psnGPCR

Code	QUS
Name	Quisqualic acid
Synonyms	QUISQUALATE
Identifier	(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
Formula	C5 H7 N3 O5
Molecular Weight	189.126
SMILES	C([C@@H](C(=O)O)N)N1C(=O)NC(=O)O1
PubChem	40539
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	5
Networks	6

This ligand is also present in the following 6 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6N51

Aminoacid

Metabotropic glutamate

mGlu5; mGlu5

Homo sapiens

Quisqualate

2019-01-23

10.1038/s41586-019-0881-4

A 2D representation of the interactions of QUS in 6N51
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:S42	S:S:W100	12.36	0	No	Yes	6	3	2	1
S:S:Q46	S:S:W100	4.38	1	Yes	Yes	3	3	2	1
S:S:Q46	S:S:S250	4.33	1	Yes	No	3	3	2	2
S:S:R61	S:S:Y64	7.2	1	Yes	Yes	5	4	2	1
S:S:R61	S:S:W100	13.99	1	Yes	Yes	5	3	2	1
S:S:R310	S:S:R61	8.53	1	Yes	Yes	5	5	2	2
S:S:R68	S:S:Y64	7.2	1	Yes	Yes	4	4	2	1
S:S:W100	S:S:Y64	4.82	1	Yes	Yes	3	4	1	1
S:S:R310	S:S:Y64	13.38	1	Yes	Yes	5	4	2	1
S:S:D394	S:S:Y64	4.6	1	Yes	Yes	5	4	2	1
S:S:K396	S:S:Y64	3.58	1	Yes	Yes	4	4	1	1
L:L:?903	S:S:Y64	10.35	1	Yes	Yes	0	4	0	1
S:S:R68	S:S:Y172	5.14	1	Yes	Yes	4	7	2	2
S:S:D394	S:S:R68	9.53	1	Yes	Yes	5	4	2	2
L:L:?903	S:S:W100	7.73	1	Yes	Yes	0	3	0	1
S:S:S152	S:S:S176	6.52	1	No	Yes	9	7	1	2
S:S:S152	S:S:Y223	5.09	1	No	Yes	9	7	1	1
L:L:?903	S:S:S152	4.08	1	Yes	No	0	9	0	1
S:S:S173	S:S:Y172	6.36	1	No	Yes	5	7	1	2
S:S:K396	S:S:S173	3.06	1	Yes	No	4	5	1	1
L:L:?903	S:S:S173	4.08	1	Yes	No	0	5	0	1
S:S:T175	S:S:V192	3.17	1	No	No	8	7	1	2
S:S:T175	S:S:Y223	3.75	1	No	Yes	8	7	1	1
L:L:?903	S:S:T175	8.01	1	Yes	No	0	8	0	1
S:S:D195	S:S:S176	2.94	0	Yes	Yes	8	7	2	2
S:S:D195	S:S:Q198	5.22	0	Yes	Yes	8	9	2	2
S:S:D195	S:S:Y223	4.6	0	Yes	Yes	8	7	2	1
S:S:D305	S:S:Q198	11.75	1	Yes	Yes	8	9	1	2
S:S:E279	S:S:T219	4.23	0	No	No	4	5	1	2
S:S:G224	S:S:Y223	4.35	0	No	Yes	8	7	2	1
S:S:S304	S:S:Y223	5.09	1	No	Yes	8	7	2	1
S:S:D305	S:S:Y223	5.75	1	Yes	Yes	8	7	1	1
L:L:?903	S:S:Y223	16.72	1	Yes	Yes	0	7	0	1
S:S:E279	S:S:S250	7.19	0	No	No	4	3	1	2
L:L:?903	S:S:E279	4.5	1	Yes	No	0	4	0	1
S:S:D305	S:S:S304	2.94	1	Yes	No	8	8	1	2
S:S:D305	S:S:K396	4.15	1	Yes	Yes	8	4	1	1
L:L:?903	S:S:D305	4.61	1	Yes	Yes	0	8	0	1
L:L:?903	S:S:G306	4.65	1	Yes	No	0	5	0	1
S:S:D394	S:S:S395	2.94	1	Yes	No	5	5	2	2
S:S:K396	S:S:S395	4.59	1	Yes	No	4	5	1	2
L:L:?903	S:S:K396	4.79	1	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	6.95
Average Nodes In Shell	27.00
Average Hubs In Shell	15.00
Average Links In Shell	42.00
Average Links Mediated by Hubs In Shell	39.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of QUS in 6N51
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S42	R:R:W100	12.36	0	No	Yes	6	3	2	1
R:R:Q46	R:R:W100	4.38	2	Yes	Yes	3	3	2	1
R:R:Q46	R:R:S250	4.33	2	Yes	No	3	3	2	2
R:R:R61	R:R:Y64	7.2	2	Yes	Yes	5	4	2	1
R:R:R61	R:R:W100	13.99	2	Yes	Yes	5	3	2	1
R:R:R310	R:R:R61	8.53	2	Yes	Yes	5	5	2	2
R:R:R68	R:R:Y64	7.2	2	Yes	Yes	4	4	2	1
R:R:W100	R:R:Y64	4.82	2	Yes	Yes	3	4	1	1
R:R:R310	R:R:Y64	13.38	2	Yes	Yes	5	4	2	1
R:R:D394	R:R:Y64	4.6	2	Yes	Yes	5	4	2	1
R:R:K396	R:R:Y64	3.58	2	Yes	Yes	4	4	1	1
M:M:?903	R:R:Y64	11.94	2	Yes	Yes	0	4	0	1
R:R:R68	R:R:Y172	5.14	2	Yes	Yes	4	7	2	2
R:R:D394	R:R:R68	9.53	2	Yes	Yes	5	4	2	2
M:M:?903	R:R:W100	7.73	2	Yes	Yes	0	3	0	1
R:R:S152	R:R:S176	6.52	2	No	Yes	9	7	1	2
R:R:S152	R:R:Y223	5.09	2	No	Yes	9	7	1	1
M:M:?903	R:R:S152	3.06	2	Yes	No	0	9	0	1
R:R:S173	R:R:Y172	6.36	2	No	Yes	5	7	1	2
R:R:K396	R:R:S173	3.06	2	Yes	No	4	5	1	1
M:M:?903	R:R:S173	5.1	2	Yes	No	0	5	0	1
R:R:T175	R:R:V192	3.17	2	No	No	8	7	1	2
R:R:T175	R:R:Y223	3.75	2	No	Yes	8	7	1	1
M:M:?903	R:R:T175	6.01	2	Yes	No	0	8	0	1
R:R:D195	R:R:S176	2.94	0	Yes	Yes	8	7	2	2
R:R:D195	R:R:Q198	5.22	0	Yes	Yes	8	9	2	2
R:R:D195	R:R:Y223	4.6	0	Yes	Yes	8	7	2	1
R:R:D305	R:R:Q198	11.75	2	Yes	Yes	8	9	1	2
R:R:E279	R:R:T219	4.23	0	No	No	4	5	1	2
R:R:G224	R:R:Y223	4.35	0	No	Yes	8	7	2	1
R:R:S304	R:R:Y223	5.09	2	No	Yes	8	7	2	1
R:R:D305	R:R:Y223	5.75	2	Yes	Yes	8	7	1	1
M:M:?903	R:R:Y223	15.12	2	Yes	Yes	0	7	0	1
R:R:E279	R:R:S250	7.19	0	No	No	4	3	1	2
M:M:?903	R:R:E279	4.5	2	Yes	No	0	4	0	1
R:R:D305	R:R:S304	2.94	2	Yes	No	8	8	1	2
R:R:D305	R:R:K396	4.15	2	Yes	Yes	8	4	1	1
M:M:?903	R:R:D305	5.53	2	Yes	Yes	0	8	0	1
M:M:?903	R:R:G306	4.65	2	Yes	No	0	5	0	1
R:R:D394	R:R:S395	2.94	2	Yes	No	5	5	2	2
R:R:K396	R:R:S395	4.59	2	Yes	No	4	5	1	2
M:M:?903	R:R:K396	5.75	2	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	6.94
Average Nodes In Shell	27.00
Average Hubs In Shell	15.00
Average Links In Shell	42.00
Average Links Mediated by Hubs In Shell	39.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7DGE

Aminoacid

Metabotropic glutamate

mGlu1; mGlu1

Homo sapiens

Quisqualate

3.65

2021-09-22

10.1007/s13238-020-00808-5

A 2D representation of the interactions of QUS in 7DGE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R71	R:R:S52	7.91	1	Yes	No	4	5	2	2
R:R:S52	R:R:Y74	5.09	1	No	Yes	5	5	2	1
R:R:S52	R:R:W110	7.41	1	No	Yes	5	3	2	1
R:R:Q56	R:R:W110	4.38	0	Yes	Yes	3	3	2	1
R:R:R71	R:R:Y74	16.46	1	Yes	Yes	4	5	2	1
R:R:R78	R:R:Y74	21.61	1	Yes	Yes	5	5	2	1
R:R:W110	R:R:Y74	8.68	1	Yes	Yes	3	5	1	1
R:R:R323	R:R:Y74	14.4	1	Yes	Yes	5	5	1	1
R:R:E325	R:R:Y74	5.61	1	Yes	Yes	1	5	2	1
L:L:?901	R:R:Y74	9.55	1	Yes	Yes	0	5	0	1
R:R:R78	R:R:Y185	6.17	1	Yes	Yes	5	8	2	2
R:R:K409	R:R:R78	6.19	1	Yes	Yes	4	5	1	2
R:R:S164	R:R:W110	14.83	0	No	Yes	5	3	2	1
R:R:E292	R:R:W110	8.72	1	Yes	Yes	4	3	1	1
L:L:?901	R:R:W110	8.51	1	Yes	Yes	0	3	0	1
R:R:S165	R:R:S189	6.52	0	No	No	9	7	1	2
L:L:?901	R:R:S165	6.12	1	Yes	No	0	9	0	1
R:R:S186	R:R:Y185	3.82	1	No	Yes	5	8	1	2
R:R:K409	R:R:S186	12.24	1	Yes	No	4	5	1	1
L:L:?901	R:R:S186	4.08	1	Yes	No	0	5	0	1
R:R:D208	R:R:T188	10.12	1	Yes	Yes	8	7	2	1
R:R:T188	R:R:Y236	4.99	1	Yes	Yes	7	7	1	1
R:R:D318	R:R:T188	4.34	1	Yes	Yes	8	7	1	1
L:L:?901	R:R:T188	10.01	1	Yes	Yes	0	7	0	1
R:R:D208	R:R:Q211	5.22	1	Yes	Yes	8	9	2	2
R:R:D208	R:R:Y236	10.34	1	Yes	Yes	8	7	2	1
R:R:D208	R:R:F290	5.97	1	Yes	Yes	8	6	2	2
R:R:Q211	R:R:S317	8.66	0	Yes	Yes	9	8	2	2
R:R:D318	R:R:Q211	6.53	1	Yes	Yes	8	9	1	2
R:R:E292	R:R:T232	15.52	1	Yes	No	4	5	1	2
R:R:F290	R:R:Y236	7.22	1	Yes	Yes	6	7	2	1
R:R:E292	R:R:Y236	5.61	1	Yes	Yes	4	7	1	1
R:R:S317	R:R:Y236	5.09	1	Yes	Yes	8	7	2	1
R:R:G319	R:R:Y236	4.35	1	No	Yes	5	7	1	1
L:L:?901	R:R:Y236	24.68	1	Yes	Yes	0	7	0	1
R:R:F290	R:R:S317	10.57	1	Yes	Yes	6	8	2	2
L:L:?901	R:R:E292	5.4	1	Yes	Yes	0	4	0	1
R:R:G293	R:R:R323	4.5	1	No	Yes	3	5	2	1
R:R:G293	R:R:V326	3.68	1	No	Yes	3	4	2	2
R:R:D318	R:R:L342	13.57	1	Yes	Yes	8	4	1	2
R:R:D318	R:R:K409	9.68	1	Yes	Yes	8	4	1	1
L:L:?901	R:R:D318	4.61	1	Yes	Yes	0	8	0	1
L:L:?901	R:R:G319	6.97	1	Yes	No	0	5	0	1
R:R:E325	R:R:R323	12.79	1	Yes	Yes	1	5	2	1
R:R:R323	R:R:V326	7.85	1	Yes	Yes	5	4	1	2
L:L:?901	R:R:R323	4.95	1	Yes	Yes	0	5	0	1
R:R:K409	R:R:L342	4.23	1	Yes	Yes	4	4	1	2
R:R:F412	R:R:L342	10.96	1	Yes	Yes	7	4	2	2
R:R:K409	R:R:S408	12.24	1	Yes	No	4	6	1	2
R:R:F412	R:R:K409	3.72	1	Yes	Yes	7	4	2	1
L:L:?901	R:R:K409	4.79	1	Yes	Yes	0	4	0	1
R:R:A321	R:R:D318	3.09	0	No	Yes	6	8	2	1

Statistics	Value
Average Number Of Links	11.00
Average Number Of Links With An Hub	8.00
Average Interaction Strength	8.15
Average Nodes In Shell	31.00
Average Hubs In Shell	21.00
Average Links In Shell	52.00
Average Links Mediated by Hubs In Shell	51.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7FD8

Aminoacid

Metabotropic glutamate

mGlu5; mGlu5

Homo sapiens

Quisqualate

3.8

2021-09-08

10.1016/j.celrep.2021.109648

A 2D representation of the interactions of QUS in 7FD8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R61	R:R:S42	5.27	1	Yes	No	5	6	2	2
R:R:S42	R:R:W100	9.88	1	No	Yes	6	3	2	1
R:R:R61	R:R:Y64	12.35	1	Yes	Yes	5	4	2	1
R:R:R61	R:R:W100	4	1	Yes	Yes	5	3	2	1
R:R:R68	R:R:Y64	13.38	3	Yes	Yes	4	4	2	1
R:R:R310	R:R:Y64	22.64	31	No	Yes	5	4	2	1
L:L:?902	R:R:Y64	10.35	1	Yes	Yes	0	4	0	1
R:R:G150	R:R:W100	2.81	0	No	Yes	5	3	2	1
R:R:S151	R:R:W100	8.65	0	No	Yes	4	3	2	1
R:R:E279	R:R:W100	6.54	1	Yes	Yes	4	3	1	1
L:L:?902	R:R:W100	10.05	1	Yes	Yes	0	3	0	1
R:R:I156	R:R:S152	3.1	1	Yes	Yes	5	9	2	1
R:R:S152	R:R:S176	6.52	1	Yes	Yes	9	7	1	2
R:R:L179	R:R:S152	4.5	1	Yes	Yes	8	9	2	1
L:L:?902	R:R:S152	3.06	1	Yes	Yes	0	9	0	1
R:R:I156	R:R:L179	8.56	1	Yes	Yes	5	8	2	2
R:R:K396	R:R:S173	7.65	0	Yes	No	4	5	1	2
R:R:T175	R:R:V192	3.17	1	Yes	Yes	8	7	1	2
R:R:D195	R:R:T175	5.78	1	Yes	Yes	8	8	2	1
R:R:T175	R:R:Y223	3.75	1	Yes	Yes	8	7	1	1
R:R:D305	R:R:T175	4.34	1	Yes	Yes	8	8	2	1
L:L:?902	R:R:T175	7.01	1	Yes	Yes	0	8	0	1
R:R:L179	R:R:S176	4.5	1	Yes	Yes	8	7	2	2
R:R:D195	R:R:S176	2.94	1	Yes	Yes	8	7	2	2
R:R:D195	R:R:F277	4.78	1	Yes	Yes	8	7	2	2
R:R:E279	R:R:T219	12.7	1	Yes	No	4	5	1	2
R:R:T219	R:R:T282	7.85	1	No	Yes	5	4	2	2
R:R:G224	R:R:Y223	4.35	1	No	Yes	8	7	2	1
R:R:F277	R:R:Y223	10.32	1	Yes	Yes	7	7	2	1
R:R:S304	R:R:Y223	3.82	1	Yes	Yes	8	7	2	1
R:R:D305	R:R:Y223	6.9	1	Yes	Yes	8	7	2	1
L:L:?902	R:R:Y223	23.88	1	Yes	Yes	0	7	0	1
R:R:F277	R:R:G224	3.01	1	Yes	No	7	8	2	2
R:R:E279	R:R:S250	8.62	1	Yes	No	4	3	1	2
R:R:S250	R:R:T282	4.8	1	No	Yes	3	4	2	2
R:R:F277	R:R:S304	10.57	1	Yes	Yes	7	8	2	2
R:R:E279	R:R:T282	4.23	1	Yes	Yes	4	4	1	2
L:L:?902	R:R:E279	6.3	1	Yes	Yes	0	4	0	1
R:R:D305	R:R:S304	5.89	1	Yes	Yes	8	8	2	2
R:R:D305	R:R:K396	5.53	1	Yes	Yes	8	4	2	1
L:L:?902	R:R:G306	6.97	1	Yes	No	0	5	0	1
R:R:K396	R:R:S395	4.59	0	Yes	No	4	5	1	2
L:L:?902	R:R:K396	3.83	1	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	8.93
Average Nodes In Shell	29.00
Average Hubs In Shell	19.00
Average Links In Shell	43.00
Average Links Mediated by Hubs In Shell	43.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of QUS in 7FD8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:R61	S:S:S42	5.27	2	Yes	No	5	6	2	2
S:S:S42	S:S:W100	9.88	2	No	Yes	6	3	2	1
S:S:R61	S:S:Y64	12.35	2	Yes	Yes	5	4	2	1
S:S:R61	S:S:W100	4	2	Yes	Yes	5	3	2	1
S:S:R68	S:S:Y64	13.38	4	Yes	Yes	4	4	2	1
S:S:R310	S:S:Y64	22.64	44	No	Yes	5	4	2	1
M:M:?902	S:S:Y64	10.35	2	Yes	Yes	0	4	0	1
S:S:G150	S:S:W100	2.81	0	No	Yes	5	3	2	1
S:S:S151	S:S:W100	8.65	0	No	Yes	4	3	2	1
S:S:E279	S:S:W100	6.54	2	Yes	Yes	4	3	1	1
M:M:?902	S:S:W100	10.05	2	Yes	Yes	0	3	0	1
S:S:I156	S:S:S152	3.1	2	Yes	Yes	5	9	2	1
S:S:S152	S:S:S176	6.52	2	Yes	Yes	9	7	1	2
S:S:L179	S:S:S152	4.5	2	Yes	Yes	8	9	2	1
M:M:?902	S:S:S152	3.06	2	Yes	Yes	0	9	0	1
S:S:I156	S:S:L179	8.56	2	Yes	Yes	5	8	2	2
S:S:K396	S:S:S173	7.65	0	Yes	No	4	5	1	2
S:S:T175	S:S:V192	3.17	2	Yes	Yes	8	7	1	2
S:S:D195	S:S:T175	5.78	2	Yes	Yes	8	8	2	1
S:S:T175	S:S:Y223	3.75	2	Yes	Yes	8	7	1	1
S:S:D305	S:S:T175	4.34	2	Yes	Yes	8	8	2	1
M:M:?902	S:S:T175	7.01	2	Yes	Yes	0	8	0	1
S:S:L179	S:S:S176	4.5	2	Yes	Yes	8	7	2	2
S:S:D195	S:S:S176	2.94	2	Yes	Yes	8	7	2	2
S:S:D195	S:S:F277	4.78	2	Yes	Yes	8	7	2	2
S:S:E279	S:S:T219	12.7	2	Yes	No	4	5	1	2
S:S:T219	S:S:T282	7.85	2	No	Yes	5	4	2	2
S:S:G224	S:S:Y223	4.35	2	No	Yes	8	7	2	1
S:S:F277	S:S:Y223	10.32	2	Yes	Yes	7	7	2	1
S:S:S304	S:S:Y223	3.82	2	Yes	Yes	8	7	2	1
S:S:D305	S:S:Y223	6.9	2	Yes	Yes	8	7	2	1
M:M:?902	S:S:Y223	23.88	2	Yes	Yes	0	7	0	1
S:S:F277	S:S:G224	3.01	2	Yes	No	7	8	2	2
S:S:E279	S:S:S250	8.62	2	Yes	No	4	3	1	2
S:S:S250	S:S:T282	4.8	2	No	Yes	3	4	2	2
S:S:F277	S:S:S304	10.57	2	Yes	Yes	7	8	2	2
S:S:E279	S:S:T282	4.23	2	Yes	Yes	4	4	1	2
M:M:?902	S:S:E279	6.3	2	Yes	Yes	0	4	0	1
S:S:D305	S:S:S304	5.89	2	Yes	Yes	8	8	2	2
S:S:D305	S:S:K396	5.53	2	Yes	Yes	8	4	2	1
M:M:?902	S:S:G306	6.97	2	Yes	No	0	5	0	1
S:S:K396	S:S:S395	4.59	0	Yes	No	4	5	1	2
M:M:?902	S:S:K396	3.83	2	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	8.93
Average Nodes In Shell	29.00
Average Hubs In Shell	19.00
Average Links In Shell	43.00
Average Links Mediated by Hubs In Shell	43.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8T7H

Aminoacid

Metabotropic glutamate

mGlu5; mGlu5

Homo sapiens

Quisqualate

3.3

2023-10-11

10.1101/2023.08.29.555158

A 2D representation of the interactions of QUS in 8T7H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R61	R:R:S42	6.59	2	Yes	No	5	6	2	2
R:R:S42	R:R:W100	7.41	2	No	Yes	6	3	2	1
R:R:R61	R:R:Y64	12.35	2	Yes	Yes	5	4	2	1
R:R:R61	R:R:W100	5	2	Yes	Yes	5	3	2	1
R:R:R68	R:R:Y64	8.23	2	Yes	Yes	4	4	2	1
R:R:R310	R:R:Y64	11.32	0	Yes	Yes	5	4	2	1
R:R:D394	R:R:Y64	6.9	2	Yes	Yes	5	4	2	1
L:L:?1	R:R:Y64	7.16	2	Yes	Yes	0	4	0	1
R:R:D394	R:R:R68	8.34	2	Yes	Yes	5	4	2	2
R:R:S151	R:R:W100	4.94	0	No	Yes	4	3	2	1
R:R:E279	R:R:W100	3.27	2	No	Yes	4	3	1	1
L:L:?1	R:R:W100	4.64	2	Yes	Yes	0	3	0	1
R:R:S152	R:R:S176	6.52	2	No	No	9	7	1	2
R:R:S152	R:R:Y223	3.82	2	No	Yes	9	7	1	1
L:L:?1	R:R:S152	4.08	2	Yes	No	0	9	0	1
R:R:K396	R:R:S173	9.18	0	No	No	4	5	1	2
R:R:T175	R:R:V192	3.17	0	No	No	8	7	1	2
R:R:D195	R:R:T175	2.89	0	Yes	No	8	8	2	1
L:L:?1	R:R:T175	3	2	Yes	No	0	8	0	1
R:R:D195	R:R:S176	2.94	0	Yes	No	8	7	2	2
R:R:F399	R:R:V192	9.18	2	Yes	No	7	7	2	2
R:R:G224	R:R:Y223	4.35	0	No	Yes	8	7	2	1
R:R:F277	R:R:Y223	3.09	2	Yes	Yes	7	7	2	1
R:R:S304	R:R:Y223	3.82	2	Yes	Yes	8	7	2	1
R:R:D305	R:R:Y223	5.75	2	No	Yes	8	7	2	1
L:L:?1	R:R:Y223	19.1	2	Yes	Yes	0	7	0	1
R:R:E279	R:R:S250	5.75	2	No	No	4	3	1	2
R:R:F277	R:R:S304	6.61	2	Yes	Yes	7	8	2	2
L:L:?1	R:R:E279	6.3	2	Yes	No	0	4	0	1
R:R:D305	R:R:S304	5.89	2	No	Yes	8	8	2	2
L:L:?1	R:R:G306	3.48	2	Yes	No	0	5	0	1
R:R:F399	R:R:K396	6.2	2	Yes	No	7	4	2	1
L:L:?1	R:R:K396	2.87	2	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	6.33
Average Nodes In Shell	25.00
Average Hubs In Shell	12.00
Average Links In Shell	33.00
Average Links Mediated by Hubs In Shell	29.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of QUS in 8T7H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:R61	S:S:S42	6.59	1	Yes	No	5	6	2	2
S:S:S42	S:S:W100	7.41	1	No	Yes	6	3	2	1
S:S:R61	S:S:Y64	12.35	1	Yes	Yes	5	4	2	1
S:S:R61	S:S:W100	5	1	Yes	Yes	5	3	2	1
S:S:R68	S:S:Y64	9.26	1	Yes	Yes	4	4	2	1
S:S:R310	S:S:Y64	11.32	0	Yes	Yes	5	4	2	1
S:S:D394	S:S:Y64	5.75	1	Yes	Yes	5	4	2	1
M:M:?1	S:S:Y64	7.16	1	Yes	Yes	0	4	0	1
S:S:D394	S:S:R68	14.29	1	Yes	Yes	5	4	2	2
S:S:S151	S:S:W100	4.94	0	No	Yes	4	3	2	1
S:S:E279	S:S:W100	3.27	1	No	Yes	4	3	1	1
M:M:?1	S:S:W100	4.64	1	Yes	Yes	0	3	0	1
S:S:S152	S:S:S176	6.52	1	No	Yes	9	7	1	2
S:S:S152	S:S:Y223	3.82	1	No	Yes	9	7	1	1
M:M:?1	S:S:S152	4.08	1	Yes	No	0	9	0	1
S:S:K396	S:S:S173	9.18	0	Yes	No	4	5	1	2
S:S:T175	S:S:V192	3.17	0	No	No	8	7	1	2
S:S:D195	S:S:T175	2.89	0	Yes	No	8	8	2	1
M:M:?1	S:S:T175	3	1	Yes	No	0	8	0	1
S:S:D195	S:S:S176	2.94	0	Yes	Yes	8	7	2	2
S:S:F399	S:S:V192	9.18	1	Yes	No	7	7	2	2
S:S:G224	S:S:Y223	4.35	0	No	Yes	8	7	2	1
S:S:F277	S:S:Y223	3.09	1	Yes	Yes	7	7	2	1
S:S:S304	S:S:Y223	3.82	1	Yes	Yes	8	7	2	1
S:S:D305	S:S:Y223	5.75	1	Yes	Yes	8	7	2	1
M:M:?1	S:S:Y223	21.49	1	Yes	Yes	0	7	0	1
S:S:E279	S:S:S250	5.75	1	No	No	4	3	1	2
S:S:F277	S:S:S304	7.93	1	Yes	Yes	7	8	2	2
M:M:?1	S:S:E279	6.3	1	Yes	No	0	4	0	1
S:S:D305	S:S:S304	5.89	1	Yes	Yes	8	8	2	2
S:S:D305	S:S:K396	2.77	1	Yes	Yes	8	4	2	1
M:M:?1	S:S:G306	3.48	1	Yes	No	0	5	0	1
S:S:F399	S:S:K396	6.2	1	Yes	Yes	7	4	2	1
M:M:?1	S:S:K396	2.87	1	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	6.63
Average Nodes In Shell	25.00
Average Hubs In Shell	15.00
Average Links In Shell	34.00
Average Links Mediated by Hubs In Shell	32.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8T8M

Aminoacid

Metabotropic glutamate

mGlu5; mGlu5

Homo sapiens

Quisqualate

2023-10-11

10.1101/2023.08.29.555158

A 2D representation of the interactions of QUS in 8T8M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R61	R:R:S42	5.27	2	Yes	No	5	6	2	2
R:R:S42	R:R:W100	6.18	2	No	Yes	6	3	2	1
R:R:R61	R:R:Y64	13.38	2	Yes	Yes	5	4	2	1
R:R:R61	R:R:W100	5	2	Yes	Yes	5	3	2	1
R:R:R68	R:R:Y64	16.46	2	Yes	Yes	4	4	2	1
R:R:W100	R:R:Y64	3.86	2	Yes	Yes	3	4	1	1
R:R:R310	R:R:Y64	7.2	0	No	Yes	5	4	2	1
R:R:D394	R:R:Y64	3.45	2	Yes	Yes	5	4	2	1
L:L:?1	R:R:Y64	5.57	2	Yes	Yes	0	4	0	1
R:R:D394	R:R:R68	11.91	2	Yes	Yes	5	4	2	2
R:R:S151	R:R:W100	6.18	0	No	Yes	4	3	2	1
R:R:E279	R:R:W100	5.45	2	No	Yes	4	3	1	1
L:L:?1	R:R:W100	9.28	2	Yes	Yes	0	3	0	1
R:R:G150	R:R:S173	3.71	0	No	No	5	5	2	1
R:R:S152	R:R:S176	6.52	2	No	Yes	9	7	1	2
R:R:N222	R:R:S152	2.98	2	Yes	No	6	9	2	1
L:L:?1	R:R:S152	4.08	2	Yes	No	0	9	0	1
R:R:K396	R:R:S173	7.65	2	Yes	No	4	5	1	1
L:L:?1	R:R:S173	6.12	2	Yes	No	0	5	0	1
R:R:T175	R:R:V192	3.17	0	No	Yes	8	7	1	2
R:R:D195	R:R:T175	5.78	0	No	No	8	8	2	1
L:L:?1	R:R:T175	4	2	Yes	No	0	8	0	1
R:R:N222	R:R:S176	4.47	2	Yes	Yes	6	7	2	2
R:R:F399	R:R:V192	6.55	0	Yes	Yes	7	7	2	2
R:R:D195	R:R:F277	5.97	0	No	Yes	8	7	2	2
R:R:Q198	R:R:Y223	3.38	2	Yes	Yes	9	7	2	1
R:R:Q198	R:R:S304	4.33	2	Yes	Yes	9	8	2	2
R:R:D305	R:R:Q198	9.14	2	Yes	Yes	8	9	1	2
R:R:G224	R:R:Y223	2.9	0	No	Yes	8	7	2	1
R:R:F277	R:R:Y223	12.38	2	Yes	Yes	7	7	2	1
R:R:S304	R:R:Y223	6.36	2	Yes	Yes	8	7	2	1
R:R:D305	R:R:Y223	5.75	2	Yes	Yes	8	7	1	1
L:L:?1	R:R:Y223	14.33	2	Yes	Yes	0	7	0	1
R:R:E279	R:R:S250	2.87	2	No	Yes	4	3	1	2
R:R:F277	R:R:S304	6.61	2	Yes	Yes	7	8	2	2
L:L:?1	R:R:E279	6.3	2	Yes	No	0	4	0	1
R:R:D305	R:R:S304	2.94	2	Yes	Yes	8	8	1	2
R:R:D305	R:R:G306	3.35	2	Yes	No	8	5	1	1
R:R:D305	R:R:K396	4.15	2	Yes	Yes	8	4	1	1
L:L:?1	R:R:D305	8.29	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:G306	5.81	2	Yes	No	0	5	0	1
R:R:F399	R:R:K396	3.72	0	Yes	Yes	7	4	2	1
L:L:?1	R:R:K396	5.75	2	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	6.95
Average Nodes In Shell	28.00
Average Hubs In Shell	17.00
Average Links In Shell	43.00
Average Links Mediated by Hubs In Shell	41.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of QUS in 8T8M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:R61	S:S:S42	6.59	1	Yes	No	5	6	2	2
S:S:S42	S:S:W100	4.94	1	No	Yes	6	3	2	1
S:S:R61	S:S:Y64	12.35	1	Yes	Yes	5	4	2	1
S:S:R61	S:S:W100	4	1	Yes	Yes	5	3	2	1
S:S:R68	S:S:Y64	8.23	1	Yes	Yes	4	4	2	1
S:S:W100	S:S:Y64	3.86	1	Yes	Yes	3	4	1	1
S:S:R310	S:S:Y64	10.29	1	Yes	Yes	5	4	2	1
M:M:?1	S:S:Y64	7.96	1	Yes	Yes	0	4	0	1
S:S:S151	S:S:W100	8.65	0	No	Yes	4	3	2	1
S:S:E279	S:S:W100	9.81	1	Yes	Yes	4	3	1	1
M:M:?1	S:S:W100	9.28	1	Yes	Yes	0	3	0	1
S:S:S152	S:S:S176	6.52	1	Yes	Yes	9	7	1	2
S:S:N222	S:S:S152	2.98	1	Yes	Yes	6	9	2	1
S:S:S152	S:S:Y223	3.82	1	Yes	Yes	9	7	1	1
M:M:?1	S:S:S152	4.08	1	Yes	Yes	0	9	0	1
S:S:T175	S:S:V192	3.17	0	No	Yes	8	7	1	2
S:S:D195	S:S:T175	2.89	1	Yes	No	8	8	2	1
M:M:?1	S:S:T175	6.01	1	Yes	No	0	8	0	1
S:S:N222	S:S:S176	5.96	1	Yes	Yes	6	7	2	2
S:S:D195	S:S:F277	4.78	1	Yes	No	8	7	2	2
S:S:S250	S:S:T219	3.2	1	Yes	Yes	3	5	2	2
S:S:E279	S:S:T219	4.23	1	Yes	Yes	4	5	1	2
S:S:G224	S:S:Y223	4.35	0	No	Yes	8	7	2	1
S:S:F277	S:S:Y223	10.32	1	No	Yes	7	7	2	1
S:S:S304	S:S:Y223	5.09	0	No	Yes	8	7	2	1
M:M:?1	S:S:Y223	12.74	1	Yes	Yes	0	7	0	1
S:S:E279	S:S:S250	2.87	1	Yes	Yes	4	3	1	2
M:M:?1	S:S:E279	8.1	1	Yes	Yes	0	4	0	1
M:M:?1	S:S:G306	4.65	1	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	7.55
Average Nodes In Shell	22.00
Average Hubs In Shell	15.00
Average Links In Shell	29.00
Average Links Mediated by Hubs In Shell	29.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8TAO

Aminoacid

Metabotropic glutamate

mGlu5; mGlu5

Homo sapiens

Quisqualate

CDPPB

2.9

2023-10-11

10.1101/2023.08.29.555158

A 2D representation of the interactions of QUS in 8TAO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R61	R:R:S42	6.59	2	Yes	No	5	6	2	2
R:R:S42	R:R:W100	4.94	2	No	Yes	6	3	2	1
R:R:R61	R:R:Y64	11.32	2	Yes	Yes	5	4	2	1
R:R:R61	R:R:W100	4	2	Yes	Yes	5	3	2	1
R:R:R68	R:R:Y64	12.35	2	Yes	Yes	4	4	2	1
R:R:W100	R:R:Y64	3.86	2	Yes	Yes	3	4	1	1
R:R:R310	R:R:Y64	11.32	2	No	Yes	5	4	1	1
L:L:?1	R:R:Y64	7.96	2	Yes	Yes	0	4	0	1
R:R:R68	R:R:Y172	7.2	2	Yes	Yes	4	7	2	2
R:R:S151	R:R:W100	8.65	0	No	Yes	4	3	2	1
R:R:E279	R:R:W100	5.45	2	No	Yes	4	3	1	1
L:L:?1	R:R:W100	8.51	2	Yes	Yes	0	3	0	1
R:R:S152	R:R:S176	6.52	2	No	Yes	9	7	1	2
R:R:L179	R:R:S152	3	2	Yes	No	8	9	2	1
L:L:?1	R:R:S152	4.08	2	Yes	No	0	9	0	1
R:R:S173	R:R:Y172	5.09	2	No	Yes	5	7	1	2
R:R:K396	R:R:S173	4.59	2	No	No	4	5	1	1
L:L:?1	R:R:S173	4.08	2	Yes	No	0	5	0	1
R:R:T175	R:R:V192	3.17	0	No	Yes	8	7	1	2
L:L:?1	R:R:T175	3	2	Yes	No	0	8	0	1
R:R:L179	R:R:S176	3	2	Yes	Yes	8	7	2	2
R:R:D305	R:R:Q198	14.36	2	Yes	No	8	9	1	2
R:R:G224	R:R:Y223	4.35	2	No	Yes	8	7	2	1
R:R:F277	R:R:Y223	17.54	2	Yes	Yes	7	7	2	1
R:R:S304	R:R:Y223	3.82	2	No	Yes	8	7	2	1
R:R:D305	R:R:Y223	6.9	2	Yes	Yes	8	7	1	1
L:L:?1	R:R:Y223	13.53	2	Yes	Yes	0	7	0	1
R:R:F277	R:R:G224	3.01	2	Yes	No	7	8	2	2
R:R:F277	R:R:S304	7.93	2	Yes	No	7	8	2	2
L:L:?1	R:R:E279	5.4	2	Yes	No	0	4	0	1
R:R:G280	R:R:R310	3	0	No	No	3	5	2	1
R:R:D305	R:R:S304	2.94	2	Yes	No	8	8	1	2
R:R:D305	R:R:G306	3.35	2	Yes	No	8	5	1	1
L:L:?1	R:R:D305	4.61	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:G306	4.65	2	Yes	No	0	5	0	1
L:L:?1	R:R:R310	3.3	2	Yes	No	0	5	0	1
L:L:?1	R:R:K396	5.75	2	Yes	No	0	4	0	1
R:R:E279	R:R:S250	2.87	2	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	11.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	5.90
Average Nodes In Shell	26.00
Average Hubs In Shell	12.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	35.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of QUS in 8TAO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:R61	S:S:S42	6.59	0	No	No	5	6	2	2
S:S:S42	S:S:W100	4.94	0	No	Yes	6	3	2	1
S:S:R61	S:S:Y64	12.35	0	No	Yes	5	4	2	1
S:S:R68	S:S:Y64	10.29	1	Yes	Yes	4	4	2	1
S:S:W100	S:S:Y64	4.82	1	Yes	Yes	3	4	1	1
S:S:R310	S:S:Y64	10.29	1	Yes	Yes	5	4	2	1
M:M:?1	S:S:Y64	7.96	1	Yes	Yes	0	4	0	1
S:S:S151	S:S:W100	4.94	0	No	Yes	4	3	2	1
S:S:E279	S:S:W100	5.45	1	Yes	Yes	4	3	1	1
M:M:?1	S:S:W100	7.73	1	Yes	Yes	0	3	0	1
S:S:G150	S:S:S173	3.71	0	No	No	5	5	2	1
S:S:S152	S:S:S176	6.52	1	No	Yes	9	7	1	2
S:S:N222	S:S:S152	5.96	1	Yes	No	6	9	2	1
M:M:?1	S:S:S152	4.08	1	Yes	No	0	9	0	1
S:S:K396	S:S:S173	7.65	0	No	No	4	5	2	1
M:M:?1	S:S:S173	8.16	1	Yes	No	0	5	0	1
S:S:T175	S:S:V192	3.17	0	No	Yes	8	7	1	2
S:S:D195	S:S:T175	7.23	0	No	No	8	8	2	1
M:M:?1	S:S:T175	4	1	Yes	No	0	8	0	1
S:S:N222	S:S:S176	4.47	1	Yes	Yes	6	7	2	2
S:S:D195	S:S:Q198	7.83	0	No	Yes	8	9	2	2
S:S:D195	S:S:Y223	5.75	0	No	Yes	8	7	2	1
S:S:Q198	S:S:S304	2.89	1	Yes	No	9	8	2	2
S:S:D305	S:S:Q198	13.05	1	Yes	Yes	8	9	1	2
S:S:E279	S:S:T219	4.23	1	Yes	No	4	5	1	2
S:S:G224	S:S:Y223	4.35	0	No	Yes	8	7	2	1
S:S:F277	S:S:Y223	3.09	0	Yes	Yes	7	7	2	1
S:S:S304	S:S:Y223	3.82	1	No	Yes	8	7	2	1
S:S:D305	S:S:Y223	4.6	1	Yes	Yes	8	7	1	1
M:M:?1	S:S:Y223	19.9	1	Yes	Yes	0	7	0	1
S:S:E279	S:S:S250	5.75	1	Yes	No	4	3	1	2
M:M:?1	S:S:E279	5.4	1	Yes	Yes	0	4	0	1
S:S:D305	S:S:S304	2.94	1	Yes	No	8	8	1	2
S:S:D305	S:S:G306	3.35	1	Yes	No	8	5	1	1
M:M:?1	S:S:D305	3.69	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:G306	4.65	1	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	7.29
Average Nodes In Shell	27.00
Average Hubs In Shell	13.00
Average Links In Shell	36.00
Average Links Mediated by Hubs In Shell	32.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	9.09
Average Number Of Links With An Hub	5.27
Average Interaction Strength	7.32
Average Nodes In Shell	26.91
Average Hubs In Shell	15.73
Average Links In Shell	39.55
Average Links Mediated by Hubs In Shell	37.55

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)