CodeU9S
Name(2R,3S)-oxirane-2,3-dicarboxylic acid
Synonymscis-2,3-epoxysuccinic acid
Identifier
FormulaC4 H4 O5
Molecular Weight132.072
SMILES
PubChem2734802
Formal Charge0
Total Atoms13
Total Chiral Atoms2
Total Bonds13
Total Aromatic Bonds0
Networks4
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This ligand is also present in the following 4 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JPN A Alicarboxylic acid Succinate Succinate Homo Sapiens Cis-Epoxysuccinic acid - Gi1/Beta1/Gamma1 2.9 2024-05-22 doi.org/10.1038/s41422-024-00968-7

A 2D representation of the interactions of U9S in 8JPN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y30 4.47 5 Yes Yes 0 8 0 1
L:L:?1 R:R:L79 5.28 5 Yes No 0 6 0 1
L:L:?1 R:R:Y83 5.37 5 Yes No 0 5 0 1
L:L:?1 R:R:R99 12.05 5 Yes No 0 6 0 1
L:L:?1 R:R:L102 3.17 5 Yes No 0 7 0 1
L:L:?1 R:R:H103 4.91 5 Yes No 0 5 0 1
L:L:?1 R:R:D174 6.22 5 Yes No 0 5 0 1
L:L:?1 R:R:R281 19.47 5 Yes Yes 0 6 0 1
R:R:L26 R:R:Y30 5.86 0 No Yes 6 8 2 1
R:R:I278 R:R:L26 2.85 0 No No 4 6 2 2
R:R:L76 R:R:Y30 7.03 5 Yes Yes 8 8 2 1
R:R:L79 R:R:Y30 7.03 5 No Yes 6 8 1 1
R:R:I80 R:R:Y30 4.84 5 Yes Yes 6 8 2 1
R:R:P282 R:R:Y30 2.78 5 Yes Yes 5 8 2 1
R:R:F285 R:R:Y30 7.22 0 No Yes 7 8 2 1
R:R:F72 R:R:L102 6.09 5 Yes No 7 7 2 1
R:R:F285 R:R:F72 11.79 0 No Yes 7 7 2 2
R:R:L102 R:R:T75 4.42 0 No No 7 6 1 2
R:R:I80 R:R:L76 2.85 5 Yes Yes 6 8 2 2
R:R:L79 R:R:Y83 5.86 5 No No 6 5 1 1
R:R:I161 R:R:R99 3.76 0 No No 4 6 2 1
R:R:D174 R:R:S177 5.89 0 No No 5 4 1 2
R:R:R281 R:R:Y277 9.26 0 Yes Yes 6 5 1 2
R:R:I278 R:R:R281 3.76 0 No Yes 4 6 2 1
R:R:P282 R:R:R281 2.88 5 Yes Yes 5 6 2 1
R:R:D174 R:R:N173 1.35 0 No No 5 4 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.62
Average Nodes In Shell21.00
Average Hubs In Shell8.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WP1 A Alicarboxylic acid Succinate Succinate Homo Sapiens Cis-Epoxysuccinic acid - Gi1/Beta1/Gamma2 3.15 2024-09-11 doi.org/10.1016/j.celrep.2024.114381

A 2D representation of the interactions of U9S in 8WP1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L26 R:R:Y30 5.86 2 Yes Yes 6 8 2 1
R:R:L26 R:R:Y83 5.86 2 Yes No 6 5 2 1
R:R:I278 R:R:L26 5.71 0 Yes Yes 4 6 2 2
R:R:L26 R:R:P282 3.28 2 Yes Yes 6 5 2 2
R:R:R281 R:R:Y30 3.09 2 Yes Yes 6 8 1 1
R:R:P282 R:R:Y30 2.78 2 Yes Yes 5 8 2 1
R:R:F285 R:R:Y30 9.28 0 No Yes 7 8 2 1
L:L:?1 R:R:Y30 4.16 2 Yes Yes 0 8 0 1
R:R:F72 R:R:L102 6.09 0 Yes Yes 7 7 2 1
R:R:F285 R:R:F72 13.93 0 No Yes 7 7 2 2
R:R:N98 R:R:T75 5.85 0 No No 4 6 2 2
R:R:L102 R:R:T75 8.84 2 Yes No 7 6 1 2
R:R:L79 R:R:N98 4.12 2 No No 6 4 1 2
R:R:L79 R:R:R99 3.64 2 No Yes 6 6 1 1
L:L:?1 R:R:L79 3.69 2 Yes No 0 6 0 1
L:L:?1 R:R:Y83 5.2 2 Yes No 0 5 0 1
R:R:C95 R:R:R99 2.79 2 No Yes 9 6 2 1
R:R:C172 R:R:C95 5.46 2 No No 9 9 2 2
R:R:I161 R:R:R99 7.52 0 No Yes 4 6 2 1
R:R:C172 R:R:R99 4.18 2 No Yes 9 6 2 1
L:L:?1 R:R:R99 16.18 2 Yes Yes 0 6 0 1
R:R:H103 R:R:L102 3.86 2 Yes Yes 5 7 1 1
L:L:?1 R:R:L102 7.37 2 Yes Yes 0 7 0 1
R:R:H103 R:R:L154 2.57 2 Yes Yes 5 7 1 2
R:R:H103 R:R:I157 2.65 2 Yes Yes 5 4 1 2
R:R:F175 R:R:H103 4.53 2 Yes Yes 4 5 2 1
L:L:?1 R:R:H103 7.99 2 Yes Yes 0 5 0 1
R:R:I157 R:R:L154 2.85 2 Yes Yes 4 7 2 2
R:R:I157 R:R:I161 4.42 2 Yes No 4 4 2 2
R:R:F175 R:R:I157 6.28 2 Yes Yes 4 4 2 2
R:R:D174 R:R:S177 8.83 2 Yes No 5 4 1 2
R:R:D174 R:R:Y277 4.6 2 Yes Yes 5 5 1 2
R:R:D174 R:R:R281 4.76 2 Yes Yes 5 6 1 1
L:L:?1 R:R:D174 3.61 2 Yes Yes 0 5 0 1
R:R:Y248 R:R:Y277 7.94 2 Yes Yes 7 5 2 2
R:R:R281 R:R:Y248 3.09 2 Yes Yes 6 7 1 2
R:R:R281 R:R:Y277 17.49 2 Yes Yes 6 5 1 2
R:R:I278 R:R:R281 2.51 0 Yes Yes 4 6 2 1
L:L:?1 R:R:R281 14.02 2 Yes Yes 0 6 0 1
R:R:I80 R:R:Y30 2.42 0 No Yes 6 8 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.78
Average Nodes In Shell26.00
Average Hubs In Shell16.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.25
Average Interaction Strength8.01
Average Nodes In Shell21.75
Average Hubs In Shell9.00
Average Links In Shell28.50
Average Links Mediated by Hubs In Shell24.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)