CodeRVZ
Name2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile
Synonyms
Identifier2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile
FormulaC17 H12 N6 S
Molecular Weight332.382
SMILESc1ccc(cc1)c2c(c(nc(c2C#N)SCc3[nH]ccn3)N)C#N
PubChem11174953
Formal Charge0
Total Atoms36
Total Chiral Atoms0
Total Bonds38
Total Aromatic Bonds17
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7ARO A Nucleotide Adenosine A2A Homo sapiens LUF5833 Na - 3.12 2021-04-07 10.1021/acs.jmedchem.0c01856

A 2D representation of the interactions of RVZ in 7ARO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Y271 R:R:Y9 15.89 1 No No 3 5 1 2
R:R:A59 R:R:V84 3.39 0 No No 6 6 2 1
L:L:?1 R:R:V84 5.28 1 Yes No 0 6 0 1
R:R:L85 R:R:Y176 3.52 1 No Yes 4 6 2 2
R:R:L85 R:R:M177 4.24 1 No Yes 4 6 2 1
R:R:F168 R:R:V172 18.35 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 33.65 1 Yes Yes 0 4 0 1
L:L:?1 R:R:E169 17.83 1 Yes No 0 3 0 1
R:R:M174 R:R:N253 8.41 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
L:L:?1 R:R:M177 4.01 1 Yes Yes 0 6 0 1
L:L:?1 R:R:L249 10.78 1 Yes No 0 5 0 1
L:L:?1 R:R:N253 6.81 1 Yes No 0 5 0 1
R:R:L267 R:R:Y271 9.38 1 No No 3 3 1 1
L:L:?1 R:R:L267 5.88 1 Yes No 0 3 0 1
R:R:I274 R:R:M270 4.37 1 No No 4 4 1 1
L:L:?1 R:R:M270 11.01 1 Yes No 0 4 0 1
L:L:?1 R:R:Y271 14.12 1 Yes No 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 12.13 1 Yes No 0 4 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub2.00
Average Interaction Strength12.15
Average Nodes In Shell20.00
Average Hubs In Shell5.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub2.00
Average Interaction Strength12.15
Average Nodes In Shell20.00
Average Hubs In Shell5.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell17.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)