CodeS12
NameO-[(S)-hydroxy{[(2S)-2-hydroxy-3-(octadec-9-enoyloxy)propyl]oxy}phosphoryl]-L-serine
Synonyms1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine
Identifier(2S)-2-azanyl-3-[[(2S)-3-octadec-9-enoyloxy-2-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid
FormulaC24 H46 N O9 P
Molecular Weight523.597
SMILESCCCCCCCCC=CCCCCCCCC(=O)OC[C@@H](CO[P@@](=O)(O)OC[C@@H](C(=O)O)N)O
PubChem137349977
Formal Charge0
Total Atoms81
Total Chiral Atoms2
Total Bonds80
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8SAI A Orphan A orphans GPR34 Homo sapiens 1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine - Gi1/Beta1/Gamma2 3.27 2023-10-04 10.1073/pnas.2308435120

A 2D representation of the interactions of S12 in 8SAI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K128 R:R:T193 7.51 2 No No 8 5 1 2
R:R:K128 R:R:R208 4.95 2 No Yes 8 5 1 1
L:L:?1 R:R:K128 5.27 2 Yes No 0 8 0 1
R:R:F186 R:R:T132 6.49 2 Yes Yes 7 5 2 1
R:R:M189 R:R:T132 3.01 2 No Yes 4 5 1 1
R:R:I190 R:R:T132 4.56 2 No Yes 5 5 2 1
L:L:?1 R:R:T132 9.65 2 Yes Yes 0 5 0 1
R:R:Y135 R:R:Y282 4.96 2 Yes Yes 5 6 1 2
R:R:R286 R:R:Y135 5.14 2 Yes Yes 6 5 1 1
R:R:L313 R:R:Y135 2.34 2 No Yes 5 5 2 1
L:L:?1 R:R:Y135 24.11 2 Yes Yes 0 5 0 1
R:R:M136 R:R:N137 2.8 0 No No 5 8 1 2
R:R:A182 R:R:M136 3.22 0 No No 7 5 2 1
L:L:?1 R:R:M136 5.29 2 Yes No 0 5 0 1
R:R:L223 R:R:Y139 12.89 0 No No 5 7 1 2
R:R:I140 R:R:L144 2.85 0 Yes No 7 7 1 2
R:R:A182 R:R:I140 3.25 0 No Yes 7 7 2 1
L:L:?1 R:R:I140 2.67 2 Yes Yes 0 7 0 1
R:R:F147 R:R:I143 3.77 15 No Yes 5 5 2 1
R:R:I143 R:R:M226 5.83 0 Yes No 5 5 1 2
R:R:I143 R:R:I230 2.94 0 Yes No 5 9 1 2
L:L:?1 R:R:I143 4 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L181 3.88 2 Yes No 0 4 0 1
R:R:F186 R:R:I190 6.28 2 Yes No 7 5 2 2
R:R:F219 R:R:M189 3.73 2 No No 5 4 1 1
L:L:?1 R:R:M189 9.25 2 Yes No 0 4 0 1
R:R:M203 R:R:R208 4.96 0 No Yes 4 5 2 1
R:R:Y207 R:R:Y289 6.95 2 Yes Yes 3 4 2 1
R:R:Q293 R:R:Y207 9.02 2 Yes Yes 4 3 1 2
R:R:H211 R:R:R208 2.26 0 Yes Yes 4 5 2 1
L:L:?1 R:R:R208 9.09 2 Yes Yes 0 5 0 1
R:R:H211 R:R:Q293 11.13 0 Yes Yes 4 4 2 1
L:L:?1 R:R:F219 10.25 2 Yes No 0 5 0 1
R:R:N220 R:R:R286 4.82 2 No Yes 4 6 1 1
R:R:I290 R:R:N220 4.25 0 No No 5 4 2 1
L:L:?1 R:R:N220 11.55 2 Yes No 0 4 0 1
L:L:?1 R:R:L223 9.06 2 Yes No 0 5 0 1
R:R:R286 R:R:V224 2.62 2 Yes No 6 4 1 2
R:R:R286 R:R:Y282 9.26 2 Yes Yes 6 6 1 2
R:R:N309 R:R:Y282 2.33 2 Yes Yes 5 6 1 2
R:R:L313 R:R:Y282 11.72 2 No Yes 5 6 2 2
R:R:R286 R:R:Y289 5.14 2 Yes Yes 6 4 1 1
R:R:N309 R:R:R286 6.03 2 Yes Yes 5 6 1 1
L:L:?1 R:R:R286 5.68 2 Yes Yes 0 6 0 1
R:R:Q293 R:R:Y289 11.27 2 Yes Yes 4 4 1 1
R:R:N309 R:R:Y289 13.96 2 Yes Yes 5 4 1 1
L:L:?1 R:R:Y289 13.15 2 Yes Yes 0 4 0 1
L:L:?1 R:R:Q293 2.49 2 Yes Yes 0 4 0 1
R:R:L313 R:R:N309 4.12 2 No Yes 5 5 2 1
L:L:?1 R:R:N309 7.7 2 Yes Yes 0 5 0 1
R:R:A99 R:R:I140 1.62 0 No Yes 8 7 2 1
R:R:I140 R:R:V178 1.54 0 Yes No 7 7 1 2
R:R:I143 R:R:V178 1.54 0 Yes No 5 7 1 2
R:R:I177 R:R:L181 1.43 0 No No 3 4 2 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub9.00
Average Interaction Strength8.32
Average Nodes In Shell37.00
Average Hubs In Shell14.00
Average Links In Shell54.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub9.00
Average Interaction Strength8.32
Average Nodes In Shell37.00
Average Hubs In Shell14.00
Average Links In Shell54.00
Average Links Mediated by Hubs In Shell47.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)