CodeUYI
NameAnamorelin
Synonyms
  • Anamorelin Hydrochloride
  • Anamorelin
Identifier
FormulaC31 H42 N6 O3
Molecular Weight546.704
SMILES
PubChem9828911
Formal Charge0
Total Atoms82
Total Chiral Atoms2
Total Bonds85
Total Aromatic Bonds16
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JSR A Peptide Ghrelin Ghrelin Homo Sapiens Anamorelin - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 2.9 2025-01-22 doi.org/10.1038/s41594-024-01481-6

A 2D representation of the interactions of UYI in 8JSR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D99 2.91 1 Yes Yes 0 6 0 1
L:L:?1 R:R:R102 13.04 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L103 5.94 1 Yes No 0 4 0 1
L:L:?1 R:R:Q120 11.43 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S123 7.52 1 Yes No 0 6 0 1
L:L:?1 R:R:E124 5.69 1 Yes Yes 0 4 0 1
L:L:?1 R:R:L181 3.96 1 Yes Yes 0 4 0 1
L:L:?1 R:R:L210 2.97 1 Yes No 0 3 0 1
L:L:?1 R:R:V214 3.2 1 Yes No 0 5 0 1
L:L:?1 R:R:R283 12.17 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F286 19.18 1 Yes No 0 4 0 1
L:L:?1 R:R:N305 8.85 1 Yes No 0 4 0 1
L:L:?1 R:R:F309 6.1 1 Yes Yes 0 5 0 1
R:R:C50 R:R:L100 6.35 1 No Yes 6 7 2 2
R:R:C50 R:R:F309 2.79 1 No Yes 6 5 2 1
R:R:D99 R:R:R102 8.34 1 Yes Yes 6 5 1 1
R:R:D99 R:R:F119 10.75 1 Yes Yes 6 4 1 2
R:R:D99 R:R:F309 4.78 1 Yes Yes 6 5 1 1
R:R:D99 R:R:Y313 5.75 1 Yes Yes 6 7 1 2
R:R:F309 R:R:L100 3.65 1 Yes Yes 5 7 1 2
R:R:F119 R:R:R102 6.41 1 Yes Yes 4 5 2 1
R:R:Q120 R:R:R102 8.18 1 Yes Yes 4 5 1 1
R:R:C198 R:R:R102 4.18 1 Yes Yes 9 5 2 1
R:R:F309 R:R:L103 4.87 1 Yes No 5 4 1 1
R:R:F119 R:R:Q120 4.68 1 Yes Yes 4 4 2 1
R:R:I178 R:R:Q120 4.12 1 No Yes 4 4 2 1
R:R:Q120 R:R:V182 8.6 1 Yes No 4 4 1 2
R:R:C198 R:R:Q120 3.05 1 Yes Yes 9 4 2 1
R:R:E124 R:R:Y128 15.71 1 Yes Yes 4 6 1 2
R:R:A175 R:R:E124 3.02 0 No Yes 7 4 2 1
R:R:E124 R:R:R283 10.47 1 Yes Yes 4 6 1 1
R:R:S217 R:R:Y128 3.82 0 No Yes 6 6 2 2
R:R:I178 R:R:V182 4.61 1 No No 4 4 2 2
R:R:A204 R:R:L181 3.15 1 No Yes 4 4 2 1
R:R:L181 R:R:L209 5.54 1 Yes Yes 4 4 1 2
R:R:L181 R:R:L210 4.15 1 Yes No 4 3 1 1
R:R:F286 R:R:P200 4.33 0 No No 4 4 1 2
R:R:A204 R:R:L209 3.15 1 No Yes 4 4 2 2
R:R:L210 R:R:S287 6.01 1 No No 3 4 1 2
R:R:S287 R:R:V214 3.23 0 No No 4 5 2 1
R:R:R283 R:R:S217 3.95 1 Yes No 6 6 1 2
R:R:F279 R:R:R283 16.03 1 Yes Yes 6 6 2 1
R:R:G282 R:R:N305 3.39 16 Yes No 4 4 2 1
R:R:F286 R:R:F290 8.57 0 No No 4 1 1 2
R:R:N305 R:R:S301 4.47 0 No No 4 4 1 2
R:R:F309 R:R:Y313 16.5 1 Yes Yes 5 7 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.92
Average Nodes In Shell32.00
Average Hubs In Shell16.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links12.50
Average Number Of Links With An Hub6.50
Average Interaction Strength8.13
Average Nodes In Shell31.50
Average Hubs In Shell16.00
Average Links In Shell44.50
Average Links Mediated by Hubs In Shell38.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)