psnGPCR

Code	TYC
Name	L-tyrosinamide
Synonyms	Tyrosine amide Tyrosinamide (2S)-2-amino-3-(4-hydroxyphenyl)propanamide L-Tyrosine amide L-tyrosinamide
Identifier	(2S)-2-amino-3-(4-hydroxyphenyl)propanamide
Formula	C9 H12 N2 O2
Molecular Weight	180.204
SMILES	c1cc(ccc1C[C@@H](C(=O)N)N)O
PubChem	151243
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	25
Total Aromatic Bonds	6
Networks	6

This ligand is also present in the following 6 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7VGX

Peptide

Neuropeptide Y

Homo sapiens

Neuropeptide Y

Gi1/Beta1/Gamma2

3.2

2022-02-23

10.1038/s41467-022-28510-6

A 2D representation of the interactions of TYC in 7VGX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C93	R:R:Q120	12.21	1	No	Yes	7	6	1	1
L:L:?36	R:R:C93	5.36	1	Yes	No	0	7	0	1
R:R:H306	R:R:L94	2.57	1	Yes	Yes	6	7	1	2
R:R:L94	R:R:M310	2.83	1	Yes	No	7	7	2	2
R:R:F302	R:R:T97	2.59	1	Yes	Yes	5	6	2	1
R:R:H306	R:R:T97	9.58	1	Yes	Yes	6	6	1	1
L:L:Q34	R:R:T97	4.25	1	Yes	Yes	0	6	2	1
L:L:?36	R:R:T97	2.49	1	Yes	Yes	0	6	0	1
R:R:N116	R:R:Q120	7.92	1	Yes	Yes	5	6	2	1
L:L:Q34	R:R:N116	2.64	1	Yes	Yes	0	5	2	2
L:L:Q34	R:R:Q120	2.56	1	Yes	Yes	0	6	2	1
L:L:?36	R:R:Q120	11.25	1	Yes	Yes	0	6	0	1
R:R:C121	R:R:S170	6.89	0	No	No	4	7	1	2
L:L:?36	R:R:C121	6.71	1	Yes	No	0	4	0	1
R:R:I124	R:R:Q219	4.12	1	Yes	No	7	6	1	1
R:R:I124	R:R:W276	3.52	1	Yes	Yes	7	8	1	2
L:L:?36	R:R:I124	4.82	1	Yes	Yes	0	7	0	1
L:L:R35	R:R:F173	4.28	1	Yes	No	0	5	1	2
R:R:R208	R:R:T212	2.59	1	Yes	No	4	5	2	2
R:R:D287	R:R:R208	7.15	1	Yes	Yes	4	4	2	2
L:L:R35	R:R:R208	6.4	1	Yes	Yes	0	4	1	2
R:R:D287	R:R:T212	8.67	1	Yes	No	4	5	2	2
L:L:R35	R:R:T212	5.17	1	Yes	No	0	5	1	2
L:L:?36	R:R:Q219	11.25	1	Yes	No	0	6	0	1
L:L:R35	R:R:N283	8.44	1	Yes	No	0	5	1	2
L:L:R35	R:R:D287	11.91	1	Yes	Yes	0	4	1	2
R:R:H306	R:R:M310	9.19	1	Yes	No	6	7	1	2
L:L:?36	R:R:H306	6.52	1	Yes	Yes	0	6	0	1
L:L:?36	L:L:R35	10.27	1	Yes	Yes	0	0	0	1
R:R:C121	R:R:T125	1.69	0	No	No	4	6	1	2
R:R:I124	R:R:S123	1.55	1	Yes	No	7	8	1	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	7.33
Average Nodes In Shell	23.00
Average Hubs In Shell	13.00
Average Links In Shell	31.00
Average Links Mediated by Hubs In Shell	29.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7X9A

Peptide

Neuropeptide Y

Homo sapiens

Neuropeptide Y

Gi1/Beta1/Gamma2

3.2

2022-05-18

10.1126/sciadv.abm1232

A 2D representation of the interactions of TYC in 7X9A
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L94	R:R:Y47	7.03	1	Yes	Yes	7	7	2	2
R:R:H306	R:R:Y47	4.36	1	Yes	Yes	6	7	1	2
R:R:C93	R:R:V89	6.83	1	No	Yes	7	7	2	2
R:R:I124	R:R:V89	4.61	1	Yes	Yes	7	7	1	2
R:R:M92	R:R:N116	8.41	1	Yes	Yes	5	5	2	2
R:R:M92	R:R:Q120	4.08	1	Yes	Yes	5	6	2	1
R:R:C93	R:R:Q120	7.63	1	No	Yes	7	6	2	1
R:R:C93	R:R:I124	3.27	1	No	Yes	7	7	2	1
R:R:H306	R:R:L94	3.86	1	Yes	Yes	6	7	1	2
R:R:Q120	R:R:T97	4.25	1	Yes	Yes	6	6	1	1
R:R:H306	R:R:T97	5.48	1	Yes	Yes	6	6	1	1
L:L:Q34	R:R:T97	9.92	1	Yes	Yes	0	6	2	1
L:L:?36	R:R:T97	6.23	1	Yes	Yes	0	6	0	1
R:R:N116	R:R:Q120	13.2	1	Yes	Yes	5	6	2	1
L:L:Q34	R:R:N116	3.96	1	Yes	Yes	0	5	2	2
L:L:Q34	R:R:Q120	6.4	1	Yes	Yes	0	6	2	1
L:L:?36	R:R:Q120	6.75	1	Yes	Yes	0	6	0	1
R:R:I124	R:R:W276	7.05	1	Yes	Yes	7	8	1	2
L:L:?36	R:R:I124	6.03	1	Yes	Yes	0	7	0	1
L:L:R35	R:R:F173	5.34	1	Yes	Yes	0	5	1	2
R:R:D287	R:R:T212	13.01	1	No	No	4	5	2	2
L:L:R35	R:R:T212	9.06	1	Yes	No	0	5	1	2
R:R:L215	R:R:L218	4.15	1	No	No	5	5	1	2
R:R:L215	R:R:Q219	6.65	1	No	No	5	6	1	1
L:L:?36	R:R:L215	4.68	1	Yes	No	0	5	0	1
L:L:?36	R:R:Q219	15.75	1	Yes	No	0	6	0	1
R:R:L279	R:R:N283	8.24	0	No	Yes	7	5	2	1
L:L:R33	R:R:N283	4.82	1	Yes	Yes	0	5	2	1
L:L:R35	R:R:N283	12.05	1	Yes	Yes	0	5	1	1
L:L:?36	R:R:N283	3.48	1	Yes	Yes	0	5	0	1
L:L:R35	R:R:D287	8.34	1	Yes	No	0	4	1	2
L:L:?36	R:R:H306	7.61	1	Yes	Yes	0	6	0	1
L:L:?36	L:L:R35	21.56	1	Yes	Yes	0	0	0	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	9.01
Average Nodes In Shell	23.00
Average Hubs In Shell	16.00
Average Links In Shell	33.00
Average Links Mediated by Hubs In Shell	30.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7X9B

Peptide

Neuropeptide Y

Homo sapiens

Neuropeptide Y

Gi1/Beta1/Gamma2

3.4

2022-05-18

10.1126/sciadv.abm1232

A 2D representation of the interactions of TYC in 7X9B
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H311	R:R:Y57	5.44	0	Yes	Yes	5	7	1	2
R:R:C103	R:R:Q130	4.58	4	No	Yes	6	6	2	1
R:R:C103	R:R:M315	3.24	4	No	Yes	6	7	2	2
R:R:F307	R:R:T107	2.59	4	Yes	No	4	6	1	2
R:R:H311	R:R:T107	2.74	0	Yes	No	5	6	1	2
L:L:Q34	R:R:T107	12.76	4	Yes	No	0	6	1	2
L:L:Q34	R:R:Y110	5.64	4	Yes	Yes	0	5	1	2
R:R:P127	R:R:Q130	3.16	0	Yes	Yes	5	6	2	1
R:R:L183	R:R:P127	3.28	4	Yes	Yes	5	5	1	2
L:L:Q34	R:R:Q130	3.84	4	Yes	Yes	0	6	1	1
L:L:?36	R:R:Q130	15.75	4	Yes	Yes	0	6	0	1
R:R:G131	R:R:L183	1.71	0	No	Yes	4	5	2	1
R:R:E205	R:R:L183	3.98	4	Yes	Yes	4	5	2	1
R:R:L183	R:R:Y219	4.69	4	Yes	Yes	5	6	1	2
L:L:R35	R:R:L183	2.43	4	Yes	Yes	0	5	1	1
L:L:?36	R:R:L183	2.34	4	Yes	Yes	0	5	0	1
L:L:R35	R:R:E205	5.82	4	Yes	Yes	0	4	1	2
L:L:R35	R:R:Y219	5.14	4	Yes	Yes	0	6	1	2
L:L:?36	R:R:S223	2.54	4	Yes	No	0	5	0	1
R:R:H285	R:R:L224	2.57	4	Yes	No	7	5	1	2
R:R:H285	R:R:L227	3.86	4	Yes	No	7	6	1	2
R:R:L284	R:R:W281	2.28	4	Yes	Yes	6	8	2	2
R:R:H285	R:R:W281	9.52	4	Yes	Yes	7	8	1	2
R:R:M315	R:R:W281	2.33	4	Yes	Yes	7	8	2	2
R:R:H285	R:R:L284	3.86	4	Yes	Yes	7	6	1	2
R:R:L284	R:R:Q288	2.66	4	Yes	Yes	6	5	2	1
L:L:?36	R:R:H285	4.35	4	Yes	Yes	0	7	0	1
R:R:F287	R:R:Q288	3.51	4	Yes	Yes	4	5	2	1
R:R:F287	R:R:F307	8.57	4	Yes	Yes	4	4	2	1
R:R:F307	R:R:Q288	2.34	4	Yes	Yes	4	5	1	1
L:L:R33	R:R:Q288	12.85	4	Yes	Yes	0	5	2	1
L:L:R35	R:R:Q288	5.84	4	Yes	Yes	0	5	1	1
L:L:?36	R:R:Q288	2.25	4	Yes	Yes	0	5	0	1
L:L:R35	R:R:D292	2.38	4	Yes	No	0	5	1	2
L:L:Q34	R:R:F307	5.86	4	Yes	Yes	0	4	1	1
L:L:?36	R:R:F307	2.06	4	Yes	Yes	0	4	0	1
R:R:H311	R:R:M315	11.82	0	Yes	Yes	5	7	1	2
L:L:?36	R:R:H311	7.61	4	Yes	Yes	0	5	0	1
L:L:R33	L:L:R35	3.2	4	Yes	Yes	0	0	2	1
L:L:?36	L:L:Q34	7.87	4	Yes	Yes	0	0	0	1
L:L:?36	L:L:R35	10.27	4	Yes	Yes	0	0	0	1

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	8.00
Average Interaction Strength	6.12
Average Nodes In Shell	26.00
Average Hubs In Shell	19.00
Average Links In Shell	41.00
Average Links Mediated by Hubs In Shell	41.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7X9C

Peptide

Neuropeptide Y

Homo sapiens

Pancreatic Hormone

Gi1/Beta1/Gamma2

2022-05-18

10.1126/sciadv.abm1232

A 2D representation of the interactions of TYC in 7X9C
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M90	R:R:V125	4.56	2	Yes	Yes	6	7	2	1
R:R:M90	R:R:W278	4.65	2	Yes	Yes	6	9	2	2
R:R:M312	R:R:M90	7.22	0	Yes	Yes	7	6	2	2
R:R:H308	R:R:T98	16.43	0	No	No	5	6	1	2
L:L:P34	R:R:T98	6.99	0	No	No	0	6	2	2
L:L:P34	R:R:Q121	3.16	0	No	No	0	7	2	1
L:L:?36	R:R:Q121	9	2	Yes	No	0	7	0	1
R:R:Q222	R:R:V125	4.3	2	Yes	Yes	6	7	1	1
R:R:V125	R:R:W278	4.9	2	Yes	Yes	7	9	1	2
L:L:?36	R:R:V125	3.78	2	Yes	Yes	0	7	0	1
R:R:Q222	R:R:T126	7.09	2	Yes	No	6	6	1	2
R:R:I129	R:R:Q222	4.12	2	Yes	Yes	8	6	2	1
R:R:I129	R:R:W278	5.87	2	Yes	Yes	8	9	2	2
L:L:R35	R:R:F174	3.21	2	Yes	Yes	0	5	1	2
R:R:D289	R:R:T215	7.23	2	Yes	No	5	5	2	2
L:L:R35	R:R:T215	9.06	2	Yes	No	0	5	1	2
R:R:L218	R:R:Q222	10.65	2	No	Yes	5	6	1	1
L:L:?36	R:R:L218	10.53	2	Yes	No	0	5	0	1
R:R:H282	R:R:L219	3.86	2	Yes	No	8	6	1	2
R:R:H282	R:R:Q222	3.71	2	Yes	Yes	8	6	1	1
L:L:?36	R:R:Q222	6.75	2	Yes	Yes	0	6	0	1
R:R:H282	R:R:Y223	10.89	2	Yes	No	8	8	1	2
R:R:H282	R:R:W278	6.35	2	Yes	Yes	8	9	1	2
R:R:L281	R:R:N285	5.49	0	No	Yes	7	6	2	1
L:L:?36	R:R:H282	4.35	2	Yes	Yes	0	8	0	1
L:L:R33	R:R:N285	7.23	2	Yes	Yes	0	6	2	1
L:L:R35	R:R:N285	4.82	2	Yes	Yes	0	6	1	1
L:L:?36	R:R:N285	4.64	2	Yes	Yes	0	6	0	1
L:L:R35	R:R:D289	5.96	2	Yes	Yes	0	5	1	2
R:R:H308	R:R:M312	10.51	0	No	Yes	5	7	1	2
L:L:?36	R:R:H308	7.61	2	Yes	No	0	5	0	1
L:L:R33	L:L:R35	4.26	2	Yes	Yes	0	0	2	1
L:L:?36	L:L:R35	9.24	2	Yes	Yes	0	0	0	1
R:R:L170	R:R:L218	2.77	0	No	No	5	5	2	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	6.99
Average Nodes In Shell	24.00
Average Hubs In Shell	13.00
Average Links In Shell	34.00
Average Links Mediated by Hubs In Shell	30.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7YON

Peptide

Neuropeptide Y

Homo sapiens

Peptide YY(3-36)

Gi1/Beta1/Gamma2

2.95

2023-03-22

10.1016/j.str.2022.11.010

A 2D representation of the interactions of TYC in 7YON
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R33	L:L:R35	5.33	6	Yes	Yes	0	0	2	1
L:L:R33	R:R:E205	3.49	6	Yes	No	0	4	2	2
L:L:Q34	R:R:T107	12.76	0	Yes	No	0	6	2	1
L:L:?36	L:L:R35	5.13	6	Yes	Yes	0	0	0	1
L:L:R35	R:R:E205	8.14	6	Yes	No	0	4	1	2
L:L:R35	R:R:Y219	9.26	6	Yes	Yes	0	6	1	2
L:L:R35	R:R:S220	3.95	6	Yes	No	0	4	1	2
L:L:?36	R:R:C103	2.68	6	Yes	No	0	6	0	1
L:L:?36	R:R:T107	7.47	6	Yes	No	0	6	0	1
L:L:?36	R:R:Q130	7.87	6	Yes	No	0	6	0	1
L:L:?36	R:R:G131	2.89	6	Yes	No	0	4	0	1
L:L:?36	R:R:H311	7.61	6	Yes	Yes	0	5	0	1
R:R:H311	R:R:Y57	7.62	6	Yes	Yes	5	7	1	2
R:R:C103	R:R:V99	5.12	6	No	No	6	7	1	2
R:R:C103	R:R:Q130	6.1	6	No	No	6	6	1	1
R:R:H311	R:R:T107	9.58	6	Yes	No	5	6	1	1
R:R:Q130	R:R:V126	4.3	6	No	Yes	6	5	1	2
R:R:H311	R:R:M315	7.88	6	Yes	No	5	7	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	5.61
Average Nodes In Shell	16.00
Average Hubs In Shell	8.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	16.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7YOO

Peptide

Neuropeptide Y

Homo sapiens

Neuropeptide Y

Gi1/Beta1/Gamma2

3.11

2023-03-22

10.1016/j.str.2022.11.010

A 2D representation of the interactions of TYC in 7YOO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R33	L:L:R35	5.33	3	Yes	Yes	0	0	2	1
L:L:R33	R:R:Q288	4.67	3	Yes	No	0	5	2	2
L:L:?36	L:L:Q34	2.25	3	Yes	Yes	0	0	0	1
L:L:Q34	R:R:T107	7.09	3	Yes	Yes	0	6	1	1
L:L:Q34	R:R:Y110	11.27	3	Yes	Yes	0	5	1	2
L:L:Q34	R:R:T111	4.25	3	Yes	No	0	4	1	2
L:L:Q34	R:R:F307	4.68	3	Yes	Yes	0	4	1	1
L:L:?36	L:L:R35	8.21	3	Yes	Yes	0	0	0	1
L:L:R35	R:R:E205	11.63	3	Yes	No	0	4	1	2
L:L:R35	R:R:Y219	9.26	3	Yes	No	0	6	1	2
L:L:R35	R:R:S220	5.27	3	Yes	No	0	4	1	2
L:L:R35	R:R:Q288	4.67	3	Yes	No	0	5	1	2
L:L:?36	R:R:C103	2.68	3	Yes	No	0	6	0	1
L:L:?36	R:R:T107	4.98	3	Yes	Yes	0	6	0	1
L:L:?36	R:R:Q130	5.62	3	Yes	Yes	0	6	0	1
L:L:?36	R:R:G131	2.89	3	Yes	No	0	4	0	1
L:L:?36	R:R:V134	3.78	3	Yes	No	0	7	0	1
L:L:?36	R:R:L183	2.34	3	Yes	No	0	5	0	1
L:L:?36	R:R:F307	3.09	3	Yes	Yes	0	4	0	1
L:L:?36	R:R:H311	7.61	3	Yes	Yes	0	5	0	1
R:R:L104	R:R:Y57	3.52	3	Yes	Yes	7	7	2	2
R:R:H311	R:R:Y57	7.62	3	Yes	Yes	5	7	1	2
R:R:C103	R:R:V99	5.12	3	No	No	6	7	1	2
R:R:C103	R:R:Q130	9.16	3	No	Yes	6	6	1	1
R:R:H311	R:R:L104	2.57	3	Yes	Yes	5	7	1	2
R:R:L104	R:R:M315	7.07	3	Yes	No	7	7	2	2
R:R:Q130	R:R:T107	4.25	3	Yes	Yes	6	6	1	1
R:R:H311	R:R:T107	10.95	3	Yes	Yes	5	6	1	1
R:R:Q130	R:R:V126	4.3	3	Yes	Yes	6	5	1	2
R:R:G131	R:R:L183	1.71	3	No	No	4	5	1	1
R:R:V134	R:R:W281	2.45	0	No	Yes	7	8	1	2
R:R:L183	R:R:Y219	7.03	3	No	No	5	6	1	2
R:R:M315	R:R:W281	2.33	3	No	Yes	7	8	2	2
R:R:F307	R:R:L284	2.44	3	Yes	No	4	6	1	2
R:R:F307	R:R:Q288	2.34	3	Yes	No	4	5	1	2
R:R:H311	R:R:M315	10.51	3	Yes	No	5	7	1	2

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	4.35
Average Nodes In Shell	25.00
Average Hubs In Shell	13.00
Average Links In Shell	36.00
Average Links Mediated by Hubs In Shell	33.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	8.17
Average Number Of Links With An Hub	5.33
Average Interaction Strength	6.57
Average Nodes In Shell	22.83
Average Hubs In Shell	13.67
Average Links In Shell	32.17
Average Links Mediated by Hubs In Shell	29.83

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)