CodeV6X
Name4-[3-methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy]furo[3,2-c]pyridine
SynonymsPF-6142
Identifier
FormulaC21 H16 N4 O2
Molecular Weight356.377
SMILES
PubChem75201901
Formal Charge0
Total Atoms43
Total Chiral Atoms0
Total Bonds47
Total Aromatic Bonds26
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JXS A Amine Dopamine D1 Homo sapiens PF-6142 - - 3 2024-09-04 doi.org/10.1016/j.neuron.2024.07.003

A 2D representation of the interactions of V6X in 8JXS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:K81 9.69 1 Yes Yes 0 6 0 1
L:L:?1 R:R:W99 9.56 1 Yes Yes 0 5 0 1
L:L:?1 R:R:V100 7.96 1 Yes No 0 5 0 1
L:L:?1 R:R:D103 4.14 1 Yes Yes 0 7 0 1
L:L:?1 R:R:I104 15.25 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S107 8.02 1 Yes No 0 7 0 1
L:L:?1 R:R:L190 14.79 1 Yes No 0 4 0 1
L:L:?1 R:R:S198 6.88 1 Yes No 0 7 0 1
L:L:?1 R:R:S202 5.73 1 Yes No 0 6 0 1
L:L:?1 R:R:F288 15.8 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F289 8.37 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F313 7.44 1 Yes No 0 4 0 1
R:R:D103 R:R:V77 7.3 1 Yes No 7 8 1 2
R:R:V77 R:R:W321 6.13 1 No Yes 8 7 2 2
R:R:W80 R:R:W99 5.62 0 No Yes 5 5 2 1
R:R:E85 R:R:K81 12.15 1 No Yes 4 6 2 1
R:R:K81 R:R:W99 5.8 1 Yes Yes 6 5 1 1
R:R:D314 R:R:K81 4.15 1 No Yes 4 6 2 1
R:R:K81 R:R:W321 4.64 1 Yes Yes 6 7 1 2
R:R:D314 R:R:E85 5.2 1 No No 4 4 2 2
R:R:W90 R:R:W99 6.56 1 Yes Yes 8 5 2 1
R:R:V100 R:R:W99 3.68 1 No Yes 5 5 1 1
R:R:D103 R:R:W99 3.35 1 Yes Yes 7 5 1 1
R:R:W321 R:R:W99 3.75 1 Yes Yes 7 5 2 1
R:R:I104 R:R:V100 3.07 1 Yes No 6 5 1 1
R:R:D103 R:R:S107 4.42 1 Yes No 7 7 1 1
R:R:D103 R:R:W321 11.17 1 Yes Yes 7 7 1 2
R:R:I104 R:R:S155 6.19 1 Yes No 6 7 1 2
R:R:I104 R:R:Y194 4.84 1 Yes Yes 6 7 1 2
R:R:S107 R:R:W285 4.94 1 No Yes 7 8 1 2
R:R:S202 R:R:T108 4.8 1 No Yes 6 6 1 2
R:R:L190 R:R:Y194 5.86 0 No Yes 4 7 1 2
R:R:F289 R:R:S199 5.28 1 Yes No 7 7 1 2
R:R:F289 R:R:S202 3.96 1 Yes No 7 6 1 1
R:R:F203 R:R:W285 4.01 1 Yes Yes 8 8 2 2
R:R:F203 R:R:F289 21.43 1 Yes Yes 8 7 2 1
R:R:F288 R:R:W285 3.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 9.02 1 Yes Yes 7 8 1 2
R:R:F288 R:R:F289 11.79 1 Yes Yes 7 7 1 1
R:R:F288 R:R:F313 7.5 1 Yes No 7 4 1 1
R:R:F288 R:R:V317 9.18 1 Yes No 7 6 1 2
R:R:F313 R:R:L291 3.65 1 No No 4 5 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.47
Average Nodes In Shell27.00
Average Hubs In Shell13.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.47
Average Nodes In Shell27.00
Average Hubs In Shell13.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell40.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)