Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 3UZC | A | Nucleotide | Adenosine | A2A | Homo sapiens | PubChem 135566609 | - | - | 3.34 | 2012-03-21 | 10.1021/jm201376w |
A 2D representation of the interactions of T4E in 3UZC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:I60 | 4.1 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:E13 | R:R:H278 | 9.85 | 1 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:H278 | R:R:I60 | 7.95 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:F168 | R:R:I66 | 5.02 | 1 | Yes | No | 4 | 4 | 1 | 2 | L:L:?1 | R:R:V84 | 9.99 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:L85 | R:R:M177 | 4.24 | 0 | No | Yes | 4 | 6 | 2 | 1 | R:R:A88 | R:R:W246 | 3.89 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:F168 | R:R:V172 | 7.87 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 3.73 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F168 | 26.13 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:M177 | R:R:Y176 | 3.59 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | L:L:?1 | R:R:M177 | 5.69 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F182 | R:R:V186 | 3.93 | 1 | Yes | No | 5 | 7 | 2 | 2 | R:R:F182 | R:R:H250 | 22.63 | 1 | Yes | No | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 4.15 | 1 | No | No | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 18.04 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F242 | R:R:N280 | 6.04 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:A277 | R:R:W246 | 9.08 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:N280 | R:R:W246 | 4.52 | 1 | No | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 3.82 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:A273 | R:R:L249 | 4.73 | 0 | No | No | 6 | 5 | 2 | 1 | L:L:?1 | R:R:L249 | 20.41 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 7.76 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:N253 | 12.89 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | No | 6 | 4 | 1 | 1 | L:L:?1 | R:R:I274 | 17.22 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:H278 | 9.48 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:A63 | R:R:H278 | 2.93 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:I252 | R:R:M270 | 2.92 | 0 | No | No | 5 | 4 | 2 | 1 | L:L:?1 | R:R:M270 | 2.84 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:E169 | R:R:F168 | 1.17 | 1 | No | Yes | 3 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 11.62 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 28.00 |
| Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5OLZ | A | Nucleotide | Adenosine | A2A | Homo sapiens | PubChem 135566609 | Na | - | 1.9 | 2018-01-17 | 10.1038/s41598-017-18570-w |
A 2D representation of the interactions of T4E in 5OLZ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:Y9 | 15.71 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:I274 | R:R:Y9 | 6.04 | 1 | No | Yes | 4 | 5 | 1 | 2 | R:R:E13 | R:R:I60 | 8.2 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:E13 | R:R:H278 | 13.54 | 1 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:A59 | R:R:V84 | 3.39 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:H278 | R:R:I60 | 11.93 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | L:L:?1 | R:R:V84 | 11.98 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:L85 | R:R:Y176 | 3.52 | 1 | No | Yes | 4 | 6 | 2 | 2 | R:R:L85 | R:R:M177 | 4.24 | 1 | No | Yes | 4 | 6 | 2 | 1 | R:R:L85 | R:R:N181 | 8.24 | 1 | No | No | 4 | 5 | 2 | 2 | R:R:A88 | R:R:W246 | 3.89 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:F168 | R:R:V172 | 14.42 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 7.46 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F168 | 32.66 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:E169 | R:R:M174 | 5.41 | 0 | No | No | 3 | 4 | 1 | 2 | R:R:E169 | R:R:H264 | 11.08 | 0 | No | No | 3 | 2 | 1 | 2 | L:L:?1 | R:R:E169 | 7.11 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:M174 | R:R:N253 | 9.82 | 0 | No | No | 4 | 5 | 2 | 1 | R:R:M177 | R:R:Y176 | 3.59 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:N181 | R:R:Y176 | 9.3 | 1 | No | Yes | 5 | 6 | 2 | 2 | R:R:M177 | R:R:N253 | 4.21 | 1 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:M177 | 6.63 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:H250 | R:R:N181 | 3.83 | 1 | Yes | No | 6 | 5 | 1 | 2 | R:R:F182 | R:R:V186 | 3.93 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:F182 | R:R:H250 | 26.02 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 6.92 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 18.04 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F242 | R:R:N280 | 8.46 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:A277 | R:R:W246 | 7.78 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:N280 | R:R:W246 | 3.39 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 5.34 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:L249 | 13.92 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 6.9 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:N253 | 11.97 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | No | 6 | 4 | 1 | 1 | L:L:?1 | R:R:I274 | 13.4 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:H278 | 7.76 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:A63 | 3.17 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:A273 | R:R:L249 | 3.15 | 0 | No | No | 6 | 5 | 2 | 1 | R:R:A81 | R:R:F168 | 2.77 | 0 | No | Yes | 5 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 10.99 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 40.00 | Average Links Mediated by Hubs In Shell | 34.00 |
| Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5OM1 | A | Nucleotide | Adenosine | A2A | Homo sapiens | PubChem 135566609 | Na | - | 2.1 | 2018-01-17 | 10.1038/s41598-017-18570-w |
A 2D representation of the interactions of T4E in 5OM1 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:Y9 | 14.59 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:I274 | R:R:Y9 | 6.04 | 1 | No | Yes | 4 | 5 | 1 | 2 | R:R:E13 | R:R:I60 | 8.2 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:E13 | R:R:H278 | 13.54 | 1 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:H278 | R:R:I60 | 11.93 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | L:L:?1 | R:R:V84 | 11.98 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:L85 | R:R:Y176 | 3.52 | 1 | No | Yes | 4 | 6 | 2 | 2 | R:R:L85 | R:R:M177 | 4.24 | 1 | No | Yes | 4 | 6 | 2 | 1 | R:R:L85 | R:R:N181 | 8.24 | 1 | No | No | 4 | 5 | 2 | 2 | R:R:A88 | R:R:W246 | 3.89 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:F168 | R:R:V172 | 14.42 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 6.22 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F168 | 31.03 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:E169 | R:R:M174 | 5.41 | 0 | No | No | 3 | 4 | 1 | 2 | R:R:E169 | R:R:H264 | 9.85 | 0 | No | No | 3 | 2 | 1 | 2 | L:L:?1 | R:R:E169 | 7.11 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:M174 | R:R:N253 | 8.41 | 0 | No | No | 4 | 5 | 2 | 1 | R:R:M177 | R:R:Y176 | 3.59 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:N181 | R:R:Y176 | 9.3 | 1 | No | Yes | 5 | 6 | 2 | 2 | L:L:?1 | R:R:M177 | 6.63 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:H250 | R:R:N181 | 3.83 | 0 | Yes | No | 6 | 5 | 1 | 2 | R:R:F182 | R:R:H250 | 26.02 | 4 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 6.92 | 0 | Yes | No | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 16.04 | 7 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:A277 | R:R:W246 | 7.78 | 0 | No | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 5.34 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:L249 | 14.85 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 6.9 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:N253 | 11.97 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | No | 6 | 4 | 1 | 1 | L:L:?1 | R:R:I274 | 13.4 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:H278 | 7.76 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:A63 | 3.17 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:A273 | R:R:L249 | 3.15 | 0 | No | No | 6 | 5 | 2 | 1 | R:R:A81 | R:R:F168 | 2.77 | 0 | No | Yes | 5 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 10.92 | Average Nodes In Shell | 28.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 35.00 | Average Links Mediated by Hubs In Shell | 30.00 |
| Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5OM4 | A | Nucleotide | Adenosine | A2A | Homo sapiens | PubChem 135566609 | Na | - | 2 | 2018-01-17 | 10.1038/s41598-017-18570-w |
A 2D representation of the interactions of T4E in 5OM4 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:Y9 | 14.59 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:I274 | R:R:Y9 | 6.04 | 1 | No | Yes | 4 | 5 | 1 | 2 | R:R:E13 | R:R:I60 | 6.83 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:E13 | R:R:H278 | 13.54 | 1 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:H278 | R:R:I60 | 11.93 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | L:L:?1 | R:R:V84 | 12.98 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:L85 | R:R:Y176 | 3.52 | 1 | No | Yes | 4 | 6 | 2 | 2 | R:R:L85 | R:R:M177 | 4.24 | 1 | No | Yes | 4 | 6 | 2 | 1 | R:R:L85 | R:R:N181 | 8.24 | 1 | No | No | 4 | 5 | 2 | 2 | R:R:A88 | R:R:W246 | 3.89 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:F168 | R:R:V172 | 14.42 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 7.46 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F168 | 32.66 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:E169 | R:R:M174 | 5.41 | 0 | No | No | 3 | 4 | 1 | 2 | R:R:E169 | R:R:H264 | 11.08 | 0 | No | No | 3 | 2 | 1 | 2 | L:L:?1 | R:R:E169 | 8 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:M174 | R:R:N253 | 8.41 | 0 | No | No | 4 | 5 | 2 | 1 | R:R:M177 | R:R:Y176 | 3.59 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:N181 | R:R:Y176 | 10.47 | 1 | No | Yes | 5 | 6 | 2 | 2 | L:L:?1 | R:R:M177 | 6.63 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:H250 | R:R:N181 | 3.83 | 1 | Yes | No | 6 | 5 | 1 | 2 | R:R:F182 | R:R:V186 | 3.93 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:F182 | R:R:H250 | 27.15 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 6.92 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 16.04 | 6 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:A277 | R:R:W246 | 7.78 | 0 | No | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 5.34 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:L249 | 14.85 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 6.9 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:I252 | R:R:M270 | 4.37 | 0 | No | No | 5 | 4 | 2 | 1 | L:L:?1 | R:R:N253 | 11.97 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | No | 6 | 4 | 1 | 1 | L:L:?1 | R:R:I274 | 12.44 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:H278 | 7.76 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:A63 | 3.17 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:A273 | R:R:L249 | 3.15 | 0 | No | No | 6 | 5 | 2 | 1 | L:L:?1 | R:R:M270 | 2.84 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:A81 | R:R:F168 | 2.77 | 0 | No | Yes | 5 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 10.46 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|