Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 3QAK | A | Nucleotide | Adenosine | A2A | Homo sapiens | UK-432097 | - | - | 2.71 | 2011-03-09 | 10.1126/science.1202793 |
![](/psngpcr/ligands/UKA/UKA_3QAK_L_L_1.png)
A 2D representation of the interactions of UKA in 3QAK colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:Y9 | 10.1 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:S67 | R:R:Y9 | 3.82 | 1 | No | Yes | 3 | 5 | 2 | 2 | R:R:Y271 | R:R:Y9 | 11.91 | 1 | Yes | Yes | 3 | 5 | 1 | 2 | R:R:I274 | R:R:Y9 | 6.04 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:E13 | R:R:I60 | 9.56 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:E13 | R:R:H278 | 11.08 | 1 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:H278 | R:R:I60 | 6.63 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:A63 | R:R:H278 | 2.93 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:I66 | R:R:V84 | 3.07 | 0 | No | No | 4 | 6 | 2 | 1 | R:R:F168 | R:R:I66 | 5.02 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:S67 | R:R:Y271 | 2.54 | 1 | No | Yes | 3 | 3 | 2 | 1 | R:R:G69 | R:R:L167 | 3.42 | 0 | No | Yes | 4 | 4 | 2 | 1 | L:L:?1 | R:R:V84 | 3.77 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F168 | R:R:L85 | 4.87 | 1 | Yes | No | 4 | 4 | 1 | 1 | R:R:L85 | R:R:M177 | 2.83 | 1 | No | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:L85 | 3.5 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:T88 | R:R:W246 | 3.64 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:T88 | 6.71 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F242 | R:R:I92 | 8.79 | 1 | Yes | No | 9 | 7 | 2 | 2 | R:R:I92 | R:R:W246 | 9.4 | 1 | No | Yes | 7 | 8 | 2 | 1 | R:R:E169 | R:R:L167 | 7.95 | 1 | No | Yes | 3 | 4 | 1 | 1 | R:R:D170 | R:R:L167 | 10.86 | 1 | No | Yes | 4 | 4 | 2 | 1 | L:L:?1 | R:R:L167 | 4.9 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F168 | R:R:V172 | 10.49 | 1 | Yes | Yes | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 7.46 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F168 | 36.97 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:D170 | R:R:E169 | 3.9 | 1 | No | No | 4 | 3 | 2 | 1 | L:L:?1 | R:R:E169 | 19.44 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:V172 | R:R:Y176 | 2.52 | 1 | Yes | Yes | 3 | 6 | 2 | 2 | R:R:M177 | R:R:V172 | 3.04 | 1 | Yes | Yes | 6 | 3 | 1 | 2 | R:R:M174 | R:R:N253 | 7.01 | 0 | No | Yes | 4 | 5 | 2 | 1 | R:R:M177 | R:R:Y176 | 5.99 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:N181 | R:R:Y176 | 11.63 | 1 | Yes | Yes | 5 | 6 | 2 | 2 | R:R:M177 | R:R:N181 | 7.01 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | R:R:M177 | R:R:N253 | 2.8 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:M177 | 2.86 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:H250 | R:R:N181 | 3.83 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | R:R:F182 | R:R:V186 | 3.93 | 1 | Yes | No | 5 | 7 | 2 | 2 | R:R:F182 | R:R:H250 | 13.58 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 4.15 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 11.02 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F242 | R:R:N280 | 7.25 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:H250 | R:R:W246 | 3.17 | 1 | Yes | Yes | 6 | 8 | 1 | 1 | R:R:S277 | R:R:W246 | 7.41 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:N280 | R:R:W246 | 5.65 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:S281 | R:R:W246 | 6.18 | 0 | No | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 9.8 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:H250 | R:R:L249 | 2.57 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | R:R:A273 | R:R:L249 | 3.15 | 0 | No | Yes | 6 | 5 | 2 | 1 | R:R:I274 | R:R:L249 | 2.85 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | R:R:L249 | R:R:S277 | 3 | 1 | Yes | Yes | 5 | 7 | 1 | 1 | L:L:?1 | R:R:L249 | 8.4 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:H250 | R:R:N253 | 2.55 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:H250 | 3.9 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:I252 | R:R:M270 | 2.92 | 0 | No | No | 5 | 4 | 2 | 1 | L:L:?1 | R:R:N253 | 9.03 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:T256 | 5.22 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:H264 | 6.5 | 1 | Yes | No | 0 | 2 | 0 | 1 | R:R:A265 | R:R:M270 | 3.22 | 0 | No | No | 4 | 4 | 2 | 1 | L:L:?1 | R:R:M270 | 12.16 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:Y271 | 10.08 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:I274 | R:R:S277 | 3.1 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | Yes | 6 | 4 | 1 | 1 | L:L:?1 | R:R:I274 | 10.11 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:H278 | R:R:S277 | 9.76 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:S277 | 3.8 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:H278 | 5.85 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:L267 | R:R:Y271 | 2.34 | 0 | No | Yes | 3 | 3 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 18.00 | Average Number Of Links With An Hub | 11.00 | Average Interaction Strength | 9.06 | Average Nodes In Shell | 41.00 | Average Hubs In Shell | 21.00 | Average Links In Shell | 68.00 | Average Links Mediated by Hubs In Shell | 64.00 |
| ![](/psngpcr/ligands/UKA/UKA_3QAK_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/UKA/UKA_3QAK_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5WF5 | A | Nucleotide | Adenosine | A2A | Homo sapiens | UK-432097 | - | - | 2.6 | 2018-02-21 | 10.1016/j.str.2017.12.013 |
![](/psngpcr/ligands/UKA/UKA_5WF5_L_L_1.png)
A 2D representation of the interactions of UKA in 5WF5 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:Y9 | 12.35 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:S67 | R:R:Y9 | 3.82 | 1 | No | Yes | 3 | 5 | 2 | 2 | R:R:Y271 | R:R:Y9 | 14.89 | 1 | Yes | Yes | 3 | 5 | 1 | 2 | R:R:I274 | R:R:Y9 | 6.04 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:E13 | R:R:I60 | 4.1 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:E13 | R:R:H278 | 12.31 | 1 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:H278 | R:R:I60 | 6.63 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:A63 | R:R:H278 | 2.93 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:F168 | R:R:I66 | 5.02 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:S67 | R:R:Y271 | 5.09 | 1 | No | Yes | 3 | 3 | 2 | 1 | R:R:G69 | R:R:L167 | 3.42 | 0 | No | Yes | 4 | 4 | 2 | 1 | R:R:A81 | R:R:F168 | 2.77 | 0 | No | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:V84 | 3.77 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F168 | R:R:L85 | 7.31 | 1 | Yes | No | 4 | 4 | 1 | 1 | R:R:L85 | R:R:M177 | 2.83 | 1 | No | Yes | 4 | 6 | 1 | 2 | L:L:?1 | R:R:L85 | 4.2 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:T88 | R:R:W246 | 4.85 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:T88 | 7.46 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F93 | R:R:Q89 | 3.51 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | R:R:Q89 | R:R:S132 | 2.89 | 1 | Yes | No | 5 | 7 | 1 | 2 | R:R:N181 | R:R:Q89 | 9.24 | 1 | No | Yes | 5 | 5 | 2 | 1 | R:R:C185 | R:R:Q89 | 6.1 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | L:L:?1 | R:R:Q89 | 4.04 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F242 | R:R:I92 | 8.79 | 1 | Yes | No | 9 | 7 | 2 | 2 | R:R:I92 | R:R:W246 | 7.05 | 1 | No | Yes | 7 | 8 | 2 | 1 | R:R:C185 | R:R:F93 | 4.19 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:E169 | R:R:L167 | 6.63 | 1 | No | Yes | 3 | 4 | 1 | 1 | R:R:D170 | R:R:L167 | 10.86 | 1 | No | Yes | 4 | 4 | 2 | 1 | L:L:?1 | R:R:L167 | 3.5 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F168 | R:R:V172 | 11.8 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 6.22 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | L:L:?1 | R:R:F168 | 34.51 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:D170 | R:R:E169 | 3.9 | 1 | No | No | 4 | 3 | 2 | 1 | L:L:?1 | R:R:E169 | 15.42 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:M177 | R:R:V172 | 3.04 | 1 | Yes | No | 6 | 3 | 2 | 2 | R:R:M174 | R:R:N253 | 8.41 | 1 | Yes | No | 4 | 5 | 1 | 1 | R:R:M174 | R:R:T256 | 4.52 | 1 | Yes | No | 4 | 4 | 1 | 1 | R:R:F257 | R:R:M174 | 4.98 | 1 | Yes | Yes | 3 | 4 | 2 | 1 | L:L:?1 | R:R:M174 | 2.86 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:M177 | R:R:N181 | 8.41 | 1 | Yes | No | 6 | 5 | 2 | 2 | R:R:M177 | R:R:N253 | 2.8 | 1 | Yes | No | 6 | 5 | 2 | 1 | R:R:F182 | R:R:V186 | 3.93 | 1 | Yes | No | 5 | 7 | 2 | 2 | R:R:F182 | R:R:H250 | 10.18 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 5.54 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 9.02 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F242 | R:R:N280 | 4.83 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:H250 | R:R:W246 | 4.23 | 1 | Yes | Yes | 6 | 8 | 1 | 1 | R:R:S277 | R:R:W246 | 7.41 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:N280 | R:R:W246 | 10.17 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 10.37 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:A273 | R:R:L249 | 3.15 | 0 | No | Yes | 6 | 5 | 2 | 1 | R:R:I274 | R:R:L249 | 2.85 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | R:R:L249 | R:R:S277 | 3 | 1 | Yes | Yes | 5 | 7 | 1 | 1 | L:L:?1 | R:R:L249 | 11.2 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 4.55 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:N253 | 9.03 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:T256 | 6.71 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:H264 | 9.11 | 1 | Yes | No | 0 | 2 | 0 | 1 | R:R:A265 | R:R:M270 | 3.22 | 0 | No | No | 4 | 4 | 2 | 1 | L:L:?1 | R:R:M270 | 8.58 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:Y271 | 7.71 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | Yes | 6 | 4 | 1 | 1 | L:L:?1 | R:R:I274 | 8.67 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:H278 | R:R:S277 | 6.97 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:S277 | 3.8 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:H278 | 5.2 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:L267 | R:R:Y271 | 2.34 | 0 | No | Yes | 3 | 3 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 19.00 | Average Number Of Links With An Hub | 11.00 | Average Interaction Strength | 8.46 | Average Nodes In Shell | 44.00 | Average Hubs In Shell | 22.00 | Average Links In Shell | 67.00 | Average Links Mediated by Hubs In Shell | 65.00 |
| ![](/psngpcr/ligands/UKA/UKA_5WF5_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/UKA/UKA_5WF5_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5WF6 | A | Nucleotide | Adenosine | A2A | Homo sapiens | UK-432097 | - | - | 2.9 | 2018-02-21 | 10.1016/j.str.2017.12.013 |
![](/psngpcr/ligands/UKA/UKA_5WF6_L_L_1.png)
A 2D representation of the interactions of UKA in 5WF6 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:Y9 | 13.47 | 1 | Yes | No | 6 | 5 | 2 | 2 | R:R:Y271 | R:R:Y9 | 13.9 | 0 | No | No | 3 | 5 | 1 | 2 | R:R:E13 | R:R:I60 | 6.83 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:E13 | R:R:H278 | 7.39 | 1 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:H278 | R:R:I60 | 5.3 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:A63 | R:R:H278 | 2.93 | 0 | No | Yes | 5 | 6 | 2 | 1 | L:L:?1 | R:R:T88 | 6.71 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:N181 | R:R:Q89 | 5.28 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:F242 | R:R:I92 | 5.02 | 1 | Yes | No | 9 | 7 | 2 | 2 | R:R:I92 | R:R:W246 | 5.87 | 1 | No | Yes | 7 | 8 | 2 | 1 | R:R:E169 | R:R:L167 | 11.93 | 1 | No | Yes | 3 | 4 | 1 | 1 | R:R:D170 | R:R:L167 | 9.5 | 1 | No | Yes | 4 | 4 | 2 | 1 | L:L:?1 | R:R:L167 | 5.6 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F168 | R:R:V172 | 11.8 | 1 | No | Yes | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 4.98 | 1 | No | Yes | 4 | 6 | 1 | 2 | L:L:?1 | R:R:F168 | 35.74 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:D170 | R:R:E169 | 3.9 | 1 | No | No | 4 | 3 | 2 | 1 | L:L:?1 | R:R:E169 | 20.11 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:M177 | R:R:V172 | 3.04 | 1 | Yes | Yes | 6 | 3 | 2 | 2 | R:R:M174 | R:R:N253 | 5.61 | 8 | No | No | 4 | 5 | 2 | 1 | R:R:M177 | R:R:Y176 | 3.59 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:N181 | R:R:Y176 | 5.81 | 1 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:M177 | R:R:N181 | 8.41 | 1 | Yes | Yes | 6 | 5 | 2 | 1 | L:L:?1 | R:R:N181 | 3.47 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F182 | R:R:H250 | 6.79 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 6.92 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 11.02 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F242 | R:R:N280 | 4.83 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:H250 | R:R:W246 | 6.35 | 1 | Yes | Yes | 6 | 8 | 1 | 1 | R:R:S277 | R:R:W246 | 7.41 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:N280 | R:R:W246 | 6.78 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 9.22 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:A273 | R:R:L249 | 3.15 | 0 | No | Yes | 6 | 5 | 2 | 1 | R:R:I274 | R:R:L249 | 7.14 | 1 | No | Yes | 4 | 5 | 1 | 1 | R:R:L249 | R:R:S277 | 3 | 1 | Yes | Yes | 5 | 7 | 1 | 1 | L:L:?1 | R:R:L249 | 11.2 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 3.25 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:I252 | R:R:M270 | 5.83 | 0 | No | No | 5 | 4 | 2 | 1 | L:L:?1 | R:R:N253 | 10.42 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:T256 | 5.22 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:H264 | 7.16 | 1 | Yes | No | 0 | 2 | 0 | 1 | L:L:?1 | R:R:M270 | 5.01 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:Y271 | 7.12 | 1 | Yes | No | 0 | 3 | 0 | 1 | L:L:?1 | R:R:I274 | 12.28 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:H278 | R:R:S277 | 6.97 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:S277 | 4.56 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:H278 | 6.5 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:L267 | R:R:Y271 | 2.34 | 0 | No | No | 3 | 3 | 2 | 1 | R:R:G69 | R:R:L167 | 1.71 | 0 | No | Yes | 4 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 16.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 9.60 | Average Nodes In Shell | 36.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 49.00 | Average Links Mediated by Hubs In Shell | 44.00 |
| ![](/psngpcr/ligands/UKA/UKA_5WF6_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/UKA/UKA_5WF6_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7EZC | A | Nucleotide | Adenosine | A2A | Homo sapiens | UKA | - | - | 3.8 | 2022-04-13 | 10.1107/S2052252522001907 |
![](/psngpcr/ligands/UKA/UKA_7EZC_L_L_1.png)
A 2D representation of the interactions of UKA in 7EZC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:Y9 | 8.98 | 0 | Yes | No | 6 | 5 | 2 | 2 | R:R:S67 | R:R:Y9 | 10.17 | 1 | No | No | 3 | 5 | 2 | 2 | R:R:Y271 | R:R:Y9 | 13.9 | 1 | Yes | No | 3 | 5 | 1 | 2 | R:R:E13 | R:R:H278 | 11.08 | 0 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:F168 | R:R:I66 | 5.02 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:S67 | R:R:Y271 | 3.82 | 1 | No | Yes | 3 | 3 | 2 | 1 | R:R:G69 | R:R:L167 | 3.42 | 0 | No | Yes | 4 | 4 | 2 | 1 | R:R:F168 | R:R:L85 | 6.09 | 1 | Yes | No | 4 | 4 | 1 | 1 | R:R:L85 | R:R:M177 | 4.24 | 1 | No | Yes | 4 | 6 | 1 | 2 | L:L:?1 | R:R:L85 | 4.2 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:T88 | R:R:W246 | 6.06 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:T88 | 8.95 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F242 | R:R:N92 | 10.87 | 1 | Yes | No | 9 | 7 | 2 | 2 | R:R:N92 | R:R:W246 | 15.82 | 1 | No | Yes | 7 | 8 | 2 | 1 | R:R:E169 | R:R:L167 | 5.3 | 1 | No | Yes | 3 | 4 | 1 | 1 | R:R:D170 | R:R:L167 | 8.14 | 0 | No | Yes | 4 | 4 | 2 | 1 | L:L:?1 | R:R:L167 | 5.6 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F168 | R:R:V172 | 13.11 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 7.46 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | L:L:?1 | R:R:F168 | 35.74 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?1 | R:R:E169 | 22.79 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:M174 | R:R:N253 | 7.01 | 0 | No | No | 4 | 5 | 2 | 1 | R:R:H250 | R:R:M177 | 3.94 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:M177 | R:R:N253 | 5.61 | 1 | Yes | No | 6 | 5 | 2 | 1 | R:R:F182 | R:R:V186 | 5.24 | 1 | Yes | No | 5 | 7 | 2 | 2 | R:R:F182 | R:R:H250 | 12.44 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:V186 | R:R:W246 | 6.13 | 1 | No | Yes | 7 | 8 | 2 | 1 | R:R:H250 | R:R:V186 | 6.92 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 13.03 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:H250 | R:R:W246 | 4.23 | 1 | Yes | Yes | 6 | 8 | 1 | 1 | R:R:S277 | R:R:W246 | 8.65 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:S281 | R:R:W246 | 3.71 | 0 | No | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 10.37 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:H250 | R:R:L249 | 6.43 | 1 | Yes | No | 6 | 5 | 1 | 1 | R:R:L249 | R:R:S277 | 9.01 | 1 | No | No | 5 | 7 | 1 | 2 | L:L:?1 | R:R:L249 | 11.9 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 3.9 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:I252 | R:R:M270 | 4.37 | 0 | No | No | 5 | 4 | 2 | 1 | L:L:?1 | R:R:N253 | 8.34 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:T256 | 5.97 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:H264 | 5.85 | 1 | Yes | No | 0 | 2 | 0 | 1 | L:L:?1 | R:R:M270 | 11.44 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:Y271 | 11.27 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | No | 6 | 4 | 1 | 1 | L:L:?1 | R:R:I274 | 10.11 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:H278 | 5.2 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:A63 | R:R:H278 | 2.93 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:L267 | R:R:Y271 | 2.34 | 0 | No | Yes | 3 | 3 | 2 | 1 | |
Statistics | Value |
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Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 10.78 | Average Nodes In Shell | 34.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 48.00 | Average Links Mediated by Hubs In Shell | 44.00 |
| ![](/psngpcr/ligands/UKA/UKA_7EZC_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/UKA/UKA_7EZC_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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