CodeTMA
NameTetramethylammonium
Synonyms
  • Tetramethylammonium
  • Trimethylaminomethane
Identifiertetramethylazanium
FormulaC4 H12 N
Molecular Weight74.145
SMILESC[N+](C)(C)C
PubChem6380
Formal Charge1
Total Atoms17
Total Chiral Atoms0
Total Bonds16
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WC5 A Amine Trace amine receptors TA1 Mus Musculus Tetramethylammonium ion - chim(NtGi1-Gs)/Beta1/Gamma2 3.3 2023-12-27 10.1016/j.cell.2023.10.014

A 2D representation of the interactions of TMA in 8WC5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I75 R:R:L71 4.28 1 Yes Yes 6 7 2 2
R:R:L71 R:R:M76 2.83 1 Yes Yes 7 7 2 2
R:R:L71 R:R:Y291 4.69 1 Yes Yes 7 7 2 1
R:R:D102 R:R:I75 16.79 1 No Yes 6 6 1 2
R:R:I75 R:R:Y291 6.04 1 Yes Yes 6 7 2 1
R:R:M76 R:R:W288 10.47 1 Yes Yes 7 5 2 2
R:R:M76 R:R:Y291 14.37 1 Yes Yes 7 7 2 1
R:R:D102 R:R:Y291 8.05 1 No Yes 6 7 1 1
L:L:?1 R:R:D102 15.14 1 Yes No 0 6 0 1
L:L:?1 R:R:S106 9.31 1 Yes No 0 6 0 1
R:R:I110 R:R:W261 10.57 0 No Yes 7 7 2 1
R:R:P183 R:R:Y287 6.95 0 No No 4 5 2 1
R:R:F257 R:R:W261 4.01 0 Yes Yes 9 7 2 1
R:R:F265 R:R:W261 3.01 1 Yes Yes 6 7 2 1
R:R:G290 R:R:W261 9.85 0 No Yes 6 7 2 1
R:R:N293 R:R:W261 11.3 0 No Yes 9 7 2 1
L:L:?1 R:R:W261 4.24 1 Yes Yes 0 7 0 1
R:R:F264 R:R:F265 11.79 1 Yes Yes 6 6 1 2
R:R:F264 R:R:T268 12.97 1 Yes Yes 6 4 1 2
R:R:F264 R:R:Y287 6.19 1 Yes No 6 5 1 1
L:L:?1 R:R:F264 4.53 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y287 8.72 1 Yes No 0 5 0 1
R:R:W288 R:R:Y291 8.68 1 Yes Yes 5 7 2 1
L:L:?1 R:R:Y291 13.08 1 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.17
Average Nodes In Shell18.00
Average Hubs In Shell11.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.17
Average Nodes In Shell18.00
Average Hubs In Shell11.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell23.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)