CodeU8S
Name3-[(2S)-2-hydroxy-2,3-dihydro-1H-imidazol-4-yl]-L-alanine
Synonyms
Identifier(2~{S})-2-azanyl-3-[(2~{S})-2-oxidanyl-2,3-dihydro-1~{H}-imidazol-4-yl]propanoic acid
FormulaC6 H11 N3 O3
Molecular Weight173.17
SMILESC1=C(N[C@H](N1)O)C[C@@H](C(=O)O)N
PubChem168719763
Formal Charge0
Total Atoms23
Total Chiral Atoms2
Total Bonds23
Total Aromatic Bonds0
Networks1
 missing image

This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8E0G A Peptide Opioid MOP Mus Musculus BU72 - - 2.1 2023-10-18  10.1186/s12915-023-01689-w

A 2D representation of the interactions of U8S in 8E0G
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:?54 R:R:S53 4.64 1 Yes No 2 4 0 1
R:R:?54 R:R:S55 3.48 1 Yes Yes 2 4 0 1
R:R:?54 R:R:?57 3.64 1 Yes Yes 2 5 0 1
R:R:?54 R:R:I144 3.31 1 Yes Yes 2 5 0 1
R:R:?54 R:R:Y148 5.44 1 Yes Yes 2 4 0 1
R:R:?54 R:R:D216 7.34 1 Yes Yes 2 4 0 1
R:R:?54 R:R:T218 5.69 1 Yes No 2 3 0 1
L:L:?1 R:R:?54 32.65 1 Yes Yes 0 2 1 0
R:R:N127 R:R:S55 8.94 0 No Yes 6 4 2 1
R:R:D216 R:R:S55 4.42 1 Yes Yes 4 4 1 1
R:R:C217 R:R:S55 3.44 1 Yes Yes 9 4 2 1
R:R:?57 R:R:L56 3.54 1 Yes Yes 5 2 1 2
R:R:D216 R:R:L56 6.79 1 Yes Yes 4 2 1 2
R:R:?57 R:R:P58 15.39 1 Yes No 5 9 1 2
R:R:?57 R:R:Q59 13.61 1 Yes No 5 2 1 2
R:R:?57 R:R:K303 6.01 1 Yes Yes 5 4 1 2
R:R:?57 R:R:W318 15.52 1 Yes Yes 5 5 1 2
R:R:D147 R:R:Q124 3.92 1 Yes Yes 6 6 2 2
R:R:Q124 R:R:Y326 7.89 1 Yes Yes 6 7 2 2
L:L:?1 R:R:Q124 13.25 1 Yes Yes 0 6 1 2
R:R:A206 R:R:I144 4.87 0 No Yes 4 5 2 1
R:R:C217 R:R:I144 3.27 1 Yes Yes 9 5 2 1
L:L:?1 R:R:I144 5.68 1 Yes Yes 0 5 1 1
R:R:D147 R:R:Y326 8.05 1 Yes Yes 6 7 2 2
L:L:?1 R:R:D147 19.82 1 Yes Yes 0 6 1 2
R:R:I198 R:R:Y148 4.84 0 No Yes 4 4 2 1
R:R:V202 R:R:Y148 8.83 0 No Yes 5 4 2 1
L:L:?1 R:R:Y148 9.34 1 Yes Yes 0 4 1 1
L:L:?1 R:R:M151 7.51 1 Yes Yes 0 7 1 2
R:R:D216 R:R:T218 13.01 1 Yes No 4 3 1 1
L:L:?1 R:R:V236 4.94 1 Yes No 0 5 1 2
R:R:I296 R:R:W318 4.7 1 No Yes 6 5 2 2
L:L:?1 R:R:I296 6.63 1 Yes No 0 6 1 2
L:L:?1 R:R:H297 4.27 1 Yes Yes 0 8 1 2
L:L:?1 R:R:V300 6.92 1 Yes No 0 5 1 2
R:R:K303 R:R:W318 13.92 1 Yes Yes 4 5 2 2
R:R:I322 R:R:W318 9.4 1 No Yes 5 5 2 2
L:L:?1 R:R:W318 3.78 1 Yes Yes 0 5 1 2
L:L:?1 R:R:I322 3.79 1 Yes No 0 5 1 2
L:L:?1 R:R:Y326 9.34 1 Yes Yes 0 7 1 2
R:R:K209 R:R:T218 3 0 No No 3 3 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.27
Average Nodes In Shell29.00
Average Hubs In Shell16.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.27
Average Nodes In Shell29.00
Average Hubs In Shell16.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell40.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)