| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IW7 | A | Orphan | Orphan | TA9 | Mus Musculus | 2-Phenylethylamine | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.97 | 2023-05-31 | doi.org/10.1038/s41586-023-06106-4 |
|
A 2D representation of the interactions of PEA in 8IW7
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D112 | 10.77 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:T113 | 17.54 | 3 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:C116 | 6.3 | 3 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:C202 | 4.72 | 3 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:Y274 | 12.79 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:V300 | 2.95 | 3 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:Y301 | 3.49 | 3 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:D112 | R:R:V85 | 7.3 | 3 | Yes | Yes | 6 | 7 | 1 | 2 | | R:R:V85 | R:R:Y301 | 5.05 | 3 | Yes | Yes | 7 | 8 | 2 | 1 | | R:R:S89 | R:R:Y301 | 3.82 | 0 | No | Yes | 6 | 8 | 2 | 1 | | R:R:C116 | R:R:D112 | 4.67 | 3 | No | Yes | 7 | 6 | 1 | 1 | | R:R:D112 | R:R:Y301 | 6.9 | 3 | Yes | Yes | 6 | 8 | 1 | 1 | | R:R:S164 | R:R:T113 | 3.2 | 0 | No | No | 7 | 4 | 2 | 1 | | R:R:C202 | R:R:L194 | 3.17 | 0 | No | No | 5 | 4 | 1 | 2 | | R:R:I275 | R:R:W271 | 5.87 | 7 | Yes | Yes | 7 | 8 | 2 | 2 | | R:R:V300 | R:R:W271 | 22.07 | 0 | No | Yes | 7 | 8 | 1 | 2 | | R:R:I275 | R:R:Y274 | 6.04 | 7 | Yes | Yes | 7 | 6 | 2 | 1 | | R:R:Y274 | R:R:Y293 | 2.98 | 0 | Yes | No | 6 | 4 | 1 | 2 | | R:R:L296 | R:R:Y274 | 8.21 | 0 | No | Yes | 5 | 6 | 2 | 1 | | R:R:V297 | R:R:Y274 | 5.05 | 0 | No | Yes | 6 | 6 | 2 | 1 | | R:R:W298 | R:R:Y301 | 7.72 | 3 | Yes | Yes | 5 | 8 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 7.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 8.37 | | Average Nodes In Shell | 18.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 21.00 | | Average Links Mediated by Hubs In Shell | 19.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IWM | A | Orphan | Orphan | TA9 | Mus Musculus | 2-Phenylethylamine | - | - | 3.17 | 2023-05-31 | doi.org/10.1038/s41586-023-06106-4 |
|
A 2D representation of the interactions of PEA in 8IWM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D112 | 10.77 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:T113 | 17.54 | 1 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:C116 | 6.3 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:C202 | 4.72 | 1 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:Y274 | 12.79 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:Y301 | 3.49 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:D112 | R:R:V85 | 7.3 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | | R:R:V85 | R:R:Y301 | 5.05 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | | R:R:S89 | R:R:Y301 | 3.82 | 0 | No | Yes | 6 | 8 | 2 | 1 | | R:R:C116 | R:R:D112 | 4.67 | 1 | No | Yes | 7 | 6 | 1 | 1 | | R:R:D112 | R:R:Y301 | 6.9 | 1 | Yes | Yes | 6 | 8 | 1 | 1 | | R:R:I275 | R:R:Y274 | 6.04 | 2 | Yes | Yes | 7 | 6 | 2 | 1 | | R:R:L296 | R:R:Y274 | 8.21 | 0 | No | Yes | 5 | 6 | 2 | 1 | | R:R:V297 | R:R:Y274 | 5.05 | 0 | No | Yes | 6 | 6 | 2 | 1 | | R:R:W298 | R:R:Y301 | 7.72 | 1 | Yes | Yes | 5 | 8 | 2 | 1 | | R:R:C202 | R:R:L194 | 3.17 | 0 | No | No | 5 | 4 | 1 | 2 | | R:R:Y274 | R:R:Y293 | 2.98 | 0 | Yes | No | 6 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 9.27 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8W89 | A | Amine | Trace Amine Receptors | TA1 | Homo Sapiens | PEA | - | chim(NtGi1L-Gs)/Beta1/Gamma2 | 3 | 2023-11-22 | doi.org/10.1038/s41586-023-06775-1 |
|
A 2D representation of the interactions of PEA in 8W89
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D103 | 13.17 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:I104 | 11.08 | 3 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:S107 | 10.2 | 3 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F186 | 5.91 | 3 | Yes | Yes | 0 | 1 | 0 | 1 | | L:L:?1 | R:R:W264 | 3.32 | 3 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F267 | 15.36 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:F268 | 8.27 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:Y294 | 6.83 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:D103 | R:R:V76 | 8.76 | 3 | Yes | Yes | 6 | 7 | 1 | 2 | | R:R:V76 | R:R:Y294 | 3.79 | 3 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:M77 | R:R:Y294 | 9.58 | 0 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S80 | R:R:Y294 | 11.45 | 0 | No | Yes | 6 | 7 | 2 | 1 | | R:R:D103 | R:R:R83 | 3.57 | 3 | Yes | No | 6 | 4 | 1 | 2 | | R:R:D103 | R:R:Y294 | 12.64 | 3 | Yes | Yes | 6 | 7 | 1 | 1 | | R:R:A155 | R:R:I104 | 3.25 | 0 | No | No | 6 | 4 | 2 | 1 | | R:R:S107 | R:R:W264 | 4.94 | 3 | No | Yes | 6 | 8 | 1 | 1 | | R:R:I111 | R:R:W264 | 10.57 | 0 | No | Yes | 8 | 8 | 2 | 1 | | R:R:F186 | R:R:M158 | 4.98 | 0 | Yes | No | 1 | 5 | 1 | 2 | | R:R:F186 | R:R:V184 | 6.55 | 0 | Yes | No | 1 | 4 | 1 | 2 | | R:R:F186 | R:R:S190 | 5.28 | 0 | Yes | No | 1 | 6 | 1 | 2 | | R:R:F186 | R:R:T194 | 10.38 | 0 | Yes | No | 1 | 5 | 1 | 2 | | R:R:F195 | R:R:F199 | 5.36 | 3 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:F195 | R:R:F268 | 4.29 | 3 | Yes | Yes | 5 | 7 | 2 | 1 | | R:R:F199 | R:R:F260 | 6.43 | 3 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:F199 | R:R:F268 | 18.22 | 3 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F260 | R:R:W264 | 4.01 | 0 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:F267 | R:R:W264 | 7.02 | 3 | Yes | Yes | 5 | 8 | 1 | 1 | | R:R:F268 | R:R:W264 | 8.02 | 3 | Yes | Yes | 7 | 8 | 1 | 1 | | R:R:G293 | R:R:W264 | 8.44 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:N296 | R:R:W264 | 9.04 | 0 | No | Yes | 9 | 8 | 2 | 1 | | R:R:F267 | R:R:F268 | 7.5 | 3 | Yes | Yes | 5 | 7 | 1 | 1 | | R:R:F267 | R:R:T271 | 7.78 | 3 | Yes | No | 5 | 5 | 1 | 2 | | R:R:F267 | R:R:I290 | 5.02 | 3 | Yes | No | 5 | 5 | 1 | 2 | | R:R:I290 | R:R:Y294 | 3.63 | 0 | No | Yes | 5 | 7 | 2 | 1 | | R:R:W291 | R:R:Y294 | 10.61 | 0 | Yes | Yes | 4 | 7 | 2 | 1 | | R:R:F186 | R:R:G191 | 3.01 | 0 | Yes | No | 1 | 4 | 1 | 2 | | R:R:I104 | R:R:I159 | 2.94 | 0 | No | Yes | 4 | 6 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 6.00 | | Average Interaction Strength | 9.27 | | Average Nodes In Shell | 29.00 | | Average Hubs In Shell | 14.00 | | Average Links In Shell | 37.00 | | Average Links Mediated by Hubs In Shell | 36.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WC6 | A | Amine | Trace Amine Receptors | TA1 | Mus Musculus | 2-Phenylethylamine | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 3.2 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 |
|
A 2D representation of the interactions of PEA in 8WC6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D102 | 11.85 | 2 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:I103 | 12.46 | 2 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:S106 | 5.83 | 2 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F185 | 4.73 | 2 | Yes | No | 0 | 2 | 0 | 1 | | L:L:?1 | R:R:F264 | 10.64 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F265 | 3.55 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:Y291 | 3.41 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:D102 | R:R:I75 | 4.2 | 2 | No | Yes | 6 | 6 | 1 | 2 | | R:R:M76 | R:R:W288 | 3.49 | 2 | Yes | Yes | 7 | 5 | 2 | 2 | | R:R:M76 | R:R:Y291 | 5.99 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S79 | R:R:Y291 | 5.09 | 0 | No | Yes | 6 | 7 | 2 | 1 | | R:R:D102 | R:R:Y291 | 11.49 | 2 | No | Yes | 6 | 7 | 1 | 1 | | R:R:A154 | R:R:I103 | 3.25 | 0 | No | No | 7 | 4 | 2 | 1 | | R:R:S106 | R:R:W261 | 3.71 | 0 | No | Yes | 6 | 7 | 1 | 2 | | R:R:F185 | R:R:P183 | 5.78 | 0 | No | No | 2 | 4 | 1 | 2 | | R:R:P183 | R:R:Y287 | 12.52 | 0 | No | No | 4 | 5 | 2 | 2 | | R:R:F185 | R:R:G190 | 4.52 | 0 | No | No | 2 | 5 | 1 | 2 | | R:R:F194 | R:R:F198 | 5.36 | 2 | Yes | Yes | 5 | 7 | 2 | 2 | | R:R:F194 | R:R:F265 | 8.57 | 2 | Yes | Yes | 5 | 6 | 2 | 1 | | R:R:F198 | R:R:W261 | 3.01 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | | R:R:F198 | R:R:F265 | 11.79 | 2 | Yes | Yes | 7 | 6 | 2 | 1 | | R:R:F264 | R:R:W261 | 3.01 | 2 | Yes | Yes | 6 | 7 | 1 | 2 | | R:R:F265 | R:R:W261 | 4.01 | 2 | Yes | Yes | 6 | 7 | 1 | 2 | | R:R:F264 | R:R:F265 | 7.5 | 2 | Yes | Yes | 6 | 6 | 1 | 1 | | R:R:F264 | R:R:T268 | 3.89 | 2 | Yes | No | 6 | 4 | 1 | 2 | | R:R:F264 | R:R:L286 | 8.53 | 2 | Yes | No | 6 | 5 | 1 | 2 | | R:R:F264 | R:R:Y287 | 7.22 | 2 | Yes | No | 6 | 5 | 1 | 2 | | R:R:W288 | R:R:Y291 | 6.75 | 2 | Yes | Yes | 5 | 7 | 2 | 1 | | R:R:F265 | R:R:S197 | 2.64 | 2 | Yes | No | 6 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 7.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 7.50 | | Average Nodes In Shell | 22.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 29.00 | | Average Links Mediated by Hubs In Shell | 25.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WCA | A | Amine | Trace Amine Receptors | TA1 | Homo Sapiens | 2-Phenylethylamine | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 3.48 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 |
|
A 2D representation of the interactions of PEA in 8WCA
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D103 | 5.27 | 3 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:I104 | 9.69 | 3 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:S107 | 8.74 | 3 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F186 | 3.55 | 3 | Yes | No | 0 | 1 | 0 | 1 | | L:L:?1 | R:R:T194 | 2.86 | 3 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:F267 | 14.18 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:F268 | 10.64 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:I290 | 2.77 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:Y294 | 4.55 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:D103 | R:R:V76 | 5.84 | 3 | No | Yes | 6 | 7 | 1 | 2 | | R:R:V76 | R:R:Y294 | 2.52 | 3 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S80 | R:R:Y294 | 5.09 | 0 | No | Yes | 6 | 7 | 2 | 1 | | R:R:D103 | R:R:Y294 | 10.34 | 3 | No | Yes | 6 | 7 | 1 | 1 | | R:R:A155 | R:R:I104 | 3.25 | 0 | No | No | 6 | 4 | 2 | 1 | | R:R:I104 | R:R:I159 | 2.94 | 0 | No | Yes | 4 | 6 | 1 | 2 | | R:R:S107 | R:R:W264 | 3.71 | 0 | No | Yes | 6 | 8 | 1 | 2 | | R:R:F154 | R:R:T194 | 2.59 | 3 | Yes | No | 4 | 5 | 2 | 1 | | R:R:F186 | R:R:G191 | 4.52 | 3 | No | No | 1 | 4 | 1 | 2 | | R:R:F186 | R:R:T194 | 3.89 | 3 | No | No | 1 | 5 | 1 | 1 | | R:R:F195 | R:R:F268 | 3.22 | 0 | No | Yes | 5 | 7 | 2 | 1 | | R:R:F268 | R:R:S198 | 2.64 | 3 | Yes | No | 7 | 6 | 1 | 2 | | R:R:F199 | R:R:W264 | 4.01 | 3 | No | Yes | 8 | 8 | 2 | 2 | | R:R:F199 | R:R:F268 | 7.5 | 3 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F267 | R:R:W264 | 2 | 3 | Yes | Yes | 5 | 8 | 1 | 2 | | R:R:F267 | R:R:F268 | 5.36 | 3 | Yes | Yes | 5 | 7 | 1 | 1 | | R:R:F267 | R:R:T271 | 5.19 | 3 | Yes | No | 5 | 5 | 1 | 2 | | R:R:F267 | R:R:L289 | 4.87 | 3 | Yes | No | 5 | 5 | 1 | 2 | | R:R:F267 | R:R:I290 | 5.02 | 3 | Yes | Yes | 5 | 5 | 1 | 1 | | R:R:F268 | R:R:T271 | 2.59 | 3 | Yes | No | 7 | 5 | 1 | 2 | | R:R:I290 | R:R:W291 | 2.35 | 3 | Yes | Yes | 5 | 4 | 1 | 2 | | R:R:I290 | R:R:Y294 | 6.04 | 3 | Yes | Yes | 5 | 7 | 1 | 1 | | R:R:W291 | R:R:Y294 | 1.93 | 3 | Yes | Yes | 4 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 6.92 | | Average Nodes In Shell | 23.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 32.00 | | Average Links Mediated by Hubs In Shell | 29.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
