Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6N51 | C | Aminoacid | Metabotropic glutamate | mGlu5; mGlu5 | Homo sapiens | Quisqualate | - | - | 4 | 2019-01-23 | 10.1038/s41586-019-0881-4 |
![](/psngpcr/ligands/QUS/QUS_6N51_L_L_903.png)
A 2D representation of the interactions of QUS in 6N51 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:S42 | S:S:W100 | 12.36 | 0 | No | Yes | 6 | 3 | 2 | 1 | S:S:Q46 | S:S:W100 | 4.38 | 1 | Yes | Yes | 3 | 3 | 2 | 1 | S:S:Q46 | S:S:S250 | 4.33 | 1 | Yes | No | 3 | 3 | 2 | 2 | S:S:R61 | S:S:Y64 | 7.2 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:R61 | S:S:W100 | 13.99 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | S:S:R310 | S:S:R61 | 8.53 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | S:S:R68 | S:S:Y64 | 7.2 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | S:S:W100 | S:S:Y64 | 4.82 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | S:S:R310 | S:S:Y64 | 13.38 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:D394 | S:S:Y64 | 4.6 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:K396 | S:S:Y64 | 3.58 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | L:L:?903 | S:S:Y64 | 10.35 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:R68 | S:S:Y172 | 5.14 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | S:S:D394 | S:S:R68 | 9.53 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | L:L:?903 | S:S:W100 | 7.73 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | S:S:S152 | S:S:S176 | 6.52 | 1 | No | Yes | 9 | 7 | 1 | 2 | S:S:S152 | S:S:Y223 | 5.09 | 1 | No | Yes | 9 | 7 | 1 | 1 | L:L:?903 | S:S:S152 | 4.08 | 1 | Yes | No | 0 | 9 | 0 | 1 | S:S:S173 | S:S:Y172 | 6.36 | 1 | No | Yes | 5 | 7 | 1 | 2 | S:S:K396 | S:S:S173 | 3.06 | 1 | Yes | No | 4 | 5 | 1 | 1 | L:L:?903 | S:S:S173 | 4.08 | 1 | Yes | No | 0 | 5 | 0 | 1 | S:S:T175 | S:S:V192 | 3.17 | 1 | No | No | 8 | 7 | 1 | 2 | S:S:T175 | S:S:Y223 | 3.75 | 1 | No | Yes | 8 | 7 | 1 | 1 | L:L:?903 | S:S:T175 | 8.01 | 1 | Yes | No | 0 | 8 | 0 | 1 | S:S:D195 | S:S:S176 | 2.94 | 0 | Yes | Yes | 8 | 7 | 2 | 2 | S:S:D195 | S:S:Q198 | 5.22 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | S:S:D195 | S:S:Y223 | 4.6 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | S:S:D305 | S:S:Q198 | 11.75 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | S:S:E279 | S:S:T219 | 4.23 | 0 | No | No | 4 | 5 | 1 | 2 | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | S:S:S304 | S:S:Y223 | 5.09 | 1 | No | Yes | 8 | 7 | 2 | 1 | S:S:D305 | S:S:Y223 | 5.75 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?903 | S:S:Y223 | 16.72 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:E279 | S:S:S250 | 7.19 | 0 | No | No | 4 | 3 | 1 | 2 | L:L:?903 | S:S:E279 | 4.5 | 1 | Yes | No | 0 | 4 | 0 | 1 | S:S:D305 | S:S:S304 | 2.94 | 1 | Yes | No | 8 | 8 | 1 | 2 | S:S:D305 | S:S:K396 | 4.15 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | L:L:?903 | S:S:D305 | 4.61 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?903 | S:S:G306 | 4.65 | 1 | Yes | No | 0 | 5 | 0 | 1 | S:S:D394 | S:S:S395 | 2.94 | 1 | Yes | No | 5 | 5 | 2 | 2 | S:S:K396 | S:S:S395 | 4.59 | 1 | Yes | No | 4 | 5 | 1 | 2 | L:L:?903 | S:S:K396 | 4.79 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 6.95 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 42.00 | Average Links Mediated by Hubs In Shell | 39.00 |
| ![](/psngpcr/ligands/QUS/QUS_6N51_L_L_903_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_6N51_L_L_903_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/QUS/QUS_6N51_M_M_903.png)
A 2D representation of the interactions of QUS in 6N51 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:S42 | R:R:W100 | 12.36 | 0 | No | Yes | 6 | 3 | 2 | 1 | R:R:Q46 | R:R:W100 | 4.38 | 2 | Yes | Yes | 3 | 3 | 2 | 1 | R:R:Q46 | R:R:S250 | 4.33 | 2 | Yes | No | 3 | 3 | 2 | 2 | R:R:R61 | R:R:Y64 | 7.2 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:R61 | R:R:W100 | 13.99 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | R:R:R310 | R:R:R61 | 8.53 | 2 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:R68 | R:R:Y64 | 7.2 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:W100 | R:R:Y64 | 4.82 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | R:R:R310 | R:R:Y64 | 13.38 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:D394 | R:R:Y64 | 4.6 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:K396 | R:R:Y64 | 3.58 | 2 | Yes | Yes | 4 | 4 | 1 | 1 | M:M:?903 | R:R:Y64 | 11.94 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:R68 | R:R:Y172 | 5.14 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | R:R:D394 | R:R:R68 | 9.53 | 2 | Yes | Yes | 5 | 4 | 2 | 2 | M:M:?903 | R:R:W100 | 7.73 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:S152 | R:R:S176 | 6.52 | 2 | No | Yes | 9 | 7 | 1 | 2 | R:R:S152 | R:R:Y223 | 5.09 | 2 | No | Yes | 9 | 7 | 1 | 1 | M:M:?903 | R:R:S152 | 3.06 | 2 | Yes | No | 0 | 9 | 0 | 1 | R:R:S173 | R:R:Y172 | 6.36 | 2 | No | Yes | 5 | 7 | 1 | 2 | R:R:K396 | R:R:S173 | 3.06 | 2 | Yes | No | 4 | 5 | 1 | 1 | M:M:?903 | R:R:S173 | 5.1 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:T175 | R:R:V192 | 3.17 | 2 | No | No | 8 | 7 | 1 | 2 | R:R:T175 | R:R:Y223 | 3.75 | 2 | No | Yes | 8 | 7 | 1 | 1 | M:M:?903 | R:R:T175 | 6.01 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:D195 | R:R:S176 | 2.94 | 0 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:D195 | R:R:Q198 | 5.22 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:D195 | R:R:Y223 | 4.6 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:D305 | R:R:Q198 | 11.75 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | R:R:E279 | R:R:T219 | 4.23 | 0 | No | No | 4 | 5 | 1 | 2 | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:S304 | R:R:Y223 | 5.09 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:D305 | R:R:Y223 | 5.75 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | M:M:?903 | R:R:Y223 | 15.12 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:E279 | R:R:S250 | 7.19 | 0 | No | No | 4 | 3 | 1 | 2 | M:M:?903 | R:R:E279 | 4.5 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:D305 | R:R:S304 | 2.94 | 2 | Yes | No | 8 | 8 | 1 | 2 | R:R:D305 | R:R:K396 | 4.15 | 2 | Yes | Yes | 8 | 4 | 1 | 1 | M:M:?903 | R:R:D305 | 5.53 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | M:M:?903 | R:R:G306 | 4.65 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:D394 | R:R:S395 | 2.94 | 2 | Yes | No | 5 | 5 | 2 | 2 | R:R:K396 | R:R:S395 | 4.59 | 2 | Yes | No | 4 | 5 | 1 | 2 | M:M:?903 | R:R:K396 | 5.75 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 6.94 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 42.00 | Average Links Mediated by Hubs In Shell | 39.00 |
| ![](/psngpcr/ligands/QUS/QUS_6N51_M_M_903_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_6N51_M_M_903_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DGE | C | Aminoacid | Metabotropic glutamate | mGlu1; mGlu1 | Homo sapiens | Quisqualate | - | - | 3.65 | 2021-09-22 | 10.1007/s13238-020-00808-5 |
![](/psngpcr/ligands/QUS/QUS_7DGE_L_L_901.png)
A 2D representation of the interactions of QUS in 7DGE colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R71 | R:R:S52 | 7.91 | 1 | Yes | No | 4 | 5 | 2 | 2 | R:R:S52 | R:R:Y74 | 5.09 | 1 | No | Yes | 5 | 5 | 2 | 1 | R:R:S52 | R:R:W110 | 7.41 | 1 | No | Yes | 5 | 3 | 2 | 1 | R:R:Q56 | R:R:W110 | 4.38 | 0 | Yes | Yes | 3 | 3 | 2 | 1 | R:R:R71 | R:R:Y74 | 16.46 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | R:R:R78 | R:R:Y74 | 21.61 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | R:R:W110 | R:R:Y74 | 8.68 | 1 | Yes | Yes | 3 | 5 | 1 | 1 | R:R:R323 | R:R:Y74 | 14.4 | 1 | Yes | Yes | 5 | 5 | 1 | 1 | R:R:E325 | R:R:Y74 | 5.61 | 1 | Yes | Yes | 1 | 5 | 2 | 1 | L:L:?901 | R:R:Y74 | 9.55 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:R78 | R:R:Y185 | 6.17 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | R:R:K409 | R:R:R78 | 6.19 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:S164 | R:R:W110 | 14.83 | 0 | No | Yes | 5 | 3 | 2 | 1 | R:R:E292 | R:R:W110 | 8.72 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | L:L:?901 | R:R:W110 | 8.51 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:S165 | R:R:S189 | 6.52 | 0 | No | No | 9 | 7 | 1 | 2 | L:L:?901 | R:R:S165 | 6.12 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:S186 | R:R:Y185 | 3.82 | 1 | No | Yes | 5 | 8 | 1 | 2 | R:R:K409 | R:R:S186 | 12.24 | 1 | Yes | No | 4 | 5 | 1 | 1 | L:L:?901 | R:R:S186 | 4.08 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:D208 | R:R:T188 | 10.12 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:T188 | R:R:Y236 | 4.99 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:D318 | R:R:T188 | 4.34 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?901 | R:R:T188 | 10.01 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:D208 | R:R:Q211 | 5.22 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:D208 | R:R:Y236 | 10.34 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:D208 | R:R:F290 | 5.97 | 1 | Yes | Yes | 8 | 6 | 2 | 2 | R:R:Q211 | R:R:S317 | 8.66 | 0 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:D318 | R:R:Q211 | 6.53 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | R:R:E292 | R:R:T232 | 15.52 | 1 | Yes | No | 4 | 5 | 1 | 2 | R:R:F290 | R:R:Y236 | 7.22 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:E292 | R:R:Y236 | 5.61 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | R:R:S317 | R:R:Y236 | 5.09 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:G319 | R:R:Y236 | 4.35 | 1 | No | Yes | 5 | 7 | 1 | 1 | L:L:?901 | R:R:Y236 | 24.68 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F290 | R:R:S317 | 10.57 | 1 | Yes | Yes | 6 | 8 | 2 | 2 | L:L:?901 | R:R:E292 | 5.4 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:G293 | R:R:R323 | 4.5 | 1 | No | Yes | 3 | 5 | 2 | 1 | R:R:G293 | R:R:V326 | 3.68 | 1 | No | Yes | 3 | 4 | 2 | 2 | R:R:D318 | R:R:L342 | 13.57 | 1 | Yes | Yes | 8 | 4 | 1 | 2 | R:R:D318 | R:R:K409 | 9.68 | 1 | Yes | Yes | 8 | 4 | 1 | 1 | L:L:?901 | R:R:D318 | 4.61 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?901 | R:R:G319 | 6.97 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:E325 | R:R:R323 | 12.79 | 1 | Yes | Yes | 1 | 5 | 2 | 1 | R:R:R323 | R:R:V326 | 7.85 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | L:L:?901 | R:R:R323 | 4.95 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:K409 | R:R:L342 | 4.23 | 1 | Yes | Yes | 4 | 4 | 1 | 2 | R:R:F412 | R:R:L342 | 10.96 | 1 | Yes | Yes | 7 | 4 | 2 | 2 | R:R:K409 | R:R:S408 | 12.24 | 1 | Yes | No | 4 | 6 | 1 | 2 | R:R:F412 | R:R:K409 | 3.72 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | L:L:?901 | R:R:K409 | 4.79 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:A321 | R:R:D318 | 3.09 | 0 | No | Yes | 6 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 8.15 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 21.00 | Average Links In Shell | 52.00 | Average Links Mediated by Hubs In Shell | 51.00 |
| ![](/psngpcr/ligands/QUS/QUS_7DGE_L_L_901_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_7DGE_L_L_901_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7FD8 | C | Aminoacid | Metabotropic glutamate | mGlu5; mGlu5 | Homo sapiens | Quisqualate | - | - | 3.8 | 2021-09-08 | 10.1016/j.celrep.2021.109648 |
![](/psngpcr/ligands/QUS/QUS_7FD8_L_L_902.png)
A 2D representation of the interactions of QUS in 7FD8 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R61 | R:R:S42 | 5.27 | 1 | Yes | No | 5 | 6 | 2 | 2 | R:R:S42 | R:R:W100 | 9.88 | 1 | No | Yes | 6 | 3 | 2 | 1 | R:R:R61 | R:R:Y64 | 12.35 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:R61 | R:R:W100 | 4 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | R:R:R68 | R:R:Y64 | 13.38 | 3 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:R310 | R:R:Y64 | 22.64 | 31 | No | Yes | 5 | 4 | 2 | 1 | L:L:?902 | R:R:Y64 | 10.35 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:G150 | R:R:W100 | 2.81 | 0 | No | Yes | 5 | 3 | 2 | 1 | R:R:S151 | R:R:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | R:R:E279 | R:R:W100 | 6.54 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | L:L:?902 | R:R:W100 | 10.05 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:I156 | R:R:S152 | 3.1 | 1 | Yes | Yes | 5 | 9 | 2 | 1 | R:R:S152 | R:R:S176 | 6.52 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | R:R:L179 | R:R:S152 | 4.5 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | L:L:?902 | R:R:S152 | 3.06 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:I156 | R:R:L179 | 8.56 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | R:R:K396 | R:R:S173 | 7.65 | 0 | Yes | No | 4 | 5 | 1 | 2 | R:R:T175 | R:R:V192 | 3.17 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:D195 | R:R:T175 | 5.78 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:T175 | R:R:Y223 | 3.75 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | R:R:D305 | R:R:T175 | 4.34 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | L:L:?902 | R:R:T175 | 7.01 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:L179 | R:R:S176 | 4.5 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:D195 | R:R:S176 | 2.94 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:D195 | R:R:F277 | 4.78 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:E279 | R:R:T219 | 12.7 | 1 | Yes | No | 4 | 5 | 1 | 2 | R:R:T219 | R:R:T282 | 7.85 | 1 | No | Yes | 5 | 4 | 2 | 2 | R:R:G224 | R:R:Y223 | 4.35 | 1 | No | Yes | 8 | 7 | 2 | 1 | R:R:F277 | R:R:Y223 | 10.32 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:S304 | R:R:Y223 | 3.82 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:D305 | R:R:Y223 | 6.9 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | L:L:?902 | R:R:Y223 | 23.88 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F277 | R:R:G224 | 3.01 | 1 | Yes | No | 7 | 8 | 2 | 2 | R:R:E279 | R:R:S250 | 8.62 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:S250 | R:R:T282 | 4.8 | 1 | No | Yes | 3 | 4 | 2 | 2 | R:R:F277 | R:R:S304 | 10.57 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:E279 | R:R:T282 | 4.23 | 1 | Yes | Yes | 4 | 4 | 1 | 2 | L:L:?902 | R:R:E279 | 6.3 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:D305 | R:R:S304 | 5.89 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:D305 | R:R:K396 | 5.53 | 1 | Yes | Yes | 8 | 4 | 2 | 1 | L:L:?902 | R:R:G306 | 6.97 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:K396 | R:R:S395 | 4.59 | 0 | Yes | No | 4 | 5 | 1 | 2 | L:L:?902 | R:R:K396 | 3.83 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 8.93 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 19.00 | Average Links In Shell | 43.00 | Average Links Mediated by Hubs In Shell | 43.00 |
| ![](/psngpcr/ligands/QUS/QUS_7FD8_L_L_902_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_7FD8_L_L_902_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/QUS/QUS_7FD8_M_M_902.png)
A 2D representation of the interactions of QUS in 7FD8 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:R61 | S:S:S42 | 5.27 | 2 | Yes | No | 5 | 6 | 2 | 2 | S:S:S42 | S:S:W100 | 9.88 | 2 | No | Yes | 6 | 3 | 2 | 1 | S:S:R61 | S:S:Y64 | 12.35 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:R61 | S:S:W100 | 4 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | S:S:R68 | S:S:Y64 | 13.38 | 4 | Yes | Yes | 4 | 4 | 2 | 1 | S:S:R310 | S:S:Y64 | 22.64 | 44 | No | Yes | 5 | 4 | 2 | 1 | M:M:?902 | S:S:Y64 | 10.35 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:G150 | S:S:W100 | 2.81 | 0 | No | Yes | 5 | 3 | 2 | 1 | S:S:S151 | S:S:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | S:S:E279 | S:S:W100 | 6.54 | 2 | Yes | Yes | 4 | 3 | 1 | 1 | M:M:?902 | S:S:W100 | 10.05 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | S:S:I156 | S:S:S152 | 3.1 | 2 | Yes | Yes | 5 | 9 | 2 | 1 | S:S:S152 | S:S:S176 | 6.52 | 2 | Yes | Yes | 9 | 7 | 1 | 2 | S:S:L179 | S:S:S152 | 4.5 | 2 | Yes | Yes | 8 | 9 | 2 | 1 | M:M:?902 | S:S:S152 | 3.06 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | S:S:I156 | S:S:L179 | 8.56 | 2 | Yes | Yes | 5 | 8 | 2 | 2 | S:S:K396 | S:S:S173 | 7.65 | 0 | Yes | No | 4 | 5 | 1 | 2 | S:S:T175 | S:S:V192 | 3.17 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | S:S:D195 | S:S:T175 | 5.78 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | S:S:T175 | S:S:Y223 | 3.75 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | S:S:D305 | S:S:T175 | 4.34 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | M:M:?902 | S:S:T175 | 7.01 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:L179 | S:S:S176 | 4.5 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | S:S:D195 | S:S:S176 | 2.94 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | S:S:D195 | S:S:F277 | 4.78 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | S:S:E279 | S:S:T219 | 12.7 | 2 | Yes | No | 4 | 5 | 1 | 2 | S:S:T219 | S:S:T282 | 7.85 | 2 | No | Yes | 5 | 4 | 2 | 2 | S:S:G224 | S:S:Y223 | 4.35 | 2 | No | Yes | 8 | 7 | 2 | 1 | S:S:F277 | S:S:Y223 | 10.32 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | S:S:S304 | S:S:Y223 | 3.82 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | S:S:D305 | S:S:Y223 | 6.9 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | M:M:?902 | S:S:Y223 | 23.88 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:F277 | S:S:G224 | 3.01 | 2 | Yes | No | 7 | 8 | 2 | 2 | S:S:E279 | S:S:S250 | 8.62 | 2 | Yes | No | 4 | 3 | 1 | 2 | S:S:S250 | S:S:T282 | 4.8 | 2 | No | Yes | 3 | 4 | 2 | 2 | S:S:F277 | S:S:S304 | 10.57 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | S:S:E279 | S:S:T282 | 4.23 | 2 | Yes | Yes | 4 | 4 | 1 | 2 | M:M:?902 | S:S:E279 | 6.3 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:D305 | S:S:S304 | 5.89 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | S:S:D305 | S:S:K396 | 5.53 | 2 | Yes | Yes | 8 | 4 | 2 | 1 | M:M:?902 | S:S:G306 | 6.97 | 2 | Yes | No | 0 | 5 | 0 | 1 | S:S:K396 | S:S:S395 | 4.59 | 0 | Yes | No | 4 | 5 | 1 | 2 | M:M:?902 | S:S:K396 | 3.83 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 8.93 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 19.00 | Average Links In Shell | 43.00 | Average Links Mediated by Hubs In Shell | 43.00 |
| ![](/psngpcr/ligands/QUS/QUS_7FD8_M_M_902_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_7FD8_M_M_902_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8T7H | C | Aminoacid | Metabotropic glutamate | mGlu5; mGlu5 | Homo sapiens | Quisqualate | - | - | 3.3 | 2023-10-11 | 10.1101/2023.08.29.555158 |
![](/psngpcr/ligands/QUS/QUS_8T7H_L_L_1.png)
A 2D representation of the interactions of QUS in 8T7H colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R61 | R:R:S42 | 6.59 | 2 | Yes | No | 5 | 6 | 2 | 2 | R:R:S42 | R:R:W100 | 7.41 | 2 | No | Yes | 6 | 3 | 2 | 1 | R:R:R61 | R:R:Y64 | 12.35 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:R61 | R:R:W100 | 5 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | R:R:R68 | R:R:Y64 | 8.23 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:R310 | R:R:Y64 | 11.32 | 0 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:D394 | R:R:Y64 | 6.9 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:Y64 | 7.16 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:D394 | R:R:R68 | 8.34 | 2 | Yes | Yes | 5 | 4 | 2 | 2 | R:R:S151 | R:R:W100 | 4.94 | 0 | No | Yes | 4 | 3 | 2 | 1 | R:R:E279 | R:R:W100 | 3.27 | 2 | No | Yes | 4 | 3 | 1 | 1 | L:L:?1 | R:R:W100 | 4.64 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:S152 | R:R:S176 | 6.52 | 2 | No | No | 9 | 7 | 1 | 2 | R:R:S152 | R:R:Y223 | 3.82 | 2 | No | Yes | 9 | 7 | 1 | 1 | L:L:?1 | R:R:S152 | 4.08 | 2 | Yes | No | 0 | 9 | 0 | 1 | R:R:K396 | R:R:S173 | 9.18 | 0 | No | No | 4 | 5 | 1 | 2 | R:R:T175 | R:R:V192 | 3.17 | 0 | No | No | 8 | 7 | 1 | 2 | R:R:D195 | R:R:T175 | 2.89 | 0 | Yes | No | 8 | 8 | 2 | 1 | L:L:?1 | R:R:T175 | 3 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:D195 | R:R:S176 | 2.94 | 0 | Yes | No | 8 | 7 | 2 | 2 | R:R:F399 | R:R:V192 | 9.18 | 2 | Yes | No | 7 | 7 | 2 | 2 | R:R:G224 | R:R:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:F277 | R:R:Y223 | 3.09 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:S304 | R:R:Y223 | 3.82 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:D305 | R:R:Y223 | 5.75 | 2 | No | Yes | 8 | 7 | 2 | 1 | L:L:?1 | R:R:Y223 | 19.1 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:E279 | R:R:S250 | 5.75 | 2 | No | No | 4 | 3 | 1 | 2 | R:R:F277 | R:R:S304 | 6.61 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | L:L:?1 | R:R:E279 | 6.3 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:D305 | R:R:S304 | 5.89 | 2 | No | Yes | 8 | 8 | 2 | 2 | L:L:?1 | R:R:G306 | 3.48 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:F399 | R:R:K396 | 6.2 | 2 | Yes | No | 7 | 4 | 2 | 1 | L:L:?1 | R:R:K396 | 2.87 | 2 | Yes | No | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 6.33 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/QUS/QUS_8T7H_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_8T7H_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/QUS/QUS_8T7H_M_M_1.png)
A 2D representation of the interactions of QUS in 8T7H colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:R61 | S:S:S42 | 6.59 | 1 | Yes | No | 5 | 6 | 2 | 2 | S:S:S42 | S:S:W100 | 7.41 | 1 | No | Yes | 6 | 3 | 2 | 1 | S:S:R61 | S:S:Y64 | 12.35 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:R61 | S:S:W100 | 5 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | S:S:R68 | S:S:Y64 | 9.26 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | S:S:R310 | S:S:Y64 | 11.32 | 0 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:D394 | S:S:Y64 | 5.75 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | M:M:?1 | S:S:Y64 | 7.16 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:D394 | S:S:R68 | 14.29 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | S:S:S151 | S:S:W100 | 4.94 | 0 | No | Yes | 4 | 3 | 2 | 1 | S:S:E279 | S:S:W100 | 3.27 | 1 | No | Yes | 4 | 3 | 1 | 1 | M:M:?1 | S:S:W100 | 4.64 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | S:S:S152 | S:S:S176 | 6.52 | 1 | No | Yes | 9 | 7 | 1 | 2 | S:S:S152 | S:S:Y223 | 3.82 | 1 | No | Yes | 9 | 7 | 1 | 1 | M:M:?1 | S:S:S152 | 4.08 | 1 | Yes | No | 0 | 9 | 0 | 1 | S:S:K396 | S:S:S173 | 9.18 | 0 | Yes | No | 4 | 5 | 1 | 2 | S:S:T175 | S:S:V192 | 3.17 | 0 | No | No | 8 | 7 | 1 | 2 | S:S:D195 | S:S:T175 | 2.89 | 0 | Yes | No | 8 | 8 | 2 | 1 | M:M:?1 | S:S:T175 | 3 | 1 | Yes | No | 0 | 8 | 0 | 1 | S:S:D195 | S:S:S176 | 2.94 | 0 | Yes | Yes | 8 | 7 | 2 | 2 | S:S:F399 | S:S:V192 | 9.18 | 1 | Yes | No | 7 | 7 | 2 | 2 | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | S:S:F277 | S:S:Y223 | 3.09 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | S:S:S304 | S:S:Y223 | 3.82 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | S:S:D305 | S:S:Y223 | 5.75 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | M:M:?1 | S:S:Y223 | 21.49 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:E279 | S:S:S250 | 5.75 | 1 | No | No | 4 | 3 | 1 | 2 | S:S:F277 | S:S:S304 | 7.93 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | M:M:?1 | S:S:E279 | 6.3 | 1 | Yes | No | 0 | 4 | 0 | 1 | S:S:D305 | S:S:S304 | 5.89 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | S:S:D305 | S:S:K396 | 2.77 | 1 | Yes | Yes | 8 | 4 | 2 | 1 | M:M:?1 | S:S:G306 | 3.48 | 1 | Yes | No | 0 | 5 | 0 | 1 | S:S:F399 | S:S:K396 | 6.2 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | M:M:?1 | S:S:K396 | 2.87 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 6.63 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| ![](/psngpcr/ligands/QUS/QUS_8T7H_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_8T7H_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8T8M | C | Aminoacid | Metabotropic glutamate | mGlu5; mGlu5 | Homo sapiens | Quisqualate | - | - | 3 | 2023-10-11 | 10.1101/2023.08.29.555158 |
![](/psngpcr/ligands/QUS/QUS_8T8M_L_L_1.png)
A 2D representation of the interactions of QUS in 8T8M colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R61 | R:R:S42 | 5.27 | 2 | Yes | No | 5 | 6 | 2 | 2 | R:R:S42 | R:R:W100 | 6.18 | 2 | No | Yes | 6 | 3 | 2 | 1 | R:R:R61 | R:R:Y64 | 13.38 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:R61 | R:R:W100 | 5 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | R:R:R68 | R:R:Y64 | 16.46 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:W100 | R:R:Y64 | 3.86 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | R:R:R310 | R:R:Y64 | 7.2 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:D394 | R:R:Y64 | 3.45 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:Y64 | 5.57 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:D394 | R:R:R68 | 11.91 | 2 | Yes | Yes | 5 | 4 | 2 | 2 | R:R:S151 | R:R:W100 | 6.18 | 0 | No | Yes | 4 | 3 | 2 | 1 | R:R:E279 | R:R:W100 | 5.45 | 2 | No | Yes | 4 | 3 | 1 | 1 | L:L:?1 | R:R:W100 | 9.28 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:G150 | R:R:S173 | 3.71 | 0 | No | No | 5 | 5 | 2 | 1 | R:R:S152 | R:R:S176 | 6.52 | 2 | No | Yes | 9 | 7 | 1 | 2 | R:R:N222 | R:R:S152 | 2.98 | 2 | Yes | No | 6 | 9 | 2 | 1 | L:L:?1 | R:R:S152 | 4.08 | 2 | Yes | No | 0 | 9 | 0 | 1 | R:R:K396 | R:R:S173 | 7.65 | 2 | Yes | No | 4 | 5 | 1 | 1 | L:L:?1 | R:R:S173 | 6.12 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:T175 | R:R:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | R:R:D195 | R:R:T175 | 5.78 | 0 | No | No | 8 | 8 | 2 | 1 | L:L:?1 | R:R:T175 | 4 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:N222 | R:R:S176 | 4.47 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F399 | R:R:V192 | 6.55 | 0 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:D195 | R:R:F277 | 5.97 | 0 | No | Yes | 8 | 7 | 2 | 2 | R:R:Q198 | R:R:Y223 | 3.38 | 2 | Yes | Yes | 9 | 7 | 2 | 1 | R:R:Q198 | R:R:S304 | 4.33 | 2 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:D305 | R:R:Q198 | 9.14 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | R:R:G224 | R:R:Y223 | 2.9 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:F277 | R:R:Y223 | 12.38 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:S304 | R:R:Y223 | 6.36 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:D305 | R:R:Y223 | 5.75 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:Y223 | 14.33 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:E279 | R:R:S250 | 2.87 | 2 | No | Yes | 4 | 3 | 1 | 2 | R:R:F277 | R:R:S304 | 6.61 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | L:L:?1 | R:R:E279 | 6.3 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:D305 | R:R:S304 | 2.94 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:D305 | R:R:G306 | 3.35 | 2 | Yes | No | 8 | 5 | 1 | 1 | R:R:D305 | R:R:K396 | 4.15 | 2 | Yes | Yes | 8 | 4 | 1 | 1 | L:L:?1 | R:R:D305 | 8.29 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:G306 | 5.81 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:F399 | R:R:K396 | 3.72 | 0 | Yes | Yes | 7 | 4 | 2 | 1 | L:L:?1 | R:R:K396 | 5.75 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 6.95 | Average Nodes In Shell | 28.00 | Average Hubs In Shell | 17.00 | Average Links In Shell | 43.00 | Average Links Mediated by Hubs In Shell | 41.00 |
| ![](/psngpcr/ligands/QUS/QUS_8T8M_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_8T8M_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/QUS/QUS_8T8M_M_M_1.png)
A 2D representation of the interactions of QUS in 8T8M colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:R61 | S:S:S42 | 6.59 | 1 | Yes | No | 5 | 6 | 2 | 2 | S:S:S42 | S:S:W100 | 4.94 | 1 | No | Yes | 6 | 3 | 2 | 1 | S:S:R61 | S:S:Y64 | 12.35 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:R61 | S:S:W100 | 4 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | S:S:R68 | S:S:Y64 | 8.23 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | S:S:W100 | S:S:Y64 | 3.86 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | S:S:R310 | S:S:Y64 | 10.29 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | M:M:?1 | S:S:Y64 | 7.96 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:S151 | S:S:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | S:S:E279 | S:S:W100 | 9.81 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | M:M:?1 | S:S:W100 | 9.28 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | S:S:S152 | S:S:S176 | 6.52 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | S:S:N222 | S:S:S152 | 2.98 | 1 | Yes | Yes | 6 | 9 | 2 | 1 | S:S:S152 | S:S:Y223 | 3.82 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | M:M:?1 | S:S:S152 | 4.08 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | S:S:T175 | S:S:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | S:S:D195 | S:S:T175 | 2.89 | 1 | Yes | No | 8 | 8 | 2 | 1 | M:M:?1 | S:S:T175 | 6.01 | 1 | Yes | No | 0 | 8 | 0 | 1 | S:S:N222 | S:S:S176 | 5.96 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | S:S:D195 | S:S:F277 | 4.78 | 1 | Yes | No | 8 | 7 | 2 | 2 | S:S:S250 | S:S:T219 | 3.2 | 1 | Yes | Yes | 3 | 5 | 2 | 2 | S:S:E279 | S:S:T219 | 4.23 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | S:S:F277 | S:S:Y223 | 10.32 | 1 | No | Yes | 7 | 7 | 2 | 1 | S:S:S304 | S:S:Y223 | 5.09 | 0 | No | Yes | 8 | 7 | 2 | 1 | M:M:?1 | S:S:Y223 | 12.74 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:E279 | S:S:S250 | 2.87 | 1 | Yes | Yes | 4 | 3 | 1 | 2 | M:M:?1 | S:S:E279 | 8.1 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | M:M:?1 | S:S:G306 | 4.65 | 1 | Yes | No | 0 | 5 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 7.55 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 29.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/QUS/QUS_8T8M_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_8T8M_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8TAO | C | Aminoacid | Metabotropic glutamate | mGlu5; mGlu5 | Homo sapiens | Quisqualate | CDPPB | - | 2.9 | 2023-10-11 | 10.1101/2023.08.29.555158 |
![](/psngpcr/ligands/QUS/QUS_8TAO_L_L_1.png)
A 2D representation of the interactions of QUS in 8TAO colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R61 | R:R:S42 | 6.59 | 2 | Yes | No | 5 | 6 | 2 | 2 | R:R:S42 | R:R:W100 | 4.94 | 2 | No | Yes | 6 | 3 | 2 | 1 | R:R:R61 | R:R:Y64 | 11.32 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:R61 | R:R:W100 | 4 | 2 | Yes | Yes | 5 | 3 | 2 | 1 | R:R:R68 | R:R:Y64 | 12.35 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:W100 | R:R:Y64 | 3.86 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | R:R:R310 | R:R:Y64 | 11.32 | 2 | No | Yes | 5 | 4 | 1 | 1 | L:L:?1 | R:R:Y64 | 7.96 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:R68 | R:R:Y172 | 7.2 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | R:R:S151 | R:R:W100 | 8.65 | 0 | No | Yes | 4 | 3 | 2 | 1 | R:R:E279 | R:R:W100 | 5.45 | 2 | No | Yes | 4 | 3 | 1 | 1 | L:L:?1 | R:R:W100 | 8.51 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:S152 | R:R:S176 | 6.52 | 2 | No | Yes | 9 | 7 | 1 | 2 | R:R:L179 | R:R:S152 | 3 | 2 | Yes | No | 8 | 9 | 2 | 1 | L:L:?1 | R:R:S152 | 4.08 | 2 | Yes | No | 0 | 9 | 0 | 1 | R:R:S173 | R:R:Y172 | 5.09 | 2 | No | Yes | 5 | 7 | 1 | 2 | R:R:K396 | R:R:S173 | 4.59 | 2 | No | No | 4 | 5 | 1 | 1 | L:L:?1 | R:R:S173 | 4.08 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:T175 | R:R:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | L:L:?1 | R:R:T175 | 3 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:L179 | R:R:S176 | 3 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:D305 | R:R:Q198 | 14.36 | 2 | Yes | No | 8 | 9 | 1 | 2 | R:R:G224 | R:R:Y223 | 4.35 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:F277 | R:R:Y223 | 17.54 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:S304 | R:R:Y223 | 3.82 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:D305 | R:R:Y223 | 6.9 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:Y223 | 13.53 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F277 | R:R:G224 | 3.01 | 2 | Yes | No | 7 | 8 | 2 | 2 | R:R:F277 | R:R:S304 | 7.93 | 2 | Yes | No | 7 | 8 | 2 | 2 | L:L:?1 | R:R:E279 | 5.4 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:G280 | R:R:R310 | 3 | 0 | No | No | 3 | 5 | 2 | 1 | R:R:D305 | R:R:S304 | 2.94 | 2 | Yes | No | 8 | 8 | 1 | 2 | R:R:D305 | R:R:G306 | 3.35 | 2 | Yes | No | 8 | 5 | 1 | 1 | L:L:?1 | R:R:D305 | 4.61 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:G306 | 4.65 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:R310 | 3.3 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:K396 | 5.75 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:E279 | R:R:S250 | 2.87 | 2 | No | No | 4 | 3 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 5.90 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 35.00 |
| ![](/psngpcr/ligands/QUS/QUS_8TAO_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_8TAO_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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![](/psngpcr/ligands/QUS/QUS_8TAO_M_M_1.png)
A 2D representation of the interactions of QUS in 8TAO colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:R61 | S:S:S42 | 6.59 | 0 | No | No | 5 | 6 | 2 | 2 | S:S:S42 | S:S:W100 | 4.94 | 0 | No | Yes | 6 | 3 | 2 | 1 | S:S:R61 | S:S:Y64 | 12.35 | 0 | No | Yes | 5 | 4 | 2 | 1 | S:S:R68 | S:S:Y64 | 10.29 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | S:S:W100 | S:S:Y64 | 4.82 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | S:S:R310 | S:S:Y64 | 10.29 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | M:M:?1 | S:S:Y64 | 7.96 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:S151 | S:S:W100 | 4.94 | 0 | No | Yes | 4 | 3 | 2 | 1 | S:S:E279 | S:S:W100 | 5.45 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | M:M:?1 | S:S:W100 | 7.73 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | S:S:G150 | S:S:S173 | 3.71 | 0 | No | No | 5 | 5 | 2 | 1 | S:S:S152 | S:S:S176 | 6.52 | 1 | No | Yes | 9 | 7 | 1 | 2 | S:S:N222 | S:S:S152 | 5.96 | 1 | Yes | No | 6 | 9 | 2 | 1 | M:M:?1 | S:S:S152 | 4.08 | 1 | Yes | No | 0 | 9 | 0 | 1 | S:S:K396 | S:S:S173 | 7.65 | 0 | No | No | 4 | 5 | 2 | 1 | M:M:?1 | S:S:S173 | 8.16 | 1 | Yes | No | 0 | 5 | 0 | 1 | S:S:T175 | S:S:V192 | 3.17 | 0 | No | Yes | 8 | 7 | 1 | 2 | S:S:D195 | S:S:T175 | 7.23 | 0 | No | No | 8 | 8 | 2 | 1 | M:M:?1 | S:S:T175 | 4 | 1 | Yes | No | 0 | 8 | 0 | 1 | S:S:N222 | S:S:S176 | 4.47 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | S:S:D195 | S:S:Q198 | 7.83 | 0 | No | Yes | 8 | 9 | 2 | 2 | S:S:D195 | S:S:Y223 | 5.75 | 0 | No | Yes | 8 | 7 | 2 | 1 | S:S:Q198 | S:S:S304 | 2.89 | 1 | Yes | No | 9 | 8 | 2 | 2 | S:S:D305 | S:S:Q198 | 13.05 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | S:S:E279 | S:S:T219 | 4.23 | 1 | Yes | No | 4 | 5 | 1 | 2 | S:S:G224 | S:S:Y223 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | S:S:F277 | S:S:Y223 | 3.09 | 0 | Yes | Yes | 7 | 7 | 2 | 1 | S:S:S304 | S:S:Y223 | 3.82 | 1 | No | Yes | 8 | 7 | 2 | 1 | S:S:D305 | S:S:Y223 | 4.6 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | M:M:?1 | S:S:Y223 | 19.9 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:E279 | S:S:S250 | 5.75 | 1 | Yes | No | 4 | 3 | 1 | 2 | M:M:?1 | S:S:E279 | 5.4 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:D305 | S:S:S304 | 2.94 | 1 | Yes | No | 8 | 8 | 1 | 2 | S:S:D305 | S:S:G306 | 3.35 | 1 | Yes | No | 8 | 5 | 1 | 1 | M:M:?1 | S:S:D305 | 3.69 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | M:M:?1 | S:S:G306 | 4.65 | 1 | Yes | No | 0 | 5 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 7.29 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 36.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| ![](/psngpcr/ligands/QUS/QUS_8TAO_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/QUS/QUS_8TAO_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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