CodeSPM
NameSpermine
Synonyms4,9-diaza-1,12-dodecanediamine
IdentifierN,N'-bis(3-aminopropyl)butane-1,4-diamine
FormulaC10 H26 N4
Molecular Weight202.34
SMILESC(CCNCCCN)CNCCCN
PubChem1103
Formal Charge0
Total Atoms40
Total Chiral Atoms0
Total Bonds39
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8SZF C Ion Calcium-sensing CaS Homo sapiens - Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW - 2.8 2024-02-07 10.1038/s41586-024-07055-2

A 2D representation of the interactions of SPM in 8SZF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E228 R:R:K225 5.4 0 No Yes 3 3 1 2
K:K:?5 R:R:E228 11.41 4 Yes No 0 3 0 1
S:S:D238 S:S:W208 16.75 4 Yes Yes 8 9 1 2
S:S:F239 S:S:G210 9.03 4 Yes No 6 8 1 2
S:S:D238 S:S:F239 3.58 4 Yes Yes 8 6 1 1
S:S:D238 S:S:S262 5.89 4 Yes No 8 7 1 1
K:K:?5 S:S:D238 11.68 4 Yes Yes 0 8 0 1
S:S:F239 S:S:V258 3.93 4 Yes Yes 6 4 1 1
S:S:F239 S:S:I259 2.51 4 Yes No 6 6 1 2
S:S:F239 S:S:S262 5.28 4 Yes No 6 7 1 1
S:S:F239 S:S:I267 2.51 4 Yes Yes 6 7 1 2
K:K:?5 S:S:F239 5.83 4 Yes Yes 0 6 0 1
K:K:?5 S:S:S240 5.75 4 Yes No 0 4 0 1
S:S:E241 S:S:V255 5.7 4 No No 5 5 1 2
S:S:E241 S:S:V258 9.98 4 No Yes 5 4 1 1
K:K:?5 S:S:E241 2.54 4 Yes No 0 5 0 1
S:S:H254 S:S:V258 4.15 0 No Yes 3 4 2 1
H:H:?9 S:S:V258 3.99 0 No Yes 0 4 2 1
K:K:?5 S:S:V258 2.85 4 Yes Yes 0 4 0 1
K:K:?5 S:S:S262 4.31 4 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.34
Average Nodes In Shell16.00
Average Hubs In Shell7.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.34
Average Nodes In Shell16.00
Average Hubs In Shell7.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell19.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)