CodeP9X
Name(5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid
SynonymsAcifran
Identifier
FormulaC12 H10 O4
Molecular Weight218.205
SMILES
PubChem76969700
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds27
Total Aromatic Bonds6
Networks13
 missing image

This ligand is also present in the following 13 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IHI A Alicarboxylic acid Hydroxycarboxylic Acid HCA2 Homo Sapiens Acifran - Gi1/Beta1/Gamma2 3.11 2023-08-30 doi.org/10.1038/s41467-023-41650-7

A 2D representation of the interactions of P9X in 8IHI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L34 R:R:L83 4.15 2 No Yes 8 6 2 1
R:R:L34 R:R:Y284 5.86 2 No Yes 8 7 2 1
R:R:E37 R:R:Y284 4.49 0 No Yes 7 7 2 1
R:R:C79 R:R:L107 9.52 0 No Yes 6 6 2 1
R:R:L83 R:R:Y87 3.52 2 Yes Yes 6 6 1 2
R:R:L107 R:R:L83 5.54 2 Yes Yes 6 6 1 1
R:R:L83 R:R:Y284 3.52 2 Yes Yes 6 7 1 1
L:L:?1 R:R:L83 9.71 2 Yes Yes 0 6 0 1
R:R:N86 R:R:W91 7.91 0 No Yes 5 4 1 2
R:R:N86 R:R:W93 7.91 0 No Yes 5 9 1 2
L:L:?1 R:R:N86 3.61 2 Yes No 0 5 0 1
R:R:W91 R:R:Y87 4.82 2 Yes Yes 4 6 2 2
R:R:F277 R:R:W91 11.02 0 Yes Yes 5 4 1 2
L:L:?1 R:R:L104 10.92 2 Yes No 0 5 0 1
R:R:L107 R:R:Y284 3.52 2 Yes Yes 6 7 1 1
L:L:?1 R:R:L107 6.07 2 Yes Yes 0 6 0 1
R:R:E196 R:R:R111 4.65 0 No Yes 5 8 2 1
R:R:R111 R:R:T283 5.17 2 Yes Yes 8 8 1 2
R:R:R111 R:R:Y284 3.09 2 Yes Yes 8 7 1 1
L:L:?1 R:R:R111 10.65 2 Yes Yes 0 8 0 1
R:R:F180 R:R:H189 11.31 2 Yes Yes 3 5 1 2
R:R:E190 R:R:F180 3.5 2 Yes Yes 4 3 2 1
R:R:F180 R:R:F193 10.72 2 Yes No 3 6 1 2
R:R:F180 R:R:R251 4.28 2 Yes Yes 3 5 1 2
R:R:F180 R:R:F276 7.5 2 Yes Yes 3 4 1 2
R:R:F180 R:R:L280 3.65 2 Yes No 3 5 1 2
L:L:?1 R:R:F180 12.81 2 Yes Yes 0 3 0 1
R:R:E190 R:R:R251 12.79 2 Yes Yes 4 5 2 2
R:R:F193 R:R:R251 3.21 2 No Yes 6 5 2 2
R:R:F276 R:R:R251 16.03 2 Yes Yes 4 5 2 2
R:R:D273 R:R:F277 7.17 0 No Yes 4 5 2 1
R:R:F276 R:R:F277 8.57 2 Yes Yes 4 5 2 1
R:R:F276 R:R:L280 4.87 2 Yes No 4 5 2 2
L:L:?1 R:R:F277 3.2 2 Yes Yes 0 5 0 1
R:R:L280 R:R:T283 5.9 2 No Yes 5 8 2 2
R:R:T283 R:R:Y284 4.99 2 Yes Yes 8 7 2 1
L:L:?1 R:R:Y284 6.17 2 Yes Yes 0 7 0 1
R:R:L80 R:R:Y284 2.34 0 No Yes 8 7 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.89
Average Nodes In Shell25.00
Average Hubs In Shell15.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IHJ A Alicarboxylic acid Hydroxycarboxylic Acid HCA3 Homo Sapiens Acifran - Gi1/Beta1/Gamma2 3.07 2023-08-30 doi.org/10.1038/s41467-023-41650-7

A 2D representation of the interactions of P9X in 8IHJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L30 R:R:Y87 9.38 3 Yes Yes 6 5 2 2
R:R:F277 R:R:L30 3.65 3 No Yes 5 6 1 2
R:R:L34 R:R:L80 6.92 0 No Yes 8 8 2 2
R:R:L34 R:R:V83 2.98 0 No No 8 6 2 1
R:R:F107 R:R:L76 3.65 3 Yes No 6 6 1 2
R:R:L80 R:R:Y284 3.52 0 Yes Yes 8 7 2 1
R:R:V83 R:R:Y87 3.79 0 No Yes 6 5 1 2
L:L:?1 R:R:V83 5.22 3 Yes No 0 6 0 1
R:R:S91 R:R:Y86 7.63 0 No Yes 4 5 2 1
R:R:W93 R:R:Y86 8.68 3 Yes Yes 9 5 2 1
R:R:C177 R:R:Y86 4.03 3 No Yes 9 5 2 1
R:R:I178 R:R:Y86 3.63 3 No Yes 3 5 1 1
L:L:?1 R:R:Y86 3.08 3 Yes Yes 0 5 0 1
R:R:F277 R:R:Y87 8.25 3 No Yes 5 5 1 2
R:R:C177 R:R:W93 3.92 3 No Yes 9 9 2 2
R:R:L104 R:R:S179 7.51 0 No No 5 5 1 2
L:L:?1 R:R:L104 10.92 3 Yes No 0 5 0 1
R:R:F107 R:R:Y284 8.25 3 Yes Yes 6 7 1 1
L:L:?1 R:R:F107 19.22 3 Yes Yes 0 6 0 1
R:R:E196 R:R:R111 3.49 0 Yes No 6 7 2 1
R:R:R111 R:R:T283 5.17 0 No No 7 8 1 2
L:L:?1 R:R:R111 10.65 3 Yes No 0 7 0 1
L:L:?1 R:R:I178 5.01 3 Yes No 0 3 0 1
R:R:F180 R:R:S179 3.96 3 Yes No 4 5 1 2
R:R:H189 R:R:S179 2.79 3 Yes No 5 5 2 2
R:R:F180 R:R:H189 5.66 3 Yes Yes 4 5 1 2
R:R:F180 R:R:F193 5.36 3 Yes No 4 5 1 2
R:R:F180 R:R:F276 10.72 3 Yes Yes 4 4 1 2
L:L:?1 R:R:F180 11.75 3 Yes Yes 0 4 0 1
R:R:E196 R:R:F193 7 0 Yes No 6 5 2 2
L:L:?1 R:R:F277 6.41 3 Yes No 0 5 0 1
R:R:L280 R:R:T283 2.95 3 No No 5 8 1 2
R:R:L280 R:R:Y284 3.52 3 No Yes 5 7 1 1
L:L:?1 R:R:L280 9.71 3 Yes No 0 5 0 1
L:L:?1 R:R:Y284 3.08 3 Yes Yes 0 7 0 1
L:L:?1 R:R:V103 2.61 3 Yes No 0 5 0 1
R:R:V176 R:R:Y86 2.52 3 Yes Yes 1 5 2 1
R:R:C79 R:R:F107 1.4 0 No Yes 6 6 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.97
Average Nodes In Shell28.00
Average Hubs In Shell13.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IHK A Alicarboxylic acid Hydroxycarboxylic Acid HCA3 Homo Sapiens Acifran - - 3.21 2023-08-30 doi.org/10.1038/s41467-023-41650-7

A 2D representation of the interactions of P9X in 8IHK
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:V83 18.28 1 Yes No 0 6 0 1
L:L:?1 R:R:Y86 5.14 1 Yes Yes 0 5 0 1
L:L:?1 R:R:V103 5.22 1 Yes No 0 5 0 1
L:L:?1 R:R:L104 7.28 1 Yes No 0 5 0 1
L:L:?1 R:R:F107 25.63 1 Yes Yes 0 6 0 1
L:L:?1 R:R:R111 11.72 1 Yes No 0 7 0 1
L:L:?1 R:R:I178 5.01 1 Yes No 0 3 0 1
L:L:?1 R:R:F180 3.2 1 Yes Yes 0 4 0 1
L:L:?1 R:R:L280 8.49 1 Yes No 0 5 0 1
L:L:?1 R:R:Y284 9.25 1 Yes Yes 0 7 0 1
R:R:L34 R:R:Y87 3.52 0 No Yes 8 5 2 2
R:R:L34 R:R:Y284 3.52 0 No Yes 8 7 2 1
R:R:L76 R:R:Y284 5.86 0 No Yes 6 7 2 1
R:R:C79 R:R:F107 4.19 0 No Yes 6 6 2 1
R:R:V83 R:R:Y87 5.05 1 No Yes 6 5 1 2
R:R:F107 R:R:V83 6.55 1 Yes No 6 6 1 1
R:R:S91 R:R:Y86 10.17 0 No Yes 4 5 2 1
R:R:W93 R:R:Y86 4.82 1 Yes Yes 9 5 2 1
R:R:V176 R:R:Y86 5.05 0 No Yes 1 5 2 1
R:R:I178 R:R:Y86 6.04 1 No Yes 3 5 1 1
R:R:V103 R:R:W93 6.13 0 No Yes 5 9 1 2
R:R:L104 R:R:S179 6.01 0 No No 5 5 1 2
R:R:F107 R:R:Y284 7.22 1 Yes Yes 6 7 1 1
R:R:E196 R:R:R111 8.14 0 No No 6 7 2 1
R:R:R111 R:R:T283 3.88 0 No No 7 8 1 2
R:R:H189 R:R:S179 4.18 1 Yes No 5 5 2 2
R:R:F180 R:R:H189 5.66 1 Yes Yes 4 5 1 2
R:R:F180 R:R:F193 8.57 1 Yes Yes 4 5 1 2
R:R:F180 R:R:R251 3.21 1 Yes Yes 4 6 1 2
R:R:F180 R:R:F276 8.57 1 Yes Yes 4 4 1 2
R:R:E196 R:R:F193 8.16 0 No Yes 6 5 2 2
R:R:F193 R:R:R251 4.28 1 Yes Yes 5 6 2 2
R:R:F193 R:R:F276 4.29 1 Yes Yes 5 4 2 2
R:R:F276 R:R:R251 11.76 1 Yes Yes 4 6 2 2
R:R:L280 R:R:Y284 7.03 1 No Yes 5 7 1 1
R:R:F82 R:R:V103 2.62 0 No No 6 5 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.92
Average Nodes In Shell26.00
Average Hubs In Shell11.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JKX A Alicarboxylic acid Hydroxycarboxylic Acid HCA3 Homo Sapiens Acifran - Gi1/Beta1/Gamma2 3.18 2025-10-29 To be published

A 2D representation of the interactions of P9X in 9JKX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:V83 6.53 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L104 3.64 2 Yes No 0 5 0 1
L:L:?1 R:R:F107 17.08 2 Yes No 0 6 0 1
L:L:?1 R:R:R111 13.85 2 Yes No 0 7 0 1
L:L:?1 R:R:I178 7.51 2 Yes Yes 0 3 0 1
L:L:?1 R:R:F180 13.88 2 Yes Yes 0 4 0 1
L:L:?1 R:R:L280 12.13 2 Yes No 0 5 0 1
L:L:?1 R:R:T283 5.17 2 Yes Yes 0 8 0 1
L:L:?1 R:R:Y284 8.22 2 Yes Yes 0 7 0 1
R:R:F21 R:R:I178 3.77 22 Yes Yes 3 3 2 1
R:R:L34 R:R:V83 4.47 2 Yes Yes 8 6 2 1
R:R:L34 R:R:Y87 14.07 2 Yes Yes 8 5 2 2
R:R:E37 R:R:Y284 7.86 0 No Yes 7 7 2 1
R:R:F107 R:R:L76 3.65 0 No Yes 6 6 1 2
R:R:L76 R:R:Y284 4.69 2 Yes Yes 6 7 2 1
R:R:L76 R:R:S287 3 2 Yes No 6 8 2 2
R:R:L80 R:R:V83 4.47 0 No Yes 8 6 2 1
R:R:V83 R:R:Y87 2.52 2 Yes Yes 6 5 1 2
R:R:F107 R:R:V103 2.62 0 No No 6 5 1 2
R:R:R111 R:R:T283 9.06 2 No Yes 7 8 1 1
R:R:I178 R:R:S181 4.64 0 Yes No 3 5 1 2
R:R:F180 R:R:S179 3.96 0 Yes No 4 5 1 2
R:R:F180 R:R:R251 3.21 0 Yes Yes 4 6 1 2
R:R:F180 R:R:F276 8.57 0 Yes No 4 4 1 2
R:R:F244 R:R:T283 2.59 2 Yes Yes 9 8 2 1
R:R:F276 R:R:L280 13.4 0 No No 4 5 2 1
R:R:T283 R:R:Y284 12.48 2 Yes Yes 8 7 1 1
R:R:S287 R:R:Y284 6.36 2 No Yes 8 7 2 1
R:R:I178 R:R:V176 1.54 0 Yes No 3 1 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.78
Average Nodes In Shell24.00
Average Hubs In Shell12.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JKY A Alicarboxylic acid Hydroxycarboxylic Acid HCA2 Homo Sapiens Acifran - Gi1/Beta1/Gamma2 2.72 2025-10-29 To be published

A 2D representation of the interactions of P9X in 9JKY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L83 19.41 1 Yes Yes 0 6 0 1
L:L:?1 R:R:M103 3.72 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L104 14.56 1 Yes No 0 5 0 1
L:L:?1 R:R:L107 21.84 1 Yes No 0 6 0 1
L:L:?1 R:R:R111 10.65 1 Yes Yes 0 8 0 1
L:L:?1 R:R:C177 4.17 1 Yes No 0 9 0 1
L:L:?1 R:R:S179 3.95 1 Yes Yes 0 4 0 1
L:L:?1 R:R:F180 10.68 1 Yes Yes 0 3 0 1
L:L:?1 R:R:F277 3.2 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y284 9.25 1 Yes Yes 0 7 0 1
R:R:L34 R:R:L83 4.15 1 No Yes 8 6 2 1
R:R:L34 R:R:Y87 7.03 1 No Yes 8 6 2 2
R:R:E37 R:R:Y284 3.37 1 No Yes 7 7 2 1
R:R:L76 R:R:Y284 5.86 0 No Yes 7 7 2 1
R:R:C79 R:R:M103 4.86 0 No Yes 6 5 2 1
R:R:L80 R:R:Y284 4.69 0 No Yes 8 7 2 1
R:R:F82 R:R:W93 4.01 1 Yes Yes 6 9 2 2
R:R:F82 R:R:M103 9.95 1 Yes Yes 6 5 2 1
R:R:L83 R:R:Y87 15.24 1 Yes Yes 6 6 1 2
R:R:L83 R:R:Y284 4.69 1 Yes Yes 6 7 1 1
R:R:W91 R:R:Y87 6.75 1 Yes Yes 4 6 2 2
R:R:F277 R:R:Y87 3.09 1 Yes Yes 5 6 1 2
R:R:F277 R:R:W91 12.03 1 Yes Yes 5 4 1 2
R:R:C100 R:R:W93 10.45 1 Yes Yes 9 9 2 2
R:R:M103 R:R:W93 3.49 1 Yes Yes 5 9 1 2
R:R:C177 R:R:W93 20.89 1 No Yes 9 9 1 2
R:R:C100 R:R:C177 7.28 1 Yes No 9 9 2 1
R:R:L104 R:R:S179 4.5 1 No Yes 5 4 1 1
R:R:L107 R:R:Y284 4.69 1 No Yes 6 7 1 1
R:R:F180 R:R:R111 3.21 1 Yes Yes 3 8 1 1
R:R:F193 R:R:R111 3.21 1 Yes Yes 6 8 2 1
R:R:E196 R:R:R111 8.14 1 Yes Yes 5 8 2 1
R:R:R111 R:R:T283 7.76 1 Yes Yes 8 8 1 2
R:R:L162 R:R:S179 3 1 No Yes 4 4 2 1
R:R:H189 R:R:L162 7.71 1 Yes No 5 4 2 2
R:R:F180 R:R:S179 3.96 1 Yes Yes 3 4 1 1
R:R:H189 R:R:S179 4.18 1 Yes Yes 5 4 2 1
R:R:F180 R:R:H189 12.44 1 Yes Yes 3 5 1 2
R:R:E190 R:R:F180 5.83 1 No Yes 4 3 2 1
R:R:F180 R:R:F193 11.79 1 Yes Yes 3 6 1 2
R:R:F180 R:R:R251 9.62 1 Yes Yes 3 5 1 2
R:R:F180 R:R:F276 9.65 1 Yes Yes 3 4 1 2
R:R:E190 R:R:R251 13.96 1 No Yes 4 5 2 2
R:R:E196 R:R:F193 7 1 Yes Yes 5 6 2 2
R:R:F193 R:R:R251 6.41 1 Yes Yes 6 5 2 2
R:R:F193 R:R:F276 4.29 1 Yes Yes 6 4 2 2
R:R:F276 R:R:R251 16.03 1 Yes Yes 4 5 2 2
R:R:F276 R:R:F277 7.5 1 Yes Yes 4 5 2 1
R:R:L280 R:R:T283 5.9 1 No Yes 5 8 2 2
R:R:L280 R:R:Y284 4.69 1 No Yes 5 7 2 1
R:R:T283 R:R:Y284 7.49 1 Yes Yes 8 7 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.14
Average Nodes In Shell30.00
Average Hubs In Shell19.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell51.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KT6 A Alicarboxylic acid Hydroxycarboxylic Acid HCA3 Homo Sapiens Acifran - Gi1/Beta1/Gamma2 3.01 2025-12-10 10.1021/acs.jmedchem.4c02567

A 2D representation of the interactions of P9X in 9KT6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:V83 13.06 3 Yes No 0 6 0 1
L:L:?1 R:R:Y86 9.25 3 Yes Yes 0 5 0 1
L:L:?1 R:R:W93 2 3 Yes Yes 0 9 0 1
L:L:?1 R:R:V103 2.61 3 Yes No 0 5 0 1
L:L:?1 R:R:L104 13.35 3 Yes No 0 5 0 1
L:L:?1 R:R:F107 16.02 3 Yes Yes 0 6 0 1
L:L:?1 R:R:R111 8.52 3 Yes Yes 0 7 0 1
L:L:?1 R:R:C177 4.17 3 Yes No 0 9 0 1
L:L:?1 R:R:F180 6.41 3 Yes Yes 0 4 0 1
L:L:?1 R:R:F277 2.14 3 Yes Yes 0 5 0 1
L:L:?1 R:R:L280 8.49 3 Yes Yes 0 5 0 1
L:L:?1 R:R:Y284 8.22 3 Yes No 0 7 0 1
R:R:I26 R:R:Y87 13.3 3 No Yes 4 5 2 2
R:R:F277 R:R:I26 2.51 0 Yes No 5 4 1 2
R:R:L76 R:R:Y284 2.34 0 No No 6 7 2 1
R:R:C79 R:R:F107 4.19 0 No Yes 6 6 2 1
R:R:V83 R:R:Y87 2.52 3 No Yes 6 5 1 2
R:R:F107 R:R:V83 5.24 3 Yes No 6 6 1 1
R:R:Y86 R:R:Y87 6.95 3 Yes Yes 5 5 1 2
R:R:W93 R:R:Y86 7.72 3 Yes Yes 9 5 1 1
R:R:V176 R:R:Y86 3.79 0 No Yes 1 5 2 1
R:R:C100 R:R:W93 6.53 3 No Yes 9 9 2 1
R:R:V103 R:R:W93 2.45 3 No Yes 5 9 1 1
R:R:C177 R:R:W93 16.98 3 No Yes 9 9 1 1
R:R:C100 R:R:C177 7.28 3 No No 9 9 2 1
R:R:F107 R:R:V103 5.24 3 Yes No 6 5 1 1
R:R:L104 R:R:L167 2.77 0 No No 5 4 1 2
R:R:L104 R:R:S179 3 0 No No 5 5 1 2
R:R:F193 R:R:R111 3.21 3 Yes Yes 5 7 2 1
R:R:F244 R:R:R111 3.21 16 Yes Yes 9 7 2 1
R:R:R111 R:R:T283 5.17 0 Yes No 7 8 1 2
R:R:F277 R:R:I178 3.77 0 Yes No 5 3 1 2
R:R:H189 R:R:S179 9.76 3 No No 5 5 2 2
R:R:F180 R:R:H189 6.79 3 Yes No 4 5 1 2
R:R:F180 R:R:F193 5.36 3 Yes Yes 4 5 1 2
R:R:F180 R:R:R251 4.28 3 Yes Yes 4 6 1 2
R:R:F180 R:R:F276 10.72 3 Yes Yes 4 4 1 2
R:R:F180 R:R:L280 4.87 3 Yes Yes 4 5 1 1
R:R:F193 R:R:R251 2.14 3 Yes Yes 5 6 2 2
R:R:F193 R:R:L280 2.44 3 Yes Yes 5 5 2 1
R:R:F276 R:R:R251 7.48 3 Yes Yes 4 6 2 2
R:R:F276 R:R:F277 2.14 3 Yes Yes 4 5 2 1
R:R:F276 R:R:L280 2.44 3 Yes Yes 4 5 2 1
R:R:T283 R:R:Y284 7.49 0 No No 8 7 2 1
R:R:F82 R:R:W93 1 0 No Yes 6 9 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.85
Average Nodes In Shell29.00
Average Hubs In Shell13.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KT8 A Alicarboxylic acid Hydroxycarboxylic Acid HCA2 Homo Sapiens Acifran - Gi1/Beta1/Gamma2 2.73 2025-12-10 10.1021/acs.jmedchem.4c02567

A 2D representation of the interactions of P9X in 9KT8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R22 R:R:W91 2 0 No Yes 3 4 2 1
R:R:I26 R:R:L30 7.14 2 No Yes 5 5 2 2
R:R:I26 R:R:Y87 3.63 2 No Yes 5 6 2 1
R:R:L30 R:R:L34 2.77 2 Yes Yes 5 8 2 2
R:R:L30 R:R:Y87 11.72 2 Yes Yes 5 6 2 1
R:R:E37 R:R:L34 2.65 0 Yes Yes 7 8 2 2
R:R:L34 R:R:Y87 2.34 2 Yes Yes 8 6 2 1
R:R:E37 R:R:Y284 3.37 0 Yes Yes 7 7 2 1
R:R:L107 R:R:L76 2.77 2 Yes No 6 7 1 2
R:R:L76 R:R:Y284 2.34 2 No Yes 7 7 2 1
R:R:C79 R:R:L107 3.17 0 No Yes 6 6 2 1
R:R:L80 R:R:L83 4.15 0 No Yes 8 6 2 1
R:R:L80 R:R:Y284 3.52 0 No Yes 8 7 2 1
R:R:L83 R:R:Y87 2.34 2 Yes Yes 6 6 1 1
R:R:L83 R:R:M103 2.83 2 Yes No 6 5 1 1
L:L:?1 R:R:L83 3.64 2 Yes Yes 0 6 0 1
R:R:N86 R:R:W91 6.78 2 No Yes 5 4 1 1
R:R:N86 R:R:W93 9.04 2 No Yes 5 9 1 2
L:L:?1 R:R:N86 7.22 2 Yes No 0 5 0 1
R:R:W91 R:R:Y87 5.79 2 Yes Yes 4 6 1 1
L:L:?1 R:R:Y87 8.22 2 Yes Yes 0 6 0 1
R:R:S178 R:R:W91 6.18 2 No Yes 4 4 1 1
R:R:F277 R:R:W91 9.02 2 Yes Yes 5 4 1 1
L:L:?1 R:R:W91 3.99 2 Yes Yes 0 4 0 1
R:R:C100 R:R:W93 3.92 2 Yes Yes 9 9 2 2
R:R:C177 R:R:W93 5.22 2 Yes Yes 9 9 1 2
R:R:C100 R:R:L104 3.17 2 Yes Yes 9 5 2 1
R:R:C100 R:R:M167 6.48 2 Yes Yes 9 3 2 2
R:R:C100 R:R:P168 5.65 2 Yes Yes 9 4 2 2
R:R:C100 R:R:C177 7.28 2 Yes Yes 9 9 2 1
R:R:L104 R:R:M103 4.24 2 Yes No 5 5 1 1
L:L:?1 R:R:M103 7.44 2 Yes No 0 5 0 1
R:R:L104 R:R:M167 2.83 2 Yes Yes 5 3 1 2
R:R:C177 R:R:L104 3.17 2 Yes Yes 9 5 1 1
R:R:L104 R:R:S179 3 2 Yes No 5 4 1 1
L:L:?1 R:R:L104 6.07 2 Yes Yes 0 5 0 1
R:R:L107 R:R:Y284 5.86 2 Yes Yes 6 7 1 1
L:L:?1 R:R:L107 7.28 2 Yes Yes 0 6 0 1
R:R:F180 R:R:R111 2.14 2 Yes Yes 3 8 1 1
R:R:F193 R:R:R111 7.48 2 Yes Yes 6 8 2 1
R:R:E196 R:R:R111 10.47 2 No Yes 5 8 2 1
R:R:F244 R:R:R111 4.28 2 Yes Yes 8 8 2 1
R:R:R111 R:R:T283 3.88 2 Yes No 8 8 1 2
L:L:?1 R:R:R111 8.52 2 Yes Yes 0 8 0 1
R:R:M167 R:R:P168 5.03 2 Yes Yes 3 4 2 2
R:R:C177 R:R:P168 1.88 2 Yes Yes 9 4 1 2
R:R:L176 R:R:S178 3 0 No No 4 4 2 1
L:L:?1 R:R:C177 2.78 2 Yes Yes 0 9 0 1
L:L:?1 R:R:S178 6.58 2 Yes No 0 4 0 1
R:R:H189 R:R:S179 6.97 0 No No 5 4 2 1
L:L:?1 R:R:S179 3.95 2 Yes No 0 4 0 1
R:R:F180 R:R:H189 11.31 2 Yes No 3 5 1 2
R:R:F180 R:R:F193 12.86 2 Yes Yes 3 6 1 2
R:R:F180 R:R:F276 10.72 2 Yes Yes 3 4 1 2
L:L:?1 R:R:F180 11.75 2 Yes Yes 0 3 0 1
R:R:E196 R:R:F193 3.5 2 No Yes 5 6 2 2
R:R:F193 R:R:F276 2.14 2 Yes Yes 6 4 2 2
R:R:F244 R:R:T283 10.38 2 Yes No 8 8 2 2
R:R:D273 R:R:F277 9.55 0 No Yes 4 5 2 1
R:R:F276 R:R:F277 5.36 2 Yes Yes 4 5 2 1
R:R:F276 R:R:L280 3.65 2 Yes No 4 5 2 1
L:L:?1 R:R:F277 2.14 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L280 3.64 2 Yes No 0 5 0 1
L:L:?1 R:R:Y284 7.19 2 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub10.00
Average Interaction Strength6.03
Average Nodes In Shell36.00
Average Hubs In Shell21.00
Average Links In Shell64.00
Average Links Mediated by Hubs In Shell62.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.08
Average Number Of Links With An Hub5.23
Average Interaction Strength8.80
Average Nodes In Shell26.54
Average Hubs In Shell12.92
Average Links In Shell38.77
Average Links Mediated by Hubs In Shell36.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)