psnGPCR

Code	TY5
Name	O-benzyl-L-tyrosine
Synonyms
Identifier
Formula	C16 H17 N O3
Molecular Weight	271.311
SMILES
PubChem	725701
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	1
Total Bonds	38
Total Aromatic Bonds	12
Networks	6

This ligand is also present in the following 6 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8XIP

Peptide

Somatostatin

SST1

Homo Sapiens

Pasireotide

chim(NtGi1-Gs-CtGi1)/Beta1/Gamma2

3.29

2024-07-03

doi.org/10.1073/pnas.2400298121

A 2D representation of the interactions of TY5 in 8XIP
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	16.88	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?4	10.1	3	Yes	Yes	0	0	1	0
L:L:?1	L:L:?6	21.05	3	Yes	Yes	0	0	1	1
L:L:?1	R:R:N209	6.66	3	Yes	No	0	5	1	1
L:L:?1	R:R:M210	5.71	3	Yes	Yes	0	4	1	2
L:L:?1	R:R:L220	3.36	3	Yes	Yes	0	5	1	2
L:L:?2	L:L:K3	27.98	3	Yes	Yes	0	0	1	1
L:L:?2	L:L:?4	3.61	3	Yes	Yes	0	0	1	0
L:L:?2	R:R:M141	3.37	3	Yes	Yes	0	7	1	2
L:L:?2	R:R:M210	7.85	3	Yes	Yes	0	4	1	2
L:L:?2	R:R:Q291	7.4	3	Yes	No	0	6	1	2
L:L:?4	L:L:K3	4.63	3	Yes	Yes	0	0	0	1
L:L:K3	R:R:D137	11.06	3	Yes	Yes	0	6	1	1
L:L:K3	R:R:M141	2.88	3	Yes	Yes	0	7	1	2
L:L:K3	R:R:Y313	9.55	3	Yes	Yes	0	7	1	2
L:L:?4	L:L:?6	4.27	3	Yes	Yes	0	0	0	1
L:L:?4	R:R:L114	18.17	3	Yes	No	0	6	0	1
L:L:?4	R:R:S117	8.62	3	Yes	No	0	6	0	1
L:L:?4	R:R:L134	7.95	3	Yes	No	0	5	0	1
L:L:?4	R:R:D137	10.02	3	Yes	Yes	0	6	0	1
L:L:?4	R:R:N209	4.51	3	Yes	No	0	5	0	1
L:L:?6	L:L:F5	9.16	3	Yes	No	0	0	1	2
L:L:?6	R:R:D300	3.83	3	Yes	No	0	4	1	2
R:R:L114	R:R:Y65	3.52	0	No	Yes	6	6	1	2
R:R:D137	R:R:S110	4.42	3	Yes	No	6	6	1	2
R:R:L114	R:R:T118	2.95	0	No	No	6	4	1	2
R:R:S117	R:R:W123	6.18	0	No	Yes	6	8	1	2
R:R:L134	R:R:S196	7.51	0	No	No	5	5	1	2
R:R:C208	R:R:L134	3.17	0	No	No	9	5	2	1
R:R:D137	R:R:Y313	3.45	3	Yes	Yes	6	7	1	2
R:R:A207	R:R:N209	3.13	0	No	No	5	5	2	1

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	7.99
Average Nodes In Shell	24.00
Average Hubs In Shell	12.00
Average Links In Shell	31.00
Average Links Mediated by Hubs In Shell	27.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8XIR

Peptide

Somatostatin

SST3

Homo Sapiens

Pasireotide

chim(NtGi1-Gs-CtGi1)/Beta1/Gamma2

2.52

2024-07-03

doi.org/10.1073/pnas.2400298121

A 2D representation of the interactions of TY5 in 8XIR
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	13.32	2	Yes	Yes	0	0	1	1
L:L:?1	L:L:?4	9.18	2	Yes	Yes	0	0	1	0
L:L:?1	L:L:?6	26.31	2	Yes	Yes	0	0	1	1
L:L:?1	R:R:H192	6.24	2	Yes	No	0	4	1	2
L:L:?1	R:R:W195	11.97	2	Yes	Yes	0	6	1	2
L:L:?1	R:R:R203	11.79	2	Yes	Yes	0	4	1	2
L:L:?2	L:L:K3	22.39	2	Yes	Yes	0	0	1	2
L:L:?2	L:L:?4	4.51	2	Yes	Yes	0	0	1	0
L:L:?2	R:R:M120	3.37	2	Yes	Yes	0	4	1	1
L:L:?2	R:R:D123	3.23	2	Yes	Yes	0	6	1	1
L:L:?2	R:R:Q127	6.34	2	Yes	Yes	0	7	1	2
L:L:?2	R:R:M193	6.73	2	Yes	Yes	0	4	1	2
L:L:?2	R:R:T210	4.68	2	Yes	No	0	5	1	2
L:L:?2	R:R:F273	7.73	2	Yes	Yes	0	6	1	2
L:L:?2	R:R:N277	3.27	2	Yes	No	0	6	1	2
L:L:K3	R:R:D123	12.44	2	Yes	Yes	0	6	2	1
L:L:K3	R:R:Q127	4.07	2	Yes	Yes	0	7	2	2
L:L:K3	R:R:F273	6.2	2	Yes	Yes	0	6	2	2
L:L:?4	L:L:?6	9.61	2	Yes	Yes	0	0	0	1
L:L:?4	R:R:L100	14.76	2	Yes	Yes	0	7	0	1
L:L:?4	R:R:Q103	9.83	2	Yes	No	0	5	0	1
L:L:?4	R:R:W109	4.67	2	Yes	Yes	0	8	0	1
L:L:?4	R:R:V119	13.44	2	Yes	No	0	5	0	1
L:L:?4	R:R:M120	4.64	2	Yes	Yes	0	4	0	1
L:L:?4	R:R:D123	6.68	2	Yes	Yes	0	6	0	1
L:L:?4	R:R:C191	2.6	2	Yes	No	0	9	0	1
L:L:?6	L:L:F5	26.35	2	Yes	No	0	0	1	2
L:L:?6	R:R:E287	6.23	2	Yes	No	0	1	1	2
R:R:L100	R:R:Y51	3.52	2	Yes	Yes	7	7	1	2
R:R:L100	R:R:L97	4.15	2	Yes	Yes	7	6	1	2
R:R:L97	R:R:Y303	9.38	2	Yes	No	6	6	2	2
R:R:F99	R:R:W109	5.01	0	No	Yes	5	8	2	1
R:R:F99	R:R:V119	5.24	0	No	No	5	5	2	1
R:R:L100	R:R:Y303	3.52	2	Yes	No	7	6	1	2
R:R:Q103	R:R:W109	4.38	2	No	Yes	5	8	1	1
R:R:F111	R:R:W109	10.02	2	No	Yes	6	8	2	1
R:R:M115	R:R:W109	3.49	2	No	Yes	5	8	2	1
R:R:C116	R:R:W109	7.84	2	No	Yes	9	8	2	1
R:R:C191	R:R:W109	11.75	2	No	Yes	9	8	1	1
R:R:F111	R:R:M115	3.73	2	No	No	6	5	2	2
R:R:C116	R:R:C191	7.28	2	No	No	9	9	2	1
R:R:M120	R:R:V178	3.04	2	Yes	No	4	4	1	2
R:R:M120	R:R:S182	6.13	2	Yes	No	4	5	1	2
R:R:M120	R:R:M193	8.66	2	Yes	Yes	4	4	1	2
R:R:D123	R:R:G124	5.03	2	Yes	No	6	4	1	2
R:R:M193	R:R:V178	9.13	2	Yes	No	4	4	2	2
R:R:M193	R:R:W195	5.82	2	Yes	Yes	4	6	2	2
R:R:R203	R:R:W195	8	2	Yes	Yes	4	6	2	2
R:R:G112	R:R:W109	1.41	0	No	Yes	7	8	2	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	7.99
Average Nodes In Shell	33.00
Average Hubs In Shell	16.00
Average Links In Shell	49.00
Average Links Mediated by Hubs In Shell	46.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9IK8

Peptide

Somatostatin

SST1

Homo Sapiens

SST analogue

Gi1/Beta1/Gamma2

2.82

2025-04-30

doi.org/10.1016/j.apsb.2025.03.043

A 2D representation of the interactions of TY5 in 9IK8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:K2	26.86	2	Yes	Yes	0	0	2	1
L:L:?1	L:L:?6	16.88	2	Yes	Yes	0	0	2	2
L:L:?1	R:R:F287	7.73	2	Yes	Yes	0	6	2	2
L:L:?3	L:L:K2	19.67	2	Yes	Yes	0	0	0	1
L:L:K2	R:R:L114	4.23	2	Yes	Yes	0	6	1	1
L:L:K2	R:R:F287	4.96	2	Yes	Yes	0	6	1	2
L:L:?3	L:L:?4	16.98	2	Yes	Yes	0	0	0	1
L:L:?3	R:R:L114	28.39	2	Yes	Yes	0	6	0	1
L:L:?3	R:R:S117	8.62	2	Yes	No	0	6	0	1
L:L:?3	R:R:L134	4.54	2	Yes	No	0	5	0	1
L:L:?3	R:R:D137	13.36	2	Yes	No	0	6	0	1
L:L:?3	R:R:N209	3.38	2	Yes	No	0	5	0	1
L:L:?3	R:R:Y313	3.85	2	Yes	Yes	0	7	0	1
L:L:?4	L:L:?5	57.37	2	Yes	No	0	0	1	2
L:L:?4	L:L:?6	10.57	2	Yes	Yes	0	0	1	2
L:L:?4	R:R:A302	7.44	2	Yes	No	0	4	1	2
L:L:?4	R:R:S305	10.63	2	Yes	No	0	4	1	2
L:L:?5	L:L:?6	24.21	2	No	Yes	0	0	2	2
R:R:L107	R:R:Y313	3.52	0	No	Yes	7	7	2	1
R:R:M108	R:R:Y313	3.59	2	No	Yes	6	7	2	1
R:R:D137	R:R:S110	8.83	2	No	Yes	6	6	1	2
R:R:V111	R:R:Y313	3.79	0	Yes	Yes	7	7	2	1
R:R:I192	R:R:L134	4.28	0	No	No	5	5	2	1
R:R:D137	R:R:Y313	4.6	2	No	Yes	6	7	1	1
R:R:L134	R:R:S196	3	0	No	No	5	5	1	2
R:R:L114	R:R:V309	2.98	2	Yes	No	6	5	1	2
R:R:L114	R:R:T118	2.95	2	Yes	No	6	4	1	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	12.35
Average Nodes In Shell	23.00
Average Hubs In Shell	10.00
Average Links In Shell	27.00
Average Links Mediated by Hubs In Shell	25.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	8.83
Average Number Of Links With An Hub	4.83
Average Interaction Strength	9.55
Average Nodes In Shell	25.83
Average Hubs In Shell	11.33
Average Links In Shell	33.67
Average Links Mediated by Hubs In Shell	30.50

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)