psnGPCR

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7YAE

Peptide

Somatostatin

SST2

Homo Sapiens

Octreotide

Gi1/Beta1/Gamma2

3.37

2023-04-19

10.1038/s41467-023-36673-z

A 2D representation of the interactions of THO in 7YAE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q102	R:R:S192	5.78	5	Yes	No	5	4	2	1
R:R:N186	R:R:S192	7.45	0	No	No	1	4	2	1
R:R:I195	R:R:T194	3.04	4	Yes	No	5	4	2	1
L:L:?8	R:R:T194	7.65	19	Yes	No	0	4	0	1
L:L:?1	R:R:P286	5.59	19	Yes	No	0	2	1	2
L:L:C7	R:R:F294	2.79	19	Yes	Yes	0	4	1	2
L:L:?1	L:L:C2	10.81	19	Yes	No	0	0	1	2
L:L:?1	L:L:C7	13.51	19	Yes	Yes	0	0	1	1
L:L:?1	L:L:?8	16.81	19	Yes	Yes	0	0	1	0
L:L:C2	L:L:C7	7.28	19	No	Yes	0	0	2	1
L:L:?8	L:L:C7	4.12	19	Yes	Yes	0	0	0	1
L:L:?1	R:R:I284	2.43	19	Yes	No	0	1	1	2
L:L:?8	R:R:S192	1.95	19	Yes	No	0	4	0	1
L:L:C7	R:R:K291	1.62	19	Yes	No	0	3	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	7.63
Average Nodes In Shell	13.00
Average Hubs In Shell	6.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	7.63
Average Nodes In Shell	13.00
Average Hubs In Shell	6.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)