Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7C4S | A | Lipid | Lysophospholipid (S1P) | S1P3 | Homo sapiens | S1P | - | - | 3.2 | 2021-06-09 | 10.1126/sciadv.abf5325 |
![](/psngpcr/ligands/S1P/S1P_7C4S_L_L_1.png)
A 2D representation of the interactions of S1P in 7C4S colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:T103 | R:R:Y22 | 4.99 | 1 | Yes | Yes | 5 | 9 | 1 | 1 | R:R:F104 | R:R:Y22 | 9.28 | 1 | Yes | Yes | 7 | 9 | 2 | 1 | R:R:W111 | R:R:Y22 | 5.79 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:P190 | R:R:Y22 | 12.52 | 0 | No | Yes | 4 | 9 | 2 | 1 | L:L:?1 | R:R:Y22 | 6.91 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?1 | R:R:E37 | 3.9 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:M118 | R:R:Y92 | 8.38 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:I284 | R:R:Y92 | 4.84 | 0 | No | Yes | 5 | 6 | 1 | 2 | R:R:N95 | R:R:S99 | 4.47 | 1 | Yes | No | 6 | 5 | 1 | 1 | R:R:N95 | R:R:R114 | 10.85 | 1 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:E115 | R:R:N95 | 5.26 | 1 | Yes | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:N95 | 9.1 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:M98 | R:R:R114 | 3.72 | 0 | No | Yes | 4 | 6 | 2 | 1 | R:R:R114 | R:R:S99 | 9.22 | 1 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:S99 | 11.06 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:G100 | 3.78 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F104 | R:R:T103 | 5.19 | 1 | Yes | Yes | 7 | 5 | 2 | 1 | R:R:R114 | R:R:T103 | 6.47 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:T103 | 4.34 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L106 | R:R:R114 | 3.64 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:R114 | R:R:W111 | 10 | 1 | Yes | Yes | 6 | 9 | 1 | 2 | R:R:E115 | R:R:W111 | 14.17 | 1 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:W111 | R:R:Y192 | 3.86 | 1 | Yes | Yes | 9 | 3 | 2 | 2 | R:R:E115 | R:R:R114 | 17.45 | 1 | Yes | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:R114 | 7.16 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:E115 | R:R:L189 | 5.3 | 1 | Yes | No | 5 | 5 | 1 | 2 | L:L:?1 | R:R:E115 | 18.55 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L122 | R:R:M118 | 4.24 | 1 | Yes | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:M118 | 7.29 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F119 | R:R:Y192 | 7.22 | 1 | Yes | Yes | 5 | 3 | 1 | 2 | R:R:F119 | R:R:Y196 | 4.13 | 1 | Yes | Yes | 5 | 6 | 1 | 2 | L:L:?1 | R:R:F119 | 16.15 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L122 | R:R:W256 | 6.83 | 1 | Yes | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:L122 | 4.08 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:T126 | R:R:W256 | 6.06 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:L189 | R:R:Y192 | 16.41 | 0 | No | Yes | 5 | 3 | 2 | 2 | R:R:Y192 | R:R:Y196 | 4.96 | 1 | Yes | Yes | 3 | 6 | 2 | 2 | R:R:F204 | R:R:W256 | 5.01 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:F204 | R:R:F260 | 32.15 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:F252 | R:R:W256 | 4.01 | 1 | No | Yes | 9 | 8 | 2 | 1 | R:R:F252 | R:R:N290 | 3.62 | 1 | No | Yes | 9 | 9 | 2 | 2 | R:R:F260 | R:R:W256 | 5.01 | 1 | Yes | Yes | 6 | 8 | 2 | 1 | R:R:A287 | R:R:W256 | 10.37 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:N290 | R:R:W256 | 7.91 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W256 | 6.71 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:I284 | 4.21 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:L122 | R:R:V288 | 2.98 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:A91 | R:R:M118 | 1.61 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:F119 | R:R:G116 | 1.51 | 1 | Yes | No | 5 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 9.00 | Average Interaction Strength | 7.94 | Average Nodes In Shell | 32.00 | Average Hubs In Shell | 18.00 | Average Links In Shell | 49.00 | Average Links Mediated by Hubs In Shell | 49.00 |
| ![](/psngpcr/ligands/S1P/S1P_7C4S_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/S1P/S1P_7C4S_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7EW3 | A | Lipid | Lysophospholipid (S1P) | S1P3 | Homo sapiens | S1P | - | Gi1/Beta1/Gamma2 | 3.1 | 2021-09-29 | 10.1038/s41422-021-00567-w |
![](/psngpcr/ligands/S1P/S1P_7EW3_L_L_1.png)
A 2D representation of the interactions of S1P in 7EW3 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:K27 | R:R:Y22 | 3.58 | 2 | No | Yes | 7 | 9 | 2 | 1 | R:R:R31 | R:R:Y22 | 2.06 | 2 | Yes | Yes | 4 | 9 | 1 | 1 | R:R:T103 | R:R:Y22 | 2.5 | 2 | No | Yes | 5 | 9 | 1 | 1 | R:R:P190 | R:R:Y22 | 12.52 | 0 | No | Yes | 4 | 9 | 2 | 1 | L:L:?1 | R:R:Y22 | 3.45 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:K27 | R:R:R31 | 2.48 | 2 | No | Yes | 7 | 4 | 2 | 1 | R:R:F104 | R:R:R31 | 5.34 | 0 | No | Yes | 7 | 4 | 2 | 1 | L:L:?1 | R:R:R31 | 8.05 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:M118 | R:R:Y92 | 7.18 | 0 | No | Yes | 6 | 6 | 1 | 2 | R:R:I284 | R:R:Y92 | 3.63 | 0 | No | Yes | 5 | 6 | 1 | 2 | R:R:N95 | R:R:S99 | 2.98 | 2 | No | No | 6 | 5 | 1 | 1 | R:R:N95 | R:R:R114 | 8.44 | 2 | No | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:N95 | 8.09 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:M98 | R:R:R114 | 2.48 | 0 | No | Yes | 4 | 6 | 2 | 1 | R:R:R114 | R:R:S99 | 9.22 | 2 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:S99 | 7.74 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:R114 | R:R:T103 | 5.17 | 2 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:T103 | 3.26 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:R114 | R:R:W111 | 9 | 2 | Yes | Yes | 6 | 9 | 1 | 2 | R:R:E115 | R:R:W111 | 18.54 | 2 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:L189 | R:R:W111 | 2.28 | 2 | Yes | Yes | 5 | 9 | 2 | 2 | R:R:P190 | R:R:W111 | 2.7 | 0 | No | Yes | 4 | 9 | 2 | 2 | R:R:W111 | R:R:Y192 | 2.89 | 2 | Yes | Yes | 9 | 3 | 2 | 2 | R:R:E115 | R:R:R114 | 3.49 | 2 | Yes | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:R114 | 2.68 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:E115 | R:R:L189 | 3.98 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:E115 | R:R:Y192 | 4.49 | 2 | Yes | Yes | 5 | 3 | 1 | 2 | L:L:?1 | R:R:E115 | 8.78 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:M118 | 2.08 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F119 | R:R:L189 | 2.44 | 0 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:F119 | R:R:Y196 | 8.25 | 0 | Yes | Yes | 5 | 6 | 1 | 2 | L:L:?1 | R:R:F119 | 4.49 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L122 | R:R:W256 | 2.28 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:L122 | 12.23 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:L189 | R:R:Y192 | 8.21 | 2 | Yes | Yes | 5 | 3 | 2 | 2 | R:R:F199 | R:R:I203 | 7.54 | 0 | No | No | 4 | 5 | 2 | 1 | R:R:F260 | R:R:I201 | 3.77 | 2 | Yes | Yes | 6 | 4 | 1 | 2 | R:R:F263 | R:R:I201 | 2.51 | 2 | Yes | Yes | 6 | 4 | 2 | 2 | L:L:?1 | R:R:I203 | 2.1 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:F204 | R:R:W256 | 6.01 | 2 | No | Yes | 7 | 8 | 2 | 2 | R:R:F204 | R:R:F260 | 35.37 | 2 | No | Yes | 7 | 6 | 2 | 1 | R:R:F260 | R:R:W256 | 5.01 | 2 | Yes | Yes | 6 | 8 | 1 | 2 | R:R:F260 | R:R:F263 | 2.14 | 2 | Yes | Yes | 6 | 6 | 1 | 2 | L:L:?1 | R:R:F260 | 4.49 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:I284 | 5.26 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:A91 | R:R:M118 | 1.61 | 0 | No | No | 5 | 6 | 2 | 1 | R:R:F119 | R:R:G116 | 1.51 | 0 | Yes | No | 5 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 5.59 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 47.00 | Average Links Mediated by Hubs In Shell | 44.00 |
| ![](/psngpcr/ligands/S1P/S1P_7EW3_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/S1P/S1P_7EW3_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7T6B | A | Lipid | Lysophospholipid (S1P) | S1P2 | Homo sapiens | S1P | - | chim(NtGi1L-G13)/Beta1/Gamma2 | 3.19 | 2022-04-06 | 10.1126/sciadv.abn0067 |
![](/psngpcr/ligands/S1P/S1P_7T6B_L_L_1.png)
A 2D representation of the interactions of S1P in 7T6B colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L98 | R:R:Y18 | 4.69 | 2 | Yes | Yes | 4 | 7 | 1 | 2 | R:R:W105 | R:R:Y18 | 8.68 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:R33 | R:R:S93 | 2.64 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:K269 | R:R:R33 | 3.71 | 2 | No | Yes | 4 | 5 | 2 | 1 | R:R:H271 | R:R:R33 | 18.05 | 2 | No | Yes | 4 | 5 | 1 | 1 | R:R:R33 | R:R:Y272 | 3.09 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | L:L:?1 | R:R:R33 | 5.37 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:N89 | R:R:R108 | 4.82 | 2 | No | Yes | 5 | 6 | 1 | 1 | R:R:A112 | R:R:N89 | 4.69 | 0 | No | No | 6 | 5 | 2 | 1 | L:L:?1 | R:R:N89 | 8.09 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:L92 | R:R:T97 | 5.9 | 0 | No | No | 4 | 5 | 2 | 2 | R:R:L92 | R:R:R108 | 4.86 | 0 | No | Yes | 4 | 6 | 2 | 1 | R:R:L98 | R:R:T97 | 2.95 | 2 | Yes | No | 4 | 5 | 1 | 2 | R:R:L98 | R:R:R108 | 3.64 | 2 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:L98 | 6.12 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:R108 | R:R:W105 | 8 | 2 | Yes | Yes | 6 | 8 | 1 | 2 | R:R:E109 | R:R:W105 | 25.08 | 2 | Yes | Yes | 5 | 8 | 1 | 2 | R:R:W105 | R:R:Y186 | 3.86 | 2 | Yes | Yes | 8 | 5 | 2 | 2 | R:R:E109 | R:R:R108 | 13.96 | 2 | Yes | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:R108 | 2.68 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:E109 | R:R:L183 | 2.65 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | R:R:E109 | R:R:Y186 | 5.61 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | L:L:?1 | R:R:E109 | 6.83 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F113 | R:R:S117 | 2.64 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | R:R:F113 | R:R:L162 | 3.65 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:F113 | R:R:Y190 | 10.32 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:F113 | R:R:V194 | 5.24 | 2 | Yes | No | 5 | 6 | 1 | 2 | L:L:?1 | R:R:F113 | 6.28 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L116 | R:R:W246 | 6.83 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:F121 | R:R:S117 | 2.64 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | R:R:S117 | R:R:S159 | 3.26 | 2 | Yes | Yes | 5 | 8 | 1 | 2 | L:L:?1 | R:R:S117 | 5.53 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F198 | R:R:V120 | 3.93 | 2 | Yes | No | 7 | 7 | 1 | 2 | R:R:I201 | R:R:V120 | 3.07 | 2 | Yes | No | 7 | 7 | 2 | 2 | R:R:V120 | R:R:W246 | 4.9 | 2 | No | Yes | 7 | 8 | 2 | 1 | R:R:F121 | R:R:S155 | 3.96 | 2 | Yes | No | 5 | 7 | 1 | 2 | R:R:F121 | R:R:I158 | 10.05 | 2 | Yes | No | 5 | 4 | 1 | 2 | R:R:F121 | R:R:I201 | 5.02 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | L:L:?1 | R:R:F121 | 3.59 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:I158 | R:R:L162 | 2.85 | 0 | No | No | 4 | 5 | 2 | 2 | R:R:L183 | R:R:V182 | 4.47 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | R:R:L183 | R:R:Y186 | 11.72 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | L:L:?1 | R:R:L183 | 4.08 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:Y186 | R:R:Y190 | 4.96 | 2 | Yes | Yes | 5 | 6 | 2 | 2 | R:R:F198 | R:R:W246 | 10.02 | 2 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:F198 | R:R:F250 | 7.5 | 2 | Yes | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:F198 | 3.59 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F242 | R:R:W246 | 6.01 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F242 | R:R:N280 | 2.42 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:A249 | R:R:W246 | 2.59 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:S277 | R:R:W246 | 7.41 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:N280 | R:R:W246 | 7.91 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 5.87 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F274 | R:R:L253 | 3.65 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:K269 | R:R:Y272 | 5.97 | 2 | No | Yes | 4 | 4 | 2 | 2 | R:R:H271 | R:R:Y272 | 8.71 | 2 | No | Yes | 4 | 4 | 1 | 2 | L:L:?1 | R:R:H271 | 3.79 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:F274 | R:R:S277 | 3.96 | 0 | No | No | 6 | 7 | 1 | 2 | L:L:?1 | R:R:F274 | 7.18 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:I197 | 2.1 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:C193 | R:R:I197 | 1.64 | 0 | No | No | 5 | 5 | 2 | 1 | R:R:F113 | R:R:G110 | 1.51 | 2 | Yes | No | 5 | 6 | 1 | 2 | R:R:L98 | R:R:Q15 | 1.33 | 2 | Yes | No | 4 | 2 | 1 | 2 | R:R:Q34 | R:R:R33 | 1.17 | 0 | No | Yes | 3 | 5 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 10.00 | Average Interaction Strength | 5.08 | Average Nodes In Shell | 44.00 | Average Hubs In Shell | 21.00 | Average Links In Shell | 64.00 | Average Links Mediated by Hubs In Shell | 58.00 |
| ![](/psngpcr/ligands/S1P/S1P_7T6B_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/S1P/S1P_7T6B_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7TD3 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | S1P | - | Gi1/Beta1/Gamma2 | 3 | 2022-02-09 | 10.1038/s41467-022-28417-2 |
![](/psngpcr/ligands/S1P/S1P_7TD3_L_L_1.png)
A 2D representation of the interactions of S1P in 7TD3 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:K34 | R:R:Y29 | 9.55 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:T109 | R:R:Y29 | 6.24 | 2 | No | Yes | 5 | 7 | 1 | 1 | R:R:Y110 | R:R:Y29 | 2.98 | 0 | Yes | Yes | 5 | 7 | 2 | 1 | R:R:W117 | R:R:Y29 | 6.75 | 2 | Yes | Yes | 9 | 7 | 2 | 1 | R:R:P196 | R:R:Y29 | 16.69 | 2 | No | Yes | 3 | 7 | 2 | 1 | L:L:?1 | R:R:Y29 | 7.77 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:K34 | R:R:T32 | 4.5 | 2 | Yes | No | 6 | 8 | 1 | 2 | R:R:P196 | R:R:T32 | 5.25 | 2 | No | No | 3 | 8 | 2 | 2 | R:R:K34 | R:R:P196 | 5.02 | 2 | Yes | No | 6 | 3 | 1 | 2 | R:R:F291 | R:R:K34 | 4.96 | 0 | No | Yes | 1 | 6 | 2 | 1 | L:L:?1 | R:R:K34 | 3.12 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:M124 | R:R:Y98 | 7.18 | 2 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:L297 | R:R:Y98 | 10.55 | 2 | No | Yes | 5 | 6 | 1 | 2 | R:R:N101 | R:R:S105 | 2.98 | 2 | Yes | No | 5 | 4 | 1 | 1 | R:R:N101 | R:R:R120 | 4.82 | 2 | Yes | Yes | 5 | 6 | 1 | 1 | R:R:E121 | R:R:N101 | 3.94 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | R:R:M124 | R:R:N101 | 5.61 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:N101 | 12.14 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:G106 | R:R:S105 | 3.71 | 0 | No | No | 4 | 4 | 2 | 1 | L:L:?1 | R:R:S105 | 7.74 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:R120 | R:R:T109 | 6.47 | 2 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:T109 | 5.43 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:R120 | R:R:W117 | 6 | 2 | Yes | Yes | 6 | 9 | 1 | 2 | R:R:E121 | R:R:W117 | 16.36 | 2 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:L195 | R:R:W117 | 3.42 | 2 | Yes | Yes | 3 | 9 | 1 | 2 | R:R:W117 | R:R:Y198 | 4.82 | 2 | Yes | Yes | 9 | 4 | 2 | 2 | R:R:E121 | R:R:R120 | 8.14 | 2 | Yes | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:R120 | 8.05 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:E121 | R:R:L195 | 6.63 | 2 | Yes | Yes | 5 | 3 | 1 | 1 | R:R:E121 | R:R:Y198 | 5.61 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | L:L:?1 | R:R:E121 | 8.78 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L297 | R:R:M124 | 4.24 | 2 | No | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:M124 | 4.17 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F125 | R:R:L195 | 3.65 | 2 | Yes | Yes | 5 | 3 | 1 | 1 | R:R:F125 | R:R:Y198 | 10.32 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | R:R:F125 | R:R:Y202 | 7.22 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:C206 | R:R:F125 | 4.19 | 2 | No | Yes | 6 | 5 | 2 | 1 | L:L:?1 | R:R:F125 | 17.05 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L128 | R:R:S131 | 3 | 0 | No | No | 6 | 9 | 1 | 2 | R:R:L128 | R:R:W269 | 9.11 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:L128 | 5.1 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:S129 | R:R:S171 | 6.52 | 0 | No | No | 6 | 8 | 1 | 2 | L:L:?1 | R:R:S129 | 6.64 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:L195 | R:R:V194 | 2.98 | 2 | Yes | Yes | 3 | 4 | 1 | 2 | R:R:L195 | R:R:Y198 | 10.55 | 2 | Yes | Yes | 3 | 4 | 1 | 2 | L:L:?1 | R:R:L195 | 4.08 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:Y198 | R:R:Y202 | 4.96 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | R:R:C206 | R:R:Y202 | 9.41 | 2 | No | Yes | 6 | 7 | 2 | 2 | L:L:?1 | R:R:L297 | 8.16 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:L112 | R:R:R120 | 2.43 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:E121 | R:R:G122 | 1.64 | 2 | Yes | No | 5 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 7.56 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 16.00 | Average Links In Shell | 51.00 | Average Links Mediated by Hubs In Shell | 47.00 |
| ![](/psngpcr/ligands/S1P/S1P_7TD3_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/S1P/S1P_7TD3_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7VIE | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | S1P | - | Gi1/Beta1/Gamma2 | 2.86 | 2022-09-28 | 10.1073/pnas.2117716119 |
![](/psngpcr/ligands/S1P/S1P_7VIE_L_L_1.png)
A 2D representation of the interactions of S1P in 7VIE colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I25 | R:R:Y29 | 4.84 | 0 | No | Yes | 4 | 7 | 2 | 1 | R:R:K34 | R:R:Y29 | 4.78 | 2 | No | Yes | 6 | 7 | 1 | 1 | R:R:T109 | R:R:Y29 | 3.75 | 2 | No | Yes | 5 | 7 | 2 | 1 | R:R:Y110 | R:R:Y29 | 12.91 | 2 | No | Yes | 5 | 7 | 2 | 1 | R:R:P196 | R:R:Y29 | 15.3 | 0 | No | Yes | 3 | 7 | 2 | 1 | L:L:?1 | R:R:Y29 | 3.45 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F291 | R:R:K34 | 3.72 | 0 | Yes | No | 1 | 6 | 2 | 1 | L:L:?1 | R:R:K34 | 7.27 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:N101 | R:R:Y98 | 5.81 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:L297 | R:R:Y98 | 3.52 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:N101 | R:R:S105 | 7.45 | 2 | Yes | No | 5 | 4 | 1 | 1 | R:R:N101 | R:R:R120 | 3.62 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:M124 | R:R:N101 | 7.01 | 2 | No | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:N101 | 11.13 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:S105 | 5.53 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:T109 | R:R:Y110 | 3.75 | 2 | No | No | 5 | 5 | 2 | 2 | R:R:R120 | R:R:T109 | 5.17 | 2 | Yes | No | 6 | 5 | 2 | 2 | R:R:R120 | R:R:W117 | 6 | 2 | Yes | Yes | 6 | 9 | 2 | 2 | R:R:E121 | R:R:W117 | 16.36 | 2 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:L195 | R:R:W117 | 4.56 | 2 | No | Yes | 3 | 9 | 2 | 2 | R:R:W117 | R:R:Y198 | 6.75 | 2 | Yes | Yes | 9 | 4 | 2 | 2 | R:R:E121 | R:R:R120 | 6.98 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:E121 | R:R:L195 | 6.63 | 2 | Yes | No | 5 | 3 | 1 | 2 | R:R:E121 | R:R:Y198 | 5.61 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | L:L:?1 | R:R:E121 | 7.81 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L297 | R:R:M124 | 4.24 | 2 | Yes | No | 5 | 6 | 1 | 1 | L:L:?1 | R:R:M124 | 8.33 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:C206 | R:R:F125 | 4.19 | 0 | No | No | 6 | 5 | 2 | 1 | L:L:?1 | R:R:F125 | 17.94 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:L128 | R:R:W269 | 5.69 | 2 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:L128 | 5.1 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F265 | R:R:V132 | 5.24 | 2 | Yes | No | 9 | 7 | 2 | 2 | R:R:V132 | R:R:W269 | 4.9 | 2 | No | Yes | 7 | 8 | 2 | 1 | R:R:L195 | R:R:Y198 | 7.03 | 2 | No | Yes | 3 | 4 | 2 | 2 | R:R:F210 | R:R:F265 | 4.29 | 2 | No | Yes | 7 | 9 | 2 | 2 | R:R:F210 | R:R:W269 | 12.03 | 2 | No | Yes | 7 | 8 | 2 | 1 | R:R:F265 | R:R:W269 | 13.03 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F265 | R:R:N303 | 6.04 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:N303 | R:R:W269 | 7.91 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W269 | 3.36 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:L297 | 9.18 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L272 | 3.06 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:L276 | 3.06 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:I203 | R:R:L276 | 2.85 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:G106 | R:R:S105 | 1.86 | 0 | No | No | 4 | 4 | 2 | 1 | R:R:A300 | R:R:L272 | 1.58 | 0 | No | No | 7 | 6 | 2 | 1 | R:R:A300 | R:R:L297 | 1.58 | 0 | No | Yes | 7 | 5 | 2 | 1 | R:R:F125 | R:R:G122 | 1.51 | 0 | No | No | 5 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 7.10 | Average Nodes In Shell | 32.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 48.00 | Average Links Mediated by Hubs In Shell | 42.00 |
| ![](/psngpcr/ligands/S1P/S1P_7VIE_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/S1P/S1P_7VIE_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7WF7 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | S1P | - | Gi1/Beta1/Gamma2 | 3.4 | 2022-01-05 | 10.1038/s41589-021-00930-3 |
![](/psngpcr/ligands/S1P/S1P_7WF7_L_L_1.png)
A 2D representation of the interactions of S1P in 7WF7 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I25 | R:R:Y29 | 2.42 | 0 | No | Yes | 4 | 7 | 2 | 1 | R:R:K34 | R:R:Y29 | 3.58 | 4 | No | Yes | 6 | 7 | 1 | 1 | R:R:L35 | R:R:Y29 | 5.86 | 0 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:P196 | R:R:Y29 | 12.52 | 0 | No | Yes | 3 | 7 | 2 | 1 | L:L:?1 | R:R:Y29 | 6.91 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F291 | R:R:K34 | 9.93 | 0 | No | No | 1 | 6 | 2 | 1 | L:L:?1 | R:R:K34 | 7.27 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:L35 | R:R:Y110 | 3.52 | 0 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:N101 | R:R:Y98 | 2.33 | 4 | No | Yes | 5 | 6 | 1 | 2 | R:R:M124 | R:R:Y98 | 2.39 | 0 | No | Yes | 6 | 6 | 1 | 2 | R:R:L297 | R:R:Y98 | 5.86 | 4 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:N101 | R:R:R120 | 4.82 | 4 | No | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:N101 | 9.1 | 4 | Yes | No | 0 | 5 | 0 | 1 | R:R:L104 | R:R:Q116 | 5.32 | 4 | No | No | 4 | 4 | 2 | 2 | R:R:L104 | R:R:R120 | 4.86 | 4 | No | Yes | 4 | 6 | 2 | 1 | R:R:T109 | R:R:Y110 | 3.75 | 4 | No | Yes | 5 | 5 | 1 | 2 | R:R:R120 | R:R:T109 | 3.88 | 4 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:T109 | 5.43 | 4 | Yes | No | 0 | 5 | 0 | 1 | R:R:Q116 | R:R:R120 | 2.34 | 4 | No | Yes | 4 | 6 | 2 | 1 | R:R:F118 | R:R:W117 | 7.02 | 4 | No | Yes | 6 | 9 | 2 | 2 | R:R:R120 | R:R:W117 | 5 | 4 | Yes | Yes | 6 | 9 | 1 | 2 | R:R:E121 | R:R:W117 | 11.99 | 4 | Yes | Yes | 5 | 9 | 1 | 2 | R:R:L195 | R:R:W117 | 2.28 | 4 | No | Yes | 3 | 9 | 1 | 2 | R:R:E121 | R:R:F118 | 2.33 | 4 | Yes | No | 5 | 6 | 1 | 2 | L:L:?1 | R:R:R120 | 8.95 | 4 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:E121 | R:R:L195 | 7.95 | 4 | Yes | No | 5 | 3 | 1 | 1 | R:R:E121 | R:R:Y198 | 6.73 | 4 | Yes | No | 5 | 4 | 1 | 2 | L:L:?1 | R:R:E121 | 8.78 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:M124 | R:R:S123 | 3.07 | 0 | No | No | 6 | 4 | 1 | 2 | L:L:?1 | R:R:M124 | 4.17 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:F125 | R:R:S129 | 3.96 | 4 | Yes | No | 5 | 6 | 1 | 2 | R:R:F125 | R:R:L174 | 3.65 | 4 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:F125 | R:R:G175 | 3.01 | 4 | Yes | No | 5 | 6 | 1 | 2 | R:R:F125 | R:R:Y202 | 11.35 | 4 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:C206 | R:R:F125 | 4.19 | 0 | No | Yes | 6 | 5 | 2 | 1 | L:L:?1 | R:R:F125 | 12.56 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L174 | R:R:Y202 | 5.86 | 4 | Yes | Yes | 5 | 7 | 2 | 2 | L:L:?1 | R:R:L195 | 3.06 | 4 | Yes | No | 0 | 3 | 0 | 1 | R:R:Y198 | R:R:Y202 | 9.93 | 0 | No | Yes | 4 | 7 | 2 | 2 | R:R:L272 | R:R:L297 | 2.77 | 4 | No | Yes | 6 | 5 | 2 | 1 | L:L:?1 | R:R:L297 | 6.12 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:E121 | R:R:G122 | 1.64 | 4 | Yes | No | 5 | 6 | 1 | 2 | R:R:A300 | R:R:L272 | 1.58 | 4 | No | No | 7 | 6 | 2 | 2 | R:R:A300 | R:R:L297 | 1.58 | 4 | No | Yes | 7 | 5 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 7.24 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 44.00 | Average Links Mediated by Hubs In Shell | 40.00 |
| ![](/psngpcr/ligands/S1P/S1P_7WF7_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/S1P/S1P_7WF7_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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