CodeSY9
NameStrychnine
SynonymsStrychnidin-10-one
Identifier
FormulaC21 H22 N2 O2
Molecular Weight334.412
SMILES
PubChem441071
Formal Charge0
Total Atoms47
Total Chiral Atoms7
Total Bonds53
Total Aromatic Bonds6
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XP6 T2 Sensory Taste2 TAS2R46 Homo Sapiens Strychnine - chim(Gs-CtGt3)/Beta1/Gamma2 3.01 2022-10-12 doi.org/10.1126/science.abo1633

A 2D representation of the interactions of SY9 in 7XP6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L58 R:R:L62 2.77 0 Yes Yes 4 4 2 1
R:R:L58 R:R:N92 6.87 0 Yes Yes 4 8 2 2
R:R:V61 R:R:W88 7.36 0 No Yes 4 4 2 1
R:R:L62 R:R:W88 3.42 2 Yes Yes 4 4 1 1
R:R:F269 R:R:L62 8.53 2 Yes Yes 4 4 2 1
L:L:?1 R:R:L62 2.88 2 Yes Yes 0 4 0 1
R:R:N65 R:R:T69 4.39 0 No No 4 4 1 2
L:L:?1 R:R:N65 18.09 2 Yes No 0 4 0 1
R:R:W88 R:R:Y85 2.89 2 Yes No 4 2 1 1
R:R:V179 R:R:Y85 5.05 0 No No 4 2 2 1
L:L:?1 R:R:Y85 4.88 2 Yes No 0 2 0 1
R:R:N92 R:R:W88 10.17 2 Yes Yes 8 4 2 1
L:L:?1 R:R:W88 34.75 2 Yes Yes 0 4 0 1
R:R:N184 R:R:N92 6.81 2 Yes Yes 5 8 2 2
R:R:F252 R:R:N176 3.62 0 No No 2 3 1 2
R:R:N184 R:R:T180 2.92 2 Yes No 5 2 2 1
L:L:?1 R:R:T180 3.07 2 Yes No 0 2 0 1
R:R:C264 R:R:S248 3.44 0 Yes No 3 5 2 1
L:L:?1 R:R:S248 3.12 2 Yes No 0 5 0 1
R:R:E265 R:R:F261 11.66 0 No No 3 1 1 2
L:L:?1 R:R:E265 9.19 2 Yes No 0 3 0 1
L:L:?1 R:R:F252 1.69 2 Yes No 0 2 0 1
R:R:T180 R:R:V249 1.59 0 No No 2 3 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.71
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub1.50
Average Interaction Strength9.71
Average Nodes In Shell19.50
Average Hubs In Shell7.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell17.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)