02 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 4.99 | 1 | No | Yes | 4 | 7 | 2 | 2 | R:R:S211 | R:R:Y207 | 10.17 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S211 | 11.12 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S215 | 4.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:F307 | 27.86 | 0 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F299 | R:R:W303 | 8.02 | 0 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F306 | R:R:W303 | 12.03 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:F307 | R:R:W303 | 8.02 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:N329 | R:R:W303 | 4.52 | 1 | Yes | Yes | 6 | 8 | 1 | 1 | R:R:G332 | R:R:W303 | 11.26 | 0 | No | Yes | 6 | 8 | 2 | 1 | L:L:?1 | R:R:W303 | 5.37 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F306 | R:R:F307 | 13.93 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:N310 | 4.83 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:F306 | R:R:N329 | 9.67 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F306 | 9.84 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F307 | R:R:N310 | 3.62 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F307 | 13.12 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F325 | R:R:N310 | 3.62 | 0 | No | Yes | 4 | 6 | 2 | 1 | L:L:?1 | R:R:N310 | 9.25 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 17.44 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:N329 | 11.1 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:S215 | R:R:V172 | 3.23 | 0 | No | No | 6 | 5 | 1 | 2 | R:R:N310 | R:R:S212 | 2.98 | 1 | Yes | No | 6 | 6 | 1 | 2 | L:L:?1 | R:R:A208 | 2.12 | 1 | Yes | No | 0 | 6 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 8.66 | Average Nodes In Shell | 32.00 | Average Hubs In Shell | 16.00 | Average Links In Shell | 50.00 | Average Links Mediated by Hubs In Shell | 47.00 |
| ![](/psngpcr/ligands/P32/P32_5F8U_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P32/P32_5F8U_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6H7O | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Cyanopindolol | - | - | 2.8 | 2018-10-17 | 10.1126/science.aau5595 |
![](/psngpcr/ligands/P32/P32_6H7O_L_L_1.png)
A 2D representation of the interactions of P32 in 6H7O colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 7.3 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V95 | R:R:W330 | 4.9 | 1 | No | Yes | 7 | 6 | 2 | 2 | R:R:V95 | R:R:Y333 | 7.57 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:F97 | R:R:W107 | 5.01 | 1 | No | Yes | 4 | 7 | 2 | 2 | R:R:F97 | R:R:W117 | 8.02 | 1 | No | Yes | 4 | 6 | 2 | 1 | R:R:G98 | R:R:W117 | 4.22 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:W107 | R:R:W117 | 14.99 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | L:L:?1 | R:R:W117 | 5.37 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F201 | R:R:T118 | 5.19 | 1 | Yes | No | 4 | 6 | 1 | 2 | R:R:D121 | R:R:Y333 | 10.34 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D121 | 20.11 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:I177 | R:R:V122 | 4.61 | 1 | Yes | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:V122 | 12.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:V125 | R:R:W303 | 11.03 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:V125 | 7.02 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S215 | R:R:T126 | 9.59 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:I129 | R:R:W303 | 8.22 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:P176 | R:R:Y207 | 4.17 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:I177 | R:R:W182 | 7.05 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F201 | R:R:I177 | 5.02 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:F201 | R:R:W182 | 12.03 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:W182 | R:R:Y207 | 5.79 | 1 | Yes | Yes | 5 | 7 | 2 | 1 | R:R:F201 | R:R:T203 | 7.78 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:F201 | R:R:Y207 | 6.19 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | L:L:?1 | R:R:F201 | 8.2 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 8.74 | 1 | No | Yes | 4 | 7 | 2 | 1 | R:R:S211 | R:R:Y207 | 16.53 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:Y207 | 6.32 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:S211 | 10.11 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F307 | R:R:S212 | 5.28 | 1 | Yes | No | 7 | 6 | 1 | 2 | R:R:N310 | R:R:S212 | 5.96 | 1 | No | No | 6 | 6 | 1 | 2 | L:L:?1 | R:R:S215 | 4.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:F307 | 21.43 | 0 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F306 | R:R:W303 | 7.02 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:F307 | R:R:W303 | 10.02 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:G332 | R:R:W303 | 11.26 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:N335 | R:R:W303 | 6.78 | 0 | No | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W303 | 4.6 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F306 | R:R:F307 | 12.86 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:N310 | 4.83 | 1 | Yes | No | 7 | 6 | 1 | 1 | R:R:F306 | R:R:F325 | 4.29 | 1 | Yes | No | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 13.29 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F306 | 10.66 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F307 | 10.66 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N310 | 13.87 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 15.12 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:N329 | 14.8 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 6.75 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y333 | 6.32 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S215 | R:R:V172 | 3.23 | 0 | No | No | 6 | 5 | 1 | 2 | R:R:N204 | R:R:Y207 | 2.33 | 0 | No | Yes | 5 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 9.58 | Average Nodes In Shell | 35.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 51.00 | Average Links Mediated by Hubs In Shell | 47.00 |
| ![](/psngpcr/ligands/P32/P32_6H7O_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P32/P32_6H7O_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8DCS | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Cyanopindolol | - | Gs/Beta1/Gamma2 | 2.5 | 2022-07-27 | 10.1038/s41467-022-31823-1 |
![](/psngpcr/ligands/P32/P32_8DCS_L_L_1.png)
A 2D representation of the interactions of P32 in 8DCS colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 11.69 | 3 | No | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 3.79 | 3 | No | Yes | 7 | 7 | 2 | 1 | R:R:V95 | R:R:Y333 | 6.31 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:F97 | R:R:W117 | 10.02 | 0 | No | No | 4 | 6 | 2 | 1 | R:R:W107 | R:R:W117 | 11.25 | 22 | Yes | No | 7 | 6 | 2 | 1 | R:R:F201 | R:R:T118 | 5.19 | 3 | Yes | No | 4 | 6 | 1 | 2 | R:R:D121 | R:R:Y333 | 10.34 | 3 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D121 | 20.11 | 3 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:V122 | 12.04 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:S215 | R:R:T126 | 9.59 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:F201 | R:R:W182 | 7.02 | 3 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:T203 | R:R:W182 | 3.64 | 3 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:W182 | R:R:Y207 | 4.82 | 3 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:F201 | R:R:T203 | 7.78 | 3 | Yes | Yes | 4 | 4 | 1 | 1 | R:R:F201 | R:R:Y207 | 4.13 | 3 | Yes | Yes | 4 | 7 | 1 | 2 | L:L:?1 | R:R:F201 | 7.38 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 4.99 | 3 | Yes | Yes | 4 | 7 | 1 | 2 | L:L:?1 | R:R:T203 | 3.97 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:S211 | R:R:Y207 | 13.99 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S211 | 10.11 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:N310 | R:R:S212 | 4.47 | 3 | No | No | 6 | 6 | 1 | 2 | L:L:?1 | R:R:S215 | 4.04 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:F307 | 24.65 | 3 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F306 | R:R:W303 | 7.02 | 3 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F307 | R:R:W303 | 9.02 | 3 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F306 | R:R:F307 | 11.79 | 3 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:F325 | 6.43 | 3 | Yes | No | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 9.67 | 3 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F306 | 9.84 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F307 | R:R:N310 | 3.62 | 3 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F307 | 6.56 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N310 | 7.4 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 11.63 | 3 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:N329 | 11.1 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 7.72 | 3 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y333 | 3.95 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:W117 | 3.07 | 3 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:A208 | 2.12 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:A208 | R:R:V314 | 1.7 | 0 | No | No | 6 | 5 | 1 | 2 | R:R:S211 | R:R:V172 | 1.62 | 0 | No | Yes | 6 | 5 | 1 | 2 | R:R:S215 | R:R:V172 | 1.62 | 0 | No | Yes | 6 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 7.82 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 41.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| ![](/psngpcr/ligands/P32/P32_8DCS_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P32/P32_8DCS_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|