CodeUGU
NameDinoprost
SynonymsDinoprost; Prostaglandin F2a; PGF2alpha
Identifier(~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-3,5-bis(oxidanyl)-2-[(~{E},3~{S})-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid
FormulaC20 H34 O5
Molecular Weight354.481
SMILESCCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O)O
PubChem5280363
Formal Charge0
Total Atoms59
Total Chiral Atoms5
Total Bonds59
Total Aromatic Bonds0
Networks2
 missing image

This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IUK A Lipid Prostanoid FP-alpha Homo Sapiens PGF2-alpha - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 2.67 2023-07-12 10.1038/s41467-023-38411-x

A 2D representation of the interactions of UGU in 8IUK
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F32 R:R:F36 3.22 0 No Yes 4 8 2 1
R:R:F32 R:R:R291 16.03 0 No No 4 8 2 1
L:L:?1 R:R:S33 17.05 2 Yes No 0 7 0 1
R:R:F36 R:R:T294 10.38 2 Yes No 8 9 1 1
R:R:F36 R:R:W295 14.03 2 Yes Yes 8 5 1 2
R:R:F36 R:R:I298 3.77 2 Yes Yes 8 8 1 2
L:L:?1 R:R:F36 3.25 2 Yes Yes 0 8 0 1
R:R:G85 R:R:M37 3.49 0 No No 7 7 1 2
R:R:H81 R:R:T294 2.74 2 No No 8 9 1 1
R:R:H81 R:R:I298 5.3 2 No Yes 8 8 1 2
L:L:?1 R:R:H81 8.59 2 Yes No 0 8 0 1
R:R:F111 R:R:N84 6.04 2 No Yes 6 6 2 1
R:R:M115 R:R:N84 2.8 2 Yes Yes 8 6 1 1
R:R:N84 R:R:S118 2.98 2 Yes No 6 7 1 2
L:L:?1 R:R:N84 12.84 2 Yes Yes 0 6 0 1
L:L:?1 R:R:G85 3.43 2 Yes No 0 7 0 1
R:R:F111 R:R:M115 3.73 2 No Yes 6 8 2 1
R:R:F187 R:R:M115 4.98 2 Yes Yes 8 8 2 1
L:L:?1 R:R:M115 7.55 2 Yes Yes 0 8 0 1
R:R:G119 R:R:W262 2.81 0 No Yes 7 9 1 2
L:L:?1 R:R:G119 3.43 2 Yes No 0 7 0 1
R:R:F187 R:R:W185 4.01 2 Yes Yes 8 8 2 2
R:R:L290 R:R:W185 6.83 0 No Yes 7 8 1 2
R:R:N296 R:R:W262 12.43 2 Yes Yes 9 9 2 2
R:R:Q297 R:R:W262 12.05 2 No Yes 8 9 1 2
R:R:L287 R:R:R291 15.79 2 No No 6 8 1 1
L:L:?1 R:R:L287 3.7 2 Yes No 0 6 0 1
L:L:?1 R:R:L290 7.39 2 Yes No 0 7 0 1
L:L:?1 R:R:R291 7.3 2 Yes No 0 8 0 1
L:L:?1 R:R:T294 14.77 2 Yes No 0 9 0 1
R:R:I298 R:R:W295 11.74 2 Yes Yes 8 5 2 2
R:R:N296 R:R:Q297 7.92 2 Yes No 9 8 2 1
L:L:?1 R:R:Q297 6.22 2 Yes No 0 8 0 1
L:L:?1 R:R:A293 2.1 2 Yes No 0 8 0 1
R:R:A88 R:R:G85 1.95 0 No No 8 7 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.51
Average Nodes In Shell25.00
Average Hubs In Shell10.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XJL A Lipid Prostanoid FP-alpha Homo Sapiens PGF2-alpha - chim(NtGi2-Gs-CtGq)/Beta1/Gamma2 2.77 2024-02-28 To be published

A 2D representation of the interactions of UGU in 8XJL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V30 R:R:Y92 8.83 0 No Yes 6 8 2 1
L:L:?1 R:R:S33 7.66 1 Yes No 0 7 0 1
R:R:G85 R:R:M37 5.24 0 No No 7 7 1 2
R:R:G40 R:R:H81 4.77 1 No Yes 9 8 2 1
R:R:G40 R:R:I298 5.29 1 No No 9 8 2 2
R:R:D77 R:R:N44 6.73 1 Yes Yes 9 9 2 2
R:R:H81 R:R:N44 3.83 1 Yes Yes 8 9 1 2
R:R:D77 R:R:P122 6.44 1 Yes No 9 9 2 2
R:R:D77 R:R:Q297 10.44 1 Yes Yes 9 8 2 1
R:R:H81 R:R:I298 5.3 1 Yes No 8 8 1 2
L:L:?1 R:R:H81 11.24 1 Yes Yes 0 8 0 1
R:R:F111 R:R:N84 4.83 1 Yes Yes 6 6 2 1
R:R:C114 R:R:N84 4.72 0 No Yes 4 6 2 1
R:R:M115 R:R:N84 8.41 1 No Yes 8 6 1 1
R:R:N84 R:R:S118 7.45 1 Yes No 6 7 1 2
L:L:?1 R:R:N84 4 1 Yes Yes 0 6 0 1
R:R:K96 R:R:Y92 4.78 1 No Yes 5 8 2 1
R:R:T184 R:R:Y92 13.73 1 No Yes 9 8 1 1
L:L:?1 R:R:Y92 7.69 1 Yes Yes 0 8 0 1
R:R:K96 R:R:T184 4.5 1 No No 5 9 2 1
R:R:F111 R:R:M115 4.98 1 Yes No 6 8 2 1
L:L:?1 R:R:M115 5.15 1 Yes No 0 8 0 1
R:R:P122 R:R:Q297 9.47 1 No Yes 9 8 2 1
R:R:Q180 R:R:W185 21.9 1 Yes Yes 8 8 2 1
R:R:S182 R:R:W185 3.71 0 Yes Yes 8 8 2 1
R:R:L287 R:R:S182 6.01 0 No Yes 6 8 1 2
L:L:?1 R:R:T184 5.37 1 Yes No 0 9 0 1
R:R:F187 R:R:W185 6.01 1 Yes Yes 8 8 2 1
R:R:L290 R:R:W185 9.11 1 No Yes 7 8 1 1
L:L:?1 R:R:W185 4.15 1 Yes Yes 0 8 0 1
R:R:N296 R:R:W262 12.43 1 Yes Yes 9 9 2 2
R:R:Q297 R:R:W262 6.57 1 Yes Yes 8 9 1 2
R:R:F265 R:R:L290 7.31 0 No No 8 7 2 1
R:R:L287 R:R:R291 6.07 0 No No 6 8 1 2
L:L:?1 R:R:L287 4.04 1 Yes No 0 6 0 1
L:L:?1 R:R:L290 6.05 1 Yes No 0 7 0 1
R:R:T294 R:R:W295 4.85 0 No Yes 9 5 1 2
L:L:?1 R:R:T294 7.52 1 Yes No 0 9 0 1
R:R:I298 R:R:W295 8.22 1 No Yes 8 5 2 2
R:R:N296 R:R:Q297 9.24 1 Yes Yes 9 8 2 1
L:L:?1 R:R:Q297 6.79 1 Yes Yes 0 8 0 1
R:R:A88 R:R:S33 3.42 0 No No 8 7 2 1
L:L:?1 R:R:G85 2.49 1 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.01
Average Nodes In Shell33.00
Average Hubs In Shell15.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links12.50
Average Number Of Links With An Hub4.00
Average Interaction Strength6.76
Average Nodes In Shell29.00
Average Hubs In Shell12.50
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell33.50

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)