| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6N51 | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | - | - | 4 | 2019-01-23 | doi.org/10.1038/s41586-019-0881-4 |
|
A 2D representation of the interactions of QUS in 6N51
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?903 | S:S:Y64 | 10.54 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:?903 | S:S:W100 | 7.88 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | L:L:?903 | S:S:S152 | 4.15 | 2 | Yes | No | 0 | 9 | 0 | 1 | | L:L:?903 | S:S:S173 | 4.15 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?903 | S:S:T175 | 8.15 | 2 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?903 | S:S:Y223 | 17.02 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?903 | S:S:E279 | 4.58 | 2 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?903 | S:S:D305 | 4.69 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?903 | S:S:G306 | 4.73 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?903 | S:S:K396 | 4.88 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:S42 | S:S:W100 | 12.36 | 0 | No | Yes | 6 | 3 | 2 | 1 | | S:S:Q46 | S:S:W100 | 4.38 | 2 | Yes | Yes | 3 | 3 | 2 | 1 | | S:S:Q46 | S:S:S250 | 4.33 | 2 | Yes | No | 3 | 3 | 2 | 2 | | S:S:R61 | S:S:Y64 | 7.2 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 13.99 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R310 | S:S:R61 | 8.53 | 2 | Yes | Yes | 5 | 5 | 2 | 2 | | S:S:R68 | S:S:Y64 | 7.2 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:W100 | S:S:Y64 | 4.82 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | | S:S:R310 | S:S:Y64 | 13.38 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:D394 | S:S:Y64 | 4.6 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:K396 | S:S:Y64 | 3.58 | 2 | Yes | Yes | 4 | 4 | 1 | 1 | | S:S:R68 | S:S:Y172 | 5.14 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | | S:S:D394 | S:S:R68 | 9.53 | 2 | Yes | Yes | 5 | 4 | 2 | 2 | | S:S:S152 | S:S:S176 | 6.52 | 2 | No | Yes | 9 | 7 | 1 | 2 | | S:S:S152 | S:S:Y223 | 5.09 | 2 | No | Yes | 9 | 7 | 1 | 1 | | S:S:S173 | S:S:Y172 | 6.36 | 2 | No | Yes | 5 | 7 | 1 | 2 | | S:S:K396 | S:S:S173 | 3.06 | 2 | Yes | No | 4 | 5 | 1 | 1 | | S:S:T175 | S:S:V192 | 3.17 | 2 | No | No | 8 | 7 | 1 | 2 | | S:S:T175 | S:S:Y223 | 3.75 | 2 | No | Yes | 8 | 7 | 1 | 1 | | S:S:D195 | S:S:S176 | 2.94 | 0 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:D195 | S:S:Q198 | 5.22 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | | S:S:D195 | S:S:Y223 | 4.6 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | | S:S:D305 | S:S:Q198 | 11.75 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | | S:S:E279 | S:S:T219 | 4.23 | 0 | No | No | 4 | 5 | 1 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:S304 | S:S:Y223 | 5.09 | 2 | No | Yes | 8 | 7 | 2 | 1 | | S:S:D305 | S:S:Y223 | 5.75 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | | S:S:E279 | S:S:S250 | 7.19 | 0 | No | No | 4 | 3 | 1 | 2 | | S:S:D305 | S:S:S304 | 2.94 | 2 | Yes | No | 8 | 8 | 1 | 2 | | S:S:D305 | S:S:K396 | 4.15 | 2 | Yes | Yes | 8 | 4 | 1 | 1 | | S:S:D394 | S:S:S395 | 2.94 | 2 | Yes | No | 5 | 5 | 2 | 2 | | S:S:K396 | S:S:S395 | 4.59 | 2 | Yes | No | 4 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 10.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 7.08 | | Average Nodes In Shell | 27.00 | | Average Hubs In Shell | 15.00 | | Average Links In Shell | 42.00 | | Average Links Mediated by Hubs In Shell | 39.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of QUS in 6N51
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | M:M:?903 | R:R:Y64 | 12.16 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | M:M:?903 | R:R:W100 | 7.88 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | M:M:?903 | R:R:S152 | 3.11 | 1 | Yes | No | 0 | 9 | 0 | 1 | | M:M:?903 | R:R:S173 | 5.19 | 1 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?903 | R:R:T175 | 6.12 | 1 | Yes | No | 0 | 8 | 0 | 1 | | M:M:?903 | R:R:Y223 | 15.4 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?903 | R:R:E279 | 4.58 | 1 | Yes | No | 0 | 4 | 0 | 1 | | M:M:?903 | R:R:D305 | 5.63 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | M:M:?903 | R:R:G306 | 4.73 | 1 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?903 | R:R:K396 | 5.85 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:S42 | R:R:W100 | 12.36 | 0 | No | Yes | 6 | 3 | 2 | 1 | | R:R:Q46 | R:R:W100 | 4.38 | 1 | Yes | Yes | 3 | 3 | 2 | 1 | | R:R:Q46 | R:R:S250 | 4.33 | 1 | Yes | No | 3 | 3 | 2 | 2 | | R:R:R61 | R:R:Y64 | 7.2 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 13.99 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R310 | R:R:R61 | 8.53 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | | R:R:R68 | R:R:Y64 | 7.2 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:W100 | R:R:Y64 | 4.82 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | | R:R:R310 | R:R:Y64 | 13.38 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:D394 | R:R:Y64 | 4.6 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:K396 | R:R:Y64 | 3.58 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | | R:R:R68 | R:R:Y172 | 5.14 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | | R:R:D394 | R:R:R68 | 9.53 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | | R:R:S152 | R:R:S176 | 6.52 | 1 | No | Yes | 9 | 7 | 1 | 2 | | R:R:S152 | R:R:Y223 | 5.09 | 1 | No | Yes | 9 | 7 | 1 | 1 | | R:R:S173 | R:R:Y172 | 6.36 | 1 | No | Yes | 5 | 7 | 1 | 2 | | R:R:K396 | R:R:S173 | 3.06 | 1 | Yes | No | 4 | 5 | 1 | 1 | | R:R:T175 | R:R:V192 | 3.17 | 1 | No | No | 8 | 7 | 1 | 2 | | R:R:T175 | R:R:Y223 | 3.75 | 1 | No | Yes | 8 | 7 | 1 | 1 | | R:R:D195 | R:R:S176 | 2.94 | 0 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:D195 | R:R:Q198 | 5.22 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:D195 | R:R:Y223 | 4.6 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:D305 | R:R:Q198 | 11.75 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:E279 | R:R:T219 | 4.23 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 5.09 | 1 | No | Yes | 8 | 7 | 2 | 1 | | R:R:D305 | R:R:Y223 | 5.75 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:E279 | R:R:S250 | 7.19 | 0 | No | No | 4 | 3 | 1 | 2 | | R:R:D305 | R:R:S304 | 2.94 | 1 | Yes | No | 8 | 8 | 1 | 2 | | R:R:D305 | R:R:K396 | 4.15 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | R:R:D394 | R:R:S395 | 2.94 | 1 | Yes | No | 5 | 5 | 2 | 2 | | R:R:K396 | R:R:S395 | 4.59 | 1 | Yes | No | 4 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 10.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 7.06 | | Average Nodes In Shell | 27.00 | | Average Hubs In Shell | 15.00 | | Average Links In Shell | 42.00 | | Average Links Mediated by Hubs In Shell | 39.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DGE | C | Aminoacid | Metabotropic Glutamate | mGlu1; mGlu1 | Homo Sapiens | Quisqualate | - | - | 3.65 | 2021-09-22 | doi.org/10.1007/s13238-020-00808-5 |
|
A 2D representation of the interactions of QUS in 7DGE
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R71 | R:R:S52 | 7.91 | 1 | Yes | No | 4 | 5 | 2 | 2 | | R:R:S52 | R:R:Y74 | 5.09 | 1 | No | Yes | 5 | 5 | 2 | 1 | | R:R:S52 | R:R:W110 | 7.41 | 1 | No | Yes | 5 | 3 | 2 | 1 | | R:R:Q56 | R:R:W110 | 4.38 | 0 | Yes | Yes | 3 | 3 | 2 | 1 | | R:R:R71 | R:R:Y74 | 16.46 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | | R:R:R78 | R:R:Y74 | 21.61 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | | R:R:W110 | R:R:Y74 | 8.68 | 1 | Yes | Yes | 3 | 5 | 1 | 1 | | R:R:R323 | R:R:Y74 | 14.4 | 1 | Yes | Yes | 5 | 5 | 1 | 1 | | R:R:E325 | R:R:Y74 | 5.61 | 1 | Yes | Yes | 1 | 5 | 2 | 1 | | L:L:?901 | R:R:Y74 | 9.73 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:R78 | R:R:Y185 | 6.17 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:K409 | R:R:R78 | 6.19 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:S164 | R:R:W110 | 14.83 | 0 | No | Yes | 5 | 3 | 2 | 1 | | R:R:E292 | R:R:W110 | 8.72 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | L:L:?901 | R:R:W110 | 8.66 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | R:R:S165 | R:R:S189 | 6.52 | 0 | No | No | 9 | 7 | 1 | 2 | | L:L:?901 | R:R:S165 | 6.23 | 1 | Yes | No | 0 | 9 | 0 | 1 | | R:R:S186 | R:R:Y185 | 3.82 | 1 | No | Yes | 5 | 8 | 1 | 2 | | R:R:K409 | R:R:S186 | 12.24 | 1 | Yes | No | 4 | 5 | 1 | 1 | | L:L:?901 | R:R:S186 | 4.15 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:D208 | R:R:T188 | 10.12 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:T188 | R:R:Y236 | 4.99 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | | R:R:D318 | R:R:T188 | 4.34 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | L:L:?901 | R:R:T188 | 10.19 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:D208 | R:R:Q211 | 5.22 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:D208 | R:R:Y236 | 10.34 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:D208 | R:R:F290 | 5.97 | 1 | Yes | Yes | 8 | 6 | 2 | 2 | | R:R:Q211 | R:R:S317 | 8.66 | 0 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:D318 | R:R:Q211 | 6.53 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:E292 | R:R:T232 | 15.52 | 1 | Yes | No | 4 | 5 | 1 | 2 | | R:R:F290 | R:R:Y236 | 7.22 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | | R:R:E292 | R:R:Y236 | 5.61 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | | R:R:S317 | R:R:Y236 | 5.09 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:G319 | R:R:Y236 | 4.35 | 1 | No | Yes | 5 | 7 | 1 | 1 | | L:L:?901 | R:R:Y236 | 25.13 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:F290 | R:R:S317 | 10.57 | 1 | Yes | Yes | 6 | 8 | 2 | 2 | | L:L:?901 | R:R:E292 | 5.5 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:G293 | R:R:R323 | 4.5 | 1 | No | Yes | 3 | 5 | 2 | 1 | | R:R:G293 | R:R:V326 | 3.68 | 1 | No | Yes | 3 | 4 | 2 | 2 | | R:R:D318 | R:R:L342 | 13.57 | 1 | Yes | Yes | 8 | 4 | 1 | 2 | | R:R:D318 | R:R:K409 | 9.68 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | L:L:?901 | R:R:D318 | 4.69 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?901 | R:R:G319 | 7.1 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:E325 | R:R:R323 | 12.79 | 1 | Yes | Yes | 1 | 5 | 2 | 1 | | R:R:R323 | R:R:V326 | 7.85 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | L:L:?901 | R:R:R323 | 5.04 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:K409 | R:R:L342 | 4.23 | 1 | Yes | Yes | 4 | 4 | 1 | 2 | | R:R:F412 | R:R:L342 | 10.96 | 1 | Yes | Yes | 7 | 4 | 2 | 2 | | R:R:K409 | R:R:S408 | 12.24 | 1 | Yes | No | 4 | 6 | 1 | 2 | | R:R:F412 | R:R:K409 | 3.72 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | | L:L:?901 | R:R:K409 | 4.88 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:A321 | R:R:D318 | 3.09 | 0 | No | Yes | 6 | 8 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 8.30 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 21.00 | | Average Links In Shell | 52.00 | | Average Links Mediated by Hubs In Shell | 51.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7FD8 | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | - | - | 3.8 | 2021-09-08 | doi.org/10.1016/j.celrep.2021.109648 |
|
A 2D representation of the interactions of QUS in 7FD8
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R61 | R:R:S42 | 5.27 | 1 | Yes | No | 5 | 6 | 2 | 2 | | R:R:S42 | R:R:W100 | 9.88 | 1 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 12.35 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 4 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R68 | R:R:Y64 | 13.38 | 3 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:R310 | R:R:Y64 | 22.64 | 31 | No | Yes | 5 | 4 | 2 | 1 | | L:L:?902 | R:R:Y64 | 10.54 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:G150 | R:R:W100 | 2.81 | 0 | No | Yes | 5 | 3 | 2 | 1 | | R:R:S151 | R:R:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 6.54 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | L:L:?902 | R:R:W100 | 10.24 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | R:R:I156 | R:R:S152 | 3.1 | 1 | Yes | Yes | 5 | 9 | 2 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | | R:R:L179 | R:R:S152 | 4.5 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | | L:L:?902 | R:R:S152 | 3.11 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | | R:R:I156 | R:R:L179 | 8.56 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:K396 | R:R:S173 | 7.65 | 1 | Yes | No | 4 | 5 | 1 | 2 | | R:R:T175 | R:R:V192 | 3.17 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:D195 | R:R:T175 | 5.78 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:T175 | R:R:Y223 | 3.75 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:D305 | R:R:T175 | 4.34 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | | L:L:?902 | R:R:T175 | 7.14 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:L179 | R:R:S176 | 4.5 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:D195 | R:R:S176 | 2.94 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:L329 | R:R:V192 | 2.98 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | | R:R:D195 | R:R:F277 | 4.78 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:Q198 | R:R:S304 | 8.66 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:D305 | R:R:Q198 | 15.66 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:E279 | R:R:T219 | 12.7 | 1 | Yes | No | 4 | 5 | 1 | 2 | | R:R:T219 | R:R:T282 | 7.85 | 1 | No | Yes | 5 | 4 | 2 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 1 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 10.32 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 3.82 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:D305 | R:R:Y223 | 6.9 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | L:L:?902 | R:R:Y223 | 24.32 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:F277 | R:R:G224 | 3.01 | 1 | Yes | No | 7 | 8 | 2 | 2 | | R:R:E279 | R:R:S250 | 8.62 | 1 | Yes | No | 4 | 3 | 1 | 2 | | R:R:S250 | R:R:T282 | 4.8 | 1 | No | Yes | 3 | 4 | 2 | 2 | | R:R:F277 | R:R:S304 | 10.57 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | | R:R:E279 | R:R:T282 | 4.23 | 1 | Yes | Yes | 4 | 4 | 1 | 2 | | L:L:?902 | R:R:E279 | 6.41 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:D305 | R:R:S304 | 5.89 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:D305 | R:R:L329 | 4.07 | 1 | Yes | Yes | 8 | 5 | 1 | 2 | | R:R:D305 | R:R:K396 | 5.53 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | L:L:?902 | R:R:D305 | 2.82 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?902 | R:R:G306 | 7.1 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:K396 | R:R:S395 | 4.59 | 1 | Yes | No | 4 | 5 | 1 | 2 | | L:L:?902 | R:R:K396 | 3.9 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 8.40 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 21.00 | | Average Links In Shell | 48.00 | | Average Links Mediated by Hubs In Shell | 48.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of QUS in 7FD8
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:R61 | S:S:S42 | 5.27 | 2 | Yes | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:W100 | 9.88 | 2 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 12.35 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 4 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R68 | S:S:Y64 | 13.38 | 4 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:R310 | S:S:Y64 | 22.64 | 44 | No | Yes | 5 | 4 | 2 | 1 | | M:M:?902 | S:S:Y64 | 10.54 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:G150 | S:S:W100 | 2.81 | 0 | No | Yes | 5 | 3 | 2 | 1 | | S:S:S151 | S:S:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 6.54 | 2 | Yes | Yes | 4 | 3 | 1 | 1 | | M:M:?902 | S:S:W100 | 10.24 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:I156 | S:S:S152 | 3.1 | 2 | Yes | Yes | 5 | 9 | 2 | 1 | | S:S:S152 | S:S:S176 | 6.52 | 2 | Yes | Yes | 9 | 7 | 1 | 2 | | S:S:L179 | S:S:S152 | 4.5 | 2 | Yes | Yes | 8 | 9 | 2 | 1 | | M:M:?902 | S:S:S152 | 3.11 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | | S:S:I156 | S:S:L179 | 8.56 | 2 | Yes | Yes | 5 | 8 | 2 | 2 | | S:S:K396 | S:S:S173 | 7.65 | 2 | Yes | No | 4 | 5 | 1 | 2 | | S:S:T175 | S:S:V192 | 3.17 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | | S:S:D195 | S:S:T175 | 5.78 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | | S:S:T175 | S:S:Y223 | 3.75 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | | S:S:D305 | S:S:T175 | 4.34 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | | M:M:?902 | S:S:T175 | 7.14 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | S:S:L179 | S:S:S176 | 4.5 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:D195 | S:S:S176 | 2.94 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:L329 | S:S:V192 | 2.98 | 2 | Yes | Yes | 5 | 7 | 2 | 2 | | S:S:D195 | S:S:F277 | 4.78 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:Q198 | S:S:S304 | 8.66 | 2 | Yes | Yes | 9 | 8 | 2 | 2 | | S:S:D305 | S:S:Q198 | 15.66 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | | S:S:E279 | S:S:T219 | 12.7 | 2 | Yes | No | 4 | 5 | 1 | 2 | | S:S:T219 | S:S:T282 | 7.85 | 2 | No | Yes | 5 | 4 | 2 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 2 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F277 | S:S:Y223 | 10.32 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | S:S:S304 | S:S:Y223 | 3.82 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | | S:S:D305 | S:S:Y223 | 6.9 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | | M:M:?902 | S:S:Y223 | 24.32 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:F277 | S:S:G224 | 3.01 | 2 | Yes | No | 7 | 8 | 2 | 2 | | S:S:E279 | S:S:S250 | 8.62 | 2 | Yes | No | 4 | 3 | 1 | 2 | | S:S:S250 | S:S:T282 | 4.8 | 2 | No | Yes | 3 | 4 | 2 | 2 | | S:S:F277 | S:S:S304 | 10.57 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | | S:S:E279 | S:S:T282 | 4.23 | 2 | Yes | Yes | 4 | 4 | 1 | 2 | | M:M:?902 | S:S:E279 | 6.41 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:D305 | S:S:S304 | 5.89 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | | S:S:D305 | S:S:L329 | 4.07 | 2 | Yes | Yes | 8 | 5 | 1 | 2 | | S:S:D305 | S:S:K396 | 5.53 | 2 | Yes | Yes | 8 | 4 | 1 | 1 | | M:M:?902 | S:S:D305 | 2.82 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | M:M:?902 | S:S:G306 | 7.1 | 2 | Yes | No | 0 | 5 | 0 | 1 | | S:S:K396 | S:S:S395 | 4.59 | 2 | Yes | No | 4 | 5 | 1 | 2 | | M:M:?902 | S:S:K396 | 3.9 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 8.40 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 21.00 | | Average Links In Shell | 48.00 | | Average Links Mediated by Hubs In Shell | 48.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8T7H | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | - | - | 3.3 | 2023-10-11 | doi.org/10.1101/2023.08.29.555158 |
|
A 2D representation of the interactions of QUS in 8T7H
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:Y64 | 7.3 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:W100 | 4.73 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | L:L:?1 | R:R:S152 | 4.15 | 2 | Yes | No | 0 | 9 | 0 | 1 | | L:L:?1 | R:R:T175 | 3.06 | 2 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:Y223 | 19.46 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:E279 | 6.41 | 2 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:D305 | 2.82 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:G306 | 3.55 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:K396 | 2.93 | 2 | Yes | No | 0 | 4 | 0 | 1 | | R:R:R61 | R:R:S42 | 6.59 | 2 | Yes | No | 5 | 6 | 2 | 2 | | R:R:S42 | R:R:W100 | 7.41 | 2 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 12.35 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 5 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R68 | R:R:Y64 | 8.23 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:R310 | R:R:Y64 | 11.32 | 0 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:D394 | R:R:Y64 | 6.9 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:D394 | R:R:R68 | 8.34 | 2 | Yes | Yes | 5 | 4 | 2 | 2 | | R:R:S151 | R:R:W100 | 4.94 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 3.27 | 2 | No | Yes | 4 | 3 | 1 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 2 | No | No | 9 | 7 | 1 | 2 | | R:R:S152 | R:R:Y223 | 3.82 | 2 | No | Yes | 9 | 7 | 1 | 1 | | R:R:K396 | R:R:S173 | 9.18 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:T175 | R:R:V192 | 3.17 | 0 | No | No | 8 | 7 | 1 | 2 | | R:R:D195 | R:R:T175 | 2.89 | 0 | Yes | No | 8 | 8 | 2 | 1 | | R:R:D195 | R:R:S176 | 2.94 | 0 | Yes | No | 8 | 7 | 2 | 2 | | R:R:F399 | R:R:V192 | 9.18 | 2 | Yes | No | 7 | 7 | 2 | 2 | | R:R:Q198 | R:R:S304 | 5.78 | 2 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:D305 | R:R:Q198 | 15.66 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 3.09 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 3.82 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:D305 | R:R:Y223 | 5.75 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:E279 | R:R:S250 | 5.75 | 2 | No | No | 4 | 3 | 1 | 2 | | R:R:F277 | R:R:S304 | 6.61 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | | R:R:D305 | R:R:S304 | 5.89 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:F399 | R:R:K396 | 6.2 | 2 | Yes | No | 7 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 6.05 | | Average Nodes In Shell | 26.00 | | Average Hubs In Shell | 14.00 | | Average Links In Shell | 36.00 | | Average Links Mediated by Hubs In Shell | 32.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of QUS in 8T7H
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | M:M:?1 | S:S:Y64 | 7.3 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | M:M:?1 | S:S:W100 | 4.73 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | M:M:?1 | S:S:S152 | 4.15 | 1 | Yes | No | 0 | 9 | 0 | 1 | | M:M:?1 | S:S:T175 | 3.06 | 1 | Yes | No | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:Y223 | 21.89 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?1 | S:S:E279 | 6.41 | 1 | Yes | No | 0 | 4 | 0 | 1 | | M:M:?1 | S:S:D305 | 2.82 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:G306 | 3.55 | 1 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:K396 | 2.93 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:R61 | S:S:S42 | 6.59 | 1 | Yes | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:W100 | 7.41 | 1 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 12.35 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 5 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R68 | S:S:Y64 | 9.26 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:R310 | S:S:Y64 | 11.32 | 0 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:D394 | S:S:Y64 | 5.75 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:D394 | S:S:R68 | 14.29 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | | S:S:S151 | S:S:W100 | 4.94 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 3.27 | 1 | No | Yes | 4 | 3 | 1 | 1 | | S:S:S152 | S:S:S176 | 6.52 | 1 | No | Yes | 9 | 7 | 1 | 2 | | S:S:S152 | S:S:Y223 | 3.82 | 1 | No | Yes | 9 | 7 | 1 | 1 | | S:S:K396 | S:S:S173 | 9.18 | 1 | Yes | No | 4 | 5 | 1 | 2 | | S:S:T175 | S:S:V192 | 3.17 | 0 | No | No | 8 | 7 | 1 | 2 | | S:S:D195 | S:S:T175 | 2.89 | 0 | Yes | No | 8 | 8 | 2 | 1 | | S:S:D195 | S:S:S176 | 2.94 | 0 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:F399 | S:S:V192 | 9.18 | 1 | Yes | No | 7 | 7 | 2 | 2 | | S:S:Q198 | S:S:S304 | 5.78 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | S:S:D305 | S:S:Q198 | 14.36 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F277 | S:S:Y223 | 3.09 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | S:S:S304 | S:S:Y223 | 3.82 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | S:S:D305 | S:S:Y223 | 5.75 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | S:S:E279 | S:S:S250 | 5.75 | 1 | No | No | 4 | 3 | 1 | 2 | | S:S:F277 | S:S:S304 | 7.93 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | | S:S:D305 | S:S:S304 | 5.89 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | | S:S:D305 | S:S:K396 | 2.77 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | S:S:F399 | S:S:K396 | 6.2 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 6.32 | | Average Nodes In Shell | 26.00 | | Average Hubs In Shell | 16.00 | | Average Links In Shell | 37.00 | | Average Links Mediated by Hubs In Shell | 35.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8T8M | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | - | - | 3 | 2023-10-11 | doi.org/10.1101/2023.08.29.555158 |
|
A 2D representation of the interactions of QUS in 8T8M
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:Y64 | 5.67 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:W100 | 9.45 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | L:L:?1 | R:R:S152 | 4.15 | 2 | Yes | No | 0 | 9 | 0 | 1 | | L:L:?1 | R:R:S173 | 6.23 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:T175 | 4.08 | 2 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:Y223 | 14.59 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:E279 | 6.41 | 2 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:D305 | 8.45 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:G306 | 5.91 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:K396 | 5.85 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:R61 | R:R:S42 | 5.27 | 2 | Yes | No | 5 | 6 | 2 | 2 | | R:R:S42 | R:R:W100 | 6.18 | 2 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 13.38 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 5 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R68 | R:R:Y64 | 16.46 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:W100 | R:R:Y64 | 3.86 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | | R:R:R310 | R:R:Y64 | 7.2 | 0 | No | Yes | 5 | 4 | 2 | 1 | | R:R:D394 | R:R:Y64 | 3.45 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:D394 | R:R:R68 | 11.91 | 2 | Yes | Yes | 5 | 4 | 2 | 2 | | R:R:S151 | R:R:W100 | 6.18 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 5.45 | 2 | No | Yes | 4 | 3 | 1 | 1 | | R:R:G150 | R:R:S173 | 3.71 | 0 | No | No | 5 | 5 | 2 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 2 | No | Yes | 9 | 7 | 1 | 2 | | R:R:N222 | R:R:S152 | 2.98 | 2 | Yes | No | 6 | 9 | 2 | 1 | | R:R:K396 | R:R:S173 | 7.65 | 2 | Yes | No | 4 | 5 | 1 | 1 | | R:R:T175 | R:R:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | | R:R:D195 | R:R:T175 | 5.78 | 0 | No | No | 8 | 8 | 2 | 1 | | R:R:N222 | R:R:S176 | 4.47 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | | R:R:F399 | R:R:V192 | 6.55 | 0 | Yes | Yes | 7 | 7 | 2 | 2 | | R:R:D195 | R:R:F277 | 5.97 | 0 | No | Yes | 8 | 7 | 2 | 2 | | R:R:Q198 | R:R:Y223 | 3.38 | 2 | Yes | Yes | 9 | 7 | 2 | 1 | | R:R:Q198 | R:R:S304 | 4.33 | 2 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:D305 | R:R:Q198 | 9.14 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:G224 | R:R:Y223 | 2.9 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 12.38 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 6.36 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:D305 | R:R:Y223 | 5.75 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:E279 | R:R:S250 | 2.87 | 2 | No | Yes | 4 | 3 | 1 | 2 | | R:R:F277 | R:R:S304 | 6.61 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | | R:R:D305 | R:R:S304 | 2.94 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:D305 | R:R:G306 | 3.35 | 2 | Yes | No | 8 | 5 | 1 | 1 | | R:R:D305 | R:R:K396 | 4.15 | 2 | Yes | Yes | 8 | 4 | 1 | 1 | | R:R:F399 | R:R:K396 | 3.72 | 0 | Yes | Yes | 7 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 10.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 7.08 | | Average Nodes In Shell | 28.00 | | Average Hubs In Shell | 17.00 | | Average Links In Shell | 43.00 | | Average Links Mediated by Hubs In Shell | 41.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of QUS in 8T8M
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | M:M:?1 | S:S:Y64 | 8.11 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | M:M:?1 | S:S:W100 | 9.45 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | M:M:?1 | S:S:S152 | 4.15 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | | M:M:?1 | S:S:T175 | 6.12 | 1 | Yes | No | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:Y223 | 12.97 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?1 | S:S:E279 | 8.25 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | M:M:?1 | S:S:G306 | 4.73 | 1 | Yes | No | 0 | 5 | 0 | 1 | | S:S:R61 | S:S:S42 | 6.59 | 1 | Yes | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:W100 | 4.94 | 1 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 12.35 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 4 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R68 | S:S:Y64 | 8.23 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:W100 | S:S:Y64 | 3.86 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | | S:S:R310 | S:S:Y64 | 10.29 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:S151 | S:S:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 9.81 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | S:S:S152 | S:S:S176 | 6.52 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | | S:S:N222 | S:S:S152 | 2.98 | 1 | Yes | Yes | 6 | 9 | 2 | 1 | | S:S:S152 | S:S:Y223 | 3.82 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | | S:S:T175 | S:S:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | | S:S:D195 | S:S:T175 | 2.89 | 1 | Yes | No | 8 | 8 | 2 | 1 | | S:S:N222 | S:S:S176 | 5.96 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | | S:S:D195 | S:S:F277 | 4.78 | 1 | Yes | No | 8 | 7 | 2 | 2 | | S:S:S250 | S:S:T219 | 3.2 | 1 | Yes | Yes | 3 | 5 | 2 | 2 | | S:S:E279 | S:S:T219 | 4.23 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F277 | S:S:Y223 | 10.32 | 1 | No | Yes | 7 | 7 | 2 | 1 | | S:S:S304 | S:S:Y223 | 5.09 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:E279 | S:S:S250 | 2.87 | 1 | Yes | Yes | 4 | 3 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 7.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 7.68 | | Average Nodes In Shell | 22.00 | | Average Hubs In Shell | 15.00 | | Average Links In Shell | 29.00 | | Average Links Mediated by Hubs In Shell | 29.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8TAO | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | CDPPB | - | 2.9 | 2023-10-11 | doi.org/10.1101/2023.08.29.555158 |
|
A 2D representation of the interactions of QUS in 8TAO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:Y64 | 8.11 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:W100 | 8.66 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | L:L:?1 | R:R:S152 | 4.15 | 2 | Yes | No | 0 | 9 | 0 | 1 | | L:L:?1 | R:R:S173 | 4.15 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:T175 | 3.06 | 2 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:Y223 | 13.78 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:E279 | 5.5 | 2 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:D305 | 4.69 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:G306 | 4.73 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:R310 | 3.36 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:K396 | 5.85 | 2 | Yes | No | 0 | 4 | 0 | 1 | | R:R:R61 | R:R:S42 | 6.59 | 2 | Yes | No | 5 | 6 | 2 | 2 | | R:R:S42 | R:R:W100 | 4.94 | 2 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 11.32 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 4 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R68 | R:R:Y64 | 12.35 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:W100 | R:R:Y64 | 3.86 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | | R:R:R310 | R:R:Y64 | 11.32 | 2 | No | Yes | 5 | 4 | 1 | 1 | | R:R:R68 | R:R:Y172 | 7.2 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | | R:R:S151 | R:R:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 5.45 | 2 | No | Yes | 4 | 3 | 1 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 2 | No | Yes | 9 | 7 | 1 | 2 | | R:R:L179 | R:R:S152 | 3 | 2 | Yes | No | 8 | 9 | 2 | 1 | | R:R:S173 | R:R:Y172 | 5.09 | 2 | No | Yes | 5 | 7 | 1 | 2 | | R:R:K396 | R:R:S173 | 4.59 | 2 | No | No | 4 | 5 | 1 | 1 | | R:R:T175 | R:R:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | | R:R:L179 | R:R:S176 | 3 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:D305 | R:R:Q198 | 14.36 | 2 | Yes | No | 8 | 9 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 2 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 17.54 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 3.82 | 2 | No | Yes | 8 | 7 | 2 | 1 | | R:R:D305 | R:R:Y223 | 6.9 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:F277 | R:R:G224 | 3.01 | 2 | Yes | No | 7 | 8 | 2 | 2 | | R:R:E279 | R:R:S250 | 2.87 | 2 | No | No | 4 | 3 | 1 | 2 | | R:R:F277 | R:R:S304 | 7.93 | 2 | Yes | No | 7 | 8 | 2 | 2 | | R:R:G280 | R:R:R310 | 3 | 0 | No | No | 3 | 5 | 2 | 1 | | R:R:D305 | R:R:S304 | 2.94 | 2 | Yes | No | 8 | 8 | 1 | 2 | | R:R:D305 | R:R:G306 | 3.35 | 2 | Yes | No | 8 | 5 | 1 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 6.00 | | Average Nodes In Shell | 26.00 | | Average Hubs In Shell | 12.00 | | Average Links In Shell | 38.00 | | Average Links Mediated by Hubs In Shell | 35.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of QUS in 8TAO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | M:M:?1 | S:S:Y64 | 8.11 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | M:M:?1 | S:S:W100 | 7.88 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | M:M:?1 | S:S:S152 | 4.15 | 1 | Yes | No | 0 | 9 | 0 | 1 | | M:M:?1 | S:S:S173 | 8.31 | 1 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:T175 | 4.08 | 1 | Yes | No | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:Y223 | 20.27 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?1 | S:S:E279 | 5.5 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | M:M:?1 | S:S:D305 | 3.75 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:G306 | 4.73 | 1 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:K396 | 2.93 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:R61 | S:S:S42 | 6.59 | 0 | No | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:W100 | 4.94 | 0 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 12.35 | 0 | No | Yes | 5 | 4 | 2 | 1 | | S:S:R68 | S:S:Y64 | 10.29 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:W100 | S:S:Y64 | 4.82 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | | S:S:R310 | S:S:Y64 | 10.29 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:D394 | S:S:R68 | 10.72 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | | S:S:S151 | S:S:W100 | 4.94 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 5.45 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | S:S:G150 | S:S:S173 | 3.71 | 0 | No | No | 5 | 5 | 2 | 1 | | S:S:S152 | S:S:S176 | 6.52 | 1 | No | Yes | 9 | 7 | 1 | 2 | | S:S:N222 | S:S:S152 | 5.96 | 1 | Yes | No | 6 | 9 | 2 | 1 | | S:S:K396 | S:S:S173 | 7.65 | 1 | Yes | No | 4 | 5 | 1 | 1 | | S:S:T175 | S:S:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | | S:S:D195 | S:S:T175 | 7.23 | 0 | No | No | 8 | 8 | 2 | 1 | | S:S:N222 | S:S:S176 | 4.47 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | | S:S:L329 | S:S:V192 | 2.98 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | | S:S:F399 | S:S:V192 | 6.55 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | | S:S:D195 | S:S:Q198 | 7.83 | 0 | No | Yes | 8 | 9 | 2 | 2 | | S:S:D195 | S:S:Y223 | 5.75 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:Q198 | S:S:S304 | 2.89 | 1 | Yes | No | 9 | 8 | 2 | 2 | | S:S:D305 | S:S:Q198 | 13.05 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | S:S:E279 | S:S:T219 | 4.23 | 1 | Yes | No | 4 | 5 | 1 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F277 | S:S:Y223 | 3.09 | 0 | Yes | Yes | 7 | 7 | 2 | 1 | | S:S:S304 | S:S:Y223 | 3.82 | 1 | No | Yes | 8 | 7 | 2 | 1 | | S:S:D305 | S:S:Y223 | 4.6 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | S:S:E279 | S:S:S250 | 5.75 | 1 | Yes | No | 4 | 3 | 1 | 2 | | S:S:D305 | S:S:S304 | 2.94 | 1 | Yes | No | 8 | 8 | 1 | 2 | | S:S:D305 | S:S:G306 | 3.35 | 1 | Yes | No | 8 | 5 | 1 | 1 | | S:S:D305 | S:S:K396 | 2.77 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | S:S:K396 | S:S:L329 | 2.82 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | S:S:F399 | S:S:L329 | 6.09 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | | S:S:D394 | S:S:K396 | 4.15 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:F399 | S:S:K396 | 3.72 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 10.00 | | Average Number Of Links With An Hub | 6.00 | | Average Interaction Strength | 6.97 | | Average Nodes In Shell | 30.00 | | Average Hubs In Shell | 17.00 | | Average Links In Shell | 45.00 | | Average Links Mediated by Hubs In Shell | 42.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8X0B | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | VU0424465 | - | 3.1 | 2024-11-06 | doi.org/10.1038/s41467-024-55439-9 |
|
A 2D representation of the interactions of QUS in 8X0B
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R61 | R:R:S42 | 7.91 | 2 | Yes | No | 5 | 6 | 2 | 2 | | R:R:S42 | R:R:Y64 | 3.82 | 2 | No | Yes | 6 | 4 | 2 | 1 | | R:R:S42 | R:R:W100 | 8.65 | 2 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 15.43 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 4 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R310 | R:R:R61 | 4.26 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:R68 | R:R:Y64 | 17.49 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:W100 | R:R:Y64 | 4.82 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | | R:R:R310 | R:R:Y64 | 19.55 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:Y64 | 10.66 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:R68 | R:R:Y172 | 10.29 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | | R:R:S151 | R:R:W100 | 9.88 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 5.45 | 2 | Yes | Yes | 4 | 3 | 1 | 1 | | L:L:?1 | R:R:W100 | 10.35 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | R:R:G150 | R:R:Y172 | 4.35 | 2 | No | Yes | 5 | 7 | 2 | 2 | | R:R:G150 | R:R:S173 | 3.71 | 2 | No | Yes | 5 | 5 | 2 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 2 | Yes | Yes | 9 | 7 | 1 | 2 | | R:R:L179 | R:R:S152 | 3 | 2 | Yes | Yes | 8 | 9 | 2 | 1 | | R:R:N222 | R:R:S152 | 2.98 | 2 | Yes | Yes | 6 | 9 | 2 | 1 | | R:R:S152 | R:R:Y223 | 5.09 | 2 | Yes | Yes | 9 | 7 | 1 | 1 | | L:L:?1 | R:R:S152 | 3.15 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | | R:R:S173 | R:R:Y172 | 7.63 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | | R:R:K396 | R:R:S173 | 3.06 | 2 | Yes | Yes | 4 | 5 | 1 | 1 | | L:L:?1 | R:R:S173 | 4.2 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:D195 | R:R:T175 | 4.34 | 2 | Yes | No | 8 | 8 | 2 | 1 | | L:L:?1 | R:R:T175 | 6.18 | 2 | Yes | No | 0 | 8 | 0 | 1 | | R:R:L179 | R:R:S176 | 3 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:N222 | R:R:S176 | 5.96 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | | R:R:Q198 | R:R:S304 | 5.78 | 2 | Yes | No | 9 | 8 | 2 | 2 | | R:R:D305 | R:R:Q198 | 6.53 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:S250 | R:R:T219 | 6.4 | 2 | Yes | No | 3 | 5 | 2 | 2 | | R:R:E279 | R:R:T219 | 9.88 | 2 | Yes | No | 4 | 5 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 4.13 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 6.36 | 2 | No | Yes | 8 | 7 | 2 | 1 | | L:L:?1 | R:R:Y223 | 21.32 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:E279 | R:R:S250 | 8.62 | 2 | Yes | Yes | 4 | 3 | 1 | 2 | | R:R:F277 | R:R:S304 | 3.96 | 2 | Yes | No | 7 | 8 | 2 | 2 | | L:L:?1 | R:R:E279 | 6.49 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:G280 | R:R:R310 | 3 | 0 | No | Yes | 3 | 5 | 2 | 1 | | R:R:D305 | R:R:L329 | 6.79 | 2 | Yes | Yes | 8 | 5 | 1 | 2 | | R:R:D305 | R:R:K396 | 11.06 | 2 | Yes | Yes | 8 | 4 | 1 | 1 | | L:L:?1 | R:R:D305 | 6.64 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:G306 | 5.98 | 2 | Yes | No | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:R310 | 14.29 | 2 | No | Yes | 1 | 5 | 2 | 1 | | R:R:R310 | R:R:V313 | 7.85 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | | L:L:?1 | R:R:R310 | 4.25 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:V313 | 2.92 | 2 | No | Yes | 1 | 4 | 2 | 2 | | R:R:F399 | R:R:L329 | 6.09 | 2 | Yes | Yes | 7 | 5 | 2 | 2 | | R:R:F399 | R:R:K396 | 3.72 | 2 | Yes | Yes | 7 | 4 | 2 | 1 | | L:L:?1 | R:R:K396 | 3.94 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:A308 | R:R:K396 | 1.61 | 0 | No | Yes | 5 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 9.00 | | Average Interaction Strength | 7.56 | | Average Nodes In Shell | 34.00 | | Average Hubs In Shell | 23.00 | | Average Links In Shell | 52.00 | | Average Links Mediated by Hubs In Shell | 52.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of QUS in 8X0B
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:R61 | S:S:S42 | 6.59 | 1 | Yes | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:W100 | 8.65 | 1 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 12.35 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 4 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R310 | S:S:R61 | 3.2 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:R68 | S:S:Y64 | 18.52 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:W100 | S:S:Y64 | 4.82 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | | S:S:R310 | S:S:Y64 | 15.43 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | M:M:?1 | S:S:Y64 | 9.84 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:R68 | S:S:Y172 | 11.32 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | | S:S:S151 | S:S:W100 | 9.88 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 5.45 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | M:M:?1 | S:S:W100 | 11.15 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:G150 | S:S:Y172 | 4.35 | 1 | No | Yes | 5 | 7 | 2 | 2 | | S:S:G150 | S:S:S173 | 3.71 | 1 | No | Yes | 5 | 5 | 2 | 1 | | S:S:S152 | S:S:S176 | 6.52 | 1 | No | Yes | 9 | 7 | 1 | 2 | | S:S:S152 | S:S:Y223 | 5.09 | 1 | No | Yes | 9 | 7 | 1 | 1 | | M:M:?1 | S:S:S152 | 6.3 | 1 | Yes | No | 0 | 9 | 0 | 1 | | S:S:S173 | S:S:Y172 | 7.63 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | | S:S:K396 | S:S:S173 | 4.59 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | | M:M:?1 | S:S:S173 | 4.2 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:D195 | S:S:T175 | 2.89 | 1 | Yes | No | 8 | 8 | 2 | 1 | | S:S:D305 | S:S:T175 | 2.89 | 1 | Yes | No | 8 | 8 | 1 | 1 | | M:M:?1 | S:S:T175 | 6.18 | 1 | Yes | No | 0 | 8 | 0 | 1 | | S:S:D195 | S:S:F277 | 5.97 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:Q198 | S:S:Y223 | 3.38 | 1 | Yes | Yes | 9 | 7 | 2 | 1 | | S:S:F277 | S:S:Q198 | 7.03 | 1 | Yes | Yes | 7 | 9 | 2 | 2 | | S:S:D305 | S:S:Q198 | 6.53 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | S:S:S250 | S:S:T219 | 6.4 | 1 | Yes | No | 3 | 5 | 2 | 2 | | S:S:E279 | S:S:T219 | 9.88 | 1 | Yes | No | 4 | 5 | 1 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F277 | S:S:Y223 | 9.28 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | M:M:?1 | S:S:Y223 | 21.32 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:E279 | S:S:S250 | 8.62 | 1 | Yes | Yes | 4 | 3 | 1 | 2 | | M:M:?1 | S:S:E279 | 5.56 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:G280 | S:S:R310 | 3 | 0 | No | Yes | 3 | 5 | 2 | 1 | | S:S:D305 | S:S:L329 | 4.07 | 1 | Yes | Yes | 8 | 5 | 1 | 2 | | S:S:D305 | S:S:K396 | 9.68 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | M:M:?1 | S:S:D305 | 5.69 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:G306 | 7.18 | 1 | Yes | No | 0 | 5 | 0 | 1 | | S:S:D312 | S:S:R310 | 15.48 | 1 | No | Yes | 1 | 5 | 2 | 1 | | S:S:R310 | S:S:V313 | 7.85 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | M:M:?1 | S:S:R310 | 5.1 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:D312 | S:S:V313 | 4.38 | 1 | No | Yes | 1 | 4 | 2 | 2 | | S:S:F399 | S:S:L329 | 7.31 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | | S:S:F399 | S:S:K396 | 3.72 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | | M:M:?1 | S:S:K396 | 7.89 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 8.22 | | Average Nodes In Shell | 30.00 | | Average Hubs In Shell | 20.00 | | Average Links In Shell | 47.00 | | Average Links Mediated by Hubs In Shell | 47.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8X0C | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | VU0424465 | - | 3.2 | 2024-11-06 | doi.org/10.1038/s41467-024-55439-9 |
|
A 2D representation of the interactions of QUS in 8X0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R61 | R:R:S42 | 6.59 | 1 | Yes | No | 5 | 6 | 2 | 2 | | R:R:S42 | R:R:Y64 | 3.82 | 1 | No | Yes | 6 | 4 | 2 | 1 | | R:R:S42 | R:R:W100 | 8.65 | 1 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 14.4 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 4 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R310 | R:R:R61 | 4.26 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:R68 | R:R:Y64 | 14.4 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:W100 | R:R:Y64 | 4.82 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | | R:R:R310 | R:R:Y64 | 19.55 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:Y64 | 11.48 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:R68 | R:R:Y172 | 11.32 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | | R:R:S151 | R:R:W100 | 9.88 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 6.54 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | L:L:?1 | R:R:W100 | 11.15 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | R:R:G150 | R:R:Y172 | 2.9 | 1 | No | Yes | 5 | 7 | 2 | 2 | | R:R:G150 | R:R:S173 | 3.71 | 1 | No | Yes | 5 | 5 | 2 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | | R:R:L179 | R:R:S152 | 3 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | | R:R:N222 | R:R:S152 | 2.98 | 1 | Yes | Yes | 6 | 9 | 2 | 1 | | R:R:S152 | R:R:Y223 | 3.82 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | | L:L:?1 | R:R:S152 | 3.15 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | | R:R:S173 | R:R:Y172 | 7.63 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | | R:R:K396 | R:R:S173 | 4.59 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | | L:L:?1 | R:R:S173 | 4.2 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:T175 | R:R:V192 | 3.17 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:D195 | R:R:T175 | 2.89 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:D305 | R:R:T175 | 2.89 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | | L:L:?1 | R:R:T175 | 6.18 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:L179 | R:R:S176 | 4.5 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:N222 | R:R:S176 | 5.96 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | | R:R:L329 | R:R:V192 | 2.98 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | | R:R:F399 | R:R:V192 | 9.18 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | | R:R:Q198 | R:R:Y223 | 3.38 | 1 | Yes | Yes | 9 | 7 | 2 | 1 | | R:R:F277 | R:R:Q198 | 3.51 | 1 | Yes | Yes | 7 | 9 | 2 | 2 | | R:R:Q198 | R:R:S304 | 7.22 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:D305 | R:R:Q198 | 6.53 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:S250 | R:R:T219 | 6.4 | 1 | Yes | No | 3 | 5 | 2 | 2 | | R:R:E279 | R:R:T219 | 9.88 | 1 | Yes | No | 4 | 5 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 3.09 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 5.09 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | L:L:?1 | R:R:Y223 | 18.04 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:E279 | R:R:S250 | 8.62 | 1 | Yes | Yes | 4 | 3 | 1 | 2 | | R:R:F277 | R:R:S304 | 3.96 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | | L:L:?1 | R:R:E279 | 7.41 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:G280 | R:R:R310 | 3 | 1 | No | Yes | 3 | 5 | 2 | 1 | | R:R:G280 | R:R:V313 | 3.68 | 1 | No | Yes | 3 | 4 | 2 | 2 | | R:R:D305 | R:R:L329 | 5.43 | 1 | Yes | Yes | 8 | 5 | 1 | 2 | | R:R:D305 | R:R:K396 | 9.68 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | L:L:?1 | R:R:D305 | 6.64 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:G306 | 5.98 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:R310 | 14.29 | 1 | No | Yes | 1 | 5 | 2 | 1 | | R:R:R310 | R:R:V313 | 9.15 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | L:L:?1 | R:R:R310 | 4.25 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:V313 | 4.38 | 1 | No | Yes | 1 | 4 | 2 | 2 | | R:R:F399 | R:R:L329 | 6.09 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | | R:R:F399 | R:R:K396 | 4.96 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | | L:L:?1 | R:R:K396 | 7.89 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 10.00 | | Average Interaction Strength | 7.85 | | Average Nodes In Shell | 34.00 | | Average Hubs In Shell | 26.00 | | Average Links In Shell | 58.00 | | Average Links Mediated by Hubs In Shell | 58.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
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A 2D representation of the interactions of QUS in 8X0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:R61 | S:S:S42 | 6.59 | 2 | Yes | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:W100 | 8.65 | 2 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 14.4 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 5 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R310 | S:S:R61 | 3.2 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:R68 | S:S:Y64 | 15.43 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:W100 | S:S:Y64 | 4.82 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | | S:S:R310 | S:S:Y64 | 16.46 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | | M:M:?1 | S:S:Y64 | 9.84 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:R68 | S:S:Y172 | 11.32 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | | S:S:S151 | S:S:W100 | 9.88 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 6.54 | 2 | Yes | Yes | 4 | 3 | 1 | 1 | | M:M:?1 | S:S:W100 | 11.15 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:G150 | S:S:Y172 | 2.9 | 2 | No | Yes | 5 | 7 | 2 | 2 | | S:S:G150 | S:S:S173 | 3.71 | 2 | No | Yes | 5 | 5 | 2 | 1 | | S:S:S152 | S:S:S176 | 6.52 | 2 | Yes | Yes | 9 | 7 | 1 | 2 | | S:S:N222 | S:S:S152 | 2.98 | 2 | Yes | Yes | 6 | 9 | 2 | 1 | | S:S:S152 | S:S:Y223 | 5.09 | 2 | Yes | Yes | 9 | 7 | 1 | 1 | | M:M:?1 | S:S:S152 | 6.3 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | | S:S:S173 | S:S:Y172 | 7.63 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | | S:S:K396 | S:S:S173 | 4.59 | 2 | Yes | Yes | 4 | 5 | 1 | 1 | | M:M:?1 | S:S:S173 | 4.2 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:T175 | 5.15 | 2 | Yes | No | 0 | 8 | 0 | 1 | | S:S:N222 | S:S:S176 | 5.96 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | | S:S:S250 | S:S:T219 | 6.4 | 2 | Yes | No | 3 | 5 | 2 | 2 | | S:S:E279 | S:S:T219 | 9.88 | 2 | Yes | No | 4 | 5 | 1 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F277 | S:S:Y223 | 11.35 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | S:S:S304 | S:S:Y223 | 5.09 | 2 | No | Yes | 8 | 7 | 2 | 1 | | M:M:?1 | S:S:Y223 | 21.32 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:E279 | S:S:S250 | 7.19 | 2 | Yes | Yes | 4 | 3 | 1 | 2 | | S:S:F277 | S:S:S304 | 6.61 | 2 | Yes | No | 7 | 8 | 2 | 2 | | M:M:?1 | S:S:E279 | 6.49 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:G280 | S:S:R310 | 3 | 2 | No | Yes | 3 | 5 | 2 | 1 | | S:S:G280 | S:S:V313 | 3.68 | 2 | No | Yes | 3 | 4 | 2 | 2 | | S:S:D305 | S:S:K396 | 11.06 | 0 | No | Yes | 8 | 4 | 2 | 1 | | M:M:?1 | S:S:G306 | 5.98 | 2 | Yes | No | 0 | 5 | 0 | 1 | | S:S:D312 | S:S:R310 | 14.29 | 2 | No | Yes | 1 | 5 | 2 | 1 | | S:S:R310 | S:S:V313 | 7.85 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | | M:M:?1 | S:S:R310 | 5.1 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:D312 | S:S:V313 | 2.92 | 2 | No | Yes | 1 | 4 | 2 | 2 | | S:S:F399 | S:S:K396 | 4.96 | 2 | Yes | Yes | 7 | 4 | 2 | 1 | | M:M:?1 | S:S:K396 | 6.9 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 10.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 8.24 | | Average Nodes In Shell | 29.00 | | Average Hubs In Shell | 18.00 | | Average Links In Shell | 43.00 | | Average Links Mediated by Hubs In Shell | 43.00 |
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Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8X0D | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | VU0424465 | - | 3.5 | 2024-11-06 | doi.org/10.1038/s41467-024-55439-9 |
|
A 2D representation of the interactions of QUS in 8X0D
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R61 | R:R:S42 | 7.91 | 1 | Yes | No | 5 | 6 | 2 | 2 | | R:R:S42 | R:R:Y64 | 3.82 | 1 | No | Yes | 6 | 4 | 2 | 1 | | R:R:S42 | R:R:W100 | 7.41 | 1 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 17.49 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 5 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R68 | R:R:Y64 | 18.52 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:W100 | R:R:Y64 | 5.79 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | | R:R:R310 | R:R:Y64 | 17.49 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:Y64 | 9.84 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:R68 | R:R:Y172 | 14.4 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | | R:R:K396 | R:R:R68 | 3.71 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | | R:R:G150 | R:R:W100 | 2.81 | 1 | No | Yes | 5 | 3 | 2 | 1 | | R:R:S151 | R:R:W100 | 11.12 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 8.72 | 1 | No | Yes | 4 | 3 | 1 | 1 | | L:L:?1 | R:R:W100 | 11.95 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | R:R:G150 | R:R:Y172 | 4.35 | 1 | No | Yes | 5 | 7 | 2 | 2 | | R:R:G150 | R:R:S173 | 3.71 | 1 | No | Yes | 5 | 5 | 2 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 1 | No | Yes | 9 | 7 | 1 | 2 | | R:R:N222 | R:R:S152 | 2.98 | 1 | Yes | No | 6 | 9 | 2 | 1 | | L:L:?1 | R:R:S152 | 5.25 | 1 | Yes | No | 0 | 9 | 0 | 1 | | R:R:S173 | R:R:Y172 | 7.63 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | | R:R:K396 | R:R:S173 | 3.06 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | | L:L:?1 | R:R:S173 | 3.15 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:D195 | R:R:T175 | 2.89 | 1 | Yes | No | 8 | 8 | 2 | 1 | | L:L:?1 | R:R:T175 | 4.12 | 1 | Yes | No | 0 | 8 | 0 | 1 | | R:R:N222 | R:R:S176 | 5.96 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | | R:R:D195 | R:R:F277 | 5.97 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:Q198 | R:R:Y223 | 5.64 | 1 | Yes | Yes | 9 | 7 | 2 | 1 | | R:R:F277 | R:R:Q198 | 7.03 | 1 | Yes | Yes | 7 | 9 | 2 | 2 | | R:R:Q198 | R:R:S304 | 5.78 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:E279 | R:R:T219 | 8.47 | 1 | No | No | 4 | 5 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 9.28 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 3.82 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | L:L:?1 | R:R:Y223 | 19.68 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:F277 | R:R:S304 | 10.57 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | | L:L:?1 | R:R:E279 | 11.12 | 1 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:G306 | 5.98 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:R310 | 5.96 | 1 | No | Yes | 1 | 5 | 2 | 1 | | R:R:R310 | R:R:V313 | 6.54 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | R:R:R310 | R:R:S395 | 3.95 | 1 | Yes | No | 5 | 5 | 1 | 2 | | L:L:?1 | R:R:R310 | 3.4 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:V313 | 4.38 | 1 | No | Yes | 1 | 4 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 8.28 | | Average Nodes In Shell | 28.00 | | Average Hubs In Shell | 17.00 | | Average Links In Shell | 43.00 | | Average Links Mediated by Hubs In Shell | 42.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of QUS in 8X0D
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:R61 | S:S:S42 | 7.91 | 2 | Yes | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:Y64 | 3.82 | 2 | No | Yes | 6 | 4 | 2 | 1 | | S:S:S42 | S:S:W100 | 7.41 | 2 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 15.43 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 5 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R310 | S:S:R61 | 3.2 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:R68 | S:S:Y64 | 16.46 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:W100 | S:S:Y64 | 4.82 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | | S:S:R310 | S:S:Y64 | 18.52 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | | M:M:?1 | S:S:Y64 | 9.84 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:R68 | S:S:Y172 | 11.32 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | | S:S:G150 | S:S:W100 | 2.81 | 2 | No | Yes | 5 | 3 | 2 | 1 | | S:S:S151 | S:S:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 8.72 | 2 | Yes | Yes | 4 | 3 | 1 | 1 | | M:M:?1 | S:S:W100 | 11.15 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:G150 | S:S:Y172 | 4.35 | 2 | No | Yes | 5 | 7 | 2 | 2 | | S:S:G150 | S:S:S173 | 3.71 | 2 | No | Yes | 5 | 5 | 2 | 1 | | S:S:S152 | S:S:S176 | 6.52 | 2 | No | Yes | 9 | 7 | 1 | 2 | | S:S:L179 | S:S:S152 | 3 | 2 | Yes | No | 8 | 9 | 2 | 1 | | M:M:?1 | S:S:S152 | 6.3 | 2 | Yes | No | 0 | 9 | 0 | 1 | | S:S:S173 | S:S:Y172 | 5.09 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | | S:S:K396 | S:S:S173 | 3.06 | 2 | Yes | Yes | 4 | 5 | 1 | 1 | | M:M:?1 | S:S:S173 | 4.2 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:D195 | S:S:T175 | 8.67 | 2 | Yes | No | 8 | 8 | 2 | 1 | | M:M:?1 | S:S:T175 | 7.22 | 2 | Yes | No | 0 | 8 | 0 | 1 | | S:S:L179 | S:S:S176 | 4.5 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:D195 | S:S:Q198 | 5.22 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | | S:S:D195 | S:S:Y223 | 8.05 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | | S:S:D195 | S:S:F277 | 4.78 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:Q198 | S:S:S304 | 8.66 | 0 | Yes | No | 9 | 8 | 2 | 2 | | S:S:D305 | S:S:Q198 | 6.53 | 2 | No | Yes | 8 | 9 | 1 | 2 | | S:S:E279 | S:S:T219 | 8.47 | 2 | Yes | No | 4 | 5 | 1 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F277 | S:S:Y223 | 4.13 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | S:S:S304 | S:S:Y223 | 6.36 | 2 | No | Yes | 8 | 7 | 2 | 1 | | M:M:?1 | S:S:Y223 | 21.32 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:E279 | S:S:S250 | 2.87 | 2 | Yes | No | 4 | 3 | 1 | 2 | | S:S:F277 | S:S:S304 | 6.61 | 2 | Yes | No | 7 | 8 | 2 | 2 | | M:M:?1 | S:S:E279 | 7.41 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:G280 | S:S:R310 | 3 | 2 | No | Yes | 3 | 5 | 2 | 1 | | S:S:G280 | S:S:V313 | 3.68 | 2 | No | Yes | 3 | 4 | 2 | 2 | | S:S:D305 | S:S:K396 | 9.68 | 2 | No | Yes | 8 | 4 | 1 | 1 | | M:M:?1 | S:S:D305 | 4.75 | 2 | Yes | No | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:G306 | 4.78 | 2 | Yes | No | 0 | 5 | 0 | 1 | | S:S:R310 | S:S:V313 | 7.85 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | | M:M:?1 | S:S:R310 | 3.4 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:K396 | S:S:S395 | 3.06 | 2 | Yes | No | 4 | 5 | 1 | 2 | | S:S:F399 | S:S:K396 | 4.96 | 2 | Yes | Yes | 7 | 4 | 2 | 1 | | M:M:?1 | S:S:K396 | 5.92 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 7.00 | | Average Interaction Strength | 7.84 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 18.00 | | Average Links In Shell | 49.00 | | Average Links Mediated by Hubs In Shell | 49.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8X0E | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | - | - | 3.4 | 2024-11-06 | doi.org/10.1038/s41467-024-55439-9 |
|
A 2D representation of the interactions of QUS in 8X0E
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R61 | R:R:S42 | 6.59 | 1 | Yes | No | 5 | 6 | 2 | 2 | | R:R:S42 | R:R:Y64 | 3.82 | 1 | No | Yes | 6 | 4 | 2 | 1 | | R:R:S42 | R:R:W100 | 6.18 | 1 | No | Yes | 6 | 3 | 2 | 1 | | R:R:Q46 | R:R:W100 | 3.29 | 1 | Yes | Yes | 3 | 3 | 2 | 1 | | R:R:Q46 | R:R:S250 | 5.78 | 1 | Yes | No | 3 | 3 | 2 | 2 | | R:R:R61 | R:R:Y64 | 8.23 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 5 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R310 | R:R:R61 | 3.2 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:R68 | R:R:Y64 | 15.43 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:W100 | R:R:Y64 | 3.86 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | | R:R:R310 | R:R:Y64 | 13.38 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:Y64 | 9.02 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:R68 | R:R:Y172 | 10.29 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | | R:R:K396 | R:R:R68 | 3.71 | 1 | Yes | Yes | 4 | 4 | 1 | 2 | | R:R:S151 | R:R:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 4.36 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | L:L:?1 | R:R:W100 | 9.56 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | R:R:G150 | R:R:Y172 | 2.9 | 1 | No | Yes | 5 | 7 | 2 | 2 | | R:R:G150 | R:R:S173 | 3.71 | 1 | No | Yes | 5 | 5 | 2 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 1 | Yes | No | 9 | 7 | 1 | 2 | | R:R:N222 | R:R:S152 | 2.98 | 1 | No | Yes | 6 | 9 | 2 | 1 | | R:R:S152 | R:R:Y223 | 5.09 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | | L:L:?1 | R:R:S152 | 4.2 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | | R:R:S173 | R:R:Y172 | 2.54 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | | R:R:K396 | R:R:S173 | 6.12 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | | L:L:?1 | R:R:S173 | 7.35 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:D195 | R:R:T175 | 10.12 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:T175 | R:R:Y223 | 2.5 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:D305 | R:R:T175 | 2.89 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | | L:L:?1 | R:R:T175 | 6.18 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:N222 | R:R:S176 | 4.47 | 1 | No | No | 6 | 7 | 2 | 2 | | R:R:D195 | R:R:Q198 | 7.83 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:D195 | R:R:Y223 | 8.05 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:D195 | R:R:F277 | 8.36 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:F277 | R:R:Q198 | 5.86 | 1 | Yes | Yes | 7 | 9 | 2 | 2 | | R:R:D305 | R:R:Q198 | 5.22 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:S250 | R:R:T219 | 3.2 | 1 | No | Yes | 3 | 5 | 2 | 2 | | R:R:E279 | R:R:T219 | 12.7 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 6.19 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:E279 | R:R:Y223 | 3.37 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | | L:L:?1 | R:R:Y223 | 18.86 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:E279 | R:R:S250 | 2.87 | 1 | Yes | No | 4 | 3 | 1 | 2 | | L:L:?1 | R:R:E279 | 2.78 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:G280 | R:R:R310 | 3 | 0 | No | Yes | 3 | 5 | 2 | 1 | | R:R:M281 | R:R:R310 | 2.48 | 1 | No | Yes | 2 | 5 | 2 | 1 | | R:R:D312 | R:R:M281 | 2.77 | 1 | No | No | 1 | 2 | 2 | 2 | | R:R:D305 | R:R:L329 | 5.43 | 1 | Yes | Yes | 8 | 5 | 1 | 2 | | R:R:D305 | R:R:K396 | 8.3 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | L:L:?1 | R:R:D305 | 6.64 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:G306 | 5.98 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:R310 | 11.91 | 1 | No | Yes | 1 | 5 | 2 | 1 | | R:R:R310 | R:R:V313 | 9.15 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | L:L:?1 | R:R:R310 | 3.4 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:V313 | 4.38 | 1 | No | Yes | 1 | 4 | 2 | 2 | | R:R:K396 | R:R:L329 | 2.82 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:F399 | R:R:L329 | 4.87 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | | R:R:F399 | R:R:K396 | 3.72 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | | L:L:?1 | R:R:K396 | 3.94 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 10.00 | | Average Interaction Strength | 7.08 | | Average Nodes In Shell | 33.00 | | Average Hubs In Shell | 22.00 | | Average Links In Shell | 59.00 | | Average Links Mediated by Hubs In Shell | 57.00 |
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Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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A 2D representation of the interactions of QUS in 8X0E
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:R61 | S:S:S42 | 5.27 | 2 | Yes | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:Y64 | 3.82 | 2 | No | Yes | 6 | 4 | 2 | 1 | | S:S:S42 | S:S:W100 | 7.41 | 2 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 11.32 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 5 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R310 | S:S:R61 | 3.2 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:R68 | S:S:Y64 | 15.43 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:W100 | S:S:Y64 | 4.82 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | | S:S:R310 | S:S:Y64 | 14.4 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | | M:M:?1 | S:S:Y64 | 9.84 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:K396 | S:S:R68 | 3.71 | 0 | Yes | Yes | 4 | 4 | 1 | 2 | | S:S:G150 | S:S:W100 | 2.81 | 2 | No | Yes | 5 | 3 | 2 | 1 | | S:S:S151 | S:S:W100 | 9.88 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 5.45 | 2 | Yes | Yes | 4 | 3 | 1 | 1 | | M:M:?1 | S:S:W100 | 11.15 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:G150 | S:S:S173 | 3.71 | 2 | No | No | 5 | 5 | 2 | 2 | | S:S:S152 | S:S:S176 | 6.52 | 2 | No | No | 9 | 7 | 1 | 2 | | S:S:S152 | S:S:Y223 | 2.54 | 2 | No | Yes | 9 | 7 | 1 | 1 | | M:M:?1 | S:S:S152 | 5.25 | 2 | Yes | No | 0 | 9 | 0 | 1 | | S:S:K396 | S:S:S173 | 3.06 | 0 | Yes | No | 4 | 5 | 1 | 2 | | S:S:D195 | S:S:T175 | 2.89 | 2 | Yes | No | 8 | 8 | 2 | 1 | | M:M:?1 | S:S:T175 | 5.15 | 2 | Yes | No | 0 | 8 | 0 | 1 | | S:S:D195 | S:S:Q198 | 2.61 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | | S:S:D195 | S:S:F277 | 5.97 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:Q198 | S:S:Y223 | 4.51 | 2 | Yes | Yes | 9 | 7 | 2 | 1 | | S:S:F277 | S:S:Q198 | 8.2 | 2 | Yes | Yes | 7 | 9 | 2 | 2 | | S:S:D305 | S:S:Q198 | 5.22 | 0 | No | Yes | 8 | 9 | 2 | 2 | | S:S:S250 | S:S:T219 | 3.2 | 2 | Yes | No | 3 | 5 | 2 | 2 | | S:S:E279 | S:S:T219 | 7.06 | 2 | Yes | No | 4 | 5 | 1 | 2 | | S:S:F277 | S:S:Y223 | 7.22 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | M:M:?1 | S:S:Y223 | 18.86 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:E279 | S:S:S250 | 5.75 | 2 | Yes | Yes | 4 | 3 | 1 | 2 | | M:M:?1 | S:S:E279 | 4.63 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:G280 | S:S:R310 | 3 | 0 | No | Yes | 3 | 5 | 2 | 1 | | S:S:D305 | S:S:K396 | 8.3 | 0 | No | Yes | 8 | 4 | 2 | 1 | | M:M:?1 | S:S:G306 | 4.78 | 2 | Yes | No | 0 | 5 | 0 | 1 | | S:S:D312 | S:S:R310 | 13.1 | 2 | No | Yes | 1 | 5 | 2 | 1 | | S:S:R310 | S:S:V313 | 7.85 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | | M:M:?1 | S:S:R310 | 3.4 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:D312 | S:S:V313 | 4.38 | 2 | No | Yes | 1 | 4 | 2 | 2 | | S:S:F399 | S:S:K396 | 4.96 | 0 | Yes | Yes | 7 | 4 | 2 | 1 | | M:M:?1 | S:S:K396 | 2.96 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 6.00 | | Average Interaction Strength | 7.34 | | Average Nodes In Shell | 27.00 | | Average Hubs In Shell | 15.00 | | Average Links In Shell | 42.00 | | Average Links Mediated by Hubs In Shell | 40.00 |
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Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8X0F | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | VU0424465 | - | 3.3 | 2024-11-06 | doi.org/10.1038/s41467-024-55439-9 |
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A 2D representation of the interactions of QUS in 8X0F
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:S42 | R:R:W100 | 8.65 | 0 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 6.17 | 0 | No | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 4 | 0 | No | Yes | 5 | 3 | 2 | 1 | | R:R:R68 | R:R:Y64 | 15.43 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:R310 | R:R:Y64 | 12.35 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:Y64 | 9.02 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:R68 | R:R:Y172 | 7.2 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | | R:R:S151 | R:R:W100 | 9.88 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 6.54 | 2 | Yes | Yes | 4 | 3 | 1 | 1 | | L:L:?1 | R:R:W100 | 11.15 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | R:R:G150 | R:R:S173 | 3.71 | 0 | No | Yes | 5 | 5 | 2 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 2 | No | Yes | 9 | 7 | 1 | 2 | | R:R:L179 | R:R:S152 | 3 | 2 | Yes | No | 8 | 9 | 2 | 1 | | L:L:?1 | R:R:S152 | 3.15 | 2 | Yes | No | 0 | 9 | 0 | 1 | | R:R:S173 | R:R:Y172 | 5.09 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | | R:R:K396 | R:R:S173 | 3.06 | 2 | Yes | Yes | 4 | 5 | 1 | 1 | | L:L:?1 | R:R:S173 | 6.3 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:T175 | 5.15 | 2 | Yes | No | 0 | 8 | 0 | 1 | | R:R:L179 | R:R:S176 | 4.5 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:Q198 | R:R:Y223 | 3.38 | 2 | Yes | Yes | 9 | 7 | 2 | 1 | | R:R:F277 | R:R:Q198 | 5.86 | 2 | Yes | Yes | 7 | 9 | 2 | 2 | | R:R:Q198 | R:R:S304 | 4.33 | 2 | Yes | No | 9 | 8 | 2 | 2 | | R:R:D305 | R:R:Q198 | 5.22 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:S250 | R:R:T219 | 3.2 | 2 | No | No | 3 | 5 | 2 | 2 | | R:R:E279 | R:R:T219 | 7.06 | 2 | Yes | No | 4 | 5 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 6.19 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 5.09 | 2 | No | Yes | 8 | 7 | 2 | 1 | | L:L:?1 | R:R:Y223 | 22.14 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:E279 | R:R:S250 | 4.31 | 2 | Yes | No | 4 | 3 | 1 | 2 | | R:R:F277 | R:R:S304 | 5.28 | 2 | Yes | No | 7 | 8 | 2 | 2 | | L:L:?1 | R:R:E279 | 5.56 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:G280 | R:R:R310 | 4.5 | 0 | No | Yes | 3 | 5 | 2 | 1 | | R:R:D305 | R:R:L329 | 6.79 | 2 | Yes | Yes | 8 | 5 | 1 | 2 | | R:R:D305 | R:R:K396 | 8.3 | 2 | Yes | Yes | 8 | 4 | 1 | 1 | | L:L:?1 | R:R:D305 | 5.69 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:G306 | 7.18 | 2 | Yes | No | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:R310 | 3.57 | 0 | No | Yes | 1 | 5 | 2 | 1 | | L:L:?1 | R:R:R310 | 4.25 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:F399 | R:R:L329 | 4.87 | 2 | Yes | Yes | 7 | 5 | 2 | 2 | | R:R:F399 | R:R:K396 | 3.72 | 2 | Yes | Yes | 7 | 4 | 2 | 1 | | L:L:?1 | R:R:K396 | 3.94 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:A308 | R:R:K396 | 1.61 | 0 | No | Yes | 5 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 7.59 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 17.00 | | Average Links In Shell | 43.00 | | Average Links Mediated by Hubs In Shell | 42.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of QUS in 8X0F
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:R61 | S:S:S42 | 6.59 | 1 | Yes | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:W100 | 11.12 | 1 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 9.26 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 4 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R68 | S:S:Y64 | 16.46 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:W100 | S:S:Y64 | 4.82 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | | S:S:R310 | S:S:Y64 | 13.38 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | M:M:?1 | S:S:Y64 | 9.02 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:R68 | S:S:Y172 | 8.23 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | | S:S:K396 | S:S:R68 | 3.71 | 1 | Yes | Yes | 4 | 4 | 1 | 2 | | S:S:S151 | S:S:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 5.45 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | M:M:?1 | S:S:W100 | 10.35 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:G150 | S:S:Y172 | 5.79 | 1 | No | Yes | 5 | 7 | 2 | 2 | | S:S:G150 | S:S:S173 | 3.71 | 1 | No | Yes | 5 | 5 | 2 | 1 | | S:S:S152 | S:S:S176 | 3.26 | 1 | No | Yes | 9 | 7 | 1 | 2 | | S:S:S152 | S:S:Y223 | 5.09 | 1 | No | Yes | 9 | 7 | 1 | 1 | | M:M:?1 | S:S:S152 | 7.35 | 1 | Yes | No | 0 | 9 | 0 | 1 | | S:S:S173 | S:S:Y172 | 3.82 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | | S:S:K396 | S:S:S173 | 3.06 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | | M:M:?1 | S:S:S173 | 6.3 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:T175 | S:S:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | | M:M:?1 | S:S:T175 | 4.12 | 1 | Yes | No | 0 | 8 | 0 | 1 | | S:S:L329 | S:S:V192 | 4.47 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | | S:S:F399 | S:S:V192 | 3.93 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | | S:S:F277 | S:S:Q198 | 3.51 | 1 | Yes | Yes | 7 | 9 | 2 | 2 | | S:S:Q198 | S:S:S304 | 7.22 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | S:S:D305 | S:S:Q198 | 6.53 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | S:S:E279 | S:S:T219 | 7.06 | 1 | Yes | No | 4 | 5 | 1 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F277 | S:S:Y223 | 5.16 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | S:S:E279 | S:S:Y223 | 3.37 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | | S:S:S304 | S:S:Y223 | 3.82 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | M:M:?1 | S:S:Y223 | 18.86 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:E279 | S:S:S250 | 4.31 | 1 | Yes | No | 4 | 3 | 1 | 2 | | S:S:F277 | S:S:S304 | 9.25 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | | M:M:?1 | S:S:E279 | 6.49 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:G280 | S:S:R310 | 4.5 | 0 | No | Yes | 3 | 5 | 2 | 1 | | S:S:D305 | S:S:L329 | 5.43 | 1 | Yes | Yes | 8 | 5 | 1 | 2 | | S:S:D305 | S:S:K396 | 8.3 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | M:M:?1 | S:S:D305 | 4.75 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:G306 | 5.98 | 1 | Yes | No | 0 | 5 | 0 | 1 | | S:S:D312 | S:S:R310 | 14.29 | 1 | No | Yes | 1 | 5 | 2 | 1 | | S:S:R310 | S:S:V313 | 6.54 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | M:M:?1 | S:S:R310 | 3.4 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:D312 | S:S:V313 | 2.92 | 1 | No | Yes | 1 | 4 | 2 | 2 | | S:S:F399 | S:S:L329 | 7.31 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | | S:S:F399 | S:S:K396 | 6.2 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | | M:M:?1 | S:S:K396 | 3.94 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 7.32 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 20.00 | | Average Links In Shell | 49.00 | | Average Links Mediated by Hubs In Shell | 49.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8X0G | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | - | - | 3 | 2024-11-06 | doi.org/10.1038/s41467-024-55439-9 |
|
A 2D representation of the interactions of QUS in 8X0G
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R61 | R:R:S42 | 7.91 | 1 | Yes | No | 5 | 6 | 2 | 2 | | R:R:S42 | R:R:W100 | 8.65 | 1 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 13.38 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 4 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | R:R:R310 | R:R:R61 | 3.2 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:R68 | R:R:Y64 | 16.46 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:W100 | R:R:Y64 | 4.82 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | | R:R:R310 | R:R:Y64 | 15.43 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:Y64 | 9.02 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:R68 | R:R:Y172 | 10.29 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | | R:R:S151 | R:R:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 5.45 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | L:L:?1 | R:R:W100 | 11.95 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | R:R:G150 | R:R:Y172 | 4.35 | 1 | No | Yes | 5 | 7 | 2 | 2 | | R:R:G150 | R:R:S173 | 3.71 | 1 | No | Yes | 5 | 5 | 2 | 1 | | R:R:S152 | R:R:S176 | 6.52 | 1 | No | No | 9 | 7 | 1 | 2 | | R:R:S152 | R:R:Y223 | 5.09 | 1 | No | Yes | 9 | 7 | 1 | 1 | | L:L:?1 | R:R:S152 | 6.3 | 1 | Yes | No | 0 | 9 | 0 | 1 | | R:R:S173 | R:R:Y172 | 7.63 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | | R:R:K396 | R:R:S173 | 4.59 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | | L:L:?1 | R:R:S173 | 4.2 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:D195 | R:R:T175 | 5.78 | 1 | Yes | No | 8 | 8 | 2 | 1 | | L:L:?1 | R:R:T175 | 5.15 | 1 | Yes | No | 0 | 8 | 0 | 1 | | R:R:D195 | R:R:Q198 | 5.22 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:D195 | R:R:Y223 | 8.05 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:D195 | R:R:F277 | 10.75 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:F277 | R:R:Q198 | 7.03 | 1 | Yes | Yes | 7 | 9 | 2 | 2 | | R:R:Q198 | R:R:S304 | 8.66 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:D305 | R:R:Q198 | 5.22 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:S250 | R:R:T219 | 4.8 | 1 | Yes | No | 3 | 5 | 2 | 2 | | R:R:E279 | R:R:T219 | 12.7 | 1 | Yes | No | 4 | 5 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 6.19 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:S304 | R:R:Y223 | 3.82 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | L:L:?1 | R:R:Y223 | 18.04 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:E279 | R:R:S250 | 7.19 | 1 | Yes | Yes | 4 | 3 | 1 | 2 | | R:R:F277 | R:R:S304 | 7.93 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | | L:L:?1 | R:R:E279 | 6.49 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:D305 | R:R:L329 | 6.79 | 1 | Yes | Yes | 8 | 5 | 1 | 2 | | R:R:D305 | R:R:K396 | 11.06 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | | L:L:?1 | R:R:D305 | 5.69 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:G306 | 5.98 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:R310 | 19.06 | 1 | No | Yes | 1 | 5 | 2 | 1 | | R:R:R310 | R:R:V313 | 7.85 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | L:L:?1 | R:R:R310 | 4.25 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:D312 | R:R:V313 | 4.38 | 1 | No | Yes | 1 | 4 | 2 | 2 | | R:R:F399 | R:R:L329 | 4.87 | 0 | Yes | Yes | 7 | 5 | 2 | 2 | | R:R:F399 | R:R:K396 | 4.96 | 0 | Yes | Yes | 7 | 4 | 2 | 1 | | L:L:?1 | R:R:K396 | 4.93 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:G280 | R:R:R310 | 3 | 0 | No | Yes | 3 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 7.45 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 20.00 | | Average Links In Shell | 50.00 | | Average Links Mediated by Hubs In Shell | 49.00 |
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Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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A 2D representation of the interactions of QUS in 8X0G
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:R61 | S:S:S42 | 5.27 | 2 | Yes | No | 5 | 6 | 2 | 2 | | S:S:S42 | S:S:Y64 | 3.82 | 2 | No | Yes | 6 | 4 | 2 | 1 | | S:S:S42 | S:S:W100 | 4.94 | 2 | No | Yes | 6 | 3 | 2 | 1 | | S:S:R61 | S:S:Y64 | 11.32 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:R61 | S:S:W100 | 4 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:R310 | S:S:R61 | 3.2 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:R68 | S:S:Y64 | 17.49 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:W100 | S:S:Y64 | 3.86 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | | S:S:R310 | S:S:Y64 | 17.49 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | | M:M:?1 | S:S:Y64 | 9.02 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:S151 | S:S:W100 | 11.12 | 0 | No | Yes | 4 | 3 | 2 | 1 | | S:S:E279 | S:S:W100 | 8.72 | 2 | No | Yes | 4 | 3 | 2 | 1 | | M:M:?1 | S:S:W100 | 10.35 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:G150 | S:S:S173 | 3.71 | 0 | No | No | 5 | 5 | 2 | 1 | | S:S:S152 | S:S:S176 | 6.52 | 0 | No | No | 9 | 7 | 1 | 2 | | M:M:?1 | S:S:S152 | 6.3 | 2 | Yes | No | 0 | 9 | 0 | 1 | | S:S:K396 | S:S:S173 | 7.65 | 2 | Yes | No | 4 | 5 | 1 | 1 | | M:M:?1 | S:S:S173 | 8.4 | 2 | Yes | No | 0 | 5 | 0 | 1 | | S:S:T175 | S:S:V192 | 3.17 | 0 | No | No | 8 | 7 | 1 | 2 | | S:S:D195 | S:S:T175 | 8.67 | 2 | Yes | No | 8 | 8 | 2 | 1 | | M:M:?1 | S:S:T175 | 8.25 | 2 | Yes | No | 0 | 8 | 0 | 1 | | S:S:F399 | S:S:V192 | 9.18 | 0 | Yes | No | 7 | 7 | 2 | 2 | | S:S:D195 | S:S:Q198 | 9.14 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | | S:S:D195 | S:S:Y223 | 8.05 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | | S:S:D195 | S:S:F277 | 8.36 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | | S:S:F277 | S:S:Q198 | 8.2 | 2 | Yes | Yes | 7 | 9 | 2 | 2 | | S:S:Q198 | S:S:S304 | 5.78 | 2 | Yes | No | 9 | 8 | 2 | 2 | | S:S:D305 | S:S:Q198 | 5.22 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F277 | S:S:Y223 | 7.22 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | S:S:S304 | S:S:Y223 | 5.09 | 2 | No | Yes | 8 | 7 | 2 | 1 | | M:M:?1 | S:S:Y223 | 20.5 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:F277 | S:S:S304 | 9.25 | 2 | Yes | No | 7 | 8 | 2 | 2 | | S:S:G280 | S:S:R310 | 4.5 | 0 | No | Yes | 3 | 5 | 2 | 1 | | S:S:D305 | S:S:L329 | 5.43 | 2 | Yes | Yes | 8 | 5 | 1 | 2 | | S:S:D305 | S:S:K396 | 8.3 | 2 | Yes | Yes | 8 | 4 | 1 | 1 | | M:M:?1 | S:S:D305 | 6.64 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:G306 | 5.98 | 2 | Yes | No | 0 | 5 | 0 | 1 | | S:S:D312 | S:S:R310 | 11.91 | 0 | No | Yes | 1 | 5 | 2 | 1 | | S:S:R310 | S:S:V313 | 5.23 | 2 | Yes | No | 5 | 4 | 1 | 2 | | M:M:?1 | S:S:R310 | 5.95 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:F399 | S:S:L329 | 6.09 | 0 | Yes | Yes | 7 | 5 | 2 | 2 | | S:S:F399 | S:S:K396 | 3.72 | 0 | Yes | Yes | 7 | 4 | 2 | 1 | | M:M:?1 | S:S:K396 | 3.94 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 10.00 | | Average Number Of Links With An Hub | 6.00 | | Average Interaction Strength | 8.53 | | Average Nodes In Shell | 29.00 | | Average Hubs In Shell | 14.00 | | Average Links In Shell | 44.00 | | Average Links Mediated by Hubs In Shell | 41.00 |
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Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8X0H | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | - | - | 4.1 | 2024-11-06 | doi.org/10.1038/s41467-024-55439-9 |
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A 2D representation of the interactions of QUS in 8X0H
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:S42 | R:R:W100 | 11.12 | 0 | No | Yes | 6 | 3 | 2 | 1 | | R:R:R61 | R:R:Y64 | 14.4 | 4 | No | Yes | 5 | 4 | 2 | 1 | | R:R:R61 | R:R:W100 | 4 | 4 | No | Yes | 5 | 3 | 2 | 1 | | R:R:R68 | R:R:Y64 | 12.35 | 4 | No | Yes | 4 | 4 | 2 | 1 | | R:R:W100 | R:R:Y64 | 2.89 | 4 | Yes | Yes | 3 | 4 | 1 | 1 | | R:R:R310 | R:R:Y64 | 17.49 | 4 | No | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:Y64 | 9.02 | 4 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:S151 | R:R:W100 | 11.12 | 4 | No | Yes | 4 | 3 | 2 | 1 | | R:R:E279 | R:R:W100 | 5.45 | 4 | Yes | Yes | 4 | 3 | 1 | 1 | | L:L:?1 | R:R:W100 | 13.54 | 4 | Yes | Yes | 0 | 3 | 0 | 1 | | R:R:E279 | R:R:S151 | 2.87 | 4 | Yes | No | 4 | 4 | 1 | 2 | | R:R:T175 | R:R:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | | L:L:?1 | R:R:T175 | 4.12 | 4 | Yes | No | 0 | 8 | 0 | 1 | | R:R:S250 | R:R:T219 | 6.4 | 4 | No | No | 3 | 5 | 2 | 2 | | R:R:E279 | R:R:T219 | 15.52 | 4 | Yes | No | 4 | 5 | 1 | 2 | | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | No | 8 | 7 | 2 | 1 | | R:R:F277 | R:R:Y223 | 12.38 | 0 | Yes | No | 7 | 7 | 2 | 1 | | L:L:?1 | R:R:Y223 | 25.41 | 4 | Yes | No | 0 | 7 | 0 | 1 | | R:R:E279 | R:R:S250 | 8.62 | 4 | Yes | No | 4 | 3 | 1 | 2 | | L:L:?1 | R:R:E279 | 6.49 | 4 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:G280 | R:R:R310 | 4.5 | 0 | No | No | 3 | 5 | 2 | 1 | | R:R:D305 | R:R:G306 | 3.35 | 0 | Yes | No | 8 | 5 | 2 | 1 | | R:R:D305 | R:R:K396 | 4.15 | 0 | Yes | No | 8 | 4 | 2 | 1 | | L:L:?1 | R:R:G306 | 8.37 | 4 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:R310 | 5.1 | 4 | Yes | No | 0 | 5 | 0 | 1 | | R:R:K396 | R:R:S395 | 7.65 | 0 | No | No | 4 | 5 | 1 | 2 | | L:L:?1 | R:R:K396 | 3.94 | 4 | Yes | No | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 9.50 | | Average Nodes In Shell | 21.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 27.00 | | Average Links Mediated by Hubs In Shell | 23.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of QUS in 8X0H
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:Q46 | S:S:R61 | 9.35 | 1 | Yes | Yes | 3 | 5 | 2 | 2 | | S:S:Q46 | S:S:W100 | 7.67 | 1 | Yes | Yes | 3 | 3 | 2 | 1 | | S:S:R61 | S:S:W100 | 13 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | | S:S:G150 | S:S:W100 | 5.63 | 0 | No | Yes | 5 | 3 | 2 | 1 | | S:S:S151 | S:S:W100 | 6.18 | 0 | No | Yes | 4 | 3 | 2 | 1 | | M:M:?1 | S:S:W100 | 4.78 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:S151 | S:S:Y223 | 10.17 | 0 | No | Yes | 4 | 7 | 2 | 1 | | S:S:S152 | S:S:Y223 | 5.09 | 1 | Yes | Yes | 9 | 7 | 2 | 1 | | S:S:Q198 | S:S:T175 | 12.76 | 0 | No | No | 9 | 8 | 2 | 2 | | S:S:T175 | S:S:Y223 | 3.75 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:D305 | S:S:Q198 | 10.44 | 1 | Yes | No | 8 | 9 | 1 | 2 | | S:S:F277 | S:S:M202 | 6.22 | 1 | Yes | No | 7 | 6 | 1 | 2 | | S:S:M202 | S:S:S304 | 4.6 | 1 | No | No | 6 | 8 | 2 | 2 | | S:S:E279 | S:S:T219 | 19.76 | 1 | Yes | No | 4 | 5 | 1 | 2 | | S:S:E279 | S:S:Y223 | 4.49 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | | M:M:?1 | S:S:Y223 | 14.76 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:F277 | S:S:G227 | 6.02 | 1 | Yes | No | 7 | 6 | 1 | 2 | | S:S:F277 | S:S:M228 | 3.73 | 1 | Yes | No | 7 | 4 | 1 | 2 | | S:S:E279 | S:S:S250 | 2.87 | 1 | Yes | No | 4 | 3 | 1 | 2 | | S:S:F277 | S:S:S304 | 5.28 | 1 | Yes | No | 7 | 8 | 1 | 2 | | M:M:?1 | S:S:F277 | 6.81 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?1 | S:S:E279 | 3.71 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:D305 | S:S:G306 | 3.35 | 1 | Yes | No | 8 | 5 | 1 | 1 | | S:S:D305 | S:S:L329 | 8.14 | 1 | Yes | Yes | 8 | 5 | 1 | 2 | | M:M:?1 | S:S:D305 | 11.39 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:G306 | 7.18 | 1 | Yes | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 8.11 | | Average Nodes In Shell | 21.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 26.00 | | Average Links Mediated by Hubs In Shell | 24.00 |
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Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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