CodeQW7
Name1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole
Synonyms
Identifier1-[(1~{R})-1-[2,6-bis(chloranyl)-3-methoxy-phenyl]ethyl]-6-[2-[(2~{R})-piperidin-2-yl]phenyl]benzimidazole
FormulaC27 H27 Cl2 N3 O
Molecular Weight480.429
SMILESC[C@H](c1c(ccc(c1Cl)OC)Cl)n2cnc3c2cc(cc3)c4ccccc4[C@H]5CCCCN5
PubChem146155955
Formal Charge0
Total Atoms60
Total Chiral Atoms2
Total Bonds64
Total Aromatic Bonds22
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6VCB B1 Peptide Glucagon GLP-1 Homo sapiens GLP-1 LSN3160440 Gs/Beta1/Gamma2 3.3 2020-07-22 10.1038/s41589-020-0589-7

A 2D representation of the interactions of QW7 in 6VCB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F7 R:R:L141 4.87 1 Yes No 0 5 2 2
L:L:V11 R:R:L141 4.47 1 No No 0 5 1 2
R:R:L142 W:W:?1 21.42 0 No Yes 3 0 1 0
R:R:Y145 R:R:Y148 8.94 1 Yes Yes 5 7 1 2
R:R:T149 R:R:Y145 13.73 0 No Yes 7 5 2 1
R:R:D198 R:R:Y145 14.94 1 No Yes 7 5 2 1
R:R:Y145 W:W:?1 32.83 1 Yes Yes 5 0 1 0
R:R:D198 R:R:Y148 8.05 1 No Yes 7 7 2 2
L:L:F7 R:R:Y148 7.22 1 Yes Yes 0 7 2 2
R:R:K202 W:W:?1 18.71 0 No Yes 4 0 1 0
L:L:L15 R:R:Y205 7.03 0 No Yes 0 3 1 2
R:R:S206 W:W:?1 8.85 0 No Yes 4 0 1 0
L:L:V11 W:W:?1 5.49 1 No Yes 0 0 1 0
L:L:L15 W:W:?1 12.24 0 No Yes 0 0 1 0
L:L:F7 L:L:V11 6.55 1 Yes No 0 0 2 1
R:R:I146 R:R:Y145 2.42 0 No Yes 4 5 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub1.00
Average Interaction Strength16.59
Average Nodes In Shell14.00
Average Hubs In Shell5.00
Average Links In Shell16.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub1.00
Average Interaction Strength16.59
Average Nodes In Shell14.00
Average Hubs In Shell5.00
Average Links In Shell16.00
Average Links Mediated by Hubs In Shell15.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)