CodePFS
NamePlatelet Activating Factor
SynonymsPlatelet-activating factor
Identifier
FormulaC26 H54 N O7 P
Molecular Weight523.683
SMILES
PubChem108156
Formal Charge0
Total Atoms89
Total Chiral Atoms1
Total Bonds88
Total Aromatic Bonds0
Networks2
 missing image

This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XYD A Lipid Platelet Activating Factor PAF Homo Sapiens Platelet Activating Factor - Gi1/Beta1/Gamma2 2.9 2024-11-13 doi.org/10.1016/j.celrep.2024.114422

A 2D representation of the interactions of PFS in 8XYD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R14 R:R:Y77 5.14 1 Yes Yes 4 6 2 1
R:R:Q276 R:R:R14 5.84 1 Yes Yes 4 4 2 2
R:R:F18 R:R:Y22 7.22 1 Yes Yes 5 8 2 2
R:R:F18 R:R:Y77 17.54 1 Yes Yes 5 6 2 1
R:R:F18 R:R:Q276 7.03 1 Yes Yes 5 4 2 2
R:R:F18 R:R:L279 3.65 1 Yes No 5 6 2 1
R:R:Y22 R:R:Y77 2.98 1 Yes Yes 8 6 2 1
R:R:F97 R:R:Y22 3.09 1 Yes Yes 7 8 1 2
R:R:F66 R:R:F97 12.86 0 Yes Yes 7 7 2 1
R:R:W73 R:R:Y76 4.82 1 Yes Yes 7 6 1 2
R:R:W73 R:R:Y77 4.82 1 Yes Yes 7 6 1 1
R:R:G94 R:R:W73 5.63 0 No Yes 5 7 2 1
R:R:F97 R:R:W73 4.01 1 Yes Yes 7 7 1 1
R:R:C173 R:R:W73 6.53 1 Yes Yes 9 7 2 1
L:L:?1 R:R:W73 14.04 1 Yes Yes 0 7 0 1
R:R:Y76 R:R:Y77 7.94 1 Yes Yes 6 6 2 1
R:R:C173 R:R:Y76 4.03 1 Yes Yes 9 6 2 2
L:L:?1 R:R:Y77 3.94 1 Yes Yes 0 6 0 1
R:R:F174 R:R:G94 9.03 1 Yes No 4 5 1 2
R:R:F97 R:R:F98 4.29 1 Yes Yes 7 5 1 1
L:L:?1 R:R:F97 5.46 1 Yes Yes 0 7 0 1
R:R:F98 R:R:Y102 5.16 1 Yes Yes 5 8 1 1
R:R:F174 R:R:F98 3.22 1 Yes Yes 4 5 1 1
L:L:?1 R:R:F98 21.84 1 Yes Yes 0 5 0 1
R:R:T101 R:R:Y102 8.74 0 No Yes 8 8 2 1
R:R:I191 R:R:Y102 15.71 1 No Yes 6 8 1 1
R:R:H249 R:R:Y102 6.53 1 Yes Yes 8 8 2 1
R:R:Q252 R:R:Y102 3.38 1 Yes Yes 7 8 2 1
L:L:?1 R:R:Y102 5.91 1 Yes Yes 0 8 0 1
R:R:F152 R:R:Y151 6.19 1 No No 5 7 1 2
R:R:F152 R:R:I187 12.56 1 No No 5 5 1 1
L:L:?1 R:R:F152 4.78 1 Yes No 0 5 0 1
R:R:F174 R:R:S157 6.61 1 Yes No 4 5 1 2
R:R:S157 R:R:Y177 3.82 1 No Yes 5 6 2 1
R:R:F174 R:R:Y177 7.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F174 8.87 1 Yes Yes 0 4 0 1
R:R:V184 R:R:Y177 5.05 1 Yes Yes 3 6 1 1
L:L:?1 R:R:Y177 11.83 1 Yes Yes 0 6 0 1
R:R:S181 R:R:V184 3.23 0 No Yes 4 3 2 1
R:R:L260 R:R:V184 2.98 1 Yes Yes 1 3 2 1
L:L:?1 R:R:V184 3.34 1 Yes Yes 0 3 0 1
L:L:?1 R:R:I187 10.4 1 Yes No 0 5 0 1
R:R:H188 R:R:Q252 8.65 1 Yes Yes 4 7 1 2
R:R:H188 R:R:W255 3.17 1 Yes Yes 4 5 1 1
R:R:H188 R:R:T256 15.06 1 Yes No 4 5 1 2
L:L:?1 R:R:H188 15.85 1 Yes Yes 0 4 0 1
R:R:F190 R:R:I191 3.77 1 No No 5 6 1 1
R:R:F190 R:R:S194 7.93 1 No No 5 6 1 1
L:L:?1 R:R:F190 7.51 1 Yes No 0 5 0 1
L:L:?1 R:R:I191 7.2 1 Yes No 0 6 0 1
L:L:?1 R:R:S194 4.21 1 Yes No 0 6 0 1
R:R:H248 R:R:H249 10.75 1 Yes Yes 7 8 2 2
R:R:H248 R:R:Q252 18.54 1 Yes Yes 7 7 2 2
R:R:H248 R:R:H275 5.97 1 Yes Yes 7 5 2 1
R:R:H248 R:R:T278 6.85 1 Yes Yes 7 7 2 2
R:R:H248 R:R:L279 3.86 1 Yes No 7 6 2 1
R:R:H249 R:R:Q252 3.71 1 Yes Yes 8 7 2 2
R:R:H275 R:R:V251 6.92 1 Yes No 5 5 1 2
R:R:T278 R:R:V251 4.76 1 Yes No 7 5 2 2
R:R:T256 R:R:W255 3.64 1 No Yes 5 5 2 1
R:R:E259 R:R:W255 13.08 1 Yes Yes 2 5 2 1
R:R:H275 R:R:W255 24.33 1 Yes Yes 5 5 1 1
L:L:?1 R:R:W255 12.77 1 Yes Yes 0 5 0 1
R:R:L260 R:R:T256 2.95 1 Yes No 1 5 2 2
R:R:H275 R:R:Q276 3.71 1 Yes Yes 5 4 1 2
R:R:H275 R:R:T278 5.48 1 Yes Yes 5 7 1 2
L:L:?1 R:R:H275 4.32 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L279 3.1 1 Yes No 0 6 0 1
R:R:C95 R:R:F174 2.79 0 No Yes 6 4 2 1
R:R:P19 R:R:Y77 2.78 0 No Yes 5 6 2 1
R:R:I271 R:R:W255 1.17 0 No Yes 4 5 2 1
L:L:?1 R:R:A148 0.88 1 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links18.00
Average Number Of Links With An Hub11.00
Average Interaction Strength8.12
Average Nodes In Shell42.00
Average Hubs In Shell25.00
Average Links In Shell72.00
Average Links Mediated by Hubs In Shell68.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links17.50
Average Number Of Links With An Hub10.00
Average Interaction Strength8.27
Average Nodes In Shell41.00
Average Hubs In Shell23.50
Average Links In Shell67.50
Average Links Mediated by Hubs In Shell63.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)