CodeUJL
NameSEP-363856
SynonymsUlotaront; SEP-363856; SEP-856
Identifier1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine
FormulaC9 H13 N O S
Molecular Weight183.271
SMILESCNC[C@H]1c2c(ccs2)CCO1
PubChem89532783
Formal Charge0
Total Atoms25
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds5
Networks6
 missing image

This ligand is also present in the following 6 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JLK A Amine Trace amine receptors TA1 Mus Musclus Ulotaront - chim(NtGi1-Gs)/Beta1/Gamma2 3.22 2023-11-15 10.1038/s41586-023-06804-z

A 2D representation of the interactions of UJL in 8JLK
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D102 R:R:I75 5.6 1 No Yes 6 6 1 2
R:R:D102 R:R:Y291 11.49 1 No No 6 7 1 1
L:L:?1 R:R:D102 19.17 1 Yes No 0 6 0 1
R:R:I103 R:R:Y153 3.63 0 Yes No 4 4 1 2
R:R:A154 R:R:I103 3.25 0 No Yes 7 4 2 1
R:R:I103 R:R:I158 2.94 0 Yes Yes 4 5 1 2
L:L:?1 R:R:I103 17.28 1 Yes Yes 0 4 0 1
R:R:S106 R:R:W261 3.71 1 No Yes 6 7 1 1
L:L:?1 R:R:S106 9.09 1 Yes No 0 6 0 1
R:R:S107 R:R:Y153 3.82 0 No No 5 4 2 2
R:R:S107 R:R:S197 3.26 0 No Yes 5 5 2 1
R:R:P183 R:R:Y287 6.95 0 No No 4 5 2 1
R:R:F185 R:R:S189 6.61 1 Yes Yes 2 6 1 2
R:R:F185 R:R:G190 4.52 1 Yes No 2 5 1 2
R:R:A193 R:R:F185 4.16 0 No Yes 4 2 2 1
L:L:?1 R:R:F185 3.69 1 Yes Yes 0 2 0 1
R:R:G190 R:R:S189 3.71 1 No Yes 5 6 2 2
R:R:F194 R:R:F198 5.36 1 No Yes 5 7 2 2
R:R:F194 R:R:F265 8.57 1 No Yes 5 6 2 1
R:R:F265 R:R:S197 6.61 1 Yes Yes 6 5 1 1
L:L:?1 R:R:S197 3.03 1 Yes Yes 0 5 0 1
R:R:F198 R:R:W261 4.01 1 Yes Yes 7 7 2 1
R:R:F198 R:R:F265 13.93 1 Yes Yes 7 6 2 1
R:R:F264 R:R:W261 6.01 1 Yes Yes 6 7 1 1
R:R:F265 R:R:W261 5.01 1 Yes Yes 6 7 1 1
R:R:G290 R:R:W261 9.85 0 No Yes 6 7 2 1
R:R:N293 R:R:W261 9.04 0 No Yes 9 7 2 1
L:L:?1 R:R:W261 3.45 1 Yes Yes 0 7 0 1
R:R:F264 R:R:F265 15 1 Yes Yes 6 6 1 1
R:R:F264 R:R:T268 10.38 1 Yes No 6 4 1 2
R:R:F264 R:R:L286 7.31 1 Yes No 6 5 1 2
R:R:F264 R:R:Y287 4.13 1 Yes No 6 5 1 1
L:L:?1 R:R:F264 11.06 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F265 4.91 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y287 7.1 1 Yes No 0 5 0 1
R:R:W288 R:R:Y291 13.5 0 No No 5 7 2 1
L:L:?1 R:R:Y291 8.28 1 Yes No 0 7 0 1
R:R:I110 R:R:S197 1.55 0 No Yes 7 5 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.71
Average Nodes In Shell28.00
Average Hubs In Shell11.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JLO A Amine Trace amine receptors TA1 Homo Sapiens Ulotaront - Gs/Beta1/Gamma2 3.52 2023-11-15 10.1038/s41586-023-06804-z

A 2D representation of the interactions of UJL in 8JLO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D103 R:R:V76 2.92 3 No Yes 6 7 1 2
R:R:M77 R:R:W291 2.33 3 Yes Yes 7 4 2 2
R:R:M77 R:R:Y294 15.57 3 Yes Yes 7 7 2 1
R:R:S80 R:R:Y294 6.36 0 No Yes 6 7 2 1
R:R:I104 R:R:T100 3.04 3 Yes No 4 4 1 2
R:R:I159 R:R:T100 3.04 3 No No 6 4 2 2
R:R:T100 R:R:V184 4.76 3 No No 4 4 2 2
R:R:D103 R:R:Y294 5.75 3 No Yes 6 7 1 1
L:L:?1 R:R:D103 17.43 3 Yes No 0 6 0 1
R:R:A155 R:R:I104 3.25 0 No Yes 6 4 2 1
R:R:I104 R:R:I159 2.94 3 Yes No 4 6 1 2
L:L:?1 R:R:I104 15 3 Yes Yes 0 4 0 1
R:R:S107 R:R:W264 3.71 0 No Yes 6 8 1 2
L:L:?1 R:R:S107 12.27 3 Yes No 0 6 0 1
R:R:F154 R:R:M158 3.73 3 No Yes 4 5 2 2
R:R:F154 R:R:T194 2.59 3 No Yes 4 5 2 1
R:R:F186 R:R:M158 3.73 3 Yes Yes 1 5 1 2
R:R:M158 R:R:S190 4.6 3 Yes No 5 6 2 2
R:R:M158 R:R:T194 3.01 3 Yes Yes 5 5 2 1
R:R:F186 R:R:V184 3.93 3 Yes No 1 4 1 2
R:R:F186 R:R:S190 5.28 3 Yes No 1 6 1 2
R:R:F186 R:R:G191 3.01 3 Yes No 1 4 1 2
R:R:F186 R:R:T194 7.78 3 Yes Yes 1 5 1 1
L:L:?1 R:R:F186 2.84 3 Yes Yes 0 1 0 1
L:L:?1 R:R:T194 3.44 3 Yes Yes 0 5 0 1
R:R:F195 R:R:F199 2.14 3 Yes Yes 5 8 2 2
R:R:F195 R:R:F268 4.29 3 Yes Yes 5 7 2 1
R:R:F199 R:R:W264 4.01 3 Yes Yes 8 8 2 2
R:R:F199 R:R:F268 18.22 3 Yes Yes 8 7 2 1
R:R:F267 R:R:W264 2 0 Yes Yes 5 8 1 2
R:R:F268 R:R:W264 4.01 3 Yes Yes 7 8 1 2
R:R:F267 R:R:T271 5.19 0 Yes No 5 5 1 2
R:R:F267 R:R:L289 3.65 0 Yes No 5 5 1 2
R:R:F267 R:R:I290 3.77 0 Yes No 5 5 1 2
L:L:?1 R:R:F267 11.38 3 Yes Yes 0 5 0 1
L:L:?1 R:R:F268 7.11 3 Yes Yes 0 7 0 1
R:R:W291 R:R:Y294 14.47 3 Yes Yes 4 7 2 1
L:L:?1 R:R:Y294 5.47 3 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.37
Average Nodes In Shell27.00
Average Hubs In Shell14.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JSP A Amine 5-Hydroxytryptamine 5-HT1A Homo Sapiens Ulotaront - Gi1/Beta1/Gamma2 3.65 2023-11-15 10.1038/s41586-023-06804-z

A 2D representation of the interactions of UJL in 8JSP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D116 R:R:V89 7.3 5 No No 8 8 1 2
R:R:V89 R:R:Y390 2.52 5 No Yes 8 8 2 2
R:R:I113 R:R:I189 8.83 0 No No 7 6 2 1
R:R:D116 R:R:Y390 11.49 5 No Yes 8 8 1 2
L:L:?1 R:R:D116 6.4 5 Yes No 0 8 0 1
R:R:S168 R:R:V117 8.08 0 No No 8 8 2 1
L:L:?1 R:R:V117 3.51 5 Yes No 0 8 0 1
R:R:C120 R:R:W358 2.61 5 No Yes 7 8 1 1
R:R:C120 R:R:Y390 2.69 5 No Yes 7 8 1 2
L:L:?1 R:R:C120 9.35 5 Yes No 0 7 0 1
R:R:I167 R:R:T121 4.56 0 No No 8 8 2 1
R:R:A203 R:R:T121 3.36 5 No No 8 8 1 1
L:L:?1 R:R:T121 10.42 5 Yes No 0 8 0 1
R:R:I124 R:R:W358 8.22 0 No Yes 8 8 2 1
L:L:?1 R:R:I189 3.36 5 Yes No 0 6 0 1
R:R:S199 R:R:Y195 6.36 0 No No 8 8 1 2
L:L:?1 R:R:S199 8.85 5 Yes No 0 8 0 1
R:R:F362 R:R:T200 5.19 5 Yes No 7 7 1 2
L:L:?1 R:R:A203 3.71 5 Yes No 0 8 0 1
R:R:F204 R:R:W358 6.01 5 Yes Yes 8 8 2 1
R:R:F204 R:R:F362 10.72 5 Yes Yes 8 7 2 1
R:R:F362 R:R:W358 3.01 5 Yes Yes 7 8 1 1
R:R:G389 R:R:W358 8.44 0 No Yes 8 8 2 1
R:R:N392 R:R:W358 11.3 0 No Yes 9 8 2 1
L:L:?1 R:R:W358 4.03 5 Yes Yes 0 8 0 1
R:R:F361 R:R:F362 3.22 5 Yes Yes 8 7 1 1
R:R:F361 R:R:I385 5.02 5 Yes No 8 6 1 2
R:R:F361 R:R:N386 2.42 5 Yes No 8 7 1 2
L:L:?1 R:R:F361 15.79 5 Yes Yes 0 8 0 1
L:L:?1 R:R:F362 8.61 5 Yes Yes 0 7 0 1
R:R:A365 R:R:F361 1.39 0 No Yes 8 8 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.40
Average Nodes In Shell25.00
Average Hubs In Shell6.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8W88 A Amine Trace amine receptors TA1 Homo Sapiens SEP-363856 - Gs/Beta1/Gamma2 2.6 2023-11-22 10.1038/s41586-023-06775-1

A 2D representation of the interactions of UJL in 8W88
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L72 R:R:V76 4.47 2 Yes Yes 7 7 2 2
R:R:L72 R:R:Y294 5.86 2 Yes Yes 7 7 2 1
R:R:D103 R:R:V76 5.84 2 No Yes 6 7 1 2
R:R:V76 R:R:Y294 3.79 2 Yes Yes 7 7 2 1
R:R:M77 R:R:Y294 11.97 0 Yes Yes 7 7 2 1
R:R:S80 R:R:Y294 8.9 0 No Yes 6 7 2 1
R:R:T100 R:R:V184 6.35 0 No No 4 4 2 1
R:R:D103 R:R:Y294 6.9 2 No Yes 6 7 1 1
L:L:?1 R:R:D103 22.25 2 Yes No 0 6 0 1
R:R:A155 R:R:I104 3.25 0 No No 6 4 2 1
L:L:?1 R:R:I104 9.85 2 Yes No 0 4 0 1
R:R:S107 R:R:W264 4.94 2 No Yes 6 8 1 1
L:L:?1 R:R:S107 12.96 2 Yes No 0 6 0 1
R:R:F260 R:R:I111 3.77 2 Yes No 9 8 2 2
R:R:I111 R:R:W264 8.22 2 No Yes 8 8 2 1
R:R:F186 R:R:V184 5.24 2 Yes No 1 4 1 1
L:L:?1 R:R:V184 5.14 2 Yes No 0 4 0 1
R:R:F186 R:R:S190 6.61 2 Yes No 1 6 1 2
R:R:F186 R:R:G191 4.52 2 Yes No 1 4 1 2
R:R:F186 R:R:T194 9.08 2 Yes No 1 5 1 2
L:L:?1 R:R:F186 6.31 2 Yes Yes 0 1 0 1
R:R:F195 R:R:F199 6.43 2 Yes Yes 5 8 2 2
R:R:F195 R:R:F268 4.29 2 Yes Yes 5 7 2 1
R:R:F268 R:R:S198 3.96 2 Yes No 7 6 1 2
R:R:F199 R:R:F260 3.22 2 Yes Yes 8 9 2 2
R:R:F199 R:R:F268 21.43 2 Yes Yes 8 7 2 1
R:R:F260 R:R:W264 4.01 2 Yes Yes 9 8 2 1
R:R:F268 R:R:W264 9.02 2 Yes Yes 7 8 1 1
R:R:G293 R:R:W264 8.44 0 No Yes 7 8 2 1
R:R:N296 R:R:W264 14.69 0 No Yes 9 8 2 1
L:L:?1 R:R:W264 3.93 2 Yes Yes 0 8 0 1
R:R:F267 R:R:F268 6.43 2 Yes Yes 5 7 1 1
R:R:F267 R:R:T271 7.78 2 Yes No 5 5 1 2
R:R:F267 R:R:L289 3.65 2 Yes No 5 5 1 2
R:R:F267 R:R:I290 3.77 2 Yes Yes 5 5 1 1
L:L:?1 R:R:F267 17.87 2 Yes Yes 0 5 0 1
L:L:?1 R:R:F268 7.36 2 Yes Yes 0 7 0 1
R:R:I290 R:R:W291 5.87 2 Yes Yes 5 4 1 2
R:R:I290 R:R:Y294 4.84 2 Yes Yes 5 7 1 1
L:L:?1 R:R:I290 3.7 2 Yes Yes 0 5 0 1
R:R:W291 R:R:Y294 13.5 2 Yes Yes 4 7 2 1
L:L:?1 R:R:Y294 7.08 2 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.64
Average Nodes In Shell30.00
Average Hubs In Shell14.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8W8B A Amine 5-Hydroxytryptamine 5-HT1A Homo Sapiens SEP-363856 - Gi1/Beta1/Gamma2 3 2023-11-22 10.1038/s41586-023-06775-1

A 2D representation of the interactions of UJL in 8W8B
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D116 R:R:V89 7.3 6 Yes No 8 8 1 2
R:R:V89 R:R:Y390 3.79 6 No Yes 8 8 2 1
R:R:L90 R:R:Y390 7.03 0 Yes Yes 8 8 2 1
R:R:A93 R:R:Y390 4 0 No Yes 7 8 2 1
R:R:C120 R:R:D116 3.11 6 No Yes 7 8 1 1
R:R:D116 R:R:Y390 12.64 6 Yes Yes 8 8 1 1
L:L:?1 R:R:D116 17.73 6 Yes Yes 0 8 0 1
R:R:S168 R:R:V117 3.23 0 No No 8 8 2 1
L:L:?1 R:R:V117 11.12 6 Yes No 0 8 0 1
R:R:C120 R:R:W358 3.92 6 No Yes 7 8 1 1
L:L:?1 R:R:C120 11.85 6 Yes No 0 7 0 1
R:R:A203 R:R:T121 3.36 0 No No 8 8 1 2
R:R:I124 R:R:W358 9.4 0 No Yes 8 8 2 1
R:R:F362 R:R:T200 3.89 6 Yes Yes 7 7 1 2
L:L:?1 R:R:A203 2.94 6 Yes No 0 8 0 1
R:R:F204 R:R:W358 4.01 6 Yes Yes 8 8 2 1
R:R:F204 R:R:F362 19.29 6 Yes Yes 8 7 2 1
R:R:F361 R:R:W358 3.01 6 Yes Yes 8 8 1 1
R:R:F362 R:R:W358 7.02 6 Yes Yes 7 8 1 1
R:R:G389 R:R:W358 7.04 0 No Yes 8 8 2 1
R:R:N392 R:R:W358 13.56 0 No Yes 9 8 2 1
L:L:?1 R:R:W358 4.25 6 Yes Yes 0 8 0 1
R:R:F361 R:R:F362 6.43 6 Yes Yes 8 7 1 1
R:R:F361 R:R:I385 3.77 6 Yes No 8 6 1 2
L:L:?1 R:R:F361 19.32 6 Yes Yes 0 8 0 1
L:L:?1 R:R:F362 7.95 6 Yes Yes 0 7 0 1
R:R:N386 R:R:W387 3.39 6 No Yes 7 8 2 2
R:R:N386 R:R:Y390 8.14 6 No Yes 7 8 2 1
R:R:W387 R:R:Y390 7.72 6 Yes Yes 8 8 2 1
L:L:?1 R:R:Y390 10.94 6 Yes Yes 0 8 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.76
Average Nodes In Shell22.00
Average Hubs In Shell10.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WC3 A Amine Trace amine receptors TA1 Mus Musculus SEP-363856 - chim(NtGi1-Gs)/Beta1/Gamma2 3 2023-12-27 10.1016/j.cell.2023.10.014

A 2D representation of the interactions of UJL in 8WC3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I75 R:R:L71 5.71 0 No Yes 6 7 2 2
R:R:L71 R:R:M76 4.24 1 Yes Yes 7 7 2 2
R:R:L71 R:R:Y291 5.86 1 Yes Yes 7 7 2 1
R:R:D102 R:R:I75 5.6 1 No No 6 6 1 2
R:R:M76 R:R:Y291 3.59 1 Yes Yes 7 7 2 1
R:R:S79 R:R:Y291 7.63 0 No Yes 6 7 2 1
R:R:D102 R:R:Y291 11.49 1 No Yes 6 7 1 1
L:L:?1 R:R:D102 16.08 1 Yes No 0 6 0 1
R:R:I103 R:R:Y153 4.84 0 No No 4 4 1 2
R:R:A154 R:R:I103 3.25 0 No No 7 4 2 1
L:L:?1 R:R:I103 14.31 1 Yes No 0 4 0 1
L:L:?1 R:R:S106 8.21 1 Yes No 0 6 0 1
R:R:I110 R:R:W261 4.7 0 No Yes 7 7 2 1
R:R:P183 R:R:Y287 8.34 0 No No 4 5 2 1
R:R:F194 R:R:F265 7.5 0 No Yes 5 6 2 1
R:R:F198 R:R:W261 3.01 1 Yes Yes 7 7 2 1
R:R:F198 R:R:F265 15 1 Yes Yes 7 6 2 1
R:R:F264 R:R:W261 3.01 1 Yes Yes 6 7 1 1
R:R:F265 R:R:W261 3.01 1 Yes Yes 6 7 1 1
R:R:G290 R:R:W261 7.04 0 No Yes 6 7 2 1
R:R:N293 R:R:W261 12.43 0 No Yes 9 7 2 1
L:L:?1 R:R:W261 4.15 1 Yes Yes 0 7 0 1
R:R:F264 R:R:F265 5.36 1 Yes Yes 6 6 1 1
R:R:F264 R:R:T268 5.19 1 Yes No 6 4 1 2
R:R:F264 R:R:L286 4.87 1 Yes No 6 5 1 2
R:R:F264 R:R:Y287 12.38 1 Yes No 6 5 1 1
L:L:?1 R:R:F264 17.76 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F265 3.33 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y287 12.82 1 Yes No 0 5 0 1
R:R:W288 R:R:Y291 4.82 1 Yes Yes 5 7 2 1
L:L:?1 R:R:Y291 5.34 1 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub4.00
Average Interaction Strength10.25
Average Nodes In Shell24.00
Average Hubs In Shell9.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.36
Average Nodes In Shell26.00
Average Hubs In Shell10.67
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell31.67

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)