CodeVFP
Name6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione
Synonyms
Identifier
FormulaC20 H17 N3 O4
Molecular Weight363.367
SMILES
PubChem75202022
Formal Charge0
Total Atoms44
Total Chiral Atoms0
Total Bonds47
Total Aromatic Bonds16
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7JOZ A Amine Dopamine D1 Homo Sapiens VFP - Gs/Beta1/Gamma2 3.8 2021-04-14 10.1038/s41467-021-23519-9

A 2D representation of the interactions of VFP in 7JOZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:V100 3.94 2 Yes No 0 5 0 1
L:L:?1 R:R:D103 7.18 2 Yes No 0 7 0 1
L:L:?1 R:R:I104 11.32 2 Yes Yes 0 6 0 1
L:L:?1 R:R:S107 9.26 2 Yes No 0 7 0 1
L:L:?1 R:R:L190 4.88 2 Yes No 0 4 0 1
L:L:?1 R:R:S198 6.62 2 Yes No 0 7 0 1
L:L:?1 R:R:S202 3.97 2 Yes No 0 6 0 1
L:L:?1 R:R:F288 13.96 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F289 9.66 2 Yes Yes 0 7 0 1
L:L:?1 R:R:N292 3.63 2 Yes No 0 6 0 1
R:R:D103 R:R:V77 7.3 2 No Yes 7 8 1 2
R:R:V77 R:R:W321 3.68 2 Yes Yes 8 7 2 2
R:R:I104 R:R:V100 3.07 2 Yes No 6 5 1 1
R:R:S162 R:R:V100 3.23 0 No No 5 5 2 1
R:R:D103 R:R:W321 15.63 2 No Yes 7 7 1 2
R:R:I104 R:R:S155 3.1 2 Yes No 6 7 1 2
R:R:I104 R:R:Y194 6.04 2 Yes Yes 6 7 1 2
R:R:S202 R:R:T108 6.4 0 No Yes 6 6 1 2
R:R:I154 R:R:S198 3.1 0 No No 5 7 2 1
R:R:L190 R:R:Y194 3.52 0 No Yes 4 7 1 2
R:R:S198 R:R:Y194 2.54 0 No Yes 7 7 1 2
R:R:F289 R:R:S199 5.28 2 Yes No 7 7 1 2
R:R:F203 R:R:F289 30.01 0 Yes Yes 8 7 2 1
R:R:F288 R:R:W285 4.01 2 Yes Yes 7 8 1 2
R:R:F289 R:R:W285 3.01 2 Yes Yes 7 8 1 2
R:R:W285 R:R:W321 2.81 2 Yes Yes 8 7 2 2
R:R:F288 R:R:F289 7.5 2 Yes Yes 7 7 1 1
R:R:F288 R:R:V317 5.24 2 Yes Yes 7 6 1 2
R:R:F313 R:R:N292 6.04 0 Yes No 4 6 2 1
R:R:F313 R:R:V317 2.62 0 Yes Yes 4 6 2 2
R:R:V317 R:R:W321 8.58 0 Yes Yes 6 7 2 2
R:R:A195 R:R:L190 1.58 0 No No 5 4 2 1
R:R:D187 R:R:S310 1.47 0 No No 5 1 1 2
L:L:?1 R:R:D187 1.2 2 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.87
Average Nodes In Shell26.00
Average Hubs In Shell12.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.87
Average Nodes In Shell26.00
Average Hubs In Shell11.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell28.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)