CodeVFP
Name6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione
Synonyms
Identifier6-(4-furo[3,2-c]pyridin-4-yloxy-2-methyl-phenyl)-1,5-dimethyl-pyrimidine-2,4-dione
FormulaC20 H17 N3 O4
Molecular Weight363.367
SMILESCc1cc(ccc1C2=C(C(=O)NC(=O)N2C)C)Oc3c4ccoc4ccn3
PubChem75202022
Formal Charge0
Total Atoms44
Total Chiral Atoms0
Total Bonds47
Total Aromatic Bonds16
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7JOZ A Amine Dopamine D1 Homo sapiens VFP - Gs/Beta1/Gamma2 3.8 2021-04-14 10.1038/s41467-021-23519-9

A 2D representation of the interactions of VFP in 7JOZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D103 R:R:V77 7.3 2 No Yes 7 8 1 2
R:R:V77 R:R:W321 3.68 2 Yes Yes 8 7 2 2
R:R:I104 R:R:V100 3.07 2 Yes No 6 5 1 1
R:R:S162 R:R:V100 3.23 0 No No 5 5 2 1
L:L:?1 R:R:V100 3.94 2 Yes No 0 5 0 1
R:R:D103 R:R:W321 15.63 2 No Yes 7 7 1 2
L:L:?1 R:R:D103 7.18 2 Yes No 0 7 0 1
R:R:I104 R:R:S155 3.1 2 Yes No 6 7 1 2
R:R:I104 R:R:Y194 6.04 2 Yes Yes 6 7 1 2
L:L:?1 R:R:I104 11.32 2 Yes Yes 0 6 0 1
L:L:?1 R:R:S107 9.26 2 Yes No 0 7 0 1
R:R:S202 R:R:T108 6.4 0 No Yes 6 6 1 2
R:R:I154 R:R:S198 3.1 0 No No 5 7 2 1
R:R:L190 R:R:Y194 3.52 0 No Yes 4 7 1 2
L:L:?1 R:R:L190 4.88 2 Yes No 0 4 0 1
R:R:S198 R:R:Y194 2.54 0 No Yes 7 7 1 2
L:L:?1 R:R:S198 6.62 2 Yes No 0 7 0 1
R:R:F289 R:R:S199 5.28 2 Yes No 7 7 1 2
L:L:?1 R:R:S202 3.97 2 Yes No 0 6 0 1
R:R:F203 R:R:F289 30.01 0 Yes Yes 8 7 2 1
R:R:F288 R:R:W285 4.01 2 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 3.01 2 Yes Yes 7 8 1 2
R:R:W285 R:R:W321 2.81 2 Yes Yes 8 7 2 2
R:R:F288 R:R:F289 7.5 2 Yes Yes 7 7 1 1
R:R:F288 R:R:V317 5.24 2 Yes Yes 7 6 1 2
L:L:?1 R:R:F288 13.96 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F289 9.66 2 Yes Yes 0 7 0 1
R:R:F313 R:R:N292 6.04 0 Yes No 4 6 2 1
L:L:?1 R:R:N292 3.63 2 Yes No 0 6 0 1
R:R:F313 R:R:V317 2.62 0 Yes Yes 4 6 2 2
R:R:V317 R:R:W321 8.58 0 Yes Yes 6 7 2 2
R:R:A195 R:R:L190 1.58 0 No No 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.44
Average Nodes In Shell24.00
Average Hubs In Shell12.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.44
Average Nodes In Shell24.00
Average Hubs In Shell12.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell29.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)