Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7VGX | A | Peptide | Neuropeptide Y | Y1 | Homo sapiens | Neuropeptide Y | - | Gi1/Beta1/Gamma2 | 3.2 | 2022-02-23 | 10.1038/s41467-022-28510-6 |
![](/psngpcr/ligands/TYC/TYC_7VGX_L_L_36.png)
A 2D representation of the interactions of TYC in 7VGX colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:C93 | R:R:Q120 | 12.21 | 1 | No | Yes | 7 | 6 | 1 | 1 | L:L:?36 | R:R:C93 | 5.36 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:H306 | R:R:L94 | 2.57 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:L94 | R:R:M310 | 2.83 | 1 | Yes | No | 7 | 7 | 2 | 2 | R:R:F302 | R:R:T97 | 2.59 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:H306 | R:R:T97 | 9.58 | 1 | Yes | Yes | 6 | 6 | 1 | 1 | L:L:Q34 | R:R:T97 | 4.25 | 1 | Yes | Yes | 0 | 6 | 2 | 1 | L:L:?36 | R:R:T97 | 2.49 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N116 | R:R:Q120 | 7.92 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | L:L:Q34 | R:R:N116 | 2.64 | 1 | Yes | Yes | 0 | 5 | 2 | 2 | L:L:Q34 | R:R:Q120 | 2.56 | 1 | Yes | Yes | 0 | 6 | 2 | 1 | L:L:?36 | R:R:Q120 | 11.25 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:C121 | R:R:S170 | 6.89 | 0 | No | No | 4 | 7 | 1 | 2 | L:L:?36 | R:R:C121 | 6.71 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:I124 | R:R:Q219 | 4.12 | 1 | Yes | No | 7 | 6 | 1 | 1 | R:R:I124 | R:R:W276 | 3.52 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | L:L:?36 | R:R:I124 | 4.82 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:R35 | R:R:F173 | 4.28 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:R208 | R:R:T212 | 2.59 | 1 | Yes | No | 4 | 5 | 2 | 2 | R:R:D287 | R:R:R208 | 7.15 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | L:L:R35 | R:R:R208 | 6.4 | 1 | Yes | Yes | 0 | 4 | 1 | 2 | R:R:D287 | R:R:T212 | 8.67 | 1 | Yes | No | 4 | 5 | 2 | 2 | L:L:R35 | R:R:T212 | 5.17 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:?36 | R:R:Q219 | 11.25 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:R35 | R:R:N283 | 8.44 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:R35 | R:R:D287 | 11.91 | 1 | Yes | Yes | 0 | 4 | 1 | 2 | R:R:H306 | R:R:M310 | 9.19 | 1 | Yes | No | 6 | 7 | 1 | 2 | L:L:?36 | R:R:H306 | 6.52 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?36 | L:L:R35 | 10.27 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | R:R:C121 | R:R:T125 | 1.69 | 0 | No | No | 4 | 6 | 1 | 2 | R:R:I124 | R:R:S123 | 1.55 | 1 | Yes | No | 7 | 8 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 7.33 | Average Nodes In Shell | 23.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/TYC/TYC_7VGX_L_L_36_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/TYC/TYC_7VGX_L_L_36_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7X9A | A | Peptide | Neuropeptide Y | Y1 | Homo sapiens | Neuropeptide Y | - | Gi1/Beta1/Gamma2 | 3.2 | 2022-05-18 | 10.1126/sciadv.abm1232 |
![](/psngpcr/ligands/TYC/TYC_7X9A_L_L_36.png)
A 2D representation of the interactions of TYC in 7X9A colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L94 | R:R:Y47 | 7.03 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:H306 | R:R:Y47 | 4.36 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:C93 | R:R:V89 | 6.83 | 1 | No | Yes | 7 | 7 | 2 | 2 | R:R:I124 | R:R:V89 | 4.61 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:M92 | R:R:N116 | 8.41 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:M92 | R:R:Q120 | 4.08 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:C93 | R:R:Q120 | 7.63 | 1 | No | Yes | 7 | 6 | 2 | 1 | R:R:C93 | R:R:I124 | 3.27 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:H306 | R:R:L94 | 3.86 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:Q120 | R:R:T97 | 4.25 | 1 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:H306 | R:R:T97 | 5.48 | 1 | Yes | Yes | 6 | 6 | 1 | 1 | L:L:Q34 | R:R:T97 | 9.92 | 1 | Yes | Yes | 0 | 6 | 2 | 1 | L:L:?36 | R:R:T97 | 6.23 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N116 | R:R:Q120 | 13.2 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | L:L:Q34 | R:R:N116 | 3.96 | 1 | Yes | Yes | 0 | 5 | 2 | 2 | L:L:Q34 | R:R:Q120 | 6.4 | 1 | Yes | Yes | 0 | 6 | 2 | 1 | L:L:?36 | R:R:Q120 | 6.75 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:I124 | R:R:W276 | 7.05 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | L:L:?36 | R:R:I124 | 6.03 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:R35 | R:R:F173 | 5.34 | 1 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:D287 | R:R:T212 | 13.01 | 1 | No | No | 4 | 5 | 2 | 2 | L:L:R35 | R:R:T212 | 9.06 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:L215 | R:R:L218 | 4.15 | 1 | No | No | 5 | 5 | 1 | 2 | R:R:L215 | R:R:Q219 | 6.65 | 1 | No | No | 5 | 6 | 1 | 1 | L:L:?36 | R:R:L215 | 4.68 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?36 | R:R:Q219 | 15.75 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:L279 | R:R:N283 | 8.24 | 0 | No | Yes | 7 | 5 | 2 | 1 | L:L:R33 | R:R:N283 | 4.82 | 1 | Yes | Yes | 0 | 5 | 2 | 1 | L:L:R35 | R:R:N283 | 12.05 | 1 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:?36 | R:R:N283 | 3.48 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R35 | R:R:D287 | 8.34 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:?36 | R:R:H306 | 7.61 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?36 | L:L:R35 | 21.56 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 9.01 | Average Nodes In Shell | 23.00 | Average Hubs In Shell | 16.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 30.00 |
| ![](/psngpcr/ligands/TYC/TYC_7X9A_L_L_36_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/TYC/TYC_7X9A_L_L_36_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7X9B | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Neuropeptide Y | - | Gi1/Beta1/Gamma2 | 3.4 | 2022-05-18 | 10.1126/sciadv.abm1232 |
![](/psngpcr/ligands/TYC/TYC_7X9B_L_L_36.png)
A 2D representation of the interactions of TYC in 7X9B colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:H311 | R:R:Y57 | 5.44 | 0 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:C103 | R:R:Q130 | 4.58 | 4 | No | Yes | 6 | 6 | 2 | 1 | R:R:C103 | R:R:M315 | 3.24 | 4 | No | Yes | 6 | 7 | 2 | 2 | R:R:F307 | R:R:T107 | 2.59 | 4 | Yes | No | 4 | 6 | 1 | 2 | R:R:H311 | R:R:T107 | 2.74 | 0 | Yes | No | 5 | 6 | 1 | 2 | L:L:Q34 | R:R:T107 | 12.76 | 4 | Yes | No | 0 | 6 | 1 | 2 | L:L:Q34 | R:R:Y110 | 5.64 | 4 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:P127 | R:R:Q130 | 3.16 | 0 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:L183 | R:R:P127 | 3.28 | 4 | Yes | Yes | 5 | 5 | 1 | 2 | L:L:Q34 | R:R:Q130 | 3.84 | 4 | Yes | Yes | 0 | 6 | 1 | 1 | L:L:?36 | R:R:Q130 | 15.75 | 4 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:G131 | R:R:L183 | 1.71 | 0 | No | Yes | 4 | 5 | 2 | 1 | R:R:E205 | R:R:L183 | 3.98 | 4 | Yes | Yes | 4 | 5 | 2 | 1 | R:R:L183 | R:R:Y219 | 4.69 | 4 | Yes | Yes | 5 | 6 | 1 | 2 | L:L:R35 | R:R:L183 | 2.43 | 4 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:?36 | R:R:L183 | 2.34 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R35 | R:R:E205 | 5.82 | 4 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:R35 | R:R:Y219 | 5.14 | 4 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?36 | R:R:S223 | 2.54 | 4 | Yes | No | 0 | 5 | 0 | 1 | R:R:H285 | R:R:L224 | 2.57 | 4 | Yes | No | 7 | 5 | 1 | 2 | R:R:H285 | R:R:L227 | 3.86 | 4 | Yes | No | 7 | 6 | 1 | 2 | R:R:L284 | R:R:W281 | 2.28 | 4 | Yes | Yes | 6 | 8 | 2 | 2 | R:R:H285 | R:R:W281 | 9.52 | 4 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:M315 | R:R:W281 | 2.33 | 4 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:H285 | R:R:L284 | 3.86 | 4 | Yes | Yes | 7 | 6 | 1 | 2 | R:R:L284 | R:R:Q288 | 2.66 | 4 | Yes | Yes | 6 | 5 | 2 | 1 | L:L:?36 | R:R:H285 | 4.35 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F287 | R:R:Q288 | 3.51 | 4 | Yes | Yes | 4 | 5 | 2 | 1 | R:R:F287 | R:R:F307 | 8.57 | 4 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:F307 | R:R:Q288 | 2.34 | 4 | Yes | Yes | 4 | 5 | 1 | 1 | L:L:R33 | R:R:Q288 | 12.85 | 4 | Yes | Yes | 0 | 5 | 2 | 1 | L:L:R35 | R:R:Q288 | 5.84 | 4 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:?36 | R:R:Q288 | 2.25 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R35 | R:R:D292 | 2.38 | 4 | Yes | No | 0 | 5 | 1 | 2 | L:L:Q34 | R:R:F307 | 5.86 | 4 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?36 | R:R:F307 | 2.06 | 4 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:H311 | R:R:M315 | 11.82 | 0 | Yes | Yes | 5 | 7 | 1 | 2 | L:L:?36 | R:R:H311 | 7.61 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R33 | L:L:R35 | 3.2 | 4 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?36 | L:L:Q34 | 7.87 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?36 | L:L:R35 | 10.27 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 6.12 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 19.00 | Average Links In Shell | 41.00 | Average Links Mediated by Hubs In Shell | 41.00 |
| ![](/psngpcr/ligands/TYC/TYC_7X9B_L_L_36_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/TYC/TYC_7X9B_L_L_36_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7X9C | A | Peptide | Neuropeptide Y | Y4 | Homo sapiens | Pancreatic Hormone | - | Gi1/Beta1/Gamma2 | 3 | 2022-05-18 | 10.1126/sciadv.abm1232 |
![](/psngpcr/ligands/TYC/TYC_7X9C_L_L_36.png)
A 2D representation of the interactions of TYC in 7X9C colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M90 | R:R:V125 | 4.56 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:M90 | R:R:W278 | 4.65 | 2 | Yes | Yes | 6 | 9 | 2 | 2 | R:R:M312 | R:R:M90 | 7.22 | 0 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:H308 | R:R:T98 | 16.43 | 0 | No | No | 5 | 6 | 1 | 2 | L:L:P34 | R:R:T98 | 6.99 | 0 | No | No | 0 | 6 | 2 | 2 | L:L:P34 | R:R:Q121 | 3.16 | 0 | No | No | 0 | 7 | 2 | 1 | L:L:?36 | R:R:Q121 | 9 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:Q222 | R:R:V125 | 4.3 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:V125 | R:R:W278 | 4.9 | 2 | Yes | Yes | 7 | 9 | 1 | 2 | L:L:?36 | R:R:V125 | 3.78 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:Q222 | R:R:T126 | 7.09 | 2 | Yes | No | 6 | 6 | 1 | 2 | R:R:I129 | R:R:Q222 | 4.12 | 2 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:I129 | R:R:W278 | 5.87 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | L:L:R35 | R:R:F174 | 3.21 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:D289 | R:R:T215 | 7.23 | 2 | Yes | No | 5 | 5 | 2 | 2 | L:L:R35 | R:R:T215 | 9.06 | 2 | Yes | No | 0 | 5 | 1 | 2 | R:R:L218 | R:R:Q222 | 10.65 | 2 | No | Yes | 5 | 6 | 1 | 1 | L:L:?36 | R:R:L218 | 10.53 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:H282 | R:R:L219 | 3.86 | 2 | Yes | No | 8 | 6 | 1 | 2 | R:R:H282 | R:R:Q222 | 3.71 | 2 | Yes | Yes | 8 | 6 | 1 | 1 | L:L:?36 | R:R:Q222 | 6.75 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:H282 | R:R:Y223 | 10.89 | 2 | Yes | No | 8 | 8 | 1 | 2 | R:R:H282 | R:R:W278 | 6.35 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | R:R:L281 | R:R:N285 | 5.49 | 0 | No | Yes | 7 | 6 | 2 | 1 | L:L:?36 | R:R:H282 | 4.35 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:R33 | R:R:N285 | 7.23 | 2 | Yes | Yes | 0 | 6 | 2 | 1 | L:L:R35 | R:R:N285 | 4.82 | 2 | Yes | Yes | 0 | 6 | 1 | 1 | L:L:?36 | R:R:N285 | 4.64 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:R35 | R:R:D289 | 5.96 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:H308 | R:R:M312 | 10.51 | 0 | No | Yes | 5 | 7 | 1 | 2 | L:L:?36 | R:R:H308 | 7.61 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:R33 | L:L:R35 | 4.26 | 2 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?36 | L:L:R35 | 9.24 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | R:R:L170 | R:R:L218 | 2.77 | 0 | No | No | 5 | 5 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 6.99 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 30.00 |
| ![](/psngpcr/ligands/TYC/TYC_7X9C_L_L_36_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/TYC/TYC_7X9C_L_L_36_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7YON | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Peptide YY(3-36) | - | Gi1/Beta1/Gamma2 | 2.95 | 2023-03-22 | 10.1016/j.str.2022.11.010 |
![](/psngpcr/ligands/TYC/TYC_7YON_L_L_36.png)
A 2D representation of the interactions of TYC in 7YON colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:R33 | L:L:R35 | 5.33 | 6 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:R33 | R:R:E205 | 3.49 | 6 | Yes | No | 0 | 4 | 2 | 2 | L:L:Q34 | R:R:T107 | 12.76 | 0 | Yes | No | 0 | 6 | 2 | 1 | L:L:?36 | L:L:R35 | 5.13 | 6 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:R35 | R:R:E205 | 8.14 | 6 | Yes | No | 0 | 4 | 1 | 2 | L:L:R35 | R:R:Y219 | 9.26 | 6 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:R35 | R:R:S220 | 3.95 | 6 | Yes | No | 0 | 4 | 1 | 2 | L:L:?36 | R:R:C103 | 2.68 | 6 | Yes | No | 0 | 6 | 0 | 1 | L:L:?36 | R:R:T107 | 7.47 | 6 | Yes | No | 0 | 6 | 0 | 1 | L:L:?36 | R:R:Q130 | 7.87 | 6 | Yes | No | 0 | 6 | 0 | 1 | L:L:?36 | R:R:G131 | 2.89 | 6 | Yes | No | 0 | 4 | 0 | 1 | L:L:?36 | R:R:H311 | 7.61 | 6 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:H311 | R:R:Y57 | 7.62 | 6 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:C103 | R:R:V99 | 5.12 | 6 | No | No | 6 | 7 | 1 | 2 | R:R:C103 | R:R:Q130 | 6.1 | 6 | No | No | 6 | 6 | 1 | 1 | R:R:H311 | R:R:T107 | 9.58 | 6 | Yes | No | 5 | 6 | 1 | 1 | R:R:Q130 | R:R:V126 | 4.3 | 6 | No | Yes | 6 | 5 | 1 | 2 | R:R:H311 | R:R:M315 | 7.88 | 6 | Yes | No | 5 | 7 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.61 | Average Nodes In Shell | 16.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 18.00 | Average Links Mediated by Hubs In Shell | 16.00 |
| ![](/psngpcr/ligands/TYC/TYC_7YON_L_L_36_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/TYC/TYC_7YON_L_L_36_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7YOO | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Neuropeptide Y | - | Gi1/Beta1/Gamma2 | 3.11 | 2023-03-22 | 10.1016/j.str.2022.11.010 |
![](/psngpcr/ligands/TYC/TYC_7YOO_L_L_36.png)
A 2D representation of the interactions of TYC in 7YOO colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:R33 | L:L:R35 | 5.33 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:R33 | R:R:Q288 | 4.67 | 3 | Yes | No | 0 | 5 | 2 | 2 | L:L:?36 | L:L:Q34 | 2.25 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:Q34 | R:R:T107 | 7.09 | 3 | Yes | Yes | 0 | 6 | 1 | 1 | L:L:Q34 | R:R:Y110 | 11.27 | 3 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:Q34 | R:R:T111 | 4.25 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:Q34 | R:R:F307 | 4.68 | 3 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?36 | L:L:R35 | 8.21 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:R35 | R:R:E205 | 11.63 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:R35 | R:R:Y219 | 9.26 | 3 | Yes | No | 0 | 6 | 1 | 2 | L:L:R35 | R:R:S220 | 5.27 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:R35 | R:R:Q288 | 4.67 | 3 | Yes | No | 0 | 5 | 1 | 2 | L:L:?36 | R:R:C103 | 2.68 | 3 | Yes | No | 0 | 6 | 0 | 1 | L:L:?36 | R:R:T107 | 4.98 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?36 | R:R:Q130 | 5.62 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?36 | R:R:G131 | 2.89 | 3 | Yes | No | 0 | 4 | 0 | 1 | L:L:?36 | R:R:V134 | 3.78 | 3 | Yes | No | 0 | 7 | 0 | 1 | L:L:?36 | R:R:L183 | 2.34 | 3 | Yes | No | 0 | 5 | 0 | 1 | L:L:?36 | R:R:F307 | 3.09 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?36 | R:R:H311 | 7.61 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L104 | R:R:Y57 | 3.52 | 3 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:H311 | R:R:Y57 | 7.62 | 3 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:C103 | R:R:V99 | 5.12 | 3 | No | No | 6 | 7 | 1 | 2 | R:R:C103 | R:R:Q130 | 9.16 | 3 | No | Yes | 6 | 6 | 1 | 1 | R:R:H311 | R:R:L104 | 2.57 | 3 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:L104 | R:R:M315 | 7.07 | 3 | Yes | No | 7 | 7 | 2 | 2 | R:R:Q130 | R:R:T107 | 4.25 | 3 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:H311 | R:R:T107 | 10.95 | 3 | Yes | Yes | 5 | 6 | 1 | 1 | R:R:Q130 | R:R:V126 | 4.3 | 3 | Yes | Yes | 6 | 5 | 1 | 2 | R:R:G131 | R:R:L183 | 1.71 | 3 | No | No | 4 | 5 | 1 | 1 | R:R:V134 | R:R:W281 | 2.45 | 0 | No | Yes | 7 | 8 | 1 | 2 | R:R:L183 | R:R:Y219 | 7.03 | 3 | No | No | 5 | 6 | 1 | 2 | R:R:M315 | R:R:W281 | 2.33 | 3 | No | Yes | 7 | 8 | 2 | 2 | R:R:F307 | R:R:L284 | 2.44 | 3 | Yes | No | 4 | 6 | 1 | 2 | R:R:F307 | R:R:Q288 | 2.34 | 3 | Yes | No | 4 | 5 | 1 | 2 | R:R:H311 | R:R:M315 | 10.51 | 3 | Yes | No | 5 | 7 | 1 | 2 | |
Statistics | Value |
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Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 4.35 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 36.00 | Average Links Mediated by Hubs In Shell | 33.00 |
| ![](/psngpcr/ligands/TYC/TYC_7YOO_L_L_36_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/TYC/TYC_7YOO_L_L_36_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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