Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8DPF | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Lorcaserin | - | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 2.84 | 2022-08-24 | 10.1016/j.celrep.2022.111211 |
![](/psngpcr/ligands/T4U/T4U_8DPF_L_L_1.png)
A 2D representation of the interactions of T4U in 8DPF colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D134 | R:R:V106 | 13.15 | 6 | No | No | 8 | 7 | 1 | 2 | R:R:V106 | R:R:Y358 | 6.31 | 6 | No | Yes | 7 | 8 | 2 | 2 | R:R:D134 | R:R:Y358 | 10.34 | 6 | No | Yes | 8 | 8 | 1 | 2 | L:L:?1 | R:R:D134 | 11.16 | 6 | Yes | No | 0 | 8 | 0 | 1 | R:R:V135 | R:R:V185 | 3.21 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:I189 | R:R:V135 | 4.61 | 7 | Yes | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:V135 | 15.75 | 6 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S138 | 10.59 | 6 | Yes | No | 0 | 6 | 0 | 1 | R:R:F328 | R:R:S219 | 5.28 | 6 | Yes | No | 7 | 7 | 1 | 1 | L:L:?1 | R:R:S219 | 3.53 | 6 | Yes | No | 0 | 7 | 0 | 1 | R:R:F223 | R:R:W324 | 4.01 | 6 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F223 | R:R:F328 | 25.72 | 6 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F328 | R:R:W324 | 2 | 6 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F327 | R:R:F328 | 3.22 | 6 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F327 | R:R:L350 | 3.65 | 6 | Yes | No | 7 | 4 | 1 | 2 | R:R:F327 | R:R:F353 | 2.14 | 6 | Yes | Yes | 7 | 6 | 1 | 2 | R:R:F327 | R:R:V354 | 7.87 | 6 | Yes | No | 7 | 7 | 1 | 1 | L:L:?1 | R:R:F327 | 7.16 | 6 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F328 | 5.72 | 6 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:V354 | R:R:Y358 | 5.05 | 6 | No | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:V354 | 3.5 | 6 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:A222 | 1.85 | 6 | Yes | No | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 7.41 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 22.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/T4U/T4U_8DPF_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/T4U/T4U_8DPF_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8DPH | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Lorcaserin | - | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.2 | 2022-08-24 | 10.1016/j.celrep.2022.111211 |
![](/psngpcr/ligands/T4U/T4U_8DPH_L_L_1.png)
A 2D representation of the interactions of T4U in 8DPH colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D134 | R:R:V106 | 11.69 | 7 | Yes | No | 8 | 7 | 1 | 2 | R:R:V106 | R:R:Y358 | 5.05 | 7 | No | Yes | 7 | 8 | 2 | 1 | R:R:D134 | R:R:W130 | 3.35 | 7 | Yes | No | 8 | 5 | 1 | 2 | R:R:D134 | R:R:Y358 | 10.34 | 7 | Yes | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:D134 | 23.92 | 7 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:V135 | R:R:V185 | 3.21 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:I189 | R:R:V135 | 4.61 | 9 | Yes | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:V135 | 19.25 | 7 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S138 | 15.88 | 7 | Yes | No | 0 | 6 | 0 | 1 | R:R:F327 | R:R:L350 | 3.65 | 7 | No | No | 7 | 4 | 1 | 2 | R:R:F327 | R:R:V354 | 7.87 | 7 | No | No | 7 | 7 | 1 | 1 | L:L:?1 | R:R:F327 | 5.72 | 7 | Yes | No | 0 | 7 | 0 | 1 | R:R:V354 | R:R:Y358 | 5.05 | 7 | No | Yes | 7 | 8 | 1 | 1 | L:L:?1 | R:R:V354 | 3.5 | 7 | Yes | No | 0 | 7 | 0 | 1 | R:R:W355 | R:R:Y358 | 9.65 | 7 | Yes | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:Y358 | 4.13 | 7 | Yes | Yes | 0 | 8 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 12.07 | Average Nodes In Shell | 13.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 16.00 | Average Links Mediated by Hubs In Shell | 13.00 |
| ![](/psngpcr/ligands/T4U/T4U_8DPH_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/T4U/T4U_8DPH_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8DPI | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Lorcaserin | - | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.4 | 2022-08-24 | 10.1016/j.celrep.2022.111211 |
![](/psngpcr/ligands/T4U/T4U_8DPI_L_L_1.png)
A 2D representation of the interactions of T4U in 8DPI colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D134 | R:R:V106 | 11.69 | 13 | No | No | 8 | 7 | 1 | 2 | R:R:V106 | R:R:Y358 | 5.05 | 13 | No | Yes | 7 | 8 | 2 | 2 | R:R:D134 | R:R:Y358 | 10.34 | 13 | No | Yes | 8 | 8 | 1 | 2 | L:L:?1 | R:R:D134 | 17.54 | 13 | Yes | No | 0 | 8 | 0 | 1 | R:R:V135 | R:R:V185 | 3.21 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:I189 | R:R:V135 | 4.61 | 9 | Yes | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:V135 | 19.25 | 13 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S138 | 14.11 | 13 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S219 | 3.53 | 13 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:A222 | 5.55 | 13 | Yes | No | 0 | 7 | 0 | 1 | R:R:F223 | R:R:F328 | 30.01 | 0 | Yes | No | 8 | 7 | 2 | 1 | R:R:F327 | R:R:F328 | 3.22 | 13 | Yes | No | 7 | 7 | 1 | 1 | R:R:F327 | R:R:V354 | 7.87 | 13 | Yes | No | 7 | 7 | 1 | 2 | L:L:?1 | R:R:F327 | 7.16 | 13 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F328 | 8.59 | 13 | Yes | No | 0 | 7 | 0 | 1 | R:R:V354 | R:R:Y358 | 5.05 | 0 | No | Yes | 7 | 8 | 2 | 2 | R:R:F327 | R:R:L350 | 2.44 | 13 | Yes | No | 7 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 10.82 | Average Nodes In Shell | 15.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 17.00 | Average Links Mediated by Hubs In Shell | 15.00 |
| ![](/psngpcr/ligands/T4U/T4U_8DPI_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/T4U/T4U_8DPI_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|