CodeSY9
NameStrychnine
SynonymsStrychnine
Identifier
FormulaC21 H22 N2 O2
Molecular Weight334.412
SMILESc1ccc2c(c1)[C@]34CC[N@@]5[C@H]3C[C@@H]6[C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C6C5
PubChem441071
Formal Charge0
Total Atoms47
Total Chiral Atoms7
Total Bonds53
Total Aromatic Bonds6
Networks1
 missing image

This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XP6 T Sensory Taste2 T2R46 Homo sapiens Strychnine - chim(Gs-CtGt3)/Beta1/Gamma2 3.01 2022-10-12 10.1126/science.abo1633

A 2D representation of the interactions of SY9 in 7XP6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L58 R:R:L62 2.77 0 Yes Yes 4 4 2 1
R:R:L58 R:R:N92 6.87 0 Yes Yes 4 8 2 2
R:R:V61 R:R:W88 7.36 0 No Yes 4 4 2 1
R:R:L62 R:R:W88 3.42 2 Yes Yes 4 4 1 1
R:R:F269 R:R:L62 8.53 2 Yes Yes 4 4 2 1
L:L:?1 R:R:L62 2.88 2 Yes Yes 0 4 0 1
R:R:N65 R:R:T69 4.39 0 No No 4 4 1 2
L:L:?1 R:R:N65 18.09 2 Yes No 0 4 0 1
R:R:W88 R:R:Y85 2.89 2 Yes No 4 2 1 1
R:R:V179 R:R:Y85 5.05 0 No No 4 2 2 1
L:L:?1 R:R:Y85 4.88 2 Yes No 0 2 0 1
R:R:N92 R:R:W88 10.17 2 Yes Yes 8 4 2 1
L:L:?1 R:R:W88 34.75 2 Yes Yes 0 4 0 1
R:R:N184 R:R:N92 6.81 2 Yes Yes 5 8 2 2
R:R:F252 R:R:N176 3.62 0 No No 2 3 1 2
R:R:N184 R:R:T180 2.92 2 Yes No 5 2 2 1
L:L:?1 R:R:T180 3.07 2 Yes No 0 2 0 1
R:R:C264 R:R:S248 3.44 0 Yes No 3 5 2 1
L:L:?1 R:R:S248 3.12 2 Yes No 0 5 0 1
R:R:E265 R:R:F261 11.66 0 No No 3 1 1 2
L:L:?1 R:R:E265 9.19 2 Yes No 0 3 0 1
L:L:?1 R:R:F252 1.69 2 Yes No 0 2 0 1
R:R:T180 R:R:V249 1.59 0 No No 2 3 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.71
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.71
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell18.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)