psnGPCR

Code	SIN
Name	Succinic acid
Synonyms	Acidum succinicum
Identifier
Formula	C4 H6 O4
Molecular Weight	118.088
SMILES
PubChem	21952380
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	13
Total Aromatic Bonds	0
Networks	7

This ligand is also present in the following 7 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6IGL

Peptide

Endothelin

ETB

Homo Sapiens

IRL1620

2.7

2018-11-21

10.1038/s41467-018-07094-0

A 2D representation of the interactions of SIN in 6IGL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q352	R:R:Y350	6.76	3	No	Yes	1	2	2	2
L:L:D8	R:R:Y350	8.05	3	Yes	Yes	0	2	1	2
L:L:E10	R:R:Y350	4.49	3	Yes	Yes	0	2	2	2
L:L:D8	R:R:Q352	15.66	3	Yes	No	0	1	1	2
L:L:?7	L:L:D8	4.03	0	No	Yes	0	0	0	1
L:L:?7	L:L:E9	18.35	0	No	No	0	0	0	1
L:L:D8	L:L:E10	10.39	3	Yes	Yes	0	0	1	2
L:L:A11	L:L:D8	6.18	0	No	Yes	0	0	2	1
L:L:E9	R:R:M245	2.71	0	No	No	0	1	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	11.19
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JPP

Alicarboxylic acid

Succinate

Homo Sapiens

Succinic acid

chim(Gs-CtGq)/Beta1/Gamma1

3.2

2024-05-22

10.1038/s41422-024-00968-7

A 2D representation of the interactions of SIN in 8JPP
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E22	R:R:Y83	8.98	0	No	Yes	5	5	2	1
R:R:L26	R:R:Y30	8.21	1	Yes	Yes	6	8	2	1
R:R:L26	R:R:Y83	8.21	1	Yes	Yes	6	5	2	1
R:R:L26	R:R:R281	3.64	1	Yes	Yes	6	6	2	1
R:R:L26	R:R:P282	4.93	1	Yes	Yes	6	5	2	2
R:R:L79	R:R:Y30	3.52	1	Yes	Yes	6	8	1	1
R:R:I80	R:R:Y30	4.84	0	Yes	Yes	6	8	2	1
R:R:P282	R:R:Y30	11.13	1	Yes	Yes	5	8	2	1
L:L:?1	R:R:Y30	10.43	1	Yes	Yes	0	8	0	1
R:R:F72	R:R:L102	7.31	1	Yes	Yes	7	7	2	2
R:R:F285	R:R:F72	12.86	1	No	Yes	7	7	1	2
R:R:L79	R:R:Y83	4.69	1	Yes	Yes	6	5	1	1
R:R:L79	R:R:N98	4.12	1	Yes	No	6	4	1	2
R:R:L79	R:R:R99	3.64	1	Yes	Yes	6	6	1	1
L:L:?1	R:R:L79	6.84	1	Yes	Yes	0	6	0	1
R:R:R281	R:R:Y83	5.14	1	Yes	Yes	6	5	1	1
L:L:?1	R:R:Y83	10.43	1	Yes	Yes	0	5	0	1
R:R:C95	R:R:R99	5.57	0	No	Yes	9	6	2	1
R:R:I161	R:R:R99	5.01	0	No	Yes	4	6	2	1
L:L:?1	R:R:R99	10.81	1	Yes	Yes	0	6	0	1
R:R:H103	R:R:L102	3.86	1	Yes	Yes	5	7	1	2
R:R:F285	R:R:L102	6.09	1	No	Yes	7	7	1	2
R:R:H103	R:R:I157	5.3	1	Yes	No	5	4	1	2
R:R:F175	R:R:H103	7.92	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:H103	8.9	1	Yes	Yes	0	5	0	1
R:R:F175	R:R:I157	10.05	1	Yes	No	4	4	1	2
R:R:D174	R:R:S177	5.89	1	Yes	No	5	4	1	2
R:R:D174	R:R:R281	10.72	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:D174	5.37	1	Yes	Yes	0	5	0	1
R:R:F175	R:R:N184	8.46	1	Yes	Yes	4	3	1	2
R:R:F175	R:R:S188	3.96	1	Yes	No	4	5	1	2
R:R:F175	R:R:R252	9.62	1	Yes	Yes	4	6	1	2
L:L:?1	R:R:F175	3.61	1	Yes	Yes	0	4	0	1
R:R:R252	R:R:S188	9.22	1	Yes	No	6	5	2	2
R:R:R252	R:R:Y277	10.29	1	Yes	Yes	6	5	2	2
R:R:R281	R:R:Y277	16.46	1	Yes	Yes	6	5	1	2
L:L:?1	R:R:R281	19.22	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F285	4.82	1	Yes	No	0	7	0	1
R:R:D174	R:R:N173	1.35	1	Yes	No	5	4	1	2

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	8.00
Average Interaction Strength	8.94
Average Nodes In Shell	26.00
Average Hubs In Shell	17.00
Average Links In Shell	39.00
Average Links Mediated by Hubs In Shell	39.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8WOG

Alicarboxylic acid

Succinate

Homo Sapiens

Succinic acid

Gi1/Beta1/Gamma2

2.97

2024-09-11

doi.org/10.1016/j.celrep.2024.114381

A 2D representation of the interactions of SIN in 8WOG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E22	R:R:L26	2.65	2	No	Yes	5	6	2	2
R:R:E22	R:R:Y83	5.61	2	No	Yes	5	5	2	1
R:R:E22	R:R:I278	4.1	2	No	Yes	5	4	2	2
R:R:L26	R:R:Y30	5.86	2	Yes	Yes	6	8	2	1
R:R:L26	R:R:Y83	4.69	2	Yes	Yes	6	5	2	1
R:R:I278	R:R:L26	4.28	2	Yes	Yes	4	6	2	2
R:R:L26	R:R:R281	4.86	2	Yes	Yes	6	6	2	1
R:R:L26	R:R:P282	3.28	2	Yes	Yes	6	5	2	2
R:R:E33	R:R:Y30	2.24	2	Yes	Yes	7	8	2	1
R:R:L76	R:R:Y30	2.34	2	No	Yes	8	8	2	1
R:R:I80	R:R:Y30	4.84	2	Yes	Yes	6	8	2	1
R:R:R281	R:R:Y30	2.06	2	Yes	Yes	6	8	1	1
R:R:P282	R:R:Y30	2.78	2	Yes	Yes	5	8	2	1
R:R:F285	R:R:Y30	7.22	2	Yes	Yes	7	8	1	1
L:L:?1	R:R:Y30	5.81	2	Yes	Yes	0	8	0	1
R:R:E33	R:R:P282	3.14	2	Yes	Yes	7	5	2	2
R:R:E33	R:R:F285	2.33	2	Yes	Yes	7	7	2	1
R:R:F72	R:R:L102	10.96	2	Yes	Yes	7	7	2	1
R:R:F285	R:R:F72	12.86	2	Yes	Yes	7	7	1	2
R:R:N98	R:R:T75	11.7	0	No	No	4	6	2	2
R:R:L102	R:R:T75	5.9	2	Yes	No	7	6	1	2
R:R:I80	R:R:L76	2.85	2	Yes	No	6	8	2	2
R:R:L79	R:R:Y83	3.52	2	No	Yes	6	5	1	1
R:R:L79	R:R:N98	2.75	2	No	No	6	4	1	2
L:L:?1	R:R:L79	4.11	2	Yes	No	0	6	0	1
R:R:R281	R:R:Y83	3.09	2	Yes	Yes	6	5	1	1
L:L:?1	R:R:Y83	9.29	2	Yes	Yes	0	5	0	1
R:R:H103	R:R:R99	4.51	2	Yes	No	5	6	1	1
R:R:I161	R:R:R99	6.26	2	Yes	No	4	6	2	1
L:L:?1	R:R:R99	7.22	2	Yes	No	0	6	0	1
R:R:H103	R:R:L102	3.86	2	Yes	Yes	5	7	1	1
R:R:F285	R:R:L102	4.87	2	Yes	Yes	7	7	1	1
L:L:?1	R:R:L102	4.11	2	Yes	Yes	0	7	0	1
R:R:H103	R:R:L154	3.86	2	Yes	Yes	5	7	1	2
R:R:H103	R:R:I157	3.98	2	Yes	Yes	5	4	1	2
R:R:F175	R:R:H103	4.53	2	Yes	Yes	4	5	2	1
L:L:?1	R:R:H103	7.64	2	Yes	Yes	0	5	0	1
R:R:I157	R:R:L154	2.85	2	Yes	Yes	4	7	2	2
R:R:I157	R:R:I161	5.89	2	Yes	Yes	4	4	2	2
R:R:F175	R:R:I157	5.02	2	Yes	Yes	4	4	2	2
R:R:F175	R:R:I161	2.51	2	Yes	Yes	4	4	2	2
R:R:D174	R:R:S177	8.83	2	No	No	5	4	1	2
R:R:D174	R:R:R281	2.38	2	No	Yes	5	6	1	1
L:L:?1	R:R:D174	5.38	2	Yes	No	0	5	0	1
R:R:R281	R:R:Y277	13.38	2	Yes	Yes	6	5	1	2
R:R:I278	R:R:R281	6.26	2	Yes	Yes	4	6	2	1
L:L:?1	R:R:R281	13.24	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:F285	3.62	2	Yes	Yes	0	7	0	1

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	6.71
Average Nodes In Shell	26.00
Average Hubs In Shell	18.00
Average Links In Shell	48.00
Average Links Mediated by Hubs In Shell	45.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8YKW

Alicarboxylic acid

Succinate

Homo Sapiens

Succinic acid

Gi1/Beta1/Gamma1

2.75

2024-05-29

10.1038/s41422-024-00984-7

A 2D representation of the interactions of SIN in 8YKW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y30	9.27	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:L79	5.48	2	Yes	No	0	6	0	1
L:L:?1	R:R:Y83	10.43	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:R99	8.41	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:L102	5.48	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:H103	7.63	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:R281	21.62	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:F285	3.61	2	Yes	Yes	0	7	0	1
R:R:E22	R:R:Y83	7.86	0	No	Yes	5	5	2	1
R:R:L26	R:R:Y30	17.58	0	No	Yes	6	8	2	1
R:R:L26	R:R:Y83	8.21	0	No	Yes	6	5	2	1
R:R:L76	R:R:Y30	4.69	0	No	Yes	8	8	2	1
R:R:I80	R:R:Y30	4.84	0	No	Yes	6	8	2	1
R:R:R281	R:R:Y30	5.14	2	Yes	Yes	6	8	1	1
R:R:P282	R:R:Y30	6.95	2	Yes	Yes	5	8	2	1
R:R:F285	R:R:Y30	8.25	2	Yes	Yes	7	8	1	1
R:R:E33	R:R:P282	3.14	2	Yes	Yes	7	5	2	2
R:R:E33	R:R:F285	3.5	2	Yes	Yes	7	7	2	1
R:R:F72	R:R:L76	3.65	0	Yes	No	7	8	2	2
R:R:F72	R:R:L102	6.09	0	Yes	Yes	7	7	2	1
R:R:F285	R:R:F72	13.93	2	Yes	Yes	7	7	1	2
R:R:N98	R:R:T75	4.39	0	No	No	4	6	2	2
R:R:L102	R:R:T75	5.9	2	Yes	No	7	6	1	2
R:R:L79	R:R:W88	4.56	0	No	Yes	6	8	1	2
R:R:L79	R:R:N98	4.12	0	No	No	6	4	1	2
R:R:R99	R:R:Y83	3.09	2	Yes	Yes	6	5	1	1
R:R:C172	R:R:W88	6.53	0	No	Yes	9	8	2	2
R:R:I161	R:R:R99	3.76	0	No	Yes	4	6	2	1
R:R:C172	R:R:R99	4.18	0	No	Yes	9	6	2	1
R:R:H103	R:R:L102	6.43	2	Yes	Yes	5	7	1	1
R:R:H103	R:R:L154	3.86	2	Yes	Yes	5	7	1	2
R:R:H103	R:R:I157	3.98	2	Yes	Yes	5	4	1	2
R:R:F175	R:R:H103	11.31	2	Yes	Yes	4	5	2	1
R:R:I157	R:R:L154	7.14	2	Yes	Yes	4	7	2	2
R:R:I157	R:R:I161	7.36	2	Yes	No	4	4	2	2
R:R:F175	R:R:I157	8.79	2	Yes	Yes	4	4	2	2
R:R:D174	R:R:R281	3.57	0	No	Yes	5	6	2	1
R:R:Y248	R:R:Y277	6.95	2	Yes	Yes	7	5	2	2
R:R:R281	R:R:Y248	3.09	2	Yes	Yes	6	7	1	2
R:R:A284	R:R:Y248	5.34	0	No	Yes	8	7	2	2
R:R:R281	R:R:Y277	14.4	2	Yes	Yes	6	5	1	2
R:R:A284	R:R:F285	2.77	0	No	Yes	8	7	2	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	8.99
Average Nodes In Shell	28.00
Average Hubs In Shell	17.00
Average Links In Shell	42.00
Average Links Mediated by Hubs In Shell	40.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	7.43
Average Number Of Links With An Hub	4.86
Average Interaction Strength	8.85
Average Nodes In Shell	21.57
Average Hubs In Shell	12.29
Average Links In Shell	31.57
Average Links Mediated by Hubs In Shell	29.43

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)