CodeVSN
Name5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine
Synonyms
Identifier
FormulaC10 H15 N5 O10 P2 S
Molecular Weight459.266
SMILES
PubChem6858270
Formal Charge0
Total Atoms43
Total Chiral Atoms4
Total Bonds45
Total Aromatic Bonds5
Networks6
 missing image

This ligand is also present in the following 6 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9PXW A Peptide Opioid MOP Homo Sapiens Naloxone GDPbetaS Gi1/Beta1/Gamma2 3.8 2025-11-12 10.1038/s41586-025-09677-6

A 2D representation of the interactions of VSN in 9PXW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:E43 A:A:R178 6.98 0 No Yes 9 9 2 1
A:A:K46 A:A:S44 4.59 3 Yes No 9 9 1 2
A:A:C224 A:A:S44 3.44 3 No No 7 9 2 2
A:A:G45 A:A:T48 3.64 3 No Yes 9 9 1 1
A:A:G45 O:O:?1 6.39 3 No Yes 9 0 1 0
A:A:D200 A:A:K46 12.44 3 No Yes 9 9 2 1
A:A:G202 A:A:K46 3.49 3 No Yes 9 9 2 1
A:A:C224 A:A:K46 3.23 3 No Yes 7 9 2 1
A:A:K46 O:O:?1 13.16 3 Yes Yes 9 0 1 0
A:A:K51 A:A:S47 4.59 0 No No 9 9 2 1
A:A:S47 O:O:?1 3.74 0 No Yes 9 0 1 0
A:A:L175 A:A:T48 2.95 3 Yes Yes 8 9 2 1
A:A:A326 A:A:T48 3.36 3 Yes Yes 9 9 1 1
A:A:T48 O:O:?1 11.01 3 Yes Yes 9 0 1 0
A:A:A326 A:A:I49 3.25 3 Yes Yes 9 7 1 2
A:A:N76 A:A:R178 3.62 9 Yes Yes 9 9 2 1
A:A:N149 A:A:R178 4.82 0 No Yes 6 9 2 1
A:A:D150 A:A:K270 12.44 3 No Yes 8 9 1 1
A:A:D150 A:A:L273 4.07 3 No Yes 8 6 1 1
A:A:D150 O:O:?1 10.14 3 No Yes 8 0 1 0
A:A:R176 A:A:S151 3.95 3 Yes No 6 8 1 1
A:A:S151 O:O:?1 7.48 3 No Yes 8 0 1 0
A:A:Q172 A:A:Y154 3.38 0 No Yes 6 9 2 2
A:A:R176 A:A:Y154 17.49 3 Yes Yes 6 9 1 2
A:A:L175 A:A:Q172 3.99 3 Yes No 8 6 2 2
A:A:Q172 A:A:T327 2.83 0 No No 6 8 2 1
A:A:R176 A:A:T327 15.52 3 Yes No 6 8 1 1
A:A:R176 O:O:?1 9.83 3 Yes Yes 6 0 1 0
A:A:R178 O:O:?1 9.83 0 Yes Yes 9 0 1 0
A:A:D200 A:A:G202 5.03 3 No No 9 9 2 2
A:A:A226 A:A:K270 3.21 0 No Yes 8 9 2 1
A:A:N269 A:A:T324 5.85 3 No Yes 9 9 1 2
A:A:A326 A:A:N269 4.69 3 Yes No 9 9 1 1
A:A:N269 O:O:?1 4.27 3 No Yes 9 0 1 0
A:A:K270 O:O:?1 23.7 3 Yes Yes 9 0 1 0
A:A:D272 A:A:L273 4.07 3 No Yes 9 6 1 1
A:A:C325 A:A:D272 7.78 3 No No 7 9 1 1
A:A:D272 O:O:?1 7.6 3 No Yes 9 0 1 0
A:A:E276 A:A:L273 3.98 0 No Yes 5 6 2 1
A:A:L273 O:O:?1 6.03 3 Yes Yes 6 0 1 0
A:A:C325 A:A:D328 3.11 3 No No 7 9 1 2
A:A:C325 O:O:?1 3.95 3 No Yes 7 0 1 0
A:A:A326 O:O:?1 3.92 3 Yes Yes 9 0 1 0
A:A:T327 O:O:?1 11.93 3 No Yes 8 0 1 0
A:A:K270 A:A:S228 1.53 3 Yes No 9 9 1 2
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.87
Average Nodes In Shell33.00
Average Hubs In Shell13.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9PXX A Peptide Opioid MOP Homo Sapiens Naloxone GDPbetaS Gi1/Beta1/Gamma2 3.1 2025-11-12 10.1038/s41586-025-09677-6

A 2D representation of the interactions of VSN in 9PXX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K46 A:A:L38 4.23 0 Yes No 9 8 1 2
A:A:E43 A:A:R242 9.3 0 No Yes 9 9 1 2
A:A:E43 O:O:?1 4.12 0 No Yes 9 0 1 0
A:A:D200 A:A:K46 6.91 0 No Yes 9 9 2 1
A:A:K46 O:O:?1 7.02 0 Yes Yes 9 0 1 0
A:A:S47 O:O:?1 9.35 0 No Yes 9 0 1 0
A:A:T48 O:O:?1 13.76 0 No Yes 9 0 1 0
A:A:A226 A:A:K270 3.21 0 No No 8 9 2 1
A:A:K270 A:A:S228 6.12 0 No No 9 9 1 2
A:A:L273 A:A:S228 6.01 0 No No 6 9 1 2
A:A:N269 A:A:T324 2.92 0 No Yes 9 9 1 2
A:A:N269 O:O:?1 5.13 0 No Yes 9 0 1 0
A:A:K270 O:O:?1 17.55 0 No Yes 9 0 1 0
A:A:L273 O:O:?1 8.61 0 No Yes 6 0 1 0
A:A:G202 A:A:K46 1.74 0 No Yes 9 9 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub1.00
Average Interaction Strength9.36
Average Nodes In Shell15.00
Average Hubs In Shell4.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell12.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9PXY A Peptide Opioid MOP Homo Sapiens Naloxone GDPbetaS Gi1/Beta1/Gamma2 3 2025-11-12 10.1038/s41586-025-09677-6

A 2D representation of the interactions of VSN in 9PXY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K46 A:A:L38 9.87 0 Yes No 9 8 1 2
A:A:G40 A:A:K46 6.97 0 No Yes 9 9 2 1
A:A:E43 A:A:R242 5.82 0 No Yes 9 9 1 2
A:A:E43 O:O:?1 3.3 0 No Yes 9 0 1 0
A:A:G45 A:A:N269 3.39 13 No No 9 9 1 1
A:A:G45 O:O:?1 3.19 13 No Yes 9 0 1 0
A:A:D200 A:A:K46 5.53 0 No Yes 9 9 2 1
A:A:K46 O:O:?1 6.14 0 Yes Yes 9 0 1 0
A:A:K51 A:A:S47 4.59 0 No No 9 9 2 1
A:A:S47 O:O:?1 3.74 0 No Yes 9 0 1 0
A:A:T48 O:O:?1 7.34 0 No Yes 9 0 1 0
A:A:A226 A:A:K270 8.03 0 No Yes 8 9 2 1
A:A:K270 A:A:S228 9.18 13 Yes No 9 9 1 2
A:A:L273 A:A:S228 9.01 13 No No 6 9 2 2
A:A:N269 O:O:?1 3.42 13 No Yes 9 0 1 0
A:A:K270 A:A:L273 4.23 13 Yes No 9 6 1 2
A:A:K270 O:O:?1 7.9 13 Yes Yes 9 0 1 0
A:A:C325 A:A:D272 6.22 0 No No 7 9 2 1
A:A:D272 O:O:?1 5.07 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.01
Average Nodes In Shell18.00
Average Hubs In Shell4.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9PY2 A Peptide Opioid MOP Homo Sapiens Loperamide GDPbetaS Gi1/Beta1/Gamma2 3.16 2025-11-12 10.1038/s41586-025-09677-6

A 2D representation of the interactions of VSN in 9PY2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K46 A:A:S44 4.59 1 Yes No 9 9 1 2
A:A:C224 A:A:S44 3.44 1 No No 7 9 2 2
A:A:G45 O:O:?1 6.39 0 No Yes 9 0 1 0
A:A:D200 A:A:K46 4.15 0 No Yes 9 9 2 1
A:A:C224 A:A:K46 4.85 1 No Yes 7 9 2 1
A:A:K46 O:O:?1 7.02 1 Yes Yes 9 0 1 0
A:A:K51 A:A:S47 6.12 1 No No 9 9 2 1
A:A:R178 A:A:S47 10.54 1 Yes No 9 9 1 1
A:A:S47 O:O:?1 3.74 1 No Yes 9 0 1 0
A:A:T48 O:O:?1 11.93 0 No Yes 9 0 1 0
A:A:D150 A:A:K270 6.91 1 No Yes 8 9 2 1
A:A:D150 A:A:L273 5.43 1 No Yes 8 6 2 2
A:A:S151 A:A:Y155 6.36 1 No Yes 8 7 1 2
A:A:R176 A:A:S151 7.91 1 Yes No 6 8 1 1
A:A:S151 O:O:?1 7.48 1 No Yes 8 0 1 0
A:A:Q172 A:A:Y154 6.76 1 No No 6 9 2 2
A:A:R176 A:A:Y154 8.23 1 Yes No 6 9 1 2
A:A:Q172 A:A:R176 11.68 1 No Yes 6 6 2 1
A:A:R176 O:O:?1 9.07 1 Yes Yes 6 0 1 0
A:A:D200 A:A:R178 4.76 0 No Yes 9 9 2 1
A:A:G202 A:A:R178 4.5 0 No Yes 9 9 2 1
A:A:R178 O:O:?1 11.34 1 Yes Yes 9 0 1 0
A:A:K270 A:A:S228 4.59 1 Yes No 9 9 1 2
A:A:L273 A:A:S228 6.01 1 Yes No 6 9 2 2
A:A:K270 A:A:L273 5.64 1 Yes Yes 9 6 1 2
A:A:K270 O:O:?1 16.68 1 Yes Yes 9 0 1 0
A:A:D272 A:A:L273 8.14 0 No Yes 9 6 1 2
A:A:C325 A:A:D272 6.22 0 No No 7 9 2 1
A:A:D272 O:O:?1 9.29 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.22
Average Nodes In Shell22.00
Average Hubs In Shell7.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9PY3 A Peptide Opioid MOP Homo Sapiens Loperamide GDPbetaS Gi1/Beta1/Gamma2 3.2 2025-11-12 To be published

A 2D representation of the interactions of VSN in 9PY3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K46 A:A:L38 5.64 17 No No 9 8 1 2
A:A:D200 A:A:L38 5.43 17 No No 9 8 2 2
A:A:G42 O:O:?1 4.26 0 No Yes 8 0 1 0
A:A:G45 A:A:T48 3.64 0 No No 9 9 2 1
A:A:D200 A:A:K46 5.53 17 No No 9 9 2 1
A:A:K46 O:O:?1 10.53 17 No Yes 9 0 1 0
A:A:S47 O:O:?1 5.61 0 No Yes 9 0 1 0
A:A:T48 O:O:?1 9.17 0 No Yes 9 0 1 0
A:A:A226 A:A:K270 4.82 0 No Yes 8 9 2 1
A:A:K270 A:A:S228 6.12 11 Yes No 9 9 1 2
A:A:L273 A:A:S228 7.51 11 No No 6 9 2 2
A:A:K270 A:A:L273 7.05 11 Yes No 9 6 1 2
A:A:K270 O:O:?1 15.8 11 Yes Yes 9 0 1 0
A:A:D272 A:A:E276 6.5 0 No No 9 5 1 2
A:A:D272 O:O:?1 5.07 0 No Yes 9 0 1 0
A:A:E43 O:O:?1 2.47 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub1.00
Average Interaction Strength7.56
Average Nodes In Shell15.00
Average Hubs In Shell2.00
Average Links In Shell16.00
Average Links Mediated by Hubs In Shell10.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9PY4 A Peptide Opioid MOP Homo Sapiens Loperamide GDPbetaS Gi1/Beta1/Gamma2 2.78 2025-11-12 10.1038/s41586-025-09677-6

A 2D representation of the interactions of VSN in 9PY4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K46 A:A:L38 8.46 8 Yes No 9 8 1 2
A:A:D200 A:A:L38 5.43 8 No No 9 8 2 2
A:A:G40 A:A:K46 3.49 0 No Yes 9 9 2 1
A:A:E43 O:O:?1 3.3 0 No Yes 9 0 1 0
A:A:D200 A:A:K46 5.53 8 No Yes 9 9 2 1
A:A:C224 A:A:K46 4.85 8 Yes Yes 7 9 2 1
A:A:K46 O:O:?1 11.41 8 Yes Yes 9 0 1 0
A:A:S47 O:O:?1 5.61 0 No Yes 9 0 1 0
A:A:T48 O:O:?1 9.17 0 No Yes 9 0 1 0
A:A:A226 A:A:K270 4.82 0 No Yes 8 9 2 1
A:A:K270 A:A:S228 6.12 5 Yes No 9 9 1 2
A:A:L273 A:A:S228 7.51 5 No No 6 9 2 2
A:A:K270 A:A:L273 8.46 5 Yes No 9 6 1 2
A:A:K270 O:O:?1 12.29 5 Yes Yes 9 0 1 0
A:A:C325 A:A:D272 4.67 0 No No 7 9 1 2
A:A:C325 O:O:?1 5.93 0 No Yes 7 0 1 0
A:A:G42 O:O:?1 2.13 0 No Yes 8 0 1 0
A:A:A41 A:A:G42 1.95 0 No No 7 8 2 1
A:A:S44 O:O:?1 1.87 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.46
Average Nodes In Shell18.00
Average Hubs In Shell4.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.83
Average Interaction Strength7.75
Average Nodes In Shell20.17
Average Hubs In Shell5.67
Average Links In Shell23.83
Average Links Mediated by Hubs In Shell19.33

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)