CodeS1P
Name(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
Synonymssphingosine 1-phosphate
Identifier[(E,2S,3R)-2-azanyl-3-hydroxy-octadec-4-enyl] dihydrogen phosphate
FormulaC18 H38 N O5 P
Molecular Weight379.472
SMILESCCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O
PubChem10883396
Formal Charge0
Total Atoms63
Total Chiral Atoms2
Total Bonds62
Total Aromatic Bonds0
Networks6
 missing image

This ligand is also present in the following 6 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7C4S A Lipid Lysophospholipid (S1P) S1P3 Homo sapiens S1P - - 3.2 2021-06-09 10.1126/sciadv.abf5325

A 2D representation of the interactions of S1P in 7C4S
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:T103 R:R:Y22 4.99 1 Yes Yes 5 9 1 1
R:R:F104 R:R:Y22 9.28 1 Yes Yes 7 9 2 1
R:R:W111 R:R:Y22 5.79 1 Yes Yes 9 9 2 1
R:R:P190 R:R:Y22 12.52 0 No Yes 4 9 2 1
L:L:?1 R:R:Y22 6.91 1 Yes Yes 0 9 0 1
L:L:?1 R:R:E37 3.9 1 Yes No 0 3 0 1
R:R:M118 R:R:Y92 8.38 1 Yes Yes 6 6 1 2
R:R:I284 R:R:Y92 4.84 0 No Yes 5 6 1 2
R:R:N95 R:R:S99 4.47 1 Yes No 6 5 1 1
R:R:N95 R:R:R114 10.85 1 Yes Yes 6 6 1 1
R:R:E115 R:R:N95 5.26 1 Yes Yes 5 6 1 1
L:L:?1 R:R:N95 9.1 1 Yes Yes 0 6 0 1
R:R:M98 R:R:R114 3.72 0 No Yes 4 6 2 1
R:R:R114 R:R:S99 9.22 1 Yes No 6 5 1 1
L:L:?1 R:R:S99 11.06 1 Yes No 0 5 0 1
L:L:?1 R:R:G100 3.78 1 Yes No 0 6 0 1
R:R:F104 R:R:T103 5.19 1 Yes Yes 7 5 2 1
R:R:R114 R:R:T103 6.47 1 Yes Yes 6 5 1 1
L:L:?1 R:R:T103 4.34 1 Yes Yes 0 5 0 1
R:R:L106 R:R:R114 3.64 0 No Yes 6 6 2 1
R:R:R114 R:R:W111 10 1 Yes Yes 6 9 1 2
R:R:E115 R:R:W111 14.17 1 Yes Yes 5 9 1 2
R:R:W111 R:R:Y192 3.86 1 Yes Yes 9 3 2 2
R:R:E115 R:R:R114 17.45 1 Yes Yes 5 6 1 1
L:L:?1 R:R:R114 7.16 1 Yes Yes 0 6 0 1
R:R:E115 R:R:L189 5.3 1 Yes No 5 5 1 2
L:L:?1 R:R:E115 18.55 1 Yes Yes 0 5 0 1
R:R:L122 R:R:M118 4.24 1 Yes Yes 6 6 1 1
L:L:?1 R:R:M118 7.29 1 Yes Yes 0 6 0 1
R:R:F119 R:R:Y192 7.22 1 Yes Yes 5 3 1 2
R:R:F119 R:R:Y196 4.13 1 Yes Yes 5 6 1 2
L:L:?1 R:R:F119 16.15 1 Yes Yes 0 5 0 1
R:R:L122 R:R:W256 6.83 1 Yes Yes 6 8 1 1
L:L:?1 R:R:L122 4.08 1 Yes Yes 0 6 0 1
R:R:T126 R:R:W256 6.06 0 No Yes 7 8 2 1
R:R:L189 R:R:Y192 16.41 0 No Yes 5 3 2 2
R:R:Y192 R:R:Y196 4.96 1 Yes Yes 3 6 2 2
R:R:F204 R:R:W256 5.01 1 Yes Yes 7 8 2 1
R:R:F204 R:R:F260 32.15 1 Yes Yes 7 6 2 2
R:R:F252 R:R:W256 4.01 1 No Yes 9 8 2 1
R:R:F252 R:R:N290 3.62 1 No Yes 9 9 2 2
R:R:F260 R:R:W256 5.01 1 Yes Yes 6 8 2 1
R:R:A287 R:R:W256 10.37 0 No Yes 7 8 2 1
R:R:N290 R:R:W256 7.91 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W256 6.71 1 Yes Yes 0 8 0 1
L:L:?1 R:R:I284 4.21 1 Yes No 0 5 0 1
R:R:L122 R:R:V288 2.98 1 Yes No 6 7 1 2
R:R:A91 R:R:M118 1.61 0 No Yes 5 6 2 1
R:R:F119 R:R:G116 1.51 1 Yes No 5 6 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub9.00
Average Interaction Strength7.94
Average Nodes In Shell32.00
Average Hubs In Shell18.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell49.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EW3 A Lipid Lysophospholipid (S1P) S1P3 Homo sapiens S1P - Gi1/Beta1/Gamma2 3.1 2021-09-29 10.1038/s41422-021-00567-w

A 2D representation of the interactions of S1P in 7EW3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K27 R:R:Y22 3.58 2 No Yes 7 9 2 1
R:R:R31 R:R:Y22 2.06 2 Yes Yes 4 9 1 1
R:R:T103 R:R:Y22 2.5 2 No Yes 5 9 1 1
R:R:P190 R:R:Y22 12.52 0 No Yes 4 9 2 1
L:L:?1 R:R:Y22 3.45 2 Yes Yes 0 9 0 1
R:R:K27 R:R:R31 2.48 2 No Yes 7 4 2 1
R:R:F104 R:R:R31 5.34 0 No Yes 7 4 2 1
L:L:?1 R:R:R31 8.05 2 Yes Yes 0 4 0 1
R:R:M118 R:R:Y92 7.18 0 No Yes 6 6 1 2
R:R:I284 R:R:Y92 3.63 0 No Yes 5 6 1 2
R:R:N95 R:R:S99 2.98 2 No No 6 5 1 1
R:R:N95 R:R:R114 8.44 2 No Yes 6 6 1 1
L:L:?1 R:R:N95 8.09 2 Yes No 0 6 0 1
R:R:M98 R:R:R114 2.48 0 No Yes 4 6 2 1
R:R:R114 R:R:S99 9.22 2 Yes No 6 5 1 1
L:L:?1 R:R:S99 7.74 2 Yes No 0 5 0 1
R:R:R114 R:R:T103 5.17 2 Yes No 6 5 1 1
L:L:?1 R:R:T103 3.26 2 Yes No 0 5 0 1
R:R:R114 R:R:W111 9 2 Yes Yes 6 9 1 2
R:R:E115 R:R:W111 18.54 2 Yes Yes 5 9 1 2
R:R:L189 R:R:W111 2.28 2 Yes Yes 5 9 2 2
R:R:P190 R:R:W111 2.7 0 No Yes 4 9 2 2
R:R:W111 R:R:Y192 2.89 2 Yes Yes 9 3 2 2
R:R:E115 R:R:R114 3.49 2 Yes Yes 5 6 1 1
L:L:?1 R:R:R114 2.68 2 Yes Yes 0 6 0 1
R:R:E115 R:R:L189 3.98 2 Yes Yes 5 5 1 2
R:R:E115 R:R:Y192 4.49 2 Yes Yes 5 3 1 2
L:L:?1 R:R:E115 8.78 2 Yes Yes 0 5 0 1
L:L:?1 R:R:M118 2.08 2 Yes No 0 6 0 1
R:R:F119 R:R:L189 2.44 0 Yes Yes 5 5 1 2
R:R:F119 R:R:Y196 8.25 0 Yes Yes 5 6 1 2
L:L:?1 R:R:F119 4.49 2 Yes Yes 0 5 0 1
R:R:L122 R:R:W256 2.28 0 No Yes 6 8 1 2
L:L:?1 R:R:L122 12.23 2 Yes No 0 6 0 1
R:R:L189 R:R:Y192 8.21 2 Yes Yes 5 3 2 2
R:R:F199 R:R:I203 7.54 0 No No 4 5 2 1
R:R:F260 R:R:I201 3.77 2 Yes Yes 6 4 1 2
R:R:F263 R:R:I201 2.51 2 Yes Yes 6 4 2 2
L:L:?1 R:R:I203 2.1 2 Yes No 0 5 0 1
R:R:F204 R:R:W256 6.01 2 No Yes 7 8 2 2
R:R:F204 R:R:F260 35.37 2 No Yes 7 6 2 1
R:R:F260 R:R:W256 5.01 2 Yes Yes 6 8 1 2
R:R:F260 R:R:F263 2.14 2 Yes Yes 6 6 1 2
L:L:?1 R:R:F260 4.49 2 Yes Yes 0 6 0 1
L:L:?1 R:R:I284 5.26 2 Yes No 0 5 0 1
R:R:A91 R:R:M118 1.61 0 No No 5 6 2 1
R:R:F119 R:R:G116 1.51 0 Yes No 5 6 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub6.00
Average Interaction Strength5.59
Average Nodes In Shell30.00
Average Hubs In Shell15.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7T6B A Lipid Lysophospholipid (S1P) S1P2 Homo sapiens S1P - chim(NtGi1L-G13)/Beta1/Gamma2 3.19 2022-04-06 10.1126/sciadv.abn0067

A 2D representation of the interactions of S1P in 7T6B
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L98 R:R:Y18 4.69 2 Yes Yes 4 7 1 2
R:R:W105 R:R:Y18 8.68 2 Yes Yes 8 7 2 2
R:R:R33 R:R:S93 2.64 2 Yes No 5 5 1 2
R:R:K269 R:R:R33 3.71 2 No Yes 4 5 2 1
R:R:H271 R:R:R33 18.05 2 No Yes 4 5 1 1
R:R:R33 R:R:Y272 3.09 2 Yes Yes 5 4 1 2
L:L:?1 R:R:R33 5.37 2 Yes Yes 0 5 0 1
R:R:N89 R:R:R108 4.82 2 No Yes 5 6 1 1
R:R:A112 R:R:N89 4.69 0 No No 6 5 2 1
L:L:?1 R:R:N89 8.09 2 Yes No 0 5 0 1
R:R:L92 R:R:T97 5.9 0 No No 4 5 2 2
R:R:L92 R:R:R108 4.86 0 No Yes 4 6 2 1
R:R:L98 R:R:T97 2.95 2 Yes No 4 5 1 2
R:R:L98 R:R:R108 3.64 2 Yes Yes 4 6 1 1
L:L:?1 R:R:L98 6.12 2 Yes Yes 0 4 0 1
R:R:R108 R:R:W105 8 2 Yes Yes 6 8 1 2
R:R:E109 R:R:W105 25.08 2 Yes Yes 5 8 1 2
R:R:W105 R:R:Y186 3.86 2 Yes Yes 8 5 2 2
R:R:E109 R:R:R108 13.96 2 Yes Yes 5 6 1 1
L:L:?1 R:R:R108 2.68 2 Yes Yes 0 6 0 1
R:R:E109 R:R:L183 2.65 2 Yes Yes 5 5 1 1
R:R:E109 R:R:Y186 5.61 2 Yes Yes 5 5 1 2
L:L:?1 R:R:E109 6.83 2 Yes Yes 0 5 0 1
R:R:F113 R:R:S117 2.64 2 Yes Yes 5 5 1 1
R:R:F113 R:R:L162 3.65 2 Yes No 5 5 1 2
R:R:F113 R:R:Y190 10.32 2 Yes Yes 5 6 1 2
R:R:F113 R:R:V194 5.24 2 Yes No 5 6 1 2
L:L:?1 R:R:F113 6.28 2 Yes Yes 0 5 0 1
R:R:L116 R:R:W246 6.83 0 No Yes 7 8 2 1
R:R:F121 R:R:S117 2.64 2 Yes Yes 5 5 1 1
R:R:S117 R:R:S159 3.26 2 Yes Yes 5 8 1 2
L:L:?1 R:R:S117 5.53 2 Yes Yes 0 5 0 1
R:R:F198 R:R:V120 3.93 2 Yes No 7 7 1 2
R:R:I201 R:R:V120 3.07 2 Yes No 7 7 2 2
R:R:V120 R:R:W246 4.9 2 No Yes 7 8 2 1
R:R:F121 R:R:S155 3.96 2 Yes No 5 7 1 2
R:R:F121 R:R:I158 10.05 2 Yes No 5 4 1 2
R:R:F121 R:R:I201 5.02 2 Yes Yes 5 7 1 2
L:L:?1 R:R:F121 3.59 2 Yes Yes 0 5 0 1
R:R:I158 R:R:L162 2.85 0 No No 4 5 2 2
R:R:L183 R:R:V182 4.47 2 Yes Yes 5 4 1 2
R:R:L183 R:R:Y186 11.72 2 Yes Yes 5 5 1 2
L:L:?1 R:R:L183 4.08 2 Yes Yes 0 5 0 1
R:R:Y186 R:R:Y190 4.96 2 Yes Yes 5 6 2 2
R:R:F198 R:R:W246 10.02 2 Yes Yes 7 8 1 1
R:R:F198 R:R:F250 7.5 2 Yes No 7 6 1 2
L:L:?1 R:R:F198 3.59 2 Yes Yes 0 7 0 1
R:R:F242 R:R:W246 6.01 2 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 2.42 2 Yes Yes 9 9 2 2
R:R:A249 R:R:W246 2.59 0 No Yes 6 8 2 1
R:R:S277 R:R:W246 7.41 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 7.91 2 Yes Yes 9 8 2 1
L:L:?1 R:R:W246 5.87 2 Yes Yes 0 8 0 1
R:R:F274 R:R:L253 3.65 0 No No 6 6 1 2
R:R:K269 R:R:Y272 5.97 2 No Yes 4 4 2 2
R:R:H271 R:R:Y272 8.71 2 No Yes 4 4 1 2
L:L:?1 R:R:H271 3.79 2 Yes No 0 4 0 1
R:R:F274 R:R:S277 3.96 0 No No 6 7 1 2
L:L:?1 R:R:F274 7.18 2 Yes No 0 6 0 1
L:L:?1 R:R:I197 2.1 2 Yes No 0 5 0 1
R:R:C193 R:R:I197 1.64 0 No No 5 5 2 1
R:R:F113 R:R:G110 1.51 2 Yes No 5 6 1 2
R:R:L98 R:R:Q15 1.33 2 Yes No 4 2 1 2
R:R:Q34 R:R:R33 1.17 0 No Yes 3 5 2 1
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub10.00
Average Interaction Strength5.08
Average Nodes In Shell44.00
Average Hubs In Shell21.00
Average Links In Shell64.00
Average Links Mediated by Hubs In Shell58.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TD3 A Lipid Lysophospholipid (S1P) S1P1 Homo sapiens S1P - Gi1/Beta1/Gamma2 3 2022-02-09 10.1038/s41467-022-28417-2

A 2D representation of the interactions of S1P in 7TD3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K34 R:R:Y29 9.55 2 Yes Yes 6 7 1 1
R:R:T109 R:R:Y29 6.24 2 No Yes 5 7 1 1
R:R:Y110 R:R:Y29 2.98 0 Yes Yes 5 7 2 1
R:R:W117 R:R:Y29 6.75 2 Yes Yes 9 7 2 1
R:R:P196 R:R:Y29 16.69 2 No Yes 3 7 2 1
L:L:?1 R:R:Y29 7.77 2 Yes Yes 0 7 0 1
R:R:K34 R:R:T32 4.5 2 Yes No 6 8 1 2
R:R:P196 R:R:T32 5.25 2 No No 3 8 2 2
R:R:K34 R:R:P196 5.02 2 Yes No 6 3 1 2
R:R:F291 R:R:K34 4.96 0 No Yes 1 6 2 1
L:L:?1 R:R:K34 3.12 2 Yes Yes 0 6 0 1
R:R:M124 R:R:Y98 7.18 2 Yes Yes 6 6 1 2
R:R:L297 R:R:Y98 10.55 2 No Yes 5 6 1 2
R:R:N101 R:R:S105 2.98 2 Yes No 5 4 1 1
R:R:N101 R:R:R120 4.82 2 Yes Yes 5 6 1 1
R:R:E121 R:R:N101 3.94 2 Yes Yes 5 5 1 1
R:R:M124 R:R:N101 5.61 2 Yes Yes 6 5 1 1
L:L:?1 R:R:N101 12.14 2 Yes Yes 0 5 0 1
R:R:G106 R:R:S105 3.71 0 No No 4 4 2 1
L:L:?1 R:R:S105 7.74 2 Yes No 0 4 0 1
R:R:R120 R:R:T109 6.47 2 Yes No 6 5 1 1
L:L:?1 R:R:T109 5.43 2 Yes No 0 5 0 1
R:R:R120 R:R:W117 6 2 Yes Yes 6 9 1 2
R:R:E121 R:R:W117 16.36 2 Yes Yes 5 9 1 2
R:R:L195 R:R:W117 3.42 2 Yes Yes 3 9 1 2
R:R:W117 R:R:Y198 4.82 2 Yes Yes 9 4 2 2
R:R:E121 R:R:R120 8.14 2 Yes Yes 5 6 1 1
L:L:?1 R:R:R120 8.05 2 Yes Yes 0 6 0 1
R:R:E121 R:R:L195 6.63 2 Yes Yes 5 3 1 1
R:R:E121 R:R:Y198 5.61 2 Yes Yes 5 4 1 2
L:L:?1 R:R:E121 8.78 2 Yes Yes 0 5 0 1
R:R:L297 R:R:M124 4.24 2 No Yes 5 6 1 1
L:L:?1 R:R:M124 4.17 2 Yes Yes 0 6 0 1
R:R:F125 R:R:L195 3.65 2 Yes Yes 5 3 1 1
R:R:F125 R:R:Y198 10.32 2 Yes Yes 5 4 1 2
R:R:F125 R:R:Y202 7.22 2 Yes Yes 5 7 1 2
R:R:C206 R:R:F125 4.19 2 No Yes 6 5 2 1
L:L:?1 R:R:F125 17.05 2 Yes Yes 0 5 0 1
R:R:L128 R:R:S131 3 0 No No 6 9 1 2
R:R:L128 R:R:W269 9.11 0 No Yes 6 8 1 2
L:L:?1 R:R:L128 5.1 2 Yes No 0 6 0 1
R:R:S129 R:R:S171 6.52 0 No No 6 8 1 2
L:L:?1 R:R:S129 6.64 2 Yes No 0 6 0 1
R:R:L195 R:R:V194 2.98 2 Yes Yes 3 4 1 2
R:R:L195 R:R:Y198 10.55 2 Yes Yes 3 4 1 2
L:L:?1 R:R:L195 4.08 2 Yes Yes 0 3 0 1
R:R:Y198 R:R:Y202 4.96 2 Yes Yes 4 7 2 2
R:R:C206 R:R:Y202 9.41 2 No Yes 6 7 2 2
L:L:?1 R:R:L297 8.16 2 Yes No 0 5 0 1
R:R:L112 R:R:R120 2.43 0 No Yes 5 6 2 1
R:R:E121 R:R:G122 1.64 2 Yes No 5 6 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub8.00
Average Interaction Strength7.56
Average Nodes In Shell30.00
Average Hubs In Shell16.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VIE A Lipid Lysophospholipid (S1P) S1P1 Homo sapiens S1P - Gi1/Beta1/Gamma2 2.86 2022-09-28 10.1073/pnas.2117716119

A 2D representation of the interactions of S1P in 7VIE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I25 R:R:Y29 4.84 0 No Yes 4 7 2 1
R:R:K34 R:R:Y29 4.78 2 No Yes 6 7 1 1
R:R:T109 R:R:Y29 3.75 2 No Yes 5 7 2 1
R:R:Y110 R:R:Y29 12.91 2 No Yes 5 7 2 1
R:R:P196 R:R:Y29 15.3 0 No Yes 3 7 2 1
L:L:?1 R:R:Y29 3.45 2 Yes Yes 0 7 0 1
R:R:F291 R:R:K34 3.72 0 Yes No 1 6 2 1
L:L:?1 R:R:K34 7.27 2 Yes No 0 6 0 1
R:R:N101 R:R:Y98 5.81 2 Yes Yes 5 6 1 2
R:R:L297 R:R:Y98 3.52 2 Yes Yes 5 6 1 2
R:R:N101 R:R:S105 7.45 2 Yes No 5 4 1 1
R:R:N101 R:R:R120 3.62 2 Yes Yes 5 6 1 2
R:R:M124 R:R:N101 7.01 2 No Yes 6 5 1 1
L:L:?1 R:R:N101 11.13 2 Yes Yes 0 5 0 1
L:L:?1 R:R:S105 5.53 2 Yes No 0 4 0 1
R:R:T109 R:R:Y110 3.75 2 No No 5 5 2 2
R:R:R120 R:R:T109 5.17 2 Yes No 6 5 2 2
R:R:R120 R:R:W117 6 2 Yes Yes 6 9 2 2
R:R:E121 R:R:W117 16.36 2 Yes Yes 5 9 1 2
R:R:L195 R:R:W117 4.56 2 No Yes 3 9 2 2
R:R:W117 R:R:Y198 6.75 2 Yes Yes 9 4 2 2
R:R:E121 R:R:R120 6.98 2 Yes Yes 5 6 1 2
R:R:E121 R:R:L195 6.63 2 Yes No 5 3 1 2
R:R:E121 R:R:Y198 5.61 2 Yes Yes 5 4 1 2
L:L:?1 R:R:E121 7.81 2 Yes Yes 0 5 0 1
R:R:L297 R:R:M124 4.24 2 Yes No 5 6 1 1
L:L:?1 R:R:M124 8.33 2 Yes No 0 6 0 1
R:R:C206 R:R:F125 4.19 0 No No 6 5 2 1
L:L:?1 R:R:F125 17.94 2 Yes No 0 5 0 1
R:R:L128 R:R:W269 5.69 2 No Yes 6 8 1 1
L:L:?1 R:R:L128 5.1 2 Yes No 0 6 0 1
R:R:F265 R:R:V132 5.24 2 Yes No 9 7 2 2
R:R:V132 R:R:W269 4.9 2 No Yes 7 8 2 1
R:R:L195 R:R:Y198 7.03 2 No Yes 3 4 2 2
R:R:F210 R:R:F265 4.29 2 No Yes 7 9 2 2
R:R:F210 R:R:W269 12.03 2 No Yes 7 8 2 1
R:R:F265 R:R:W269 13.03 2 Yes Yes 9 8 2 1
R:R:F265 R:R:N303 6.04 2 Yes Yes 9 9 2 2
R:R:N303 R:R:W269 7.91 2 Yes Yes 9 8 2 1
L:L:?1 R:R:W269 3.36 2 Yes Yes 0 8 0 1
L:L:?1 R:R:L297 9.18 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L272 3.06 2 Yes No 0 6 0 1
L:L:?1 R:R:L276 3.06 2 Yes No 0 6 0 1
R:R:I203 R:R:L276 2.85 0 No No 6 6 2 1
R:R:G106 R:R:S105 1.86 0 No No 4 4 2 1
R:R:A300 R:R:L272 1.58 0 No No 7 6 2 1
R:R:A300 R:R:L297 1.58 0 No Yes 7 5 2 1
R:R:F125 R:R:G122 1.51 0 No No 5 6 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.10
Average Nodes In Shell32.00
Average Hubs In Shell13.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell42.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WF7 A Lipid Lysophospholipid (S1P) S1P1 Homo sapiens S1P - Gi1/Beta1/Gamma2 3.4 2022-01-05 10.1038/s41589-021-00930-3

A 2D representation of the interactions of S1P in 7WF7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I25 R:R:Y29 2.42 0 No Yes 4 7 2 1
R:R:K34 R:R:Y29 3.58 4 No Yes 6 7 1 1
R:R:L35 R:R:Y29 5.86 0 Yes Yes 6 7 2 1
R:R:P196 R:R:Y29 12.52 0 No Yes 3 7 2 1
L:L:?1 R:R:Y29 6.91 4 Yes Yes 0 7 0 1
R:R:F291 R:R:K34 9.93 0 No No 1 6 2 1
L:L:?1 R:R:K34 7.27 4 Yes No 0 6 0 1
R:R:L35 R:R:Y110 3.52 0 Yes Yes 6 5 2 2
R:R:N101 R:R:Y98 2.33 4 No Yes 5 6 1 2
R:R:M124 R:R:Y98 2.39 0 No Yes 6 6 1 2
R:R:L297 R:R:Y98 5.86 4 Yes Yes 5 6 1 2
R:R:N101 R:R:R120 4.82 4 No Yes 5 6 1 1
L:L:?1 R:R:N101 9.1 4 Yes No 0 5 0 1
R:R:L104 R:R:Q116 5.32 4 No No 4 4 2 2
R:R:L104 R:R:R120 4.86 4 No Yes 4 6 2 1
R:R:T109 R:R:Y110 3.75 4 No Yes 5 5 1 2
R:R:R120 R:R:T109 3.88 4 Yes No 6 5 1 1
L:L:?1 R:R:T109 5.43 4 Yes No 0 5 0 1
R:R:Q116 R:R:R120 2.34 4 No Yes 4 6 2 1
R:R:F118 R:R:W117 7.02 4 No Yes 6 9 2 2
R:R:R120 R:R:W117 5 4 Yes Yes 6 9 1 2
R:R:E121 R:R:W117 11.99 4 Yes Yes 5 9 1 2
R:R:L195 R:R:W117 2.28 4 No Yes 3 9 1 2
R:R:E121 R:R:F118 2.33 4 Yes No 5 6 1 2
L:L:?1 R:R:R120 8.95 4 Yes Yes 0 6 0 1
R:R:E121 R:R:L195 7.95 4 Yes No 5 3 1 1
R:R:E121 R:R:Y198 6.73 4 Yes No 5 4 1 2
L:L:?1 R:R:E121 8.78 4 Yes Yes 0 5 0 1
R:R:M124 R:R:S123 3.07 0 No No 6 4 1 2
L:L:?1 R:R:M124 4.17 4 Yes No 0 6 0 1
R:R:F125 R:R:S129 3.96 4 Yes No 5 6 1 2
R:R:F125 R:R:L174 3.65 4 Yes Yes 5 5 1 2
R:R:F125 R:R:G175 3.01 4 Yes No 5 6 1 2
R:R:F125 R:R:Y202 11.35 4 Yes Yes 5 7 1 2
R:R:C206 R:R:F125 4.19 0 No Yes 6 5 2 1
L:L:?1 R:R:F125 12.56 4 Yes Yes 0 5 0 1
R:R:L174 R:R:Y202 5.86 4 Yes Yes 5 7 2 2
L:L:?1 R:R:L195 3.06 4 Yes No 0 3 0 1
R:R:Y198 R:R:Y202 9.93 0 No Yes 4 7 2 2
R:R:L272 R:R:L297 2.77 4 No Yes 6 5 2 1
L:L:?1 R:R:L297 6.12 4 Yes Yes 0 5 0 1
R:R:E121 R:R:G122 1.64 4 Yes No 5 6 1 2
R:R:A300 R:R:L272 1.58 4 No No 7 6 2 2
R:R:A300 R:R:L297 1.58 4 No Yes 7 5 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.24
Average Nodes In Shell31.00
Average Hubs In Shell12.00
Average Links In Shell44.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links12.50
Average Number Of Links With An Hub7.17
Average Interaction Strength6.75
Average Nodes In Shell33.17
Average Hubs In Shell15.83
Average Links In Shell50.50
Average Links Mediated by Hubs In Shell46.67

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)