CodeTYS
NameO-SULFO-L-TYROSINE
Synonyms
Identifier(2S)-2-azanyl-3-(4-sulfooxyphenyl)propanoic acid
FormulaC9 H11 N O6 S
Molecular Weight261.252
SMILESc1cc(ccc1C[C@@H](C(=O)O)N)OS(=O)(=O)O
PubChem514186
Formal Charge0
Total Atoms28
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds6
Networks11
 missing image

This ligand is also present in the following 11 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6MEO A Protein Chemokine CCR5 Homo sapiens Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4 - - 3.9 2018-12-12 10.1038/s41586-018-0804-9

A 2D representation of the interactions of TYS in 6MEO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:I416 R:R:V5 3.07 0 Yes No 7 5 1 2
R:R:?14 R:R:I9 7.18 3 Yes No 0 4 0 1
L:L:R324 R:R:D11 3.57 3 Yes No 9 8 1 1
R:R:?14 R:R:D11 4.87 3 Yes No 0 8 0 1
R:R:?14 R:R:N13 2.96 3 Yes No 0 8 0 1
L:L:E377 L:L:R296 6.98 3 Yes Yes 9 9 2 1
L:L:P431 L:L:R296 2.88 3 Yes Yes 9 9 2 1
L:L:I436 L:L:R296 2.51 3 Yes Yes 9 9 2 1
L:L:R296 R:R:?14 2.62 3 Yes Yes 9 0 1 0
L:L:N298 R:R:?14 8.88 0 No Yes 4 0 1 0
L:L:G321 L:L:N300 3.39 0 No No 8 8 2 1
L:L:I323 L:L:N300 7.08 3 Yes No 9 8 1 1
L:L:N300 R:R:?14 10.85 3 No Yes 8 0 1 0
L:L:T301 R:R:?14 4.24 0 No Yes 9 0 1 0
L:L:I319 R:R:?14 5.13 0 No Yes 8 0 1 0
L:L:I323 L:L:R324 7.52 3 Yes Yes 9 9 1 1
L:L:I323 L:L:P431 5.08 3 Yes Yes 9 9 1 2
L:L:I323 R:R:?14 6.15 3 Yes Yes 9 0 1 0
L:L:I413 L:L:R324 2.51 3 No Yes 9 9 2 1
L:L:Q415 L:L:R324 7.01 3 No Yes 9 9 1 1
L:L:P431 L:L:R324 2.88 3 Yes Yes 9 9 2 1
L:L:R324 R:R:?14 10.47 3 Yes Yes 9 0 1 0
L:L:E377 L:L:I413 6.83 3 Yes No 9 9 2 2
L:L:E377 L:L:P431 4.72 3 Yes Yes 9 9 2 2
L:L:E377 L:L:I436 2.73 3 Yes Yes 9 9 2 2
L:L:K414 L:L:Y380 8.36 0 No Yes 8 9 1 2
L:L:K414 L:L:R412 2.48 0 No No 8 7 1 2
L:L:K414 R:R:?14 11.14 0 No Yes 8 0 1 0
L:L:P430 L:L:Q415 4.74 3 Yes No 9 9 2 1
L:L:Q415 R:R:?14 9.56 3 No Yes 9 0 1 0
L:L:I416 L:L:M427 5.83 0 Yes No 7 7 1 2
L:L:I416 R:R:?14 2.05 0 Yes Yes 7 0 1 0
L:L:P430 L:L:P431 1.95 3 Yes Yes 9 9 2 2
L:L:K433 R:R:?14 5.06 0 No Yes 3 0 1 0
R:R:I9 R:R:S7 1.55 0 No No 4 7 1 2
L:L:I416 R:R:S7 1.55 0 Yes No 7 7 1 2
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.51
Average Nodes In Shell26.00
Average Hubs In Shell10.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6MET A Protein Chemokine CCR5 Homo sapiens Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4 - - 4.5 2018-12-12 10.1038/s41586-018-0804-9

A 2D representation of the interactions of TYS in 6MET
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:I416 R:R:V5 3.07 0 Yes No 7 5 1 2
R:R:?10 R:R:I9 7.18 2 Yes No 8 4 0 1
R:R:?10 R:R:D11 4.87 2 Yes No 8 8 0 1
L:L:R324 R:R:?10 10.47 2 Yes Yes 9 8 1 0
L:L:K414 R:R:?10 11.14 0 No Yes 8 8 1 0
L:L:Q415 R:R:?10 9.56 2 No Yes 9 8 1 0
L:L:I416 R:R:?10 2.05 0 Yes Yes 7 8 1 0
L:L:R324 R:R:D11 3.57 2 Yes No 9 8 1 1
L:L:I323 L:L:R324 7.52 2 Yes Yes 9 9 2 1
L:L:I323 L:L:P431 5.08 2 Yes Yes 9 9 2 2
L:L:I413 L:L:R324 2.51 2 No Yes 9 9 2 1
L:L:Q415 L:L:R324 7.01 2 No Yes 9 9 1 1
L:L:P431 L:L:R324 2.88 2 Yes Yes 9 9 2 1
L:L:K414 L:L:Y380 8.36 0 No Yes 8 9 1 2
L:L:K414 L:L:R412 2.48 0 No No 8 7 1 2
L:L:P430 L:L:Q415 4.74 2 Yes No 9 9 2 1
L:L:I416 L:L:M427 5.83 0 Yes No 7 7 1 2
L:L:P430 L:L:P431 1.95 2 Yes Yes 9 9 2 2
R:R:I9 R:R:S7 1.55 0 No No 4 7 1 2
L:L:I416 R:R:S7 1.55 0 Yes No 7 7 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.55
Average Nodes In Shell16.00
Average Hubs In Shell7.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TYS in 6MET
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:?14 R:R:N13 2.96 2 Yes No 7 8 0 1
L:L:R296 R:R:?14 2.62 2 Yes Yes 9 7 1 0
L:L:N298 R:R:?14 8.88 0 No Yes 4 7 1 0
L:L:N300 R:R:?14 10.85 2 No Yes 8 7 1 0
L:L:T301 R:R:?14 4.24 0 No Yes 9 7 1 0
L:L:I319 R:R:?14 5.13 0 No Yes 8 7 1 0
L:L:I323 R:R:?14 6.15 2 Yes Yes 9 7 1 0
L:L:K433 R:R:?14 5.06 0 No Yes 3 7 1 0
L:L:E377 L:L:R296 6.98 2 Yes Yes 9 9 2 1
L:L:P431 L:L:R296 2.88 2 Yes Yes 9 9 2 1
L:L:I436 L:L:R296 2.51 2 Yes Yes 9 9 2 1
L:L:G321 L:L:N300 3.39 0 No No 8 8 2 1
L:L:I323 L:L:N300 7.08 2 Yes No 9 8 1 1
L:L:I323 L:L:R324 7.52 2 Yes Yes 9 9 1 2
L:L:I323 L:L:P431 5.08 2 Yes Yes 9 9 1 2
L:L:P431 L:L:R324 2.88 2 Yes Yes 9 9 2 2
L:L:E377 L:L:P431 4.72 2 Yes Yes 9 9 2 2
L:L:E377 L:L:I436 2.73 2 Yes Yes 9 9 2 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.74
Average Nodes In Shell14.00
Average Hubs In Shell7.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EZH A Peptide Cholecystokinin CCKA Homo sapiens Cholecystokinin-8 - Gi1/Beta1/Gamma2 3.2 2021-08-25 10.1038/s41589-021-00841-3

A 2D representation of the interactions of TYS in 7EZH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 R:R:P101 3.54 3 Yes No 0 5 0 1
R:R:A193 R:R:F185 4.16 0 No No 3 4 2 1
R:R:F185 R:R:M195 8.71 3 No Yes 4 4 1 1
L:L:?2 R:R:F185 7 3 Yes No 0 4 0 1
R:R:M195 R:R:R197 16.13 3 Yes No 4 4 1 1
L:L:?2 R:R:M195 5.08 3 Yes Yes 0 4 0 1
L:L:?2 R:R:R197 15.71 3 Yes No 0 4 0 1
L:L:G4 R:R:R197 6 3 No No 0 4 2 1
L:L:M3 R:R:S348 4.6 3 Yes No 0 5 1 2
L:L:?2 L:L:D1 8.77 3 Yes No 0 0 0 1
L:L:D1 L:L:M3 9.7 3 No Yes 0 0 1 1
L:L:?2 L:L:M3 6.09 3 Yes Yes 0 0 0 1
R:R:I100 R:R:P101 3.39 0 No No 5 5 2 1
R:R:M195 R:R:V183 3.04 3 Yes No 4 3 1 2
L:L:?2 R:R:N102 2.96 3 Yes No 0 6 0 1
L:L:M3 R:R:R345 1.24 3 Yes No 0 5 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.02
Average Nodes In Shell14.00
Average Hubs In Shell3.00
Average Links In Shell16.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EZK A Peptide Cholecystokinin CCKA Homo sapiens Cholecystokinin-8 - chim(NtGi1-Gs)/Beta1/Gamma2 3.1 2021-08-25 10.1038/s41589-021-00841-3

A 2D representation of the interactions of TYS in 7EZK
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I100 R:R:P101 3.39 0 No No 5 5 2 1
R:R:F107 R:R:P101 4.33 29 Yes No 8 5 2 1
L:L:?2 R:R:P101 4.72 2 Yes No 0 5 0 1
L:L:?2 R:R:K105 7.09 2 Yes No 0 4 0 1
R:R:A193 R:R:F185 5.55 0 No Yes 3 4 2 1
R:R:F185 R:R:M195 12.44 2 Yes Yes 4 4 1 1
L:L:D1 R:R:F185 3.58 2 No Yes 0 4 1 1
L:L:?2 R:R:F185 6.12 2 Yes Yes 0 4 0 1
R:R:M195 R:R:R197 16.13 2 Yes Yes 4 4 1 1
L:L:?2 R:R:M195 5.08 2 Yes Yes 0 4 0 1
L:L:?2 R:R:R197 16.58 2 Yes Yes 0 4 0 1
L:L:G4 R:R:R197 6 2 No Yes 0 4 2 1
L:L:M3 R:R:S348 6.13 0 No No 0 5 1 2
L:L:?2 L:L:D1 5.85 2 Yes No 0 0 0 1
L:L:?2 L:L:M3 6.09 2 Yes No 0 0 0 1
R:R:M195 R:R:V183 3.04 2 Yes No 4 3 1 2
L:L:?2 R:R:N102 2.96 2 Yes No 0 6 0 1
R:R:K105 R:R:K187 1.44 0 No No 4 2 1 2
R:R:L199 R:R:R197 1.21 0 No Yes 4 4 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.81
Average Nodes In Shell17.00
Average Hubs In Shell5.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EZM A Peptide Cholecystokinin CCKA Homo sapiens Cholecystokinin-8 - chim(NtGsL-Gq)/Beta1/Gamma2 2.9 2021-08-25 10.1038/s41589-021-00841-3

A 2D representation of the interactions of TYS in 7EZM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 R:R:P101 5.9 14 Yes No 0 5 0 1
L:L:?2 R:R:K105 5.06 14 Yes No 0 4 0 1
L:L:M6 R:R:M121 4.33 0 No Yes 0 7 1 2
R:R:A193 R:R:F185 5.55 0 No No 3 4 2 1
L:L:?2 R:R:F185 4.37 14 Yes No 0 4 0 1
R:R:M195 R:R:R197 17.37 14 No No 4 4 1 1
L:L:?2 R:R:M195 4.06 14 Yes No 0 4 0 1
L:L:?2 R:R:R197 13.09 14 Yes No 0 4 0 1
L:L:G4 R:R:R197 6 0 No No 0 4 2 1
L:L:M3 R:R:S348 6.13 14 No No 0 5 1 2
L:L:?2 L:L:D1 8.77 14 Yes No 0 0 0 1
L:L:D1 L:L:M3 9.7 14 No No 0 0 1 1
L:L:?2 L:L:M3 7.11 14 Yes No 0 0 0 1
L:L:?2 L:L:M6 4.06 14 Yes No 0 0 0 1
R:R:I100 R:R:P101 3.39 0 No No 5 5 2 1
R:R:M195 R:R:V183 3.04 14 No No 4 3 1 2
L:L:?2 R:R:N102 2.96 14 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub0.00
Average Interaction Strength6.15
Average Nodes In Shell16.00
Average Hubs In Shell2.00
Average Links In Shell17.00
Average Links Mediated by Hubs In Shell10.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7MBX A Peptide Cholecystokinin CCKA Homo sapiens Cholecystokinin-8 - Gs/Beta1/Gamma1 1.95 2021-05-26 10.1371/journal.pbio.3001295

A 2D representation of the interactions of TYS in 7MBX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I100 R:R:P101 3.39 0 No Yes 5 5 2 1
R:R:F107 R:R:P101 7.22 6 Yes Yes 8 5 2 1
R:R:F109 R:R:P101 2.89 6 Yes Yes 6 5 2 1
L:L:?2 R:R:P101 3.54 6 Yes Yes 0 5 0 1
L:L:?2 R:R:K105 8.1 6 Yes No 0 4 0 1
R:R:F107 R:R:F109 11.79 6 Yes Yes 8 6 2 2
R:R:M195 R:R:V183 4.56 6 Yes No 4 3 1 2
R:R:R197 R:R:V183 3.92 6 Yes No 4 3 1 2
R:R:F185 R:R:K187 2.48 6 Yes No 4 2 1 2
R:R:A193 R:R:F185 5.55 0 No Yes 3 4 2 1
R:R:F185 R:R:M195 6.22 6 Yes Yes 4 4 1 1
L:L:?2 R:R:F185 6.12 6 Yes Yes 0 4 0 1
R:R:M195 R:R:R197 13.65 6 Yes Yes 4 4 1 1
L:L:?2 R:R:M195 7.11 6 Yes Yes 0 4 0 1
L:L:?2 R:R:R197 11.34 6 Yes Yes 0 4 0 1
L:L:G4 R:R:R197 4.5 0 No Yes 0 4 2 1
L:L:M3 R:R:E344 2.71 0 No Yes 0 1 1 2
L:L:G4 R:R:E344 8.19 0 No Yes 0 1 2 2
L:L:M3 R:R:S348 3.07 0 No No 0 5 1 2
L:L:?2 L:L:D1 6.82 6 Yes No 0 0 0 1
L:L:?2 L:L:M3 6.09 6 Yes No 0 0 0 1
R:R:L199 R:R:R197 1.21 0 No Yes 4 4 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.02
Average Nodes In Shell18.00
Average Hubs In Shell8.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7MBY A Peptide Cholecystokinin CCKA Homo sapiens Cholecystokinin-8 - chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2 2.44 2021-05-26 10.1371/journal.pbio.3001295

A 2D representation of the interactions of TYS in 7MBY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:M6 R:R:N98 14.02 0 No No 0 7 1 2
R:R:I100 R:R:P101 3.39 0 No No 5 5 2 1
R:R:F107 R:R:P101 4.33 0 Yes No 8 5 2 1
L:L:?2 R:R:P101 5.9 0 Yes No 0 5 0 1
L:L:?2 R:R:K105 8.1 0 Yes No 0 4 0 1
R:R:M195 R:R:R197 8.69 0 No Yes 4 4 2 1
R:R:L199 R:R:R197 3.64 0 No Yes 4 4 2 1
L:L:?2 R:R:R197 9.6 0 Yes Yes 0 4 0 1
L:L:G4 R:R:R197 4.5 22 Yes Yes 0 4 2 1
L:L:M3 R:R:S348 4.6 0 No Yes 0 5 1 2
L:L:G4 R:R:S348 3.71 22 Yes Yes 0 5 2 2
L:L:?2 L:L:D1 8.77 0 Yes No 0 0 0 1
L:L:?2 L:L:M3 7.11 0 Yes No 0 0 0 1
L:L:?2 L:L:M6 3.05 0 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub1.00
Average Interaction Strength7.09
Average Nodes In Shell14.00
Average Hubs In Shell5.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell12.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XOU A Peptide Cholecystokinin CCKA Homo sapiens Cholecystokinin-8 - Gs/Beta1/Gamma2 3.2 2022-07-20 10.1038/s41421-022-00420-3

A 2D representation of the interactions of TYS in 7XOU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:D1 L:L:M3 4.16 0 No No 0 0 2 1
L:L:?2 L:L:M3 6.09 10 Yes No 0 0 0 1
L:L:?2 L:L:M6 6.09 10 Yes No 0 0 0 1
L:L:?2 R:R:P101 3.54 10 Yes No 0 5 0 1
L:L:?2 R:R:K105 14.18 10 Yes No 0 4 0 1
L:L:?2 R:R:F107 3.5 10 Yes Yes 0 8 0 1
L:L:?2 R:R:T186 6.35 10 Yes Yes 0 3 0 1
L:L:M3 R:R:E344 8.12 0 No No 0 1 1 2
L:L:M6 R:R:T118 3.01 0 No No 0 6 1 2
L:L:M6 R:R:C196 4.86 0 No Yes 0 9 1 2
R:R:I100 R:R:P101 3.39 0 No No 5 5 2 1
R:R:F107 R:R:P101 14.45 10 Yes No 8 5 1 1
R:R:K105 R:R:T186 4.5 10 No Yes 4 3 1 1
R:R:K105 R:R:K187 7.18 10 No Yes 4 2 1 2
R:R:F107 R:R:F109 9.65 10 Yes No 8 6 1 2
R:R:C196 R:R:F107 4.19 0 Yes Yes 9 8 2 1
R:R:K187 R:R:T186 6.01 10 Yes Yes 2 3 2 1
R:R:A193 R:R:T186 5.03 0 No Yes 3 3 2 1
R:R:M195 R:R:T186 4.52 0 No Yes 4 3 2 1
R:R:G349 R:R:S348 3.71 0 No No 3 5 2 1
L:L:?2 R:R:S348 2.16 10 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.99
Average Nodes In Shell18.00
Average Hubs In Shell5.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XOW A Peptide Cholecystokinin CCKB Homo sapiens Gastrin - Gq/Beta1/Gamma2 3.1 2022-07-20 10.1038/s41421-022-00420-3

A 2D representation of the interactions of TYS in 7XOW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F120 R:R:P114 5.78 2 Yes No 8 5 1 1
L:L:?12 R:R:P114 5.9 2 Yes No 0 5 0 1
L:L:?12 R:R:G118 4.91 2 Yes No 0 4 0 1
R:R:F120 R:R:F122 9.65 2 Yes Yes 8 6 1 2
R:R:C127 R:R:F120 5.59 2 No Yes 9 8 2 1
R:R:C205 R:R:F120 11.17 2 Yes Yes 9 8 1 1
L:L:?12 R:R:F120 7 2 Yes Yes 0 8 0 1
R:R:C127 R:R:V195 3.42 2 No No 9 4 2 2
R:R:C127 R:R:C205 7.28 2 No Yes 9 9 2 1
R:R:C205 R:R:V195 5.12 2 Yes No 9 4 1 2
R:R:V198 R:R:V202 4.81 2 No No 1 1 2 2
R:R:Q204 R:R:V198 5.73 2 No No 4 1 1 2
R:R:Q204 R:R:V202 7.16 2 No No 4 1 1 2
L:L:?12 R:R:Q204 14.34 2 Yes No 0 4 0 1
L:L:?12 R:R:C205 3.42 2 Yes Yes 0 9 0 1
L:L:M15 R:R:C205 4.86 2 No Yes 0 9 1 1
L:L:M15 R:R:H207 3.94 2 No Yes 0 5 1 2
L:L:G13 R:R:H364 3.18 0 No No 0 1 1 2
L:L:A11 R:R:S368 3.42 0 No No 0 5 1 2
L:L:?12 L:L:G13 6.14 2 Yes No 0 0 0 1
L:L:?12 L:L:M15 8.12 2 Yes No 0 0 0 1
L:L:?12 L:L:A11 2.26 2 Yes No 0 0 0 1
R:R:G118 R:R:T119 1.82 0 No No 4 4 1 2
R:R:L113 R:R:P114 1.64 0 No No 5 5 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.51
Average Nodes In Shell19.00
Average Hubs In Shell5.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XOX A Peptide Cholecystokinin CCKB Homo sapiens Cholecystokinin-8 - Gq/Beta1/Gamma2 3.1 2022-07-20 10.1038/s41421-022-00420-3

A 2D representation of the interactions of TYS in 7XOX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F120 R:R:P114 5.78 2 Yes No 8 5 1 1
L:L:?12 R:R:P114 5.9 2 Yes No 0 5 0 1
L:L:?12 R:R:G118 4.91 2 Yes No 0 4 0 1
R:R:F120 R:R:F122 9.65 2 Yes Yes 8 6 1 2
R:R:C127 R:R:F120 5.59 2 No Yes 9 8 2 1
R:R:C205 R:R:F120 11.17 2 Yes Yes 9 8 1 1
L:L:?12 R:R:F120 7 2 Yes Yes 0 8 0 1
R:R:C127 R:R:V195 3.42 2 No No 9 4 2 2
R:R:C127 R:R:C205 7.28 2 No Yes 9 9 2 1
R:R:C205 R:R:V195 5.12 2 Yes No 9 4 1 2
R:R:V198 R:R:V202 4.81 2 No No 1 1 2 2
R:R:Q204 R:R:V198 5.73 2 No No 4 1 1 2
R:R:Q204 R:R:V202 7.16 2 No No 4 1 1 2
L:L:?12 R:R:Q204 14.34 2 Yes No 0 4 0 1
L:L:?12 R:R:C205 3.42 2 Yes Yes 0 9 0 1
L:L:M15 R:R:C205 4.86 2 No Yes 0 9 1 1
L:L:M15 R:R:H207 3.94 2 No Yes 0 5 1 2
L:L:G13 R:R:H364 3.18 0 No No 0 1 1 2
L:L:A11 R:R:S368 3.42 0 No No 0 5 1 2
L:L:?12 L:L:G13 6.14 2 Yes No 0 0 0 1
L:L:?12 L:L:M15 8.12 2 Yes No 0 0 0 1
L:L:?12 L:L:A11 2.26 2 Yes No 0 0 0 1
R:R:G118 R:R:T119 1.82 0 No No 4 4 1 2
R:R:L113 R:R:P114 1.64 0 No No 5 5 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.51
Average Nodes In Shell19.00
Average Hubs In Shell5.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IA7 A Peptide Cholecystokinin CCKB Homo sapiens Cholecystokinin-8 - chim(NtGi1L-Gq)/Beta1/Gamma2 3.1 2023-12-06 10.1038/s41421-022-00420-3

A 2D representation of the interactions of TYS in 8IA7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F120 R:R:P114 8.67 23 Yes No 8 5 2 1
L:L:?2 R:R:P114 4.72 0 Yes No 0 5 0 1
R:R:Q204 R:R:V198 4.3 0 No No 4 1 1 2
R:R:Q204 R:R:V206 2.87 0 No No 4 4 1 2
L:L:?2 R:R:Q204 7.65 0 Yes No 0 4 0 1
R:R:H364 R:R:S368 2.79 27 No No 1 5 2 2
L:L:M3 R:R:H364 9.19 27 No No 0 1 1 2
L:L:M3 R:R:S368 3.07 27 No No 0 5 1 2
L:L:?2 L:L:D1 2.92 0 Yes No 0 0 0 1
L:L:?2 L:L:M3 5.08 0 Yes No 0 0 0 1
L:L:?2 L:L:G4 13.52 0 Yes No 0 0 0 1
R:R:L113 R:R:P114 1.64 0 No No 5 5 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub0.00
Average Interaction Strength6.78
Average Nodes In Shell12.00
Average Hubs In Shell2.00
Average Links In Shell12.00
Average Links Mediated by Hubs In Shell6.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links7.75
Average Number Of Links With An Hub2.00
Average Interaction Strength6.64
Average Nodes In Shell16.92
Average Hubs In Shell5.33
Average Links In Shell20.25
Average Links Mediated by Hubs In Shell16.17

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)