| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7E2Y | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo Sapiens | Serotonin | - | Gi1/Beta1/Gamma2 | 3 | 2021-04-14 | doi.org/10.1038/s41586-021-03376-8 |
|
A 2D representation of the interactions of SRO in 7E2Y
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D116 | R:R:V89 | 10.22 | 2 | Yes | No | 8 | 8 | 1 | 2 | | R:R:L90 | R:R:Y390 | 5.86 | 0 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:A93 | R:R:Y390 | 4 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:C120 | R:R:D116 | 4.67 | 2 | No | Yes | 7 | 8 | 1 | 1 | | R:R:D116 | R:R:Y390 | 10.34 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | | L:L:?1 | R:R:D116 | 7.95 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:C120 | 10.63 | 2 | Yes | No | 0 | 7 | 0 | 1 | | R:R:I167 | R:R:T121 | 6.08 | 0 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:A203 | R:R:T121 | 3.36 | 2 | No | Yes | 8 | 8 | 1 | 2 | | R:R:I167 | R:R:S199 | 3.1 | 0 | Yes | No | 8 | 8 | 2 | 1 | | R:R:S199 | R:R:Y195 | 2.54 | 0 | No | Yes | 8 | 8 | 1 | 2 | | L:L:?1 | R:R:S199 | 7.54 | 2 | Yes | No | 0 | 8 | 0 | 1 | | R:R:F362 | R:R:T200 | 2.59 | 2 | Yes | No | 7 | 7 | 1 | 2 | | R:R:A203 | R:R:F362 | 2.77 | 2 | No | Yes | 8 | 7 | 1 | 1 | | L:L:?1 | R:R:A203 | 2.64 | 2 | Yes | No | 0 | 8 | 0 | 1 | | R:R:F204 | R:R:W358 | 4.01 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:F204 | R:R:F362 | 20.36 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F362 | R:R:W358 | 3.01 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F361 | R:R:F362 | 3.22 | 2 | No | Yes | 8 | 7 | 1 | 1 | | R:R:F361 | R:R:N386 | 7.25 | 2 | No | No | 8 | 7 | 1 | 2 | | L:L:?1 | R:R:F361 | 10.19 | 2 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F362 | 8.15 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:N386 | R:R:Y390 | 5.81 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:W387 | R:R:Y390 | 9.65 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | | L:L:?1 | R:R:Y390 | 3.92 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:A365 | 1.32 | 2 | Yes | No | 0 | 8 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 6.54 | | Average Nodes In Shell | 20.00 | | Average Hubs In Shell | 11.00 | | Average Links In Shell | 26.00 | | Average Links Mediated by Hubs In Shell | 25.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7E32 | A | Amine | 5-Hydroxytryptamine | 5-HT1D | Homo Sapiens | Serotonin | - | Gi1/Beta1/Gamma2 | 2.9 | 2021-04-21 | doi.org/10.1038/s41586-021-03376-8 |
|
A 2D representation of the interactions of SRO in 7E32
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D118 | R:R:V91 | 5.84 | 1 | No | Yes | 8 | 8 | 1 | 2 | | R:R:V91 | R:R:Y346 | 5.05 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:S95 | R:R:W343 | 6.18 | 1 | No | Yes | 7 | 7 | 2 | 2 | | R:R:S95 | R:R:Y346 | 6.36 | 1 | No | Yes | 7 | 8 | 2 | 1 | | R:R:D118 | R:R:Y346 | 9.2 | 1 | No | Yes | 8 | 8 | 1 | 1 | | L:L:?1 | R:R:D118 | 11.36 | 1 | Yes | No | 0 | 8 | 0 | 1 | | R:R:I119 | R:R:S170 | 6.19 | 0 | No | No | 7 | 8 | 1 | 2 | | L:L:?1 | R:R:I119 | 7.17 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:C122 | R:R:W314 | 6.53 | 1 | No | Yes | 7 | 8 | 1 | 1 | | L:L:?1 | R:R:C122 | 13.28 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:F310 | R:R:I126 | 5.02 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:I126 | R:R:W314 | 5.87 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | L:L:?1 | R:R:V190 | 4.99 | 1 | Yes | No | 0 | 6 | 0 | 1 | | R:R:S201 | R:R:Y197 | 10.17 | 0 | No | No | 7 | 8 | 1 | 2 | | L:L:?1 | R:R:S201 | 7.54 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:A205 | 3.96 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:F206 | R:R:F310 | 10.72 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:F206 | R:R:F318 | 20.36 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F310 | R:R:W314 | 7.02 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:F317 | R:R:W314 | 11.02 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | | R:R:F318 | R:R:W314 | 10.02 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | | R:R:G345 | R:R:W314 | 8.44 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:N348 | R:R:W314 | 12.43 | 0 | No | Yes | 9 | 8 | 2 | 1 | | L:L:?1 | R:R:W314 | 3.81 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:F317 | R:R:F318 | 3.22 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:F317 | R:R:F338 | 3.22 | 1 | Yes | No | 8 | 5 | 1 | 2 | | L:L:?1 | R:R:F317 | 11.21 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F318 | 9.17 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:S321 | 5.03 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:T342 | R:R:Y346 | 3.75 | 0 | No | Yes | 6 | 8 | 2 | 1 | | R:R:W343 | R:R:Y346 | 6.75 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | | L:L:?1 | R:R:Y346 | 4.91 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 7.49 | | Average Nodes In Shell | 24.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 32.00 | | Average Links Mediated by Hubs In Shell | 30.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7WC4 | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo Sapiens | Serotonin | - | - | 3.2 | 2022-01-26 | doi.org/10.1126/science.abl8615 |
|
A 2D representation of the interactions of SRO in 7WC4
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:W151 | 6.67 | 0 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:D155 | 12.49 | 0 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:V156 | 3.74 | 0 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:L228 | 6.95 | 0 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:F339 | 6.12 | 0 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:V127 | R:R:W151 | 3.68 | 1 | Yes | Yes | 8 | 5 | 2 | 1 | | R:R:D155 | R:R:V127 | 7.3 | 1 | No | Yes | 8 | 8 | 1 | 2 | | R:R:V127 | R:R:Y370 | 3.79 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:V130 | R:R:W151 | 13.48 | 0 | No | Yes | 4 | 5 | 2 | 1 | | R:R:W141 | R:R:W151 | 6.56 | 1 | Yes | Yes | 7 | 5 | 2 | 1 | | R:R:C227 | R:R:W141 | 14.37 | 1 | Yes | Yes | 9 | 7 | 2 | 2 | | R:R:C227 | R:R:W151 | 3.92 | 1 | Yes | Yes | 9 | 5 | 2 | 1 | | R:R:D155 | R:R:Y370 | 10.34 | 1 | No | Yes | 8 | 7 | 1 | 2 | | R:R:I210 | R:R:V156 | 4.61 | 0 | No | No | 6 | 6 | 2 | 1 | | R:R:K223 | R:R:L228 | 7.05 | 0 | No | No | 3 | 4 | 2 | 1 | | R:R:F339 | R:R:W336 | 7.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:W336 | R:R:Y370 | 3.86 | 0 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:F339 | R:R:N343 | 4.83 | 1 | Yes | No | 7 | 7 | 1 | 2 | | R:R:F339 | R:R:L362 | 7.31 | 1 | Yes | No | 7 | 3 | 1 | 2 | | R:R:F339 | R:R:V366 | 5.24 | 1 | Yes | No | 7 | 6 | 1 | 2 | | R:R:L362 | R:R:N343 | 6.87 | 1 | No | No | 3 | 7 | 2 | 2 | | R:R:V366 | R:R:Y370 | 6.31 | 1 | No | Yes | 6 | 7 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 7.19 | | Average Nodes In Shell | 17.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 22.00 | | Average Links Mediated by Hubs In Shell | 19.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XT8 | A | Amine | 5-Hydroxytryptamine | 5-HT4 | Homo Sapiens | Serotonin | - | Gs/Beta1/Gamma2 | 3.1 | 2022-07-27 | doi.org/10.1016/j.molcel.2022.05.031 |
|
A 2D representation of the interactions of SRO in 7XT8
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D100 | R:R:V73 | 7.3 | 3 | Yes | No | 7 | 7 | 1 | 2 | | R:R:V73 | R:R:Y302 | 3.79 | 3 | No | Yes | 7 | 7 | 2 | 2 | | R:R:F186 | R:R:T97 | 9.08 | 3 | Yes | No | 4 | 4 | 1 | 2 | | R:R:D100 | R:R:T104 | 4.34 | 3 | Yes | No | 7 | 7 | 1 | 1 | | R:R:D100 | R:R:Y302 | 10.34 | 3 | Yes | Yes | 7 | 7 | 1 | 2 | | L:L:?1 | R:R:D100 | 9.23 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:V101 | 13.94 | 3 | Yes | No | 0 | 5 | 0 | 1 | | R:R:T104 | R:R:W272 | 10.92 | 3 | No | Yes | 7 | 8 | 1 | 2 | | L:L:?1 | R:R:T104 | 17.55 | 3 | Yes | No | 0 | 7 | 0 | 1 | | R:R:A200 | R:R:T105 | 5.03 | 0 | No | Yes | 5 | 6 | 1 | 2 | | R:R:F186 | R:R:N162 | 3.62 | 3 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:N162 | R:R:Y192 | 8.14 | 3 | Yes | Yes | 5 | 7 | 2 | 2 | | R:R:F186 | R:R:V188 | 5.24 | 3 | Yes | Yes | 4 | 4 | 1 | 1 | | R:R:F186 | R:R:Y192 | 5.16 | 3 | Yes | Yes | 4 | 7 | 1 | 2 | | L:L:?1 | R:R:F186 | 6.21 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:V188 | R:R:Y192 | 5.05 | 3 | Yes | Yes | 4 | 7 | 1 | 2 | | R:R:A193 | R:R:V188 | 3.39 | 0 | No | Yes | 5 | 4 | 2 | 1 | | R:R:N279 | R:R:V188 | 5.91 | 3 | Yes | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:V188 | 3.8 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:F276 | R:R:S197 | 5.28 | 0 | Yes | No | 7 | 6 | 1 | 2 | | R:R:N279 | R:R:S197 | 5.96 | 3 | Yes | No | 5 | 6 | 1 | 2 | | L:L:?1 | R:R:A200 | 4.02 | 3 | Yes | No | 0 | 5 | 0 | 1 | | R:R:F201 | R:R:F276 | 19.29 | 18 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F276 | R:R:W272 | 5.01 | 0 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F275 | R:R:W294 | 9.02 | 0 | No | Yes | 6 | 4 | 1 | 2 | | R:R:F275 | R:R:L298 | 7.31 | 0 | No | No | 6 | 5 | 1 | 2 | | L:L:?1 | R:R:F275 | 6.21 | 3 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F276 | 8.29 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:N279 | R:R:W294 | 5.65 | 3 | Yes | Yes | 5 | 4 | 1 | 2 | | L:L:?1 | R:R:N279 | 10.51 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:L298 | R:R:Y302 | 14.07 | 0 | No | Yes | 5 | 7 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 8.86 | | Average Nodes In Shell | 22.00 | | Average Hubs In Shell | 13.00 | | Average Links In Shell | 31.00 | | Average Links Mediated by Hubs In Shell | 30.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XT9 | A | Amine | 5-Hydroxytryptamine | 5-HT4 | Homo Sapiens | Serotonin | - | Gs/Beta1/Gamma2 | 3.2 | 2022-07-27 | doi.org/10.1016/j.molcel.2022.05.031 |
|
A 2D representation of the interactions of SRO in 7XT9
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D100 | R:R:V73 | 8.76 | 1 | Yes | No | 7 | 7 | 1 | 2 | | R:R:V73 | R:R:Y302 | 5.05 | 1 | No | Yes | 7 | 7 | 2 | 2 | | R:R:D100 | R:R:R96 | 9.53 | 1 | Yes | No | 7 | 5 | 1 | 2 | | R:R:F186 | R:R:T97 | 10.38 | 1 | Yes | No | 4 | 4 | 1 | 2 | | R:R:D100 | R:R:T104 | 4.34 | 1 | Yes | No | 7 | 7 | 1 | 1 | | R:R:D100 | R:R:Y302 | 10.34 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | | L:L:?1 | R:R:D100 | 6.92 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:V101 | 15.2 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:T104 | R:R:W272 | 8.49 | 1 | No | Yes | 7 | 8 | 1 | 2 | | L:L:?1 | R:R:T104 | 15.04 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:F186 | R:R:N162 | 3.62 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:N162 | R:R:Y192 | 8.14 | 0 | Yes | Yes | 5 | 7 | 2 | 2 | | R:R:F186 | R:R:V188 | 5.24 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | | L:L:?1 | R:R:F186 | 6.21 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:V188 | R:R:Y192 | 6.31 | 1 | Yes | Yes | 4 | 7 | 1 | 2 | | R:R:A193 | R:R:V188 | 3.39 | 0 | No | Yes | 5 | 4 | 2 | 1 | | R:R:N279 | R:R:V188 | 5.91 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:V188 | 3.8 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:F276 | R:R:S197 | 3.96 | 0 | Yes | No | 7 | 6 | 1 | 2 | | R:R:N279 | R:R:S197 | 5.96 | 1 | Yes | No | 5 | 6 | 1 | 2 | | R:R:F201 | R:R:F276 | 20.36 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F276 | R:R:W272 | 6.01 | 0 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F275 | R:R:W294 | 11.02 | 0 | No | Yes | 6 | 4 | 1 | 2 | | R:R:F275 | R:R:L298 | 6.09 | 0 | No | No | 6 | 5 | 1 | 2 | | L:L:?1 | R:R:F275 | 8.29 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F276 | 7.25 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:N279 | R:R:W294 | 4.52 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | L:L:?1 | R:R:N279 | 9.34 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:L298 | R:R:Y302 | 12.89 | 0 | No | Yes | 5 | 7 | 2 | 2 | | R:R:S153 | R:R:V101 | 3.23 | 10 | No | No | 7 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 9.01 | | Average Nodes In Shell | 22.00 | | Average Hubs In Shell | 12.00 | | Average Links In Shell | 30.00 | | Average Links Mediated by Hubs In Shell | 28.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XTA | A | Amine | 5-Hydroxytryptamine | 5-HT4 | Homo Sapiens | Serotonin | - | Gi1/Beta1/Gamma2 | 3.2 | 2022-07-27 | doi.org/10.1016/j.molcel.2022.05.031 |
|
A 2D representation of the interactions of SRO in 7XTA
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D100 | R:R:V73 | 7.3 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | | R:R:V73 | R:R:Y302 | 5.05 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | | R:R:D100 | R:R:T104 | 4.34 | 1 | Yes | No | 7 | 7 | 1 | 1 | | R:R:D100 | R:R:Y302 | 11.49 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | | L:L:?1 | R:R:D100 | 6.92 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:S153 | R:R:V101 | 3.23 | 16 | No | No | 7 | 5 | 2 | 1 | | R:R:I157 | R:R:V101 | 4.61 | 1 | Yes | No | 5 | 5 | 2 | 1 | | L:L:?1 | R:R:V101 | 12.67 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:T104 | R:R:W272 | 7.28 | 1 | No | Yes | 7 | 8 | 1 | 2 | | L:L:?1 | R:R:T104 | 8.77 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:C196 | R:R:I152 | 4.91 | 0 | No | No | 5 | 5 | 1 | 2 | | R:R:F186 | R:R:I157 | 5.02 | 1 | Yes | Yes | 4 | 5 | 2 | 2 | | R:R:I157 | R:R:Y192 | 6.04 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | | R:R:F186 | R:R:V188 | 3.93 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:F186 | R:R:Y192 | 3.09 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | | R:R:V188 | R:R:Y192 | 5.05 | 1 | Yes | Yes | 4 | 7 | 1 | 2 | | R:R:A193 | R:R:V188 | 3.39 | 0 | No | Yes | 5 | 4 | 2 | 1 | | R:R:N279 | R:R:V188 | 4.43 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | L:L:?1 | R:R:V188 | 3.8 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:C196 | R:R:Y192 | 9.41 | 0 | No | Yes | 5 | 7 | 1 | 2 | | L:L:?1 | R:R:C196 | 6.75 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:N279 | R:R:S197 | 5.96 | 1 | Yes | No | 5 | 6 | 1 | 2 | | R:R:A200 | R:R:F276 | 2.77 | 0 | No | Yes | 5 | 7 | 2 | 1 | | R:R:F201 | R:R:F276 | 21.43 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F276 | R:R:W272 | 4.01 | 0 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F275 | R:R:W294 | 5.01 | 0 | No | Yes | 6 | 4 | 1 | 2 | | R:R:F275 | R:R:L298 | 4.87 | 0 | No | No | 6 | 5 | 1 | 2 | | L:L:?1 | R:R:F275 | 13.47 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F276 | 9.32 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:N279 | R:R:W294 | 4.52 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | L:L:?1 | R:R:N279 | 12.85 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:L298 | R:R:Y302 | 15.24 | 0 | No | Yes | 5 | 7 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 9.32 | | Average Nodes In Shell | 23.00 | | Average Hubs In Shell | 13.00 | | Average Links In Shell | 32.00 | | Average Links Mediated by Hubs In Shell | 29.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XTB | A | Amine | 5-Hydroxytryptamine | 5-HT6 | Homo Sapiens | Serotonin | - | Gs/Beta1/Gamma2 | 3.3 | 2022-07-27 | doi.org/10.1016/j.molcel.2022.05.031 |
|
A 2D representation of the interactions of SRO in 7XTB
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D106 | R:R:V79 | 7.3 | 26 | No | Yes | 7 | 7 | 1 | 2 | | R:R:V79 | R:R:Y310 | 3.79 | 26 | Yes | Yes | 7 | 7 | 2 | 2 | | R:R:D106 | R:R:Y310 | 9.2 | 26 | No | Yes | 7 | 7 | 1 | 2 | | L:L:?1 | R:R:D106 | 6.92 | 0 | Yes | No | 0 | 7 | 0 | 1 | | R:R:S158 | R:R:V107 | 6.46 | 0 | No | No | 7 | 6 | 2 | 1 | | L:L:?1 | R:R:V107 | 13.94 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:C110 | R:R:W281 | 5.22 | 0 | No | Yes | 6 | 8 | 1 | 2 | | L:L:?1 | R:R:C110 | 12.15 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:S111 | R:R:T196 | 7.99 | 0 | No | No | 7 | 6 | 2 | 1 | | R:R:A192 | R:R:F188 | 4.16 | 0 | No | No | 6 | 7 | 1 | 2 | | R:R:N288 | R:R:V189 | 4.43 | 0 | No | No | 6 | 5 | 1 | 2 | | L:L:?1 | R:R:T196 | 5.01 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:F197 | R:R:W281 | 3.01 | 10 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:F197 | R:R:F285 | 27.86 | 10 | Yes | No | 8 | 6 | 2 | 1 | | R:R:F285 | R:R:W281 | 6.01 | 10 | No | Yes | 6 | 8 | 1 | 2 | | R:R:F284 | R:R:F302 | 4.29 | 0 | No | No | 7 | 4 | 1 | 2 | | R:R:F284 | R:R:T306 | 7.78 | 0 | No | No | 7 | 4 | 1 | 2 | | L:L:?1 | R:R:F284 | 6.21 | 0 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F285 | 5.18 | 0 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:N288 | 7.01 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:T306 | R:R:Y310 | 6.24 | 0 | No | Yes | 4 | 7 | 2 | 2 | | L:L:?1 | R:R:A192 | 2.68 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:L195 | R:R:T196 | 1.47 | 0 | No | No | 3 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.39 | | Average Nodes In Shell | 20.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 23.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7YS6 | A | Amine | 5-Hydroxytryptamine | 5-HT6 | Homo Sapiens | Serotonin | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 3 | 2023-03-29 | doi.org/10.1073/pnas.2209917120 |
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A 2D representation of the interactions of SRO in 7YS6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D106 | R:R:V79 | 4.38 | 5 | No | Yes | 7 | 7 | 1 | 2 | | R:R:V79 | R:R:Y310 | 3.79 | 5 | Yes | Yes | 7 | 7 | 2 | 2 | | R:R:L162 | R:R:T103 | 4.42 | 0 | Yes | No | 5 | 4 | 2 | 2 | | R:R:L182 | R:R:T103 | 8.84 | 0 | No | No | 4 | 4 | 1 | 2 | | R:R:D106 | R:R:Y310 | 11.49 | 5 | No | Yes | 7 | 7 | 1 | 2 | | L:L:?1 | R:R:D106 | 8.08 | 0 | Yes | No | 0 | 7 | 0 | 1 | | R:R:S158 | R:R:V107 | 3.23 | 23 | No | No | 7 | 6 | 2 | 1 | | R:R:L162 | R:R:V107 | 2.98 | 0 | Yes | No | 5 | 6 | 2 | 1 | | L:L:?1 | R:R:V107 | 7.6 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:C110 | R:R:W281 | 3.92 | 0 | No | Yes | 6 | 8 | 1 | 2 | | L:L:?1 | R:R:C110 | 10.8 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:S111 | R:R:T196 | 7.99 | 0 | No | No | 7 | 6 | 2 | 1 | | L:L:?1 | R:R:L182 | 4.71 | 0 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:T196 | 5.01 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:F197 | R:R:W281 | 3.01 | 5 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:F197 | R:R:F285 | 11.79 | 5 | Yes | No | 8 | 6 | 2 | 1 | | R:R:F284 | R:R:W281 | 3.01 | 5 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F285 | R:R:W281 | 3.01 | 5 | No | Yes | 6 | 8 | 1 | 2 | | R:R:F284 | R:R:F302 | 7.5 | 5 | Yes | Yes | 7 | 4 | 1 | 2 | | R:R:F284 | R:R:T306 | 9.08 | 5 | Yes | No | 7 | 4 | 1 | 2 | | L:L:?1 | R:R:F284 | 4.14 | 0 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F285 | 8.29 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:F302 | R:R:N288 | 4.83 | 5 | Yes | No | 4 | 6 | 2 | 1 | | L:L:?1 | R:R:N288 | 9.34 | 0 | Yes | No | 0 | 6 | 0 | 1 | | R:R:F302 | R:R:T306 | 5.19 | 5 | Yes | No | 4 | 4 | 2 | 2 | | R:R:T306 | R:R:Y310 | 4.99 | 5 | No | Yes | 4 | 7 | 2 | 2 | | R:R:F284 | R:R:L305 | 2.44 | 5 | Yes | No | 7 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 7.25 | | Average Nodes In Shell | 20.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 27.00 | | Average Links Mediated by Hubs In Shell | 24.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9ARX | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo Sapiens | Serotonin | - | - | 3.24 | 2025-04-02 | doi.org/10.1038/s41467-025-57956-7 |
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A 2D representation of the interactions of SRO in 9ARX
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D155 | 9.23 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:V156 | 11.4 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S159 | 8.94 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:V235 | 3.8 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:G238 | 2.91 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S239 | 3.83 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S242 | 8.94 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F339 | 8.29 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F340 | 12.43 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:N343 | 3.5 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:V127 | R:R:W151 | 3.68 | 1 | Yes | Yes | 8 | 5 | 2 | 2 | | R:R:D155 | R:R:V127 | 4.38 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:V127 | R:R:Y370 | 3.79 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:D155 | R:R:W151 | 3.35 | 1 | Yes | Yes | 8 | 5 | 1 | 2 | | R:R:D155 | R:R:S159 | 2.94 | 1 | Yes | No | 8 | 7 | 1 | 1 | | R:R:D155 | R:R:Y370 | 10.34 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:S207 | R:R:V156 | 4.85 | 0 | No | No | 7 | 6 | 2 | 1 | | R:R:S242 | R:R:T160 | 7.99 | 0 | No | No | 6 | 7 | 1 | 2 | | R:R:L229 | R:R:V235 | 2.98 | 0 | Yes | Yes | 4 | 6 | 2 | 1 | | R:R:N343 | R:R:V235 | 4.43 | 1 | No | Yes | 7 | 6 | 1 | 1 | | R:R:V235 | R:R:V347 | 3.21 | 1 | Yes | No | 6 | 5 | 1 | 2 | | R:R:G238 | R:R:I237 | 3.53 | 0 | No | No | 6 | 4 | 1 | 2 | | R:R:F340 | R:R:S239 | 5.28 | 1 | Yes | No | 7 | 6 | 1 | 1 | | R:R:I344 | R:R:S239 | 4.64 | 0 | No | No | 5 | 6 | 2 | 1 | | R:R:F243 | R:R:F340 | 23.58 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F339 | R:R:F340 | 7.5 | 1 | No | Yes | 7 | 7 | 1 | 1 | | R:R:F339 | R:R:V366 | 3.93 | 1 | No | No | 7 | 6 | 1 | 2 | | R:R:V366 | R:R:Y370 | 6.31 | 0 | No | Yes | 6 | 7 | 2 | 2 | | R:R:L362 | R:R:N343 | 2.75 | 0 | No | No | 3 | 7 | 2 | 1 | | R:R:G238 | R:R:V241 | 1.84 | 0 | No | No | 6 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 10.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 7.33 | | Average Nodes In Shell | 24.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 30.00 | | Average Links Mediated by Hubs In Shell | 23.00 |
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Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9ARY | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo Sapiens | Serotonin | - | chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 | 3.27 | 2025-04-02 | doi.org/10.1038/s41467-025-57956-7 |
|
A 2D representation of the interactions of SRO in 9ARY
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D155 | 9.23 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:V156 | 11.4 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S159 | 8.94 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:T160 | 2.51 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:L229 | 2.35 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:V235 | 3.8 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:G238 | 2.91 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S239 | 3.83 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S242 | 8.94 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F339 | 8.29 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F340 | 12.43 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:N343 | 3.5 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:V127 | R:R:W151 | 3.68 | 1 | Yes | Yes | 8 | 5 | 2 | 2 | | R:R:D155 | R:R:V127 | 4.38 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:V127 | R:R:Y370 | 3.79 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:I152 | R:R:W151 | 3.52 | 0 | No | Yes | 5 | 5 | 2 | 2 | | R:R:D155 | R:R:W151 | 3.35 | 1 | Yes | Yes | 8 | 5 | 1 | 2 | | R:R:I152 | R:R:I210 | 2.94 | 0 | No | Yes | 5 | 6 | 2 | 2 | | R:R:I152 | R:R:L229 | 4.28 | 0 | No | Yes | 5 | 4 | 2 | 1 | | R:R:D155 | R:R:S159 | 2.94 | 1 | Yes | No | 8 | 7 | 1 | 1 | | R:R:D155 | R:R:Y370 | 10.34 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:S207 | R:R:V156 | 4.85 | 1 | No | No | 7 | 6 | 2 | 1 | | R:R:I210 | R:R:V156 | 4.61 | 1 | Yes | No | 6 | 6 | 2 | 1 | | R:R:S159 | R:R:W336 | 2.47 | 1 | No | Yes | 7 | 8 | 1 | 2 | | R:R:S242 | R:R:T160 | 7.99 | 1 | No | No | 6 | 7 | 1 | 1 | | R:R:I163 | R:R:W336 | 5.87 | 1 | No | Yes | 8 | 8 | 2 | 2 | | R:R:F340 | R:R:I163 | 2.51 | 1 | Yes | No | 7 | 8 | 1 | 2 | | R:R:I210 | R:R:S207 | 4.64 | 1 | Yes | No | 6 | 7 | 2 | 2 | | R:R:F234 | R:R:I210 | 5.02 | 0 | No | Yes | 7 | 6 | 2 | 2 | | R:R:L228 | R:R:L229 | 2.77 | 0 | No | Yes | 4 | 4 | 2 | 1 | | R:R:F234 | R:R:L229 | 7.31 | 0 | No | Yes | 7 | 4 | 2 | 1 | | R:R:L229 | R:R:V235 | 2.98 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | | R:R:N343 | R:R:V235 | 4.43 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | | R:R:V235 | R:R:V347 | 3.21 | 1 | Yes | No | 6 | 5 | 1 | 2 | | R:R:G238 | R:R:I237 | 3.53 | 0 | No | No | 6 | 4 | 1 | 2 | | R:R:G238 | R:R:V241 | 1.84 | 0 | No | No | 6 | 4 | 1 | 2 | | R:R:F340 | R:R:S239 | 5.28 | 1 | Yes | No | 7 | 6 | 1 | 1 | | R:R:I344 | R:R:S239 | 4.64 | 0 | No | No | 5 | 6 | 2 | 1 | | R:R:F243 | R:R:F244 | 5.36 | 1 | Yes | Yes | 8 | 5 | 2 | 2 | | R:R:F243 | R:R:W336 | 3.01 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:F243 | R:R:F340 | 23.58 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F244 | R:R:F340 | 2.14 | 1 | Yes | Yes | 5 | 7 | 2 | 1 | | R:R:F244 | R:R:I344 | 5.02 | 1 | Yes | No | 5 | 5 | 2 | 2 | | R:R:F340 | R:R:W336 | 2 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F339 | R:R:F340 | 7.5 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | | R:R:F339 | R:R:N343 | 2.42 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | | R:R:F339 | R:R:L362 | 2.44 | 1 | Yes | Yes | 7 | 3 | 1 | 2 | | R:R:F339 | R:R:V366 | 3.93 | 1 | Yes | No | 7 | 6 | 1 | 2 | | R:R:L362 | R:R:N343 | 2.75 | 1 | Yes | Yes | 3 | 7 | 2 | 1 | | R:R:V366 | R:R:Y370 | 6.31 | 0 | No | Yes | 6 | 7 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 12.00 | | Average Number Of Links With An Hub | 6.00 | | Average Interaction Strength | 6.51 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 15.00 | | Average Links In Shell | 50.00 | | Average Links Mediated by Hubs In Shell | 45.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
