Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 3D4S | A | Amine | Adrenergic | Beta2 | Homo sapiens | Timolol Maleate | - | - | 2.8 | 2008-06-17 | 10.1016/j.str.2008.05.001 |
A 2D representation of the interactions of TIM in 3D4S colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M82 | R:R:V86 | 7.61 | 1 | Yes | No | 7 | 7 | 2 | 2 | R:R:D113 | R:R:M82 | 4.16 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:D113 | R:R:V86 | 7.3 | 1 | Yes | No | 7 | 7 | 1 | 2 | R:R:V86 | R:R:Y316 | 5.05 | 1 | No | Yes | 7 | 6 | 2 | 1 | R:R:F193 | R:R:T110 | 6.49 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:D113 | R:R:Y316 | 11.49 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | L:L:?1 | R:R:D113 | 19.21 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S165 | R:R:V114 | 6.46 | 0 | No | No | 7 | 5 | 2 | 1 | L:L:?1 | R:R:V114 | 13.05 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:V117 | R:R:W286 | 8.58 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:V117 | 10.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S161 | R:R:T118 | 6.4 | 0 | No | Yes | 8 | 6 | 2 | 1 | R:R:S165 | R:R:T118 | 4.8 | 0 | No | Yes | 7 | 6 | 2 | 1 | R:R:S207 | R:R:T118 | 7.99 | 1 | No | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:T118 | 3.97 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:P168 | R:R:Y199 | 4.17 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:F193 | R:R:Y174 | 6.19 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:Y174 | R:R:Y199 | 6.95 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:F193 | R:R:T195 | 7.78 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F193 | R:R:Y199 | 4.13 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F193 | 7.39 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T195 | R:R:Y199 | 4.99 | 1 | No | Yes | 3 | 6 | 2 | 1 | R:R:S203 | R:R:Y199 | 12.72 | 1 | No | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:Y199 | 5.53 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:S203 | R:R:S207 | 4.89 | 1 | No | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:S203 | 6.07 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F290 | R:R:S204 | 3.96 | 1 | Yes | No | 7 | 5 | 1 | 2 | R:R:N293 | R:R:S204 | 4.47 | 0 | No | No | 5 | 5 | 1 | 2 | L:L:?1 | R:R:S207 | 4.05 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F208 | R:R:F290 | 33.22 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:F282 | R:R:W286 | 12.03 | 0 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F289 | R:R:W286 | 7.02 | 1 | Yes | Yes | 6 | 8 | 1 | 1 | R:R:F290 | R:R:W286 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:G315 | R:R:W286 | 12.67 | 0 | No | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:W286 | 4.61 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F289 | R:R:F290 | 6.43 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:F289 | R:R:Y308 | 10.32 | 1 | Yes | No | 6 | 5 | 1 | 2 | R:R:F289 | R:R:N312 | 14.5 | 1 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:F289 | 9.03 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:F290 | 13.14 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:N293 | R:R:Y308 | 5.81 | 0 | No | No | 5 | 5 | 1 | 2 | L:L:?1 | R:R:N293 | 8.33 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:N312 | R:R:Y316 | 13.96 | 1 | No | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:N312 | 13.88 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:W313 | R:R:Y316 | 13.5 | 0 | No | Yes | 5 | 6 | 2 | 1 | L:L:?1 | R:R:Y316 | 6.32 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:V87 | R:R:Y316 | 3.79 | 0 | No | Yes | 7 | 6 | 2 | 1 | R:R:N196 | R:R:Y199 | 3.49 | 0 | No | Yes | 4 | 6 | 2 | 1 | R:R:F289 | R:R:L311 | 2.44 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 8.90 | Average Nodes In Shell | 32.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 49.00 | Average Links Mediated by Hubs In Shell | 45.00 |
| Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6PS1 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Timolol | - | - | 3.2 | 2019-11-13 | 10.1107/S2052252519013137 |
A 2D representation of the interactions of TIM in 6PS1 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D113 | R:R:V86 | 7.3 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V86 | R:R:Y316 | 3.79 | 1 | No | Yes | 7 | 6 | 2 | 1 | R:R:V87 | R:R:Y316 | 3.79 | 0 | No | Yes | 7 | 6 | 2 | 1 | R:R:F193 | R:R:T110 | 3.89 | 0 | Yes | No | 4 | 4 | 1 | 2 | R:R:D113 | R:R:Y316 | 10.34 | 1 | No | Yes | 7 | 6 | 1 | 1 | L:L:?1 | R:R:D113 | 19.21 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:S165 | R:R:V114 | 6.46 | 0 | Yes | No | 7 | 5 | 2 | 1 | L:L:?1 | R:R:V114 | 13.05 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:V117 | R:R:W286 | 12.26 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:V117 | 8.03 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S165 | R:R:T118 | 4.8 | 0 | Yes | No | 7 | 6 | 2 | 2 | R:R:S207 | R:R:T118 | 9.59 | 0 | No | No | 5 | 6 | 1 | 2 | R:R:F193 | R:R:Y174 | 4.13 | 0 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:F193 | R:R:T195 | 7.78 | 0 | Yes | No | 4 | 3 | 1 | 2 | L:L:?1 | R:R:F193 | 9.03 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?1 | R:R:S207 | 4.05 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F208 | R:R:Y209 | 13.41 | 1 | Yes | No | 8 | 5 | 2 | 2 | R:R:F208 | R:R:F290 | 32.15 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F290 | R:R:Y209 | 4.13 | 1 | Yes | No | 7 | 5 | 1 | 2 | R:R:F290 | R:R:W286 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:F290 | 7.5 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:F289 | R:R:Y308 | 12.38 | 1 | Yes | No | 6 | 5 | 1 | 1 | R:R:F289 | R:R:N312 | 13.29 | 1 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:F289 | 7.39 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:F290 | 11.49 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:N293 | R:R:Y308 | 6.98 | 1 | No | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:N293 | 9.26 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:Y308 | 3.95 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:N312 | R:R:Y316 | 11.63 | 1 | No | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:N312 | 15.74 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:W313 | R:R:Y316 | 17.36 | 1 | No | Yes | 5 | 6 | 2 | 1 | L:L:?1 | R:R:Y316 | 4.74 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F290 | R:R:S204 | 2.64 | 1 | Yes | No | 7 | 5 | 1 | 2 | R:R:F289 | R:R:L311 | 2.44 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | R:R:S165 | R:R:T164 | 1.6 | 0 | Yes | No | 7 | 5 | 2 | 2 | R:R:S207 | R:R:T164 | 1.6 | 0 | No | No | 5 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 9.63 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 36.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6PS6 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Timolol | - | - | 2.7 | 2019-11-13 | 10.1107/S2052252519013137 |
A 2D representation of the interactions of TIM in 6PS6 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D113 | R:R:V86 | 8.76 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V86 | R:R:Y316 | 5.05 | 1 | No | Yes | 7 | 6 | 2 | 1 | R:R:V87 | R:R:W313 | 3.68 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | R:R:V87 | R:R:Y316 | 3.79 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:F193 | R:R:T110 | 3.89 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:D113 | R:R:Y316 | 9.2 | 1 | No | Yes | 7 | 6 | 1 | 1 | L:L:?1 | R:R:D113 | 18.3 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:S165 | R:R:V114 | 6.46 | 0 | No | No | 7 | 5 | 2 | 1 | L:L:?1 | R:R:V114 | 13.05 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:V117 | R:R:W286 | 11.03 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:V117 | 9.04 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:P168 | R:R:Y199 | 4.17 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:F193 | R:R:Y174 | 4.13 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:Y174 | R:R:Y199 | 6.95 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:F193 | R:R:T195 | 7.78 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F193 | R:R:Y199 | 4.13 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F193 | 9.85 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T195 | R:R:Y199 | 3.75 | 1 | No | Yes | 3 | 6 | 2 | 1 | R:R:S203 | R:R:Y199 | 15.26 | 0 | No | Yes | 5 | 6 | 2 | 1 | L:L:?1 | R:R:Y199 | 3.95 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N293 | R:R:S204 | 4.47 | 1 | No | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:S204 | 4.05 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F208 | R:R:F290 | 36.44 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:F282 | R:R:W286 | 13.03 | 0 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F289 | R:R:W286 | 4.01 | 1 | Yes | Yes | 6 | 8 | 1 | 1 | R:R:F290 | R:R:W286 | 7.02 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:G315 | R:R:W286 | 12.67 | 0 | No | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:W286 | 5.37 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F289 | R:R:F290 | 7.5 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:F289 | R:R:Y308 | 12.38 | 1 | Yes | No | 6 | 5 | 1 | 2 | R:R:F289 | R:R:N312 | 13.29 | 1 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:F289 | 9.03 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:F290 | 13.96 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:N293 | R:R:Y308 | 5.81 | 1 | No | No | 5 | 5 | 1 | 2 | L:L:?1 | R:R:N293 | 11.11 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:N312 | R:R:Y316 | 12.79 | 1 | No | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:N312 | 15.74 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:W313 | R:R:Y316 | 15.43 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | L:L:?1 | R:R:Y316 | 4.74 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N196 | R:R:Y199 | 3.49 | 0 | No | Yes | 4 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 9.85 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 40.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|